Distribution of markers of hepatitis C virus infection throughout the body

Seminars in Liver Disease

Volumn 20, Issue 1, 2000, Pages 85-102

  Gowans, Eric J ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Extrahepatic sites; Hepatitis C virus; Intracellular replication markers

Indexed keywords

VIRUS PROTEIN; VIRUS RNA;

ARTICLE; DISEASE MARKER; GENE AMPLIFICATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RNA ANALYSIS; VIRUS REPLICATION;

ANTIGEN-ANTIBODY COMPLEX; BIOLOGICAL MARKERS; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HEPATITIS C ANTIGENS; HUMANS; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 0033934875     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (98)

1. Agnello V, Abel G, Knight GB, Muchmore E. Detection of widespread hepatocyte infection in chronic hepatitis C. Hepatology 1998;28:573-584
2. Lanford RE, Cahvez D, Chisari FV, Sureau C. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J Virol 1995;69: 8079-8083
3. Burleson FG, Chambers TM, Wiedbrauk DL. Virology: A Laboratory Manual. San Diego: Academic Press:
4. White DO, Fenner FJ. Viral Replication in Medical Virology, 4th ed. San Diego: Academic Press, 1994
5. Gong Y, Trowbridge R, Macnaughton TB, Westaway EG, Shannon AD, Gowans EJ. Characterisation of RNA synthesis during a one-step growth curve and of the replication mechanism of bovine viral diarrhea virus. J Gen Virol 1996;77:2729-2236
6. Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, Perelson AS. Hepatitis C viral dyanamics in vivo and the antiviral effect of interferon-alfa therapy. Science 1998;282: 103-107
7. Choo Q-L, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989;244: 359-362
8. Kolykhalov AA, Agapov EV, Blight KJ, Mihalik K, Feinstone SM, Rice CM. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 1997;277:570-574
9. Negro F, Krawczynski K, Quadri R, Rubbia-Brandt L, Mondelli M, Zarski J-P, Hadengue A. Detection of genomic- and minus-strand of hepatitis C virus RNA in the liver of chronic hepatitis C patients by strand-specific semiquantitative reverse-transcriptase polymerase chain reaction. Hepatology 1999;29:536-542
10. Nakamoto Y, Kaneko S, Honda M, Unoura M, Cheong J, Harada A, Matsushima K, Kobayashi K, Murakami S. Detection of the putative E2 protein of hepatitis C virus in human liver. J Med Virol 1994;42:374-379
11. Tsutsumi M, Urashima S, Takada A, Date T, Tanaka Y. Detection of antigens related to hepatitis C virus RNA encoding the NS5 region in the livers of patients with chronic type C hepatitis. Hepatology 1994;19:265-272
12. Blight KJ, Gowans EJ. In situ hybridization and immunohistochemical staining of hepatitis C virus products. Viral Hepat Rev 1995;1:143-155
13. Lau JYN, Krawczynski K, Negro F, Gonzalez-Peralta RP. In situ detection of hepatitis C virus - a critical review. J Hepatol 1996; 24(Suppl 2):43-51
14. Scheuer PJ, Krawczynski K, Dhillon AP. Histopathology and detection of hepatitis C virus in liver. Semin Immunopathol 1997;19:27-45
15. Negro F. Detection of hepatitis C virus RNA in liver tissue: an overview. Ital J Gastroenterol Hepatol 1998;30:205-210
16. Brahic M, Haase AT. Detection of viral sequences of low reiteration frequency by in situ hybridization. Proc Natl Acad Sci USA 1978;75:6125-6129
17. Gerhardt GS, Kawasaki ES, Bancroft FC, Szabo P. Localization of a unique gene by direct hybridization in situ. Proc Natl Acad Sci USA 1981;78:3755-3759
18. Gowans EJ, Jilbert AR, Burrell CJ. Detection of specific DNA and RNA sequences in tissues and cells by in situ hybridization. In: RH Symons, ed. Nucleic Acid Probes. Boca Raton, FL: CRC Press, 1989; pp. 139-158
19. Khromykh AA, Westaway EG. Subgenomic replicons of the Flavivirus Kunjin: construction and applications. J Virol 1997;71: 1497-1505
20. Honda M, Rijnbrand R, Abell G, Kim D, Lemon SM. Natural variation in translational activities of the 5′nontranslated RNAs of hepatitis C virus genotypes 1a and 1b: evidence for a long-range RNA-RNA interaction outside of the internal ribosome entry site. J Virol 1999;73:4941-4951
21. Wang C, Le SY, Ali N, Siddiqui A. An RNA pseudoknot is an essential structural element of the internal ribosome entry site located with the hepatitis C virus 5′noncoding region. RNA 1995;1:526-537
22. Lau JYN, Davis GL. Detection of hepatitis C virus RNA genome in liver tissue by non-isotopic in situ hybridization. J Med Virol 1994;42: 268-271
23. Lamas E, Baccarini P, Housset C, Kremsdorf D, Brechet C. Detection of hepatitis C virus (HCV) RNA sequences in liver tissue by in situ hybridization. J Hepatol 1992;16:219-223
24. Tanaka Y, Enomoto N, Kojima S, Tang L, Goto M, Marumo F, Sato C. Detection of hepatitis C virus RNA in the liver by in situ hybridization. Liver 1993;13:203-208
25. Yamada G, Nishimoto H, Endou H, et al. Localization of hepatitis C viral RNA and capsid protein in human liver. Dig Dis Sci 1993;38:882-887
26. Gastaldi M, Massacrier A, Planells R, et al. Detection by in situ hybridization of hepatitis C virus positive and negative RNA strands using digoxigenin-labeled cRNA probes in human liver cells. J Hepatol 1995;23:509-518
27. Blight K, Trowbridge R, Rowland R, Gowans E. Detection of hepatitis C virus RNA by in situ hybridization. Liver 1992;12: 286-289
28. Komminoth P, Adams V, Long AA, Roth J, Saremaslani P, Flury R, Schmid M, Heitz PhU. Evaluation of methods for hepatitis C virus detection in archival liver biopsies. Path Res Pract 1994; 190:1017-1025
29. Nouri Aria KT, Sallie R, Sangar D, Alexander GJM, Smith H, Byrne J, Portmann B, Eddleston ALWF, Williams R. Detection of genomic and intermediate replicative strands of hepatitis C virus in liver tissue by in situ hybridization. J Clin Invest 1993; 91:2226-2234
30. Loriot M-A, Bronowicki J-P, Lagorce D, et al. Permissiveness of human biliary epithelial cells to infection by hepatitis C virus. Hepatology 1999;29:1587-1595
31. Endo H, Yamada G, Nakane PK, Tsuji T. Localization of hepatitis C virus RNA in human liver biopsies by in situ hybridization using thymine-thymine dimerized oligo DNA probes: improved method. Acta Med Okayama 1992;46:355-364
32. Haruna Y, Hayashi N, Hiramatsu N, Takehara T, Hagiwara H, Sasaki Y, Kasahara A, Fusamoto H, Kamada T. Detection of hepatitis C virus RNA in liver tissues by an in situ hybridization technique. J Hepatol 1993;18:96-100
33. Negro F, Pacchioni D, Shimizu Y, Miller RH, Bussolati G, Purcell RH, Bonino F. Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology. Proc Natl Acad Sci USA 1992;89:2247-2251
34. Gosvalez J, Rodriguez-Inigo E, Ramiro-Diaz JL, Bartolome J, Tomas JF, Oliva H, Carreno V. Relative quantitation and mapping of hepatitis C virus by in situ hybridization and digital image analysis. Hepatology 1998;27:1428-1434
35. Rodriguez-Inigo E, Bartolome J, deLucas S, Manzarbeitia F, Pardo M, Arocena C, Gosalvez J, Oliva H, Carreno V. Histological damage in chronic hepatitis C is not related to the extent of infection in the liver. Am J Pathol 1999;154:1877-1881
36. Nuovo GJ, Kidonnici K, MacConnell P, Lane B. Intracellular localization of polymerase chain reaction (PCR)-amplified hepatitis C cDNA. Am J Surg Pathol 1993;17:683-690
37. Lau GKK, Fang JWS, Wu PC, Davis GL, Lau JYN. Detection of hepatitis C virus genome in formalin-fixed paraffin-embedded liver tissue by in situ reverse transcription polymerase chain reaction. J Med Virol 1994;44:406-409
38. Lau GKK, Davis GL, Wu SPC, Gish RG, Balart LA, Lau JYN. Hepatitic expression of hepatitis C virus RNA in chronic hepatitis C: a study by in situ reverse-transcription polymerase chain reaction. Hepatol 1996;23:1318-1323
39. Walker FM, Dazza M-C, Dauge M-C, Boucher O, Bedel OC, Benin D, Lehy T. Detection and localization by in situ molecular biology techniques and immunohistochemistry of hepatitis C virus in livers of chronically infected patients. J Histochem Cytochem 1998;46:653-660
40. Muratori L. in situ reverse transcriptase-polymerase chain reaction: an innovative tool for hepatitis C virus RNA detection and localization, and for quantification of infected cells. Eur J Histochem 1998;42:133-136
41. Sansonno D, Cornacchiulo V, Racanelli V, Dammacco F. in situ simultaneous detection of hepatitis C virus RNA and hepatitis C virus-related antigens in hepatocellular carcinoma. Cancer 1997;80:22-33
42. Ohishi M, Sakisaka S, Harada M, et al. Detection of hepatitis-C virus and hepatitis-C virus replication in hepatocellular carcinoma by in situ hybridization. Scand J Gastroenterol 1999; 34:432-438
43. Tang L, Tanaka Y, Enomoto N, Marumo F, Sato C. Detection of hepatitis C virus RNA in hepatocellular carcinoma by in situ hybridization. Cancer 1995;76:2211-2216
44. Ohsawa M, Itomita Y, Hashimoto M, Kanno H, Aozasa K. Hepatitis C viral genome in a subset of primary hepatitic lymphomas. Mod Pathol 1998;11:471-478
45. Booth PJ, Stevens DA, Collins ME, Brownlie J. Detection of bovine viral diarrhea virus antigen and RNA in oviduct and granulosa cells of persistently infected cattle. J Reprod Fertil 1995;105:17-24
46. Desport M, Collins ME, Brownlie J. Detection of bovine virus diarrhea virus RNA by in situ hybridization with digoxigenin-labelled riboprobes. Intervirology 1994;37:269-276
47. Gowans EJ, Burrell CJ, Jilbert AR, Marmion BP. Cytoplasmic (but not nuclear) hepatitis B virus (HBV) core antigen reflects HBV DNA synthesis at the level of the infected hepatocyte. Intervirology 1996;24:220-225
48. Westaway EG. Flavivirus replication strategy. Adv Virus Res 1987;33:45-90
49. Westaway EG, Khromykh AA, Mackenzie JM. Nascent flavivirus RNA colocalized in situ with double-stranded RNA in stable replication complexes. Virology 1999;258:108-117
50. Westaway EG, Mackenzie JM, Kenney MT, Jones MK, Khromykh AA. Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures. J Virol 1997;71:6650-6661
51. Barba G, Harper F, Harada T, et al. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc Natl Acad Sci USA 1997;94:1200-1205
52. Harlow E, Lane D. Antibodies: A Laboratory Manual. New York: Cold Spring Harbor Laboratory, 1988
53. Krawczynski K, Beach MJ, Bradley DW, et al. Hepatitis C virus antigens in hepatocytes: Immunomorphologic detection and identification. Gastroenterology 1992;103:622-629
54. Di Bisceglie AM, Hoofnagle JH, Krawczynski K. Changes in hepatitis C virus antigen in liver with antiviral therapy. Gastroenterology 1993;105:858-862
55. Vargas V, Krawczynski K, Castells L, Martinez N, Esteban J, Allende H, Esteban R, Guardia J. Recurrent hepatitis C virus infection after liver transplantation: immunohistochemical assessment of the viral antigen. Liver Transplant Surg 1998;4: 320-327
56. Nouri-Aria KT, Sallie R, Mizokami M, Portmann BC, Williams R. Intrahepatic expression of hepatitis C virus antigens in chronic liver disease. J Pathol 1995;175:77-83
57. Ballardini G, Groff P, Pontisso P, Giostra F, Francesconi R, Lenzi M, Zauli D, Alberti A, Bianchi FB. Hepatitis C virus (HCV) genotype, tissue HCV antigens, hepatocellular expression of HLA-A, B, C, and intercellular adhesion-1 molecules. J Clin Invest 1995;95:2067-2075
58. Ballardini G, Groff P, Giostra F, Francesconi R, Miniero R, Ghetti S, Zauli D, Bianchi FB. Hepatocellular codistribution of c100, c33, c22 and NS5 hepatitis C virus antigens detected by using immunopurified polyclonal spontaneous human antibodies. Hepatol 1995;21:730-734
59. Gane EJ, Naoumov MB, Qian K-P, Mondelli MU, Maertens G, Portmann BC, Lau JYN, Williams R. A longitudinal analysis of hepatitis C virus replication following liver transplantation. Gastroenterology 1996;110:167-177
60. Blight K, Lesniewski RR, LaBrooy JT, Gowans EJ. Detection and distribution of hepatitis C-specific antigens in naturally infected liver. Hepatology 1994;20:553-557
61. Hiramatsu N, Hayashi N, Haruna Y, Kasahara A, Fusamoto H, Mori C, Fuke I, Okayama H, Kamada T. Immunohistochemical detection of hepatitis C virus-infected hepatocytes in chronic liver disease with monoclonal antibodies to core, envelope and NS3 regions of the hepatitis C virus genome. Hepatology 1992;16:306-311
62. Haruna Y, Hayashi N, Kamada T, Hytiroglou P, Thung SN, Gerber MA. Expression of hepatitis C virus in hepatocellular carcinoma. Cancer 1994;73:2253-2258
63. Blight K, Lesniewski R, LaBrooy J, Trowbridge R, Gowans EJ. Localization of hepatitis C virus proteins in infected liver tissue by immunofluorescence. Gastroenterol Japon 1993;28(Suppl 5): 55-58
64. Selby MJ, Choo Q-L, Berger K, et al. Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J Gen Virol 1993;74:1103-1113
65. Yap S-H, Willems M, Van den Oord J, et al. Detection of hepatitis C virus antigen by immuno-histochemical staining: a histological marker of hepatitis C virus infection. J Hepatol 1994;20: 275-281
66. Gonzalez-Peralta RP, Fang JWS, Davis GL, et al. Optimization for the detection of hepatitis C virus antigens in the liver. J Hepatol 1994;20:143-147
67. Gonzalez-Peralta RP, Fang JWS, Davis GL, et al. Significance of hepatic expression of hepatitis C viral antigens in chronic hepatitis C. Dig Dis Sci 1995;40:2595-2601
68. Dries V, Von Both I, Muller M, et al. Detection of hepatitis C virus in paraffin-embedded liver biopsies of patients negative for viral RNA in serum. Hepatology 1999;29:223-229
69. Sansonno D, Dammacco F. Hepatitis C virus c100 antigen in liver tissue from patients with acute and chronic infection. Hepatol 1993;18:240-245
70. Blight K, Rowland R, Hall PM, Lesniewski RR, Trowbridge R, LaBrooy JT, Gowans EJ. Immunohistochemical detection of the NS4 antigen of hepatitis C virus and its relation to histopathology. Am J Pathol 1993;143:1568-1573
71. Gretch DR, Bacchi CE, Corey L, et al. Persistent hepatitis C virus infection after liver transplantation: clinical and virological features. Hepatol 1995;22:1-9
72. Brody RI, Eng S, Melamed J, et al. Immunohistochemical detection of hepatitis C antigen by monoclonal antibody TORDJI-22 compared with PCR viral detection. Anat Pathol 1998;110: 32-37
73. Doughty AL, Painter DM, McCaughan GW. Nonspecificity of monoclonal antibody Tordji-22 for the detection of hepatitis C virus in liver transplant recipients with cholestatic hepatitis. Liver Transplant Surg 1999;5:40-45
74. Willems M, Moshage H, Yap SH. PCR and detection of negative HCV RNA strands. Hepatol 1993;17:526
75. McGuinness P, Bishop GA, McCaughan GW, Trowbridge R, Gowans EJ. False detection of negative strand hepatitis C RNA. Lancet 1994;343:551-552
76. Lanford RE, Sureau C, Jacob JR, White R, Fuerst T. Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand specific RT-PCR. Virology 1994; 202:606-614
77. Sangar DV, Carroll AR. A tale of two strands:reverse transcriptase polymerase chain reaction detection of hepatitis C virus replication. Hepatology 1998;28:1173-1176
78. Zehender G, Meroni L, De Maddalena C, Varchetta S, Monti G, Galli MK. Detection of hepatitis C virus RNA in CD19 peripheral blood mononuclear cells of chronically infected individuals. J Infect Dis 1997;176:1209-1214
79. Laskus T, Radkowski M, Wang L-F, Vargas H, Rakela J. Search for hepatitis C virus extrahepatic replication sites in patients with acquired immune deficiency syndrome: specific detection of negative-strand viral RNA in various tissues. Hepatol 1998;28:1398-1401
80. Laskus T, Radkowski M, Wang L-F, Jang SJ, Vargas H, Rakela J. Hepatitis C virus quasispecies in patients infected with HIV-1: correlation with extrahepatic viral replication. Virology 1998; 248:164-171
81. Radkowski M, Wang L-F, Vargas HE, Rakela J, Laskus T. Detection of hepatitis C virus replication in peripheral blood mononuclear cells after orthotopic liver transplantation. Transplantation 1998;66:664-666
82. Laskus T, Radkowski M, Wang L-F, Cianciara J, Vargas H, Rakela J. Hepatitis C virus negative strand RNA is not detected in peripheral blood mononuclear cells and viral sequences are identical to those in serum: a case against extrahepatic replication. J Gen Virol 1997;78:2747-2750
83. Mellor J, Haydon G, Blair C, Livingstone W, Simmonds P. Low level or absent in vivo replication of hepatitis C virus and hepatitis G virus/GB virus C in peripheral blood mononuclear cells. J Gen Virol 1998;79:705-714
84. Maggi F, Fornai C, Vatteroni ML, et al. Differences in hepatitis C virus quasispecies composition between liver, peripheral blood mononuclear cells and plasma. J Gen Virol 1997;79: 1521-1525
85. Lerat H, Berby F, Trabaud MA, Vidalin O, Major M, Trepo C, and Inchauspe G. Specific detection of hepatitis C virus minusstrand RNA in hematopoietic cells. J Clin Invest 1996;97: 845-851
86. Navas S, Martin JH, Quiroga JA, Catillo I, Carreno V. Genetic diverstiy and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients. J Virol 1998;72:1640-1646
87. Chang T-T, Young K-C, Yang Y-J, Lei H-Y, Wu H-L. Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection. Hepatol 1996;23: 977-981
88. Bouffard P, Hayashi PH, Acevedo R, Levy N, Zeldis JB. Hepatitis C virus is detected in a monocyte/macrophage subpopulation of peripheral blood mononuclear cells of infected patients. J Infect Dis 1992;166:1276-1280
89. Muratori L, Giostra F, Cataleta M, et al. Testing for hepatitis C virus sequences in peripheral blood mononuclear cells of patients with chronic hepatitis C in the absence of serum hepatitis C virus RNA. Liver 1994;14:124-128
90. Bronowicki J-P, Loriot M-A, Thiers V, Grignon Y, Zignego AL and Brechot C. Hepatitis C virus persistence in human hematopoietic cells injected into SCID mice. Hepatology 1998; 28:211-218
91. Moldvay J, Deny P, Pol S, Brechot C, Lamas E. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization. Blood 1994;83:2 69-273
92. Sansonno D, Iacobelli AR, Cornacchiulo V, Iodice G, Dammacco F. Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients. Clin Exp Immunol 1996;103:414-421
93. Muratori L, Gibellini D, Lenzi M, Cataleta M, Muratori P, Morelli MC, Bianchi FB. Quantification of hepatitis C virus-infected peripheral blood mononuclear cells by in situ reverse transcriptase-polymerase chain reaction. Blood 1996;7: 2768-2774
94. Hadziyannis S. Nonhepatic manifestations and combined diseases in HCV infection. Dig Dis Sci 1996;41(Suppl):63S-74S
95. Sansonno D, Cornacchiulo V, Iacobelli AR, De Stefano R, Lospalluti M, Dammacco F. Localization of hepatitis C virus antigens in liver and skin tissues of chronic hepatitis C virus-infected patients with mixed cryoglobulinemia. Hepatol 1995;21: 305-312
96. Sansonno D, De Vita S, Cornacchiulo V, Carbone A, Boiocchi M, Dammacco F. Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplasia or non-neoplastic lymphoproliferation. Blood 1996;88:4638-4645
97. Agnello V, Abel G. Localization of hepatitis C virus in cutaneous vasculitic lesions in patients with type II cryoglobulinemia. Arthritis Rheum 1997;40:2007-2015
98. Mangra A, Andriulli A, Zenarola P, Lomuto M, Cascavilla I, Quadri R, Negro F. Lack of hepatitis C virus replication intermediate RNA in diseased skin tissue of chronic hepatitis C patients. J Med Virol 1999;59:277-280