Postmyocardial infarct remodeling and heart failure: Potential contributions from pro- and antiaging factors

Cardiology Research and Practice

Volumn 1, Issue 1, 2011, Pages

  Idikio, Halliday A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; GRANULOCYTE COLONY STIMULATING FACTOR; KLOTHO PROTEIN; MELATONIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SIRTUIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; ZINC;

AGING; CALORIC RESTRICTION; CELL DEATH; DIABETES MELLITUS; DNA DAMAGE; DNA REPAIR; ENGRAFTMENT; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART VENTRICLE HYPERTROPHY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LONGEVITY; MESENCHYMAL STEM CELL; MYOCARDIAL REMODELING; NONHUMAN; OXIDATIVE STRESS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN FOLDING; REVIEW; SENESCENCE; STEM CELL TRANSPLANTATION; TELOMERE; TISSUE REGENERATION; TISSUE REPAIR;

EID: 79959446365     PISSN: None     EISSN: 20900597     Source Type: Journal    
DOI: 10.4061/2011/836806     Document Type: Review

References (104)

1. Kirkwood T. B. L., Understanding the odd science of aging Cell 2005 120 4 437 447 (Pubitemid 40269759)
2. Kuningas M., Mooijaart S. P., Van Heemst D., Zwaan B. J., Slagboom P. E., Westendorp R. G. J., Genes encoding longevity: from model organisms to humans Aging Cell 2008 7 2 270 280 (Pubitemid 351359659)
3. Kurosu H., Yamamoto M., Clark J. D., Pastor J. V., Nandi A., Gurnani P., McGuinness O. P., Chikuda H., Yamaguchi M., Kawaguchi H., Shimomura I., Takayama Y., Herz J., Kahn C. R., Rosenblatt K. P., Kuro-O M., Suppression of aging in mice by the hormone Klotho Science 2005 309 5742 1829 1833 (Pubitemid 41325087)
4. Takahashi Y., Kuro-O M., Ishikawa F., Aging mechanisims Proceedings of the National Academy of Sciences of the United States of America 2000 97 23 12407 12408
5. Maiese K., Li F., Chong Z. Z., Shang Y. C., The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacology and Therapeutics 2008 118 1 58 81
6. Stewart S., MacIntyre K., Capewell S., McMurray J. J. V., Heart failure and the aging population: an increasing burden in the 21st century? Heart 2003 89 1 49 53 (Pubitemid 36044289)
7. Terry D. F., Wilcox M. A., McCormick M. A., Perls T. T., Cardiovascular disease delay in centenarian offspring Journals of Gerontology. Series A 2004 59 4 385 389 (Pubitemid 38478738)
8. Terry D. F., Nolan V. G., Andersen S. L., Perls T. T., Cawthon R., Association of longer telomeres with better health in centenarians Journals of Gerontology. Series A 2008 63 8 809 812
9. De Magalhes J. P., Cabral J. A. S., Magalhes D., The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging Genetics 2005 169 1 265 274 (Pubitemid 40239169)
10. Zahn J. M., Poosala S., Owen A. B., Ingram D. K., Lustig A., Carter A., Weeraratna A. T., Taub D. D., Gorospe M., Mazan-Mamczarz K., Lakatta E. G., Boheler K. R., Xu X., Mattson M. P., Falco G., Ko M. S., Schlessinger D., Firman J., Kummerfeld S. K., Wood W. H., Zonderman A. B., Kim S. K., Becker K. G., AGEMAP: a gene expression database for aging in mice PLoS genetics 2007 3 11, article e201
11. Giordano F. J., Oxygen, oxidative stress, hypoxia, and heart failure Journal of Clinical Investigation 2005 115 3 500 508 (Pubitemid 40322219)
12. Murdoch C., Zhang M., Cave A., Shah A., NADPH oxidase-dependent redox signaling in cardiac hypertrophy, remodeling and failure Cardiovascular Research 2006 71 208 215
13. Lombard D. B., Chua K. F., Mostoslavsky R., Franco S., Gostissa M., Alt F. W., DNA repair, genome stability, and aging Cell 2005 120 4 497 512 (Pubitemid 40269764)
14. Calderwood S. K., Murshid A., Prince T., The shock of aging: molecular chaperones and the heat shock response in longevity and aginga mini-review Gerontology 2009 55 5 550 558
15. Yamamoto M., Clark J. D., Pastor J. V., Gurnani P., Nandi A., Kurosu H., Miyoshi M., Ogawa Y., Castrillon D. H., Rosenblatt K. P., Kuro-O M., Regulation of oxidative stress by the anti-aging hormone klotho Journal of Biological Chemistry 2005 280 45 38029 38034 (Pubitemid 41642417)
16. Liu H., Fergusson M. M., Castilho R. M., Liu J., Cao L., Chen J., Malide D., Rovira I. I., Schimel D., Kuo C. J., Gutkind J. S., Hwang P. M., Finkel T., Augmented Wnt signaling in a mammalian model of accelerated aging Science 2007 317 5839 803 806 (Pubitemid 47257917)
17. Arking D. E., Atzmon G., Arking A., Barzilai N., Dietz H. C., Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity Circulation Research 2005 96 4 412 418 (Pubitemid 40354534)
18. Rota M., LeCapitaine N., Hosoda T., Boni A., De Angelis A., Padin-Iruegas M. E., Esposito G., Vitale S., Urbanek K., Casarsa C., Giorgio M., Lscher T. F., Pelicci P. G., Anversa P., Leri A., Kajstura J., Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66 gene Circulation Research 2006 99 1 42 52 (Pubitemid 44297054)
19. Finkel T., Deng C. X., Mostoslavsky R., Recent progress in the biology and physiology of sirtuins Nature 2009 460 7255 587 591
20. Alcendor R. R., Gao S., Zhai P., Zablocki D., Holle E., Yu X., Tian B., Wagner T., Vatner S. F., Sadoshima J., Sirt1 regulates aging and resistance to oxidative stress in the heart Circulation Research 2007 100 10 1512 1521 (Pubitemid 46834764)
21. Sundaresan N. R., Gupta M., Kim G., Rajamohan S. B., Isbatan A., Gupta M. P., Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice Journal of Clinical Investigation 2009 119 9 2758 2771
22. Hipkiss A. R., Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms? Biogerontology 2008 9 1 49 55
23. Dorshkind K., Montecino-Rodriguez E., Signer R. A. J., The ageing immune system: is it ever too old to become young again? Nature Reviews Immunology 2009 9 1 57 62
24. Panda A., Arjona A., Sapey E., Bai F., Fikrig E., Montgomery R. R., Lord J. M., Shaw A. C., Human innate immunosenescence: causes and consequences for immunity in old age Trends in Immunology 2009 30 7 325 333
25. Maggio M., Guralnik J. M., Longo D. L., Ferrucci L., Interleukin-6 in aging and chronic disease: a magnificent pathway Journals of Gerontology. Series A 2006 61 6 575 584
26. Rodier F., Campisi J., Bhaumik D., Two faces of p53: aging and tumor suppression Nucleic Acids Research 2007 35 22 7475 7484
27. Vousden K. H., Prives C., Blinded by the light: the growing complexity of p53 Cell 2009 137 3 413 431
28. Lee J. H., Bodmer R., Bier E., Karin M., Sestrins at the crossroad between stress and aging Aging 2010 2 6 369 374
29. Budanov A. V., Lee J. H., Karin M., Stressin' Sestrins take an aging fight EMBO Molecular Medicine 2010 2 10 388 400
30. Riethman H., Human telomere structure and biology Annual Review of Genomics and Human Genetics 2008 9 1 19
31. Schoeftner S., Blasco M. A., A higher order of telomere regulation: telomere heterochromatin and telomeric RNAs EMBO Journal 2009 28 16 2323 2336
32. Flores I., Canela A., Vera E., Tejera A., Cotsarelis G., Blasco M. A., The longest telomeres: a general signature of adult stem cell compartments Genes and Development 2008 22 5 654 667 (Pubitemid 351342437)
33. Cherif H., Tarry J. L., Ozanne S. E., Hales C. N., Ageing and telomeres: a study into organ- and gender-specific telomere shortening Nucleic Acids Research 2003 31 5 1576 1583 (Pubitemid 36304920)
34. Salpea K. D., Nicaud V., Tiret L., Talmud P. J., Humphries S. E., The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study II Journal of Molecular Medicine 2008 86 7 815 824
35. Capper R., Britt-Compton B., Tankimanova M., Rowson J., Letsolo B., Man S., Haughton M., Baird D. M., The nature of telomere fusion and a definition of the critical telomere length in human cells Genes and Development 2007 21 19 2495 2508 (Pubitemid 47529377)
36. Adams P. D., Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence Molecular Cell 2009 36 1 2 14
37. Wong L. S. M., Oeseburg H., De Boer R. A., Van Gilst W. H., Van Veldhuisen D. J., Van Der Harst P., Telomere biology in cardiovascular disease: the TERC mouse as a model for heart failure and ageing Cardiovascular Research 2009 81 2 244 252
38. Njajou O. T., Hsueh W. C., Blackburn E. H., Newman A. B., Wu S. H., Li R., Simonsick E. M., Harris T. M., Cummings S. R., Cawthon R. M., Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study Journals of Gerontology. Series A 2009 64 8 860 864
39. Edo M. D., Andrés V., Aging, telomeres, and atherosclerosis Cardiovascular Research 2005 66 2 213 221 (Pubitemid 40471036)
40. Christensen K., Johnson T. E., Vaupel J. W., The quest for genetic determinants of human longevity: challenges and insights Nature Reviews Genetics 2006 7 6 436 448 (Pubitemid 43780487)
41. Lakatta E. G., Arterial and cardiac aging: major shareholders in cardiovascular disease enterprisespart III: cellular and molecular clues to heart and arterial aging Circulation 2003 107 3 490 497 (Pubitemid 36158054)
42. Lakatta E. G., Arterial and cardiac aging: major shareholders in cardiovascular disease enterprisespart III: cellular and molecular clues to heart and arterial aging Circulation 2003 107 3 346 354 (Pubitemid 36135235)
43. Schwartz J. B., Gibb W. J., Tran T., Aging effects on heart rate variation Journals of Gerontology 1991 46 3 M99 M106
44. Anversa P., Kajstura J., Leri A., Bolli R., Life and death of cardiac stem cells: a paradigm shift in cardiac biology Circulation 2006 113 11 1451 1463 (Pubitemid 43739442)
45. Stanton L. W., Garrard L. J., Damm D., Garrick B. L., Lam A., Kapoun A. M., Zheng Q., Protter A. A., Schreiner G. F., White R. T., Altered patterns of gene expression in response to myocardial infarction Circulation Research 2000 86 9 939 945 (Pubitemid 30324305)
46. Torella D., Rota M., Nurzynska D., Musso E., Monsen A., Shiraishi I., Zias E., Walsh K., Rosenzweig A., Sussman M. A., Urbanek K., Nadal-Ginard B., Kajstura J., Anversa P., Leri A., Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression Circulation Research 2004 94 4 514 524 (Pubitemid 38326287)
47. Phaneuf S., Leeuwenburgh C., Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age American Journal of Physiology 2002 282 2 R423 R430
48. Terman A., Brunk U. T., Autophagy in cardiac myocyte homeostasis, aging, and pathology Cardiovascular Research 2005 68 3 355 365 (Pubitemid 41566555)
49. Frantz S., Bauersachs J., Ertl G., Post-infarct remodelling: contribution of wound healing and inflammation Cardiovascular Research 2009 81 3 474 481
50. Solaini G., Harris D. A., Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion Biochemical Journal 2005 390 2 377 394 (Pubitemid 41337100)
51. Matsui Y., Takagi H., Qu X., Abdellatif M., Sakoda H., Asano T., Levine B., Sadoshima J., Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and beclin 1 in mediating autophagy Circulation Research 2007 100 6 914 922 (Pubitemid 46555697)
52. Bujak M., Kweon H. J., Chatila K., Li NA., Taffet G., Frangogiannis N. G., Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction Journal of the American College of Cardiology 2008 51 14 1384 1392 (Pubitemid 351443080)
53. Pittenger M. F., Martin B. J., Mesenchymal stem cells and their potential as cardiac therapeutics Circulation Research 2004 95 1 9 20 (Pubitemid 38931831)
54. Bergmann O., Bhardwaj R. D., Bernard S., Zdunek S., Barnabé-Heide F., Walsh S., Zupicich J., Alkass K., Buchholz B. A., Druid H., Jovinge S., Frisén J., Evidence for cardiomyocyte renewal in humans Science 2009 324 5923 98 102
55. Pfeffer M. A., Braunwald E., Ventricular remodeling after myocardial infarction: experimental observations and clinical implications Circulation 1990 81 4 1161 1172 (Pubitemid 20119612)
56. Mann D. L., Bristow M. R., Mechanisms and models in heart failure: the biomechanical model and beyond Circulation 2005 111 21 2837 2849 (Pubitemid 40791557)
57. McKay R. G., Pfeffer M. A., Pasternak R. C., Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion Circulation 1986 74 4 693 702 (Pubitemid 16007186)
58. Jugdutt B. I., Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? Circulation 2003 108 11 1395 1403 (Pubitemid 37174420)
59. Hardt S. E., Sadoshima J., Negative regulators of cardiac hypertrophy Cardiovascular Research 2004 63 3 500 509 (Pubitemid 38970194)
60. Raya T. E., Gaballa M., Anderson P., Goldman S., Left ventricular function and remodeling after myocardial infarction in aging rats American Journal of Physiology 1997 273 6 H2652 H2658
61. Latronico M. V., Condorelli G., MicroRNAs and cardiac pathology Nature reviews. Cardiology 2009 6 6 419 429
62. de Magalhes J. P., Budovsky A., Lehmann G., Costa J., Li Y., Fraifeld V., Church G. M., The human ageing genomic resources: online databases and tools for biogerontologists Aging Cell 2009 8 1 65 72
63. Rattan S. I., Anti-ageing strategies: prevention or therapy? Showing ageing from within EMBO Reports 2005 6 S25 S29
64. Yousef Z. R., Redwood S. R., Marber M. S., Postinfarction left ventricular remodelling: where are the theories and trials leading us? Heart 2000 83 1 76 80 (Pubitemid 30307644)
65. Dos Remedios C. G., Liew C. C., Allen P. D., Winslow R. L., Van Eyk J. E., Dunn M. J., Genomics, proteomics and bioinformatics of human heart failure Journal of Muscle Research and Cell Motility 2003 24 46 251 260 (Pubitemid 37323632)
66. Mudd J. O., Kass D. A., Tackling heart failure in the twenty-first century Nature 2008 451 7181 919 928 (Pubitemid 351301747)
67. Carlson M. E., Silva H. S., Conboy I. M., Aging of signal transduction pathways, and pathology Experimental Cell Research 2008 314 9 1951 1961 (Pubitemid 351649367)
68. Mergny J. L., Riou J. F., Mailliet P., Teulade-Fichou M. P., Gilson E., Natural and pharmacological regulation of telomerase Nucleic Acids Research 2002 30 4 839 865 (Pubitemid 34679653)
69. Partovian C., Simons M., Stem cell therapies in cardiovascular disease. A realistic appraisal Drug Discovery Today 2008 5 1 73 78
70. Yousef M., Schannwell C. M., Kstering M., Zeus T., Brehm M., Strauer B. E., Clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction Journal of the American College of Cardiology 2009 53 24 2262 2269
71. Drexler H., Wollert K., Bone marrow cell thrapy for MI- goal achieved Nature Reviews Cardiology 2009 6 615 616
72. Reffelmann T., Knemann S., Kloner R. A., Promise of blood- and bone marrow-derived stem cell transplantation for functional cardiac repair. Putting it in perspective with existing therapy Journal of the American College of Cardiology 2009 53 4 305 308
73. Edelberg J. M., Ballard V. L. T., Stem cell review series: regulating highly potent stem cells in aging: environmental influences on plasticity Aging Cell 2008 7 4 599 604 (Pubitemid 351998619)
74. Chiriac A., Nelson T. J., Faustino R. S., Behfar A., Terzic A., Cardiogenic induction of pluripotent stem cells streamlined through a conserved SDF-1/VEGF/BMP2 integrated network PLoS ONE 2010 5 4, article e9943
75. Zhang J., Wilson G. F., Soerens A. G., Koonce C. H., Yu J., Palecek S. P., Thomson J. A., Kamp T. J., Functional cardiomyocytes derived from human induced pluripotent stem cells Circulation Research 2009 104 4 e30 e41
76. Hanna J. H., Saha K., Jaenisch R., Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues Cell 2010 143 4 508 525
77. Warren L., Manos P. D., Ahfeldt T., Loh Y.-H., Li H., Lau F., Ebina W., Mandal P. K., Smith Z. D., Meissner A., Daley G. Q., Brack A. S., Collins J. J., Cowan C., Schlaeger T. M., Rossi D. J., Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA Cell Stem Cell 2010 7 5 618 630
78. Nelson T. J., Martinez-Fernandez A., Yamada S., Perez-Terzic C., Ikeda Y., Terzic A., Repair of acute myocardial infarction with induced pluripotent stem cells induced by human stemness factors Circulation 2009 120 5 408 416
79. Domian I. J., Chiravuri M., Meer V. D. P., Feinberg A. W., Shi XI., Shao Y., Wu S. M., Parker K. K., Chien K. R., Generation of functional ventricular heart muscle from mouse ventricular progenitor cells Science 2009 326 5951 426 429
80. Parmacek M. S., Epstein J. A., Pursuing cardiac progenitors: regeneration redux Cell 2005 120 3 295 298 (Pubitemid 40222424)
81. Matsuura K., Honda A., Nagai T., Fukushima N., Iwanaga K., Tokunaga M., Shimizu T., Okano T., Kasanuki H., Hagiwara N., Komuro I., Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice Journal of Clinical Investigation 2009 119 8 2204 2217
82. Hsieh P. C. H., Segers V. F. M., Davis M. E., MacGillivray C., Gannon J., Molkentin J. D., Robbins J., Lee R. T., Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury Nature Medicine 2007 13 8 970 974 (Pubitemid 47222045)
83. Léobon B., Garcin I., Menasché P., Vilquin J. T., Audinat E., Charpak S., Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host Proceedings of the National Academy of Sciences of the United States of America 2003 100 13 7808 7811 (Pubitemid 36760051)
84. Sesti C., Hale S. L., Lutzko C., Kloner R. A., Granulocyte colony-stimulating factor and stem cell factor improve contractile reserve of the infarcted left ventricle independent of restoring muscle mass Journal of the American College of Cardiology 2005 46 9 1662 1669 (Pubitemid 41531620)
85. Ripa R. S., Haack-Srensen M., Wang Y., Jrgensen E., Mortensen S., Bindslev L., Friis T., Kastrup J., Bone marrow-derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial Circulation 2007 116 11 I24 I30
86. De Silva R., Raval A. N., Hadi M., Gildea K. M., Bonifacino A. C., Yu Z.-X., Yau Y. Y., Leitman S. F., Bacharach S. L., Donahue R. E., Read E. J., Lederman R. J., Intracoronary infusion of autologous mononuclear cells from bone marrow or granulocyte colony-stimulating factor-mobilized apheresis product may not improve remodelling, contractile function, perfusion, or infarct size in a swine model of large myocardial infarction European Heart Journal 2008 29 14 1772 1782 (Pubitemid 352019815)
87. Lehrke S., Mazhari R., Durand D. J., Zheng M., Bedja D., Zimmet J. M., Schuleri K. H., Chi A. S., Gabrielson K. L., Hare J. M., Aging impairs the beneficial effect of granulocyte colony-stimulating factor and stem cell factor on post-myocardial infarction remodeling Circulation Research 2006 99 5 553 560 (Pubitemid 44337828)
88. Rosenzweig A., Cardiac cell therapymixed results from mixed cells New England Journal of Medicine 2006 355 12 1274 1277 (Pubitemid 44427452)
89. Gersh B. J., Simari R. D., Behfar A., Terzic C. M., Terzic A., Cardiac cell repair therapy: a clinical perspective Mayo Clinic Proceedings 2009 84 10 876 892
90. Jockers R., Maurice P., Boutin J. A., Delagrange P., Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? British Journal of Pharmacology 2008 154 6 1182 1195 (Pubitemid 351992057)
91. Chen C. H., Budas G. R., Churchill E. N., Disatnik M. H., Hurley T. D., Mochly-Rosen D., Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart Science 2008 321 5895 1493 1495
92. Luchetti F., Canonico B., Betti M., Arcangeletti M., Pilolli F., Piroddi M., Canesi L., Papa S., Galli F., Melatonin signaling and cell protection function FASEB Journal 2010 24 10 3603 3624
93. Petrosillo G., Di Venosa N., Pistolese M., Casanova G., Tiravanti E., Colantuono G., Federici A., Paradies G., Ruggiero F. M., Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia-reperfusion: role of cardiolipin FASEB Journal 2006 20 2 269 276 (Pubitemid 44933174)
94. Reiter R. J., Tan D. X., Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart Cardiovascular Research 2003 58 1 10 19 (Pubitemid 36351618)
95. Landmesser U., Wollert K. C., Drexler H., Potential novel pharmacological therapies for myocardial remodelling Cardiovascular Research 2009 81 3 519 527
96. Vaquero A., Reinberg D., Calorie restriction and the exercise of chromatin Genes and Development 2009 23 16 1849 1869
97. Morishita K., Shirai A., Kubota M., Katakura Y., Nabeshima Y. I., Takeshige K., Kamiya T., The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc Journal of Nutrition 2001 131 12 3182 3188 (Pubitemid 33136132)
98. Suh J. H., Shigeno E. T., Morrow J. D., Cox B., Rocha A. E., Frei B., Hagen T. M., Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)- -lipoic acid FASEB Journal 2001 15 3 700 706 (Pubitemid 32245988)
99. Srinivasan V., Maestroni G. J. M., Cardinali D. P., Esquifino A. I., Pandi Perumal S. R., Miller S. C., Melatonin, immune function and aging Immunity and Ageing 2005 2, article 17
100. Markus M. A., Morris B. J., Resveratrol in prevention and treatment of common clinical conditions of aging Clinical Interventions in Aging 2008 3 2 331 339 (Pubitemid 352037871)
101. Thomas D. R., Vitamins in aging, health, and longevity Clinical Interventions in Aging 2006 1 1 81 91
102. Ahmet I., Spangler E., Shukitt-Hale B., Juhaszova M., Sollott S. J., Joseph J. A., Ingram D. K., Talan M., Blueberry-enriched diet protects rat heart from ischemic damage PLoS ONE 2009 4 6, article e5954
103. Stangl V., Dreger H., Stangl K., Lorenz M., Molecular targets of tea polyphenols in the cardiovascular system Cardiovascular Research 2007 73 2 348 358 (Pubitemid 44937692)
104. Le Page C., Noirez P., Courty J., Riou B., Swynghedauw B., Besse S., Exercise training improves functional post-ischemic recovery in senescent heart Experimental Gerontology 2009 44 3 177 182