Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C

Journal of Medical Virology

Volumn 81, Issue 4, 2009, Pages 619-627

  Inokuchi, Momoko ^a   Ito, Takayoshi ^a   Uchikoshi, Manabu ^a   Shimozuma, Yuu ^a   Morikawa, Kenichi ^a   Nozawa, Hisako ^a   Shimazaki, Tomoe ^a   Hiroishi, Kazumasa ^a   Miyakawa, Yuzo ^b   Imawari, Michio ^a  

^a SHOWA UNIVERSITY   (Japan)

^b Miyakawa Memorial Research Foundation   (Japan)

Author keywords

B cells; Clonality; Cryoglobulinemia; Hepatitis C virus; Lym phoproliferative disorders

Indexed keywords

VIRUS RNA;

ADULT; ARTICLE; B LYMPHOCYTE; CD4 CD8 RATIO; CLINICAL EVALUATION; CLONAL VARIATION; CONTROLLED STUDY; CRYOGLOBULINEMIA; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LYMPHOID CELL; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PREVALENCE; VIRUS REPLICATION; AGED; AMINO ACID SEQUENCE; BLOOD; GENETICS; IMMUNOGLOBULIN HEAVY CHAIN GENE; MIDDLE AGED; MOLECULAR GENETICS; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

HEPATITIS C VIRUS;

ADULT; AGED; AMINO ACID SEQUENCE; B-LYMPHOCYTES; FEMALE; GENES, IMMUNOGLOBULIN HEAVY CHAIN; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PREVALENCE; RNA, VIRAL; VIRUS REPLICATION;

EID: 62849087838     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21388     Document Type: Article

References (36)

1. Agnello V. 1995. The aetiology of mixed cryoglobulinaemia associated with hepatitis C virus infection. Scand J Immunol 42:179-184.
2. Agnello V, Chung RT, Kaplan LM. 1992. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 327:1490-1495.
3. Barth H, Ulsenheimer A, Pape GR, Diepolder HM, Hoffmann M, Neumann-Haefelin C, Thimme R, Henneke P, Klein R, ParanhosBaccala G, Depla E, Liang TJ, Blum HE, Baumert TF. 2005. Uptake and presentation of hepatitis C virus-like particles by human dendritic cells. Blood 105:3605-3614.
4. Cacoub P, Poynard T, Ghillani P, Charlotte F, Olivi M, Piette JC, Opolon P. 1999. Extrahepatic manifestations ofchronic hepatitis C. MULTIVIRC Group. Multidepartment Virus C. Arthritis Rheum 42:2204-2212.
5. Castillo I, Rodriguez-Inigo E, Bartolome J, de Lucas S, Ortiz-Movilla N, Lopez-Alcorocho JM, Pardo M, Carreno V. 2005. Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection. Gut 54:682-685.
6. De Re V, De Vita S, Marzotto A, Rupolo M, Gloghini A, Pivetta B, Gasparotto D, Carbone A, Boiocchi M. 2000. Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia. Blood 96:3578-3584.
7. Donada C, Crucitti A, Donadon V, Tommasi L, Zanette G, Crovatto M, Santini GF, Chemello L, Alberti A. 1998. Systemic manifestations and liver disease in patients with chronic hepatitis C and type II or III mixed cryoglobulinaemia. J Viral Hepat 5:179-185.
8. Dumestre-Perard C, Ponard D, Drouet C, Leroy V, Zarski JP, Dutertre N, Colomb MG. 2002. Complement C4 monitoring in the follow-up of chronic hepatitis C treatment. Clin Exp Immunol 127:131-136.
9. Ferri C, Caracciolo F, Zignego AL, La Civita L, Monti M, Longombardo G, Lombardini F, Greco F, Capochiani E, Mazzoni A, Mazzaro C, Pasero G. 1994. Hepatitis C virus infection in patients with non- Hodgkin's lymphoma. Br J Haematol 88:392-394.
10. Frangeul L, Musset L, Cresta P, Cacoub P, Huraux JM, Lunel F. 1996. Hepatitis C virus genotypes and subtypes in patients with hepatitis C, with and without cryoglobulinemia. J Hepatol 25:427-432.
11. Ikeda K, Saitoh S, Suzuki Y, Kobayashi M, Tsubota A, Koida I, Arase Y, Fukuda M, Chayama K, Murashima N, Kumada H. 1998. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: A prospective observation of 2215 patients. J Hepatol 28:930-938.
12. Ito T, Yasui K, Mukaigawa J, Katsume A, Kohara M, Mitamura K. 2001. Acquisition of susceptibility to hepatitis C virus replication in HepG2 cells by fusion with primary human hepatocytes: Establishment of a quantitative assay for hepatitis C virus infectivity in a cell culture system. Hepatology 34:566-572.
13. Ivanovski M, Silvestri F, Pozzato G, Anand S, Mazzaro C, Burrone OR, Efremov DG. 1998. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas. Blood 91:2433-2442.
14. Kanto T, Inoue M, Miyatake H, Sato A, Sakakibara M, Yakushijin T, Oki C, Itose I, Hiramatsu N, Takehara T, Kasahara A, Hayashi N. 2004.Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. J Infect Dis 190:1919-1926.
15. Lanford RE, Chavez D, Chisari FV, Sureau C. 1995. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J Virol 69:8079-8083.
16. Laskus T, Radkowski M, Piasek A, Nowicki M, Horban A, Cianciara J, Rakela J. 2000. Hepatitis C virus in lymphoid cells of patients coinfected with human immunodeficiency virus type 1: Evidence of active replication in monocytes/macrophages and lymphocytes. J Infect Dis 181:442-448.
17. Lerat H, Rumin S, Habersetzer F, Berby F, Trabaud MA, Trepo C, Inchauspe G. 1998. In vivo tropism of hepatitis C virus genomic sequences in hematopoietic cells: Influence of viral load, viral genotype, and cell phenotype. Blood 91:3841-3849.
18. Machida K, Cheng KT, Sung VM, Shimodaira S, Lindsay KL, Levine AM, Lai MY, Lai MM. 2004. Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes. Proc Natl Acad Sci USA101:4262-4267.
19. Machida K, Cheng KT, Pavio N, Sung VM, Lai MM. 2005. Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells. J Virol 79:8079-8089.
20. Matsuura Y, Tani H, Suzuki K, Kimura-Someya T, Suzuki R, Aizaki H, Ishii K, Moriishi K, Robison CS, Whitt MA, Miyamura T. 2001. Characterization of pseudotype VSV possessing HCV envelope proteins. Virology 286:263-275.
21. Mazzaro C, Franzin F, Tulissi P, Pussini E, Crovatto M, Carniello GS, Efremov DG, Burrone O, Santini G, Pozzato G. 1996. Regression of monoclonal B-cell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy. Cancer 77: 2604-2613.
22. Moldvay J, Deny P, Pol S, Brechot C, Lamas E. 1994. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization. Blood 83:269-273.
23. Pham TN, MacParland SA, Mulrooney PM, Cooksley H, Naoumov NV, Michalak TI. 2004. Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. J Virol 78:5867-5874.
24. Pozzato G, Burrone O, Baba K, Matsumoto M, Hijiiata M, Ota Y, Mazzoran L, Baracetti S, Zorat F, Mishiro S, Efremov DG. 1999. Ethnic difference in the prevalence of monoclonal B-cell proliferation in patients affected by hepatitis C virus chronic liver disease. J Hepatol 30:990-994.
25. Radkowski M, Gallegos-Orozco JF, Jablonska J, Colby TV, Walewska-Zielecka B, Kubicka J, Wilkinson J, Adair D, Rakela J, Laskus T. 2005. Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C. Hepatology 41:106-114.
26. Ramos-Casals M, Brito-Zeron P, Yague J, Akasbi M, Bautista R, Ruano M, Claver G, Gil V, Font J. 2005. Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjogren's syndrome. Rheumatology (Oxford) 44:89-94.
27. Sansonno D, Lauletta G, Dammacco F. 2004. Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay. J Viral Hepat 11:27-32.
28. Schmidt WN, Stapleton JT, LaBrecque DR, Mitros FA, Kirby PA, Phillips MJ, Brashear DL. 2000. Hepatitis C virus (HCV) infection and cryoglobulinemia: Analysis of whole blood and plasma HCV-RNA concentrations and correlation with liver histology. Hepatology 31:737-744.
29. Sung VM, Shimodaira S, Doughty AL, Picchio GR, Can H, Yen TS, Lindsay KL, Levine AM, Lai MM. 2003. Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: The apoptotic effects of virus infection. J Virol 77:2134-2146.
30. Tong MJ, el-Farra NS, Reikes AR, Co RL. 1995. Clinical outcomes after transfusion-associated hepatitis C.N. Engl J Med 332:1463-1466.
31. Ulcickas Yood M, Quesenberry CP, Jr., Guo D, Caldwell C, Wells K, Shan J, Sanders L, Skovron ML, Iloeje U, Manos MM. 2007. Incidence of non-Hodgkin's lymphoma among individuals with chronic hepatitis B virus infection. Hepatology 46:107-112.
32. Weiner SM, Berg T, Berthold H, Weber S, Peters T, Blum HE, Hopf U, Peter HH. 1998. A clinical and virological study of hepatitis C virus-related cryoglobulinemia in Germany. J Hepatol 29:375-384.
33. Yanagi M, St Claire M, Shapiro M, Emerson SU, Purcell RH, Bukh J. 1998. Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo. Virology 244:161-172.
34. Zignego AL, Brechot C. 1999. Extrahepatic manifestations of HCV infection: Facts and controversies. J Hepatol 31:369-376.
35. Zignego AL, Giannelli F, Marrocchi ME, Mazzocca A, Ferri C, Giannini C, Monti M, Caini P, Villa GL, Laffi G, Gentilini P. 2000. T(14;18) translocation in chronic hepatitis C virus infection. Hepatology 31:474-479.
36. Zignego AL, Ferri C, Pileri SA, Caini P, Bianchi FB. 2007. Extrahepatic manifestations of Hepatitis C Virus infection: A general overview and guidelines for a clinical approach. Dig Liver Dis 39:2-17.