Stem cell therapies in cardiovascular disease. A 'realistic' appraisal

Drug Discovery Today: Therapeutic Strategies

Volumn 5, Issue 1, 2008, Pages 73-78

  Partovian, Chohreh ^a   Simons, Michael ^a  

^a Angiogenesis Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANGIOGENESIS; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE MARROW TRANSPLANTATION; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CELL FUNCTION; CELL FUSION; CELL INFILTRATION; CELL ISOLATION; CELL LINEAGE; CELL RENEWAL; CELL SUBPOPULATION; CELL SURVIVAL; CELL TYPE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CYTOLOGY; DAUGHTER CELL; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; FEASIBILITY STUDY; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CELL; HEART PROTECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MESENCHYMAL STEM CELL TRANSPLANTATION; MULTIPOTENT STEM CELL; MUSCLE REGENERATION; NONHUMAN; PATIENT SAFETY; PERCUTANEOUS CORONARY INTERVENTION; PLURIPOTENT STEM CELL; PREIMPLANTATION EMBRYO; REVIEW; SOMATIC CELL THERAPY; STEM CELL MOBILIZATION; STEM CELL TRANSPLANTATION; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 57249115836     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2008.05.001     Document Type: Review

References (47)

1. Anversa P., and Nadal-Ginard B. Myocyte renewal and ventricular remodelling. Nature 415 (2002) 240-243
2. Beltrami A.P., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114 (2003) 763-776
3. Bayes-Genis A., et al. Cardiac chimerism in recipients of peripheral-blood and bone marrow stem cells. Eur. J. Heart Fail. 6 (2004) 399-402
4. Quaini F., et al. Chimerism of the transplanted heart. N. Engl. J. Med. 346 (2002) 5-15
5. Laflamme M.A., et al. Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ. Res. 90 (2002) 634-640
6. Hsieh P.C., et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat. Med. 13 (2007) 970-974
7. Orlic D., et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 10344-10349
8. Kajstura J., et al. Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ. Res. 96 (2005) 127-137
9. Yoon Y.S., et al. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J. Clin. Invest. 115 (2005) 326-338
10. Jackson K.A., et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107 (2001) 1395-1402
11. Alvarez-Dolado M., et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425 (2003) 968-973
12. Balsam L.B., et al. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428 (2004) 668-673
13. Murry C.E., et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428 (2004) 664-668
14. Nygren J.M., et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat. Med. 10 (2004) 494-501
15. Grunewald M., et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124 (2006) 175-189
16. Urbanek K., et al. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ. Res. 97 (2005) 663-673
17. Ikeda Y., et al. Development of angiogenic cell and gene therapy by transplantation of umbilical cord blood with vascular endothelial growth factor gene. Hypertens. Res. 27 (2004) 119-128
18. Iwaguro H., et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 105 (2002) 732-738
19. Gnecchi M., et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat. Med. 11 (2005) 367-368
20. Fraidenraich D., et al. Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science 306 (2004) 247-252
21. Menasche P., et al. Myoblast transplantation for heart failure. Lancet 357 (2001) 279-280
22. Leobon B., et al. Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7808-7811
23. Menasche P., et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J. Am. Coll. Cardiol. 41 (2003) 1078-1083
24. Dib N., et al. Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up. Circulation 112 (2005) 1748-1755
25. Gavira J.J., et al. Autologous skeletal myoblast transplantation in patients with nonacute myocardial infarction: 1-year follow-up. J. Thorac. Cardiovasc. Surg. 131 (2006) 799-804
26. Hagege A.A., et al. Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients. Circulation 114 1 Suppl. (2006) I108-113
27. Kastrup J., et al. Myocardial regeneration induced by granulocyte-colony-stimulating factor mobilization of stem cells in patients with acute or chronic ischaemic heart disease: a non-invasive alternative for clinical stem cell therapy?. Eur. Heart J. 27 (2006) 2748-2754
28. Spangrude G.J., et al. Purification and characterization of mouse hematopoietic stem cells. Science 241 (1988) 58-62
29. Pittenger M.F., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
30. Le Blanc K., et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp. Hematol. 31 (2003) 890-896
31. Wollert K.C., et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364 (2004) 141-148
32. Meyer G.P., et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (bone marrow transfer to enhance ST-elevation infarct regeneration) trial. Circulation 113 (2006) 1287-1294
33. Assmus B., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106 (2002) 3009-3017
34. Britten M.B., et al. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation 108 (2003) 2212-2218
35. Assmus B., et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N. Engl. J. Med. 355 (2006) 1222-1232
36. Schachinger V., et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N. Engl. J. Med. 355 (2006) 1210-1221
37. Chen S.L., et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am. J. Cardiol. 94 (2004) 92-95
38. Lunde K., et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N. Engl. J. Med. 355 (2006) 1199-1209
39. Janssens S., et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 367 (2006) 113-121
40. Ince H., et al. Prevention of left ventricular remodeling with granulocyte colony-stimulating factor after acute myocardial infarction: final 1-year results of the front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by granulocyte colony-stimulating factor (FIRSTLINE-AMI) trial. Circulation 112 9 Suppl. (2005) I73-80
41. Zohlnhofer D., et al. Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. JAMA 295 (2006) 1003-1010
42. Ripa R.S., et al. Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial. Circulation 113 (2006) 1983-1992
43. Kang H.J., et al. Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial. Circulation 114 1 Suppl. (2006) I145-151
44. Chien K.R. Stem cells: lost in translation. Nature 428 (2004) 607-608
45. Martin J.F. Stem cells and the heart: ethics, organization and funding. Nat. Clin. Pract. Cardiovasc. Med. 3 1 Suppl. (2006) S136-137
46. Strauer B.E., et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106 (2002) 1913-1918
47. Schachinger V., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI trial. J. Am. Coll. Cardiol. 44 (2004) 1690-1699