HCV in peripheral blood mononuclear cells are predominantly carried on the surface of cells in HIV/HCV co-infected individuals

Journal of Medical Virology

Volumn 82, Issue 12, 2010, Pages 2032-2037

  Natarajan, Ven ^a   Kottilil, Shyam ^b   Hazen, Allison ^a   Adelsberger, Joseph ^a   Murphy, Alison A ^b   Polis, Michael A ^b   Kovacs, Joseph A ^c  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Extra hepatic HCV reservoir; HCV; HIV; NK cells

Indexed keywords

NUCLEASE; VIRUS RNA;

ADULT; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CELL FRACTIONATION; CELL SURFACE; CLINICAL ARTICLE; FREEZE THAWING; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MIXED INFECTION; MONOCYTE; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; T LYMPHOCYTE;

ADULT; B-LYMPHOCYTES; DISEASE RESERVOIRS; FLOW CYTOMETRY; HEPACIVIRUS; HEPATITIS C; HIV INFECTIONS; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; MONOCYTES; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 78049379221     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21906     Document Type: Article

References (16)

1. Alter MJ. 1999. Hepatitis C virus infection in the United States. J Hepatol 31: 88-91.
2. Benhamou Y, Bochet M, Di Martino V, Charlotte F, Azria F, Coutellier A, Vidaud M, Bricaire F, Opolon P, Katlama C, Poynard T. 1999. Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group. Hepatology (Baltimore, MD) 30: 1054-1058.
3. Blackard JT, Kemmer N, Sherman KE. 2006. Extrahepatic replication of HCV: Insights into clinical manifestations and biological consequences. Hepatology (Baltimore, MD) 44: 15-22.
4. Blackard JT, Hiasa Y, Smeaton L, Jamieson DJ, Rodriguez I, Mayer KH, Chung RT. 2007. Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection. J Infect Dis 195: 1765-1773.
5. Boisvert J, He XS, Cheung R, Keeffe EB, Wright T, Greenberg HB. 2001. Quantitative analysis of hepatitis C virus in peripheral blood and liver: Replication detected only in liver. J Infect Dis 184: 827-835.
6. Bonacini M, Louie S, Bzowej N, Wohl AR. 2004. Survival in patients with HIV infection and viral hepatitis B or C: A cohort study. AIDS 18: 2039-2045.
7. Corado J, Toro F, Rivera H, Bianco NE, Deibis L, De Sanctis JB. 1997. Impairment of natural killer (NK) cytotoxic activity in hepatitis C virus (HCV) infection. Clin Exp Immunol 109: 451-457.
8. Hamilton JP, Thuluvath PJ. 2008. Claudin-1 and its potential role in HCV entry: Another piece of the puzzle. J Clin Gastroenterol 42: 3-4.
9. Laskus T, Operskalski EA, Radkowski M, Wilkinson J, Mack WJ, deGiacomo M, Al-Harthi L, Chen Z, Xu J, Kovacs A. 2007. Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women. J Infect Dis 195: 124-133.
10. Lerat H, Shimizu YK, Lemon SM. 2000. Cell type-specific enhancement of hepatitis C virus internal ribosome entry site-directed translation due to 5' nontranslated region substitutions selected during passage of virus in lymphoblastoid cells. J Virol 74: 7024-7031.
11. Meier V, Mihm S, Braun Wietzke P, Ramadori G. 2001. HCV-RNA positivity in peripheral blood mononuclear cells of patients with chronic HCV infection: Does it really mean viral replication? World J Gastroenterol 7: 228-234.
12. Radkowski M, Kubicka J, Kisiel E, Cianciara J, Nowicki M, Rakela J, Laskus T. 2000. Detection of active hepatitis C virus and hepatitis G virus/GB virus C replication in bone marrow in human subjects. Blood 95: 3986-3989.
13. Shimizu YK, Igarashi H, Kanematu T, Fujiwara K, Wong DC, Purcell RH, Yoshikura H. 1997. Sequence analysis of the hepatitis C virus genome recovered from serum, liver, and peripheral blood mononuclear cells of infected chimpanzees. J Virol 71: 5769-5773.
14. Thomas DL. 2008. The challenge of hepatitis C in the HIV-infected person. Annu Rev Med 59: 473-485.
15. Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, Galai N, Nolt K, Nelson KE, Strathdee SA, Johnson L, Laeyendecker O, Boitnott J, Wilson LE, Vlahov D. 2000. The natural history of hepatitis C virus infection: Host, viral, and environmental factors. JAMA 284: 450-456.
16. Zhang M, O'Brien TR, Kopp WC, Goedert JJ. 2005. Lymphocyte subsets in hemophilic patients with hepatitis C virus infection with or without human immunodeficiency virus co-infection: A nested cross-sectional study. BMC Blood Disord 5: 2.