Hepatitis C virus replicates in the liver of patients who have a sustained response to antiviral treatment

Clinical Infectious Diseases

Volumn 43, Issue 10, 2006, Pages 1277-1283

  Castillo, Inmaculada ^a   Rodríguez Iñigo, Elena ^a   López Alcorocho, Juan Manuel ^a   Pardo, Margarita ^a   Bartolomé, Javier ^a   Carreño, Vicente ^a,b  

^a Foundation for the Study of Viral Hepatitis   (Spain)

^b Fundacion para el Estudio de Las Hepatitis Virales   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PEGINTERFERON; RECOMBINANT ALPHA INTERFERON; RIBAVIRIN; VIRUS RNA;

ADULT; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; FEMALE; GENETIC DISTANCE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LIVER BIOPSY; LIVER FIBROSIS; LIVER INJURY; LIVER NECROSIS; MALE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT RESPONSE; VIRUS DETECTION; VIRUS DIAGNOSIS; VIRUS REPLICATION;

ADULT; ANTIVIRAL AGENTS; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER; MALE; MIDDLE AGED; RNA, VIRAL; VIRAL LOAD; VIRUS REPLICATION;

EID: 33750742503     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/508198     Document Type: Article

References (14)

1. Castillo I, Pardo M, Bartolomé J, et al. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis 2004; 189:7-14.
2. Castillo I, Rodríguez-Iñigo E, Bartolomé J, et al. Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult HCV infection. Gut 2005; 54:682-5.
3. Radkowski M, Gallegos-Orozco JF, Jablonska J, et al. Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C. Hepatology 2005; 41:106-14.
4. Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991; 13:372-4.
5. Kwok S, Higuchi R. Avoiding false positive with PCR. Nature 1989; 339:237-8.
6. Carreño V, Pardo M, López-Alcorocho JM, Rodríguez- Iñigo E, Bartolomé J, Castillo I. Detection of hepatitis C virus (HCV) RNA in the liver of healthy, anti-HCV antibody-positive, serum HCV-RNA-negative patients with normal alanine aminotransferase levels. J Infect Dis 2006;194(1):53-60.
7. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997; 25(24):4876-82.
8. Kumar S, Tamura K, Jakobsen IB, Nei M. MEGA2: Molecular Evolutionary Genetics Analysis Software. Bioinformatics 2001;17:1244-5.
9. Gosalvez J, Rodriguez-Iñigo E, Ramiro-Diaz JL, et al. Relative quantification and mapping of hepatitis C virus by in situ hybridization and digital image analysis. Hepatology 1998;27:1428-34.
10. Madejon A, Manzano ML, Arocena C, Castillo I, Carreño V. Effects of delayed freezing of liver biopsies on the detection of hepatitis C virus RNA strands. J Hepatol 2000; 32:1019-25.
11. Pradel-Komurian F, Perret M, Deinman B, et al. Strand specific quantitative real-time PCR to study replication of hepatitis C virus genome. J Virol Methods 2004; 116:103-6.
12. Pham TNQ, MacParland SA, Mulrooney PM, Cooksley H, Naumov NV, Michalak TI. Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. J Virol 2004; 78:5867-74.
13. Lok AS, Liang RH, Chiu EK, Wong KL, Chan TK, Todd D. Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study. Gastroenterology 1991; 100:182-8.
14. Lee WM, Polson JE, Carney DS, Sahin B, Gale M. Reemergence of hepatitis C virus after 8.5 years in a patient with hypogammaglobulinemia: Evidence for an occult viral reservoir. J Infect Dis 2005; 192:1088-92.