Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection

Gut

Volumn 54, Issue 5, 2005, Pages 682-685

  Castillo, I ^a   Rodriguez Inigo E ^a   Bartolome J ^a   De Lucas, S ^a   Ortiz Movilla N ^a   Lopez Alcorocho J M ^a   Pardo, M ^a   Carreno V ^a  

^a Fund El Estud Las Hepat Virales   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; VIRUS RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; LIVER FUNCTION TEST; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA ISOLATION; VIRUS LOAD; VIRUS REPLICATION;

ADULT; CARRIER STATE; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; VIRUS REPLICATION;

EID: 17644409098     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.057281     Document Type: Article

References (15)

1. Miller RH, Purcell RH. Hepatitis C virus shares amine acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci U S A 1990;87:2057-61.
2. Clarke B. Molecular virology of hepatitis C virus. J Gen Virol 1997;78:2397-410.
3. Manzin A, Candela M, Paolucci S, et al. Presence of hepatitis C virus (HCV) genomic RNA and viral replicative intermediates in bone marrow and peripheral blood mononuclear cells from HCV-infected patients. Clin Diagn Lab Immunol 1994;1:160-3.
4. Wang JT, Shen JC, Lin JT, et al. Detection of replicative from of hepatitis C virus RNA in peripheral blood mononuclear cells. J Infect Dis 1992;166:11167-9.
5. Saleh MG, Tibbs O, Koskinas J, et al. Hepatic and extrahepatic hepatitis C virus replication in relation to response to interferon therapy. Hepatology 1994;20:1399-404.
6. Chang TT, Young KC, Yang YJ, et al. Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection. Hepatology 1996;23:977-81.
7. Shimizu YK, Iwamata A, Hijikata M, et al. Evidence for in vitro replication of hepatitis C virus genome in a human T cell line. Proc Natl Acad Sci U S A 1992;89:5477-81.
8. Shimizu YK, Igarashi H, Kiyahura T, et al. Infection of a chimpanzee with hepatitis C virus grown in cell culture. J Gen Virol 1998;79:1383-6.
9. Feray C, Samuel D, Thiers V, et al. Reinfection of liver graft by hepatitis C virus after liver transplantation. J Clin Invest 1992;89:1361-5.
10. Laskus T, Radkowski M, Wilkinson J, et al. The origin of hepatitis C virus reinfecting transplanted livers: serum-derived versus peripheral blood mononuclear cell-derived virus. J Infect Dis 2002;185:417-21.
11. Castillo I, Pardo M, Bartolomé J, et al. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis 2004;189:7-14.
12. Kwok S, Higuchi R. Avoiding false positive with PCR. Nature 1989;339:237-8.
13. Radkowski M, Wang LF, Vargas HE, et al. Detection of hepatitis C virus replication in peripheral blood mononuclear cells after orthotopic liver transplantation. Transplantation 1998;66:664-6.
14. Maratori L, Giostra F, Cataleta M, et al. Testing for hepatitis C virus sequences in peripheral blood mononuclear cells of patients with chronic hepatitis C in the absence of serum hepatitis C virus RNA. Liver 1994;14:124-8.
15. Pham TNQ, MacParland SA, Mulrooney PM, et al. Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. J Virol 2004;78:5867-74.