메뉴 건너뛰기




Volumn 30, Issue 7, 2009, Pages 325-333

Human innate immunosenescence: causes and consequences for immunity in old age

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TOLL LIKE RECEPTOR;

EID: 67649397909     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2009.05.004     Document Type: Review
Times cited : (385)

References (112)
  • 1
    • 67649404131 scopus 로고    scopus 로고
    • Blood monocytes: development, heterogeneity, and relationship with dendritic cells
    • Auffray C., et al. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu. Rev. Immunol. 27 (2009) 669-692
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 669-692
    • Auffray, C.1
  • 2
    • 22644444814 scopus 로고    scopus 로고
    • MacrophAging: a cellular and molecular review
    • Sebastian C., et al. MacrophAging: a cellular and molecular review. Immunobiology 210 (2005) 121-126
    • (2005) Immunobiology , vol.210 , pp. 121-126
    • Sebastian, C.1
  • 3
    • 0028198809 scopus 로고
    • Influence of aging on some specific and nonspecific mechanisms of the host defense system in 146 healthy subjects
    • Fietta A., et al. Influence of aging on some specific and nonspecific mechanisms of the host defense system in 146 healthy subjects. Gerontology 40 (1994) 237-245
    • (1994) Gerontology , vol.40 , pp. 237-245
    • Fietta, A.1
  • 4
    • 0034663420 scopus 로고    scopus 로고
    • Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells. B cells and macrophages
    • Ogawa T., et al. Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells. B cells and macrophages. Mech. Ageing Dev. 117 (2000) 57-68
    • (2000) Mech. Ageing Dev. , vol.117 , pp. 57-68
    • Ogawa, T.1
  • 6
    • 0028597408 scopus 로고
    • Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide
    • Clark J.A., and Peterson T.C. Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide. Mech. Ageing Dev. 77 (1994) 127-139
    • (1994) Mech. Ageing Dev. , vol.77 , pp. 127-139
    • Clark, J.A.1    Peterson, T.C.2
  • 7
    • 0031803322 scopus 로고    scopus 로고
    • Signal transduction in LPS-activated aged and young monocytes
    • Delpedro A.D., et al. Signal transduction in LPS-activated aged and young monocytes. J. Interferon Cytokine Res. 18 (1998) 429-437
    • (1998) J. Interferon Cytokine Res. , vol.18 , pp. 429-437
    • Delpedro, A.D.1
  • 8
    • 0037011794 scopus 로고    scopus 로고
    • RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects
    • Mariani E., et al. RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects. Exp. Gerontol. 37 (2002) 219-226
    • (2002) Exp. Gerontol. , vol.37 , pp. 219-226
    • Mariani, E.1
  • 9
    • 0029737506 scopus 로고    scopus 로고
    • Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly
    • Gon Y., et al. Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin. Exp. Immunol. 106 (1996) 120-126
    • (1996) Clin. Exp. Immunol. , vol.106 , pp. 120-126
    • Gon, Y.1
  • 10
    • 34548279776 scopus 로고    scopus 로고
    • Toll-like receptors in older adults
    • van Duin D., and Shaw A.C. Toll-like receptors in older adults. J. Am. Geriatr. Soc. 55 (2007) 1438-1444
    • (2007) J. Am. Geriatr. Soc. , vol.55 , pp. 1438-1444
    • van Duin, D.1    Shaw, A.C.2
  • 11
    • 0021739814 scopus 로고
    • Admission criteria for immunogerontological studies in man: the SENIEUR protocol
    • Ligthart G.J., et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 28 (1984) 47-55
    • (1984) Mech. Ageing Dev. , vol.28 , pp. 47-55
    • Ligthart, G.J.1
  • 12
    • 33846208784 scopus 로고    scopus 로고
    • Age-associated defect in human TLR-1/2 function
    • van Duin D., et al. Age-associated defect in human TLR-1/2 function. J. Immunol. 178 (2007) 970-975
    • (2007) J. Immunol. , vol.178 , pp. 970-975
    • van Duin, D.1
  • 13
    • 34249107969 scopus 로고    scopus 로고
    • Prevaccine determination of the expression of costimulatory b7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults
    • van Duin D., et al. Prevaccine determination of the expression of costimulatory b7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J. Infect. Dis. 195 (2007) 1590-1597
    • (2007) J. Infect. Dis. , vol.195 , pp. 1590-1597
    • van Duin, D.1
  • 14
    • 47749112908 scopus 로고    scopus 로고
    • Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly
    • Kong K.F., et al. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J. Virol. 82 (2008) 7613-7623
    • (2008) J. Virol. , vol.82 , pp. 7613-7623
    • Kong, K.F.1
  • 15
    • 5444225275 scopus 로고    scopus 로고
    • Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study
    • van den Biggelaar A.H.J., et al. Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study. Exp. Gerontol. 39 (2004) 1407-1414
    • (2004) Exp. Gerontol. , vol.39 , pp. 1407-1414
    • van den Biggelaar, A.H.J.1
  • 16
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • Dilger R.N., and Johnson R.W. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J. Leukoc. Biol. 84 (2008) 932-939
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 17
    • 34447321028 scopus 로고    scopus 로고
    • Ageing and Toll-like receptor expression by innate immune cells in chronic human schistosomiasis
    • Comin F., et al. Ageing and Toll-like receptor expression by innate immune cells in chronic human schistosomiasis. Clin. Exp. Immunol. 149 (2007) 274-284
    • (2007) Clin. Exp. Immunol. , vol.149 , pp. 274-284
    • Comin, F.1
  • 18
    • 0027265827 scopus 로고
    • Increased cytokine production in mononuclear cells of healthy elderly people
    • Fagiolo U., et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23 (1993) 2375-2378
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2375-2378
    • Fagiolo, U.1
  • 19
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C., et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 128 (2007) 92-105
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 92-105
    • Franceschi, C.1
  • 20
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    • Ershler W.B., and Keller E.T. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51 (2000) 245-270
    • (2000) Annu. Rev. Med. , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 21
    • 0037396220 scopus 로고    scopus 로고
    • Plasma cytokine profiles in elderly humans
    • Forsey R.J., et al. Plasma cytokine profiles in elderly humans. Mech. Ageing Dev. 124 (2003) 487-493
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 487-493
    • Forsey, R.J.1
  • 22
    • 0035093402 scopus 로고    scopus 로고
    • Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes
    • Giuliani N., et al. Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes. Exp. Gerontol. 36 (2001) 547-557
    • (2001) Exp. Gerontol. , vol.36 , pp. 547-557
    • Giuliani, N.1
  • 23
    • 0035140821 scopus 로고    scopus 로고
    • Interleukin-6 production does not increase with age
    • Beharka A.A., et al. Interleukin-6 production does not increase with age. J. Gerontol. A Biol. Sci. Med. Sci. 56 (2001) B81-B88
    • (2001) J. Gerontol. A Biol. Sci. Med. Sci. , vol.56
    • Beharka, A.A.1
  • 24
    • 0037372505 scopus 로고    scopus 로고
    • Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
    • Barbieri M., et al. Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am. J. Physiol. Endocrinol. Metab. 284 (2003) E481-E487
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.284
    • Barbieri, M.1
  • 25
    • 0037440670 scopus 로고    scopus 로고
    • Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly
    • Cohen H.J., et al. Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am. J. Med. 114 (2003) 180-187
    • (2003) Am. J. Med. , vol.114 , pp. 180-187
    • Cohen, H.J.1
  • 26
    • 0033024330 scopus 로고    scopus 로고
    • Serum IL-6 level and the development of disability in older persons
    • Ferrucci L., et al. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47 (1999) 639-646
    • (1999) J. Am. Geriatr. Soc. , vol.47 , pp. 639-646
    • Ferrucci, L.1
  • 27
    • 34347338725 scopus 로고    scopus 로고
    • Inflammation and frailty in older women
    • Leng S.X., et al. Inflammation and frailty in older women. J. Am. Geriatr. Soc. 55 (2007) 864-871
    • (2007) J. Am. Geriatr. Soc. , vol.55 , pp. 864-871
    • Leng, S.X.1
  • 28
    • 2442699834 scopus 로고    scopus 로고
    • Frailty in older adults: evidence for a phenotype
    • Fried L.P., et al. Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 56 (2001) M146-M156
    • (2001) J. Gerontol. A Biol. Sci. Med. Sci. , vol.56
    • Fried, L.P.1
  • 29
    • 57749202485 scopus 로고    scopus 로고
    • Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis
    • Di Bona D., et al. Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Res. Rev. 8 (2009) 36-42
    • (2009) Ageing Res. Rev. , vol.8 , pp. 36-42
    • Di Bona, D.1
  • 30
    • 27744600560 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis in elderly patients
    • Opal S.M., et al. The immunopathogenesis of sepsis in elderly patients. Clin. Infect. Dis. 41 Suppl 7 (2005) S504-S512
    • (2005) Clin. Infect. Dis. , vol.41 , Issue.SUPPL. 7
    • Opal, S.M.1
  • 31
    • 33745185337 scopus 로고    scopus 로고
    • Interleukin-6 in aging and chronic disease: a magnificent pathway
    • Maggio M., et al. Interleukin-6 in aging and chronic disease: a magnificent pathway. J. Gerontol. A Biol. Sci. Med. Sci. 61 (2006) 575-584
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci. , vol.61 , pp. 575-584
    • Maggio, M.1
  • 32
    • 0037012005 scopus 로고    scopus 로고
    • Overproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly
    • Gabriel P., et al. Overproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly. Exp. Gerontol. 37 (2002) 235-247
    • (2002) Exp. Gerontol. , vol.37 , pp. 235-247
    • Gabriel, P.1
  • 33
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe J.P., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6 (2008) 2853-2868
    • (2008) PLoS Biol. , vol.6 , pp. 2853-2868
    • Coppe, J.P.1
  • 34
    • 20344384993 scopus 로고    scopus 로고
    • Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes
    • Stout R.D., and Suttles J. Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes. Immunol. Rev. 205 (2005) 60-71
    • (2005) Immunol. Rev. , vol.205 , pp. 60-71
    • Stout, R.D.1    Suttles, J.2
  • 35
    • 67649396851 scopus 로고    scopus 로고
    • Straub, R.H. and Mocchegiani, E. (eds) (2004) The Neuroendocrine Immune Network in Ageing (Neuroimmune Biology, 4), Elsevier
    • Straub, R.H. and Mocchegiani, E. (eds) (2004) The Neuroendocrine Immune Network in Ageing (Neuroimmune Biology, Vol. 4), Elsevier
  • 36
    • 48149112746 scopus 로고    scopus 로고
    • Leptin beyond body weight regulation-current concepts concerning its role in immune function and inflammation
    • Lago R., et al. Leptin beyond body weight regulation-current concepts concerning its role in immune function and inflammation. Cell. Immunol. 252 (2008) 139-145
    • (2008) Cell. Immunol. , vol.252 , pp. 139-145
    • Lago, R.1
  • 37
    • 0032054571 scopus 로고    scopus 로고
    • Endocrine regulation of murine macrophage function: effects of dehydroepiandrosterone, androstenediol, and androstenetriol
    • Padgett D.A., and Loria R.M. Endocrine regulation of murine macrophage function: effects of dehydroepiandrosterone, androstenediol, and androstenetriol. J. Neuroimmunol. 84 (1998) 61-68
    • (1998) J. Neuroimmunol. , vol.84 , pp. 61-68
    • Padgett, D.A.1    Loria, R.M.2
  • 38
    • 84975806501 scopus 로고    scopus 로고
    • Inflammatory networks in ageing, age-related diseases and longevity
    • Vasto S., et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech. Ageing Dev. 128 (2007) 83-91
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 83-91
    • Vasto, S.1
  • 39
    • 0021213410 scopus 로고
    • Effects of aging on the in vitro response of human lymphocytes to interleukin-2
    • Yamashita N., et al. Effects of aging on the in vitro response of human lymphocytes to interleukin-2. Jpn. J. Med. 23 (1984) 211-215
    • (1984) Jpn. J. Med. , vol.23 , pp. 211-215
    • Yamashita, N.1
  • 40
    • 0026802522 scopus 로고
    • Immunosenescence of human NK cells: effects on tumor target recognition, lethal hit and interferon sensitivity
    • Krishnaraj R. Immunosenescence of human NK cells: effects on tumor target recognition, lethal hit and interferon sensitivity. Immunol. Lett. 34 (1992) 79-84
    • (1992) Immunol. Lett. , vol.34 , pp. 79-84
    • Krishnaraj, R.1
  • 41
    • 0033026570 scopus 로고    scopus 로고
    • NK phenotypic markers and IL2 response in NK cells from elderly people
    • Borrego F., et al. NK phenotypic markers and IL2 response in NK cells from elderly people. Exp. Gerontol. 34 (1999) 253-265
    • (1999) Exp. Gerontol. , vol.34 , pp. 253-265
    • Borrego, F.1
  • 42
    • 0026492479 scopus 로고
    • The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism
    • Vitale M., et al. The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism. Cell. Immunol. 145 (1992) 1-10
    • (1992) Cell. Immunol. , vol.145 , pp. 1-10
    • Vitale, M.1
  • 43
    • 0027381336 scopus 로고
    • Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians
    • Sansoni P., et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 82 (1993) 2767-2773
    • (1993) Blood , vol.82 , pp. 2767-2773
    • Sansoni, P.1
  • 44
    • 0021259180 scopus 로고
    • The immune status of healthy centenarians
    • Thompson J.S., et al. The immune status of healthy centenarians. J. Am. Geriatr. Soc. 32 (1984) 274-281
    • (1984) J. Am. Geriatr. Soc. , vol.32 , pp. 274-281
    • Thompson, J.S.1
  • 45
    • 0033788507 scopus 로고    scopus 로고
    • Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians
    • Miyaji C., et al. Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians. Hum. Immunol. 61 (2000) 908-916
    • (2000) Hum. Immunol. , vol.61 , pp. 908-916
    • Miyaji, C.1
  • 46
    • 0023225697 scopus 로고
    • Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing
    • Facchini A., et al. Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing. Clin. Exp. Immunol. 68 (1987) 340-347
    • (1987) Clin. Exp. Immunol. , vol.68 , pp. 340-347
    • Facchini, A.1
  • 47
    • 0025113854 scopus 로고
    • Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis
    • Mariani E., et al. Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis. Clin. Exp. Immunol. 81 (1990) 479-484
    • (1990) Clin. Exp. Immunol. , vol.81 , pp. 479-484
    • Mariani, E.1
  • 48
    • 0031240062 scopus 로고    scopus 로고
    • Natural killer cells in the late decades of human life
    • Ogata K., et al. Natural killer cells in the late decades of human life. Clin. Immunol. Immunopathol. 84 (1997) 269-275
    • (1997) Clin. Immunol. Immunopathol. , vol.84 , pp. 269-275
    • Ogata, K.1
  • 49
    • 0030607135 scopus 로고    scopus 로고
    • Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples
    • Kutza J., and Murasko D.M. Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. Mech. Ageing Dev. 90 (1996) 209-222
    • (1996) Mech. Ageing Dev. , vol.90 , pp. 209-222
    • Kutza, J.1    Murasko, D.M.2
  • 50
    • 0031842690 scopus 로고    scopus 로고
    • Age-dependent decreases of NK cell phosphoinositide turnover during spontaneous but not Fc-mediated cytolytic activity
    • Mariani E., et al. Age-dependent decreases of NK cell phosphoinositide turnover during spontaneous but not Fc-mediated cytolytic activity. Int. Immunol. 10 (1998) 981-989
    • (1998) Int. Immunol. , vol.10 , pp. 981-989
    • Mariani, E.1
  • 51
    • 0018633191 scopus 로고
    • Antibody-dependent cellular cytotoxicity effector cell capability among normal individuals
    • Edwards D.L., and Avis F.P. Antibody-dependent cellular cytotoxicity effector cell capability among normal individuals. J. Immunol. 123 (1979) 1887-1893
    • (1979) J. Immunol. , vol.123 , pp. 1887-1893
    • Edwards, D.L.1    Avis, F.P.2
  • 52
    • 0019592559 scopus 로고
    • Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans
    • Fernandes G., and Gupta S. Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans. J. Clin. Immunol. 1 (1981) 141-148
    • (1981) J. Clin. Immunol. , vol.1 , pp. 141-148
    • Fernandes, G.1    Gupta, S.2
  • 53
    • 0030014593 scopus 로고    scopus 로고
    • Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion
    • Krishnaraj R., and Bhooma T. Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion. Immunol. Lett. 50 (1996) 59-63
    • (1996) Immunol. Lett. , vol.50 , pp. 59-63
    • Krishnaraj, R.1    Bhooma, T.2
  • 54
    • 0036085174 scopus 로고    scopus 로고
    • Chemokine production by natural killer cells from nonagenarians
    • Mariani E., et al. Chemokine production by natural killer cells from nonagenarians. Eur. J. Immunol. 32 (2002) 1524-1529
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1524-1529
    • Mariani, E.1
  • 55
    • 0034916891 scopus 로고    scopus 로고
    • Association between natural killer cell activity and infection in immunologically normal elderly people
    • Ogata K., et al. Association between natural killer cell activity and infection in immunologically normal elderly people. Clin. Exp. Immunol. 124 (2001) 392-397
    • (2001) Clin. Exp. Immunol. , vol.124 , pp. 392-397
    • Ogata, K.1
  • 56
    • 42149193103 scopus 로고    scopus 로고
    • Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles
    • Mariani E., et al. Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles. Exp. Gerontol. 43 (2008) 462-471
    • (2008) Exp. Gerontol. , vol.43 , pp. 462-471
    • Mariani, E.1
  • 57
    • 0037398726 scopus 로고    scopus 로고
    • Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply
    • Mocchegiani E., et al. Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply. Mech. Ageing Dev. 124 (2003) 459-468
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 459-468
    • Mocchegiani, E.1
  • 58
    • 34247842744 scopus 로고    scopus 로고
    • The biology of NKT cells
    • Bendelac A., et al. The biology of NKT cells. Annu. Rev. Immunol. 25 (2007) 297-336
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 297-336
    • Bendelac, A.1
  • 59
    • 0037011793 scopus 로고    scopus 로고
    • Valpha24+ NKT cells are decreased in elderly humans
    • DelaRosa O., et al. Valpha24+ NKT cells are decreased in elderly humans. Exp. Gerontol. 37 (2002) 213-217
    • (2002) Exp. Gerontol. , vol.37 , pp. 213-217
    • DelaRosa, O.1
  • 60
    • 34447316133 scopus 로고    scopus 로고
    • Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood
    • Jing Y., et al. Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. Exp. Gerontol. 42 (2007) 719-732
    • (2007) Exp. Gerontol. , vol.42 , pp. 719-732
    • Jing, Y.1
  • 61
    • 34250314036 scopus 로고    scopus 로고
    • Decreased frequency and proliferative response of invariant Valpha24Vbeta11 natural killer T (iNKT) cells in healthy elderly
    • Peralbo E., et al. Decreased frequency and proliferative response of invariant Valpha24Vbeta11 natural killer T (iNKT) cells in healthy elderly. Biogerontology 7 (2006) 483-492
    • (2006) Biogerontology , vol.7 , pp. 483-492
    • Peralbo, E.1
  • 62
    • 0035915803 scopus 로고    scopus 로고
    • Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells
    • Tarazona R., et al. Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells. Mech. Ageing Dev. 121 (2000) 77-88
    • (2000) Mech. Ageing Dev. , vol.121 , pp. 77-88
    • Tarazona, R.1
  • 63
    • 34447325353 scopus 로고    scopus 로고
    • Invariant NKT and NKT-like lymphocytes: two different T cell subsets that are differentially affected by ageing
    • Peralbo E., et al. Invariant NKT and NKT-like lymphocytes: two different T cell subsets that are differentially affected by ageing. Exp. Gerontol. 42 (2007) 703-708
    • (2007) Exp. Gerontol. , vol.42 , pp. 703-708
    • Peralbo, E.1
  • 64
    • 40749155922 scopus 로고    scopus 로고
    • Induction of CD56 and TCR-independent activation of T cells with aging
    • Lemster B.H., et al. Induction of CD56 and TCR-independent activation of T cells with aging. J. Immunol. 180 (2008) 1979-1990
    • (2008) J. Immunol. , vol.180 , pp. 1979-1990
    • Lemster, B.H.1
  • 65
    • 23044510924 scopus 로고    scopus 로고
    • Diversity of NKR expression in aging T cells and in T cells of the aged: the new frontier into the exploration of protective immunity in the elderly
    • Abedin S., et al. Diversity of NKR expression in aging T cells and in T cells of the aged: the new frontier into the exploration of protective immunity in the elderly. Exp. Gerontol. 40 (2005) 537-548
    • (2005) Exp. Gerontol. , vol.40 , pp. 537-548
    • Abedin, S.1
  • 66
    • 50849117520 scopus 로고    scopus 로고
    • Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells
    • Li G., et al. Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells. J. Leukoc. Biol. 84 (2008) 824-834
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 824-834
    • Li, G.1
  • 67
    • 0038217024 scopus 로고    scopus 로고
    • Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections
    • Laupland K.B., et al. Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections. J. Infect. Dis. 187 (2003) 1452-1459
    • (2003) J. Infect. Dis. , vol.187 , pp. 1452-1459
    • Laupland, K.B.1
  • 68
    • 0020697050 scopus 로고
    • Infectious diseases in the elderly
    • Schneider E.L. Infectious diseases in the elderly. Ann. Intern. Med. 98 (1983) 395-400
    • (1983) Ann. Intern. Med. , vol.98 , pp. 395-400
    • Schneider, E.L.1
  • 69
    • 0030737716 scopus 로고    scopus 로고
    • Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis
    • Edwards S.W., and Hallett M.B. Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis. Immunol. Today 18 (1997) 320-324
    • (1997) Immunol. Today , vol.18 , pp. 320-324
    • Edwards, S.W.1    Hallett, M.B.2
  • 70
    • 21644479222 scopus 로고    scopus 로고
    • Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
    • Raza K., et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res. Ther. 7 (2005) R784-R795
    • (2005) Arthritis Res. Ther. , vol.7
    • Raza, K.1
  • 71
    • 39449099608 scopus 로고    scopus 로고
    • Age-related changes in eosinophil function in human subjects
    • Mathur S.K., et al. Age-related changes in eosinophil function in human subjects. Chest 133 (2008) 412-419
    • (2008) Chest , vol.133 , pp. 412-419
    • Mathur, S.K.1
  • 72
    • 0019914184 scopus 로고
    • Skin reactivity, basophil degranulation and IgE levels in ageing
    • Schwarzenbach H.R., et al. Skin reactivity, basophil degranulation and IgE levels in ageing. Clin. Allergy 12 (1982) 465-473
    • (1982) Clin. Allergy , vol.12 , pp. 465-473
    • Schwarzenbach, H.R.1
  • 73
    • 0022575332 scopus 로고
    • Human basophil releasability. I. Age-related changes in basophil releasability
    • Marone G., et al. Human basophil releasability. I. Age-related changes in basophil releasability. J. Allergy Clin. Immunol. 77 (1986) 377-383
    • (1986) J. Allergy Clin. Immunol. , vol.77 , pp. 377-383
    • Marone, G.1
  • 74
    • 39449133957 scopus 로고    scopus 로고
    • A mechanism for the initiation of allergen-induced T helper type 2 responses
    • Sokol C.L., et al. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9 (2008) 310-318
    • (2008) Nat. Immunol. , vol.9 , pp. 310-318
    • Sokol, C.L.1
  • 75
    • 45549087159 scopus 로고    scopus 로고
    • Basophils enhance immunological memory responses
    • Denzel A., et al. Basophils enhance immunological memory responses. Nat. Immunol. 9 (2008) 733-742
    • (2008) Nat. Immunol. , vol.9 , pp. 733-742
    • Denzel, A.1
  • 76
    • 54249156556 scopus 로고    scopus 로고
    • Aging and neutrophils: there is still much to do
    • Fortin C.F., et al. Aging and neutrophils: there is still much to do. Rejuvenation Res. 11 (2008) 873-882
    • (2008) Rejuvenation Res. , vol.11 , pp. 873-882
    • Fortin, C.F.1
  • 77
    • 0035975703 scopus 로고    scopus 로고
    • Neutrophil ageing and immunesenescence
    • Lord J.M., et al. Neutrophil ageing and immunesenescence. Mech. Ageing Dev. 122 (2001) 1521-1535
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1521-1535
    • Lord, J.M.1
  • 78
    • 34347361753 scopus 로고    scopus 로고
    • Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins
    • Tortorella C., et al. Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins. Ageing Res. Rev. 6 (2007) 81-93
    • (2007) Ageing Res. Rev. , vol.6 , pp. 81-93
    • Tortorella, C.1
  • 79
    • 0037397899 scopus 로고    scopus 로고
    • Neutrophil immunity of the elderly
    • Schroder A.K., and Rink L. Neutrophil immunity of the elderly. Mech. Ageing Dev. 124 (2003) 419-425
    • (2003) Mech. Ageing Dev. , vol.124 , pp. 419-425
    • Schroder, A.K.1    Rink, L.2
  • 80
    • 84919718194 scopus 로고    scopus 로고
    • Synergistic effects of ageing and stress on neutrophil function
    • Fulop T., et al. (Ed), Springer
    • Lord J.M., et al. Synergistic effects of ageing and stress on neutrophil function. In: Fulop T., et al. (Ed). Handbook of Immunosenescence (2009), Springer 475-498
    • (2009) Handbook of Immunosenescence , pp. 475-498
    • Lord, J.M.1
  • 81
    • 33947660464 scopus 로고    scopus 로고
    • GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals
    • Fortin C.F., et al. GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals. Biogerontology 8 (2007) 173-187
    • (2007) Biogerontology , vol.8 , pp. 173-187
    • Fortin, C.F.1
  • 82
    • 33745121896 scopus 로고    scopus 로고
    • Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease
    • Vandivier R.W., et al. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest 129 (2006) 1673-1682
    • (2006) Chest , vol.129 , pp. 1673-1682
    • Vandivier, R.W.1
  • 83
    • 33847732694 scopus 로고    scopus 로고
    • Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions
    • Fortin C.F., et al. Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions. FEBS Lett. 581 (2007) 1173-1178
    • (2007) FEBS Lett. , vol.581 , pp. 1173-1178
    • Fortin, C.F.1
  • 84
    • 0035009177 scopus 로고    scopus 로고
    • Age-related changes in membrane lipid composition, fluidity and respiratory burst in rat peritoneal neutrophils
    • Alvarez E., et al. Age-related changes in membrane lipid composition, fluidity and respiratory burst in rat peritoneal neutrophils. Clin. Exp. Immunol. 124 (2001) 95-102
    • (2001) Clin. Exp. Immunol. , vol.124 , pp. 95-102
    • Alvarez, E.1
  • 86
    • 33646580485 scopus 로고    scopus 로고
    • Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    • Fortin C.F., et al. Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions. J. Leukoc. Biol. 79 (2006) 1061-1072
    • (2006) J. Leukoc. Biol. , vol.79 , pp. 1061-1072
    • Fortin, C.F.1
  • 87
    • 5644265023 scopus 로고    scopus 로고
    • Signal transduction and functional changes in neutrophils with aging
    • Fulop T., et al. Signal transduction and functional changes in neutrophils with aging. Aging Cell 3 (2004) 217-226
    • (2004) Aging Cell , vol.3 , pp. 217-226
    • Fulop, T.1
  • 88
    • 33845954235 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay fas-induced neutrophil apoptosis in elderly humans
    • Tortorella C., et al. Role of phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways in granulocyte macrophage-colony-stimulating factor failure to delay fas-induced neutrophil apoptosis in elderly humans. J. Gerontol. A Biol. Sci. Med. Sci. 61 (2006) 1111-1118
    • (2006) J. Gerontol. A Biol. Sci. Med. Sci. , vol.61 , pp. 1111-1118
    • Tortorella, C.1
  • 89
    • 0030446825 scopus 로고    scopus 로고
    • Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects
    • Biasi D., et al. Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects. Inflammation 20 (1996) 673-681
    • (1996) Inflammation , vol.20 , pp. 673-681
    • Biasi, D.1
  • 90
    • 0035216133 scopus 로고    scopus 로고
    • Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
    • Butcher S.K., et al. Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J. Leukoc. Biol. 70 (2001) 881-886
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 881-886
    • Butcher, S.K.1
  • 91
    • 0033958830 scopus 로고    scopus 로고
    • Effect of age on human neutrophil function
    • Wenisch C., et al. Effect of age on human neutrophil function. J. Leukoc. Biol. 67 (2000) 40-45
    • (2000) J. Leukoc. Biol. , vol.67 , pp. 40-45
    • Wenisch, C.1
  • 92
    • 1342332122 scopus 로고    scopus 로고
    • Blood polymorphonuclear leukocyte migration as a predictive marker for infections in severe trauma: comparison with various inflammation parameters
    • Egger G., et al. Blood polymorphonuclear leukocyte migration as a predictive marker for infections in severe trauma: comparison with various inflammation parameters. Intensive Care Med. 30 (2004) 331-334
    • (2004) Intensive Care Med. , vol.30 , pp. 331-334
    • Egger, G.1
  • 93
    • 0024397502 scopus 로고
    • Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies
    • Niwa Y., et al. Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies. Life Sci. 44 (1989) 1655-1664
    • (1989) Life Sci. , vol.44 , pp. 1655-1664
    • Niwa, Y.1
  • 94
    • 63849217133 scopus 로고    scopus 로고
    • The divergence and interplay between pDC and mDC in humans
    • Kadowaki N. The divergence and interplay between pDC and mDC in humans. Front. Biosci. 14 (2009) 808-817
    • (2009) Front. Biosci. , vol.14 , pp. 808-817
    • Kadowaki, N.1
  • 95
    • 33846046984 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells and monocytes are differently regulated in the elderly
    • Della Bella S., et al. Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. Clin. Immunol. 122 (2007) 220-228
    • (2007) Clin. Immunol. , vol.122 , pp. 220-228
    • Della Bella, S.1
  • 96
    • 0036436469 scopus 로고    scopus 로고
    • Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing
    • Shodell M., and Siegal F.P. Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing. Scand. J. Immunol. 56 (2002) 518-521
    • (2002) Scand. J. Immunol. , vol.56 , pp. 518-521
    • Shodell, M.1    Siegal, F.P.2
  • 97
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal A., et al. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 178 (2007) 6912-6922
    • (2007) J. Immunol. , vol.178 , pp. 6912-6922
    • Agrawal, A.1
  • 98
    • 0029822246 scopus 로고    scopus 로고
    • Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals
    • Steger M.M., et al. Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin. Exp. Immunol. 105 (1996) 544-550
    • (1996) Clin. Exp. Immunol. , vol.105 , pp. 544-550
    • Steger, M.M.1
  • 99
    • 0033951305 scopus 로고    scopus 로고
    • Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells
    • Lung T.L., et al. Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells. Vaccine 18 (2000) 1606-1612
    • (2000) Vaccine , vol.18 , pp. 1606-1612
    • Lung, T.L.1
  • 100
    • 0036174828 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing
    • Bhushan M., et al. Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing. Br. J. Dermatol. 146 (2002) 32-40
    • (2002) Br. J. Dermatol. , vol.146 , pp. 32-40
    • Bhushan, M.1
  • 101
    • 33845469025 scopus 로고    scopus 로고
    • Do Langerhans cells behave similarly in elderly and younger patients with chronic periodontitis?
    • Bodineau A., et al. Do Langerhans cells behave similarly in elderly and younger patients with chronic periodontitis?. Arch Oral Biol. 52 (2007) 189-194
    • (2007) Arch Oral Biol. , vol.52 , pp. 189-194
    • Bodineau, A.1
  • 102
    • 56549121816 scopus 로고    scopus 로고
    • Increase of gingival matured dendritic cells number in elderly patients with chronic periodontitis
    • Bodineau A., et al. Increase of gingival matured dendritic cells number in elderly patients with chronic periodontitis. Arch. Oral Biol. 54 (2009) 12-16
    • (2009) Arch. Oral Biol. , vol.54 , pp. 12-16
    • Bodineau, A.1
  • 103
    • 33750624489 scopus 로고    scopus 로고
    • Deterioration of the Langerhans cell network of the human gingival epithelium with aging
    • Zavala W.D., and Cavicchia J.C. Deterioration of the Langerhans cell network of the human gingival epithelium with aging. Arch. Oral Biol. 51 (2006) 1150-1155
    • (2006) Arch. Oral Biol. , vol.51 , pp. 1150-1155
    • Zavala, W.D.1    Cavicchia, J.C.2
  • 104
    • 0036668678 scopus 로고    scopus 로고
    • Molecular interactions of FDCs with B cells in aging
    • Szakal A.K., et al. Molecular interactions of FDCs with B cells in aging. Semin. Immunol. 14 (2002) 267-274
    • (2002) Semin. Immunol. , vol.14 , pp. 267-274
    • Szakal, A.K.1
  • 105
    • 0037397605 scopus 로고    scopus 로고
    • Effects of age on antibody affinity maturation
    • Dunn-Walters D.K., et al. Effects of age on antibody affinity maturation. Biochem. Soc. Trans. 31 (2003) 447-448
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 447-448
    • Dunn-Walters, D.K.1
  • 106
    • 45949103917 scopus 로고    scopus 로고
    • Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
    • Frasca D., et al. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J. Immunol. 180 (2008) 5283-5290
    • (2008) J. Immunol. , vol.180 , pp. 5283-5290
    • Frasca, D.1
  • 107
    • 0032524932 scopus 로고    scopus 로고
    • Changes in CD8 and CD4 lymphocyte subsets. T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study
    • Wikby A., et al. Changes in CD8 and CD4 lymphocyte subsets. T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech. Ageing Dev. 102 (1998) 187-198
    • (1998) Mech. Ageing Dev. , vol.102 , pp. 187-198
    • Wikby, A.1
  • 108
    • 0033106240 scopus 로고    scopus 로고
    • Antigen presenting cell function is enhanced in healthy elderly
    • Castle S.C., et al. Antigen presenting cell function is enhanced in healthy elderly. Mech. Ageing Dev. 107 (1999) 137-145
    • (1999) Mech. Ageing Dev. , vol.107 , pp. 137-145
    • Castle, S.C.1
  • 109
    • 0034073189 scopus 로고    scopus 로고
    • Surface markers and transendothelial migration of dendritic cells from elderly subjects
    • Pietschmann P., et al. Surface markers and transendothelial migration of dendritic cells from elderly subjects. Exp. Gerontol. 35 (2000) 213-224
    • (2000) Exp. Gerontol. , vol.35 , pp. 213-224
    • Pietschmann, P.1
  • 110
    • 0036499158 scopus 로고    scopus 로고
    • Effect of aging on cytokine production in response to respiratory syncytial virus infection
    • Looney R.J., et al. Effect of aging on cytokine production in response to respiratory syncytial virus infection. J. Infect. Dis. 185 (2002) 682-685
    • (2002) J. Infect. Dis. , vol.185 , pp. 682-685
    • Looney, R.J.1
  • 111
    • 60549108257 scopus 로고    scopus 로고
    • Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA
    • Agrawal A., et al. Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J. Immunol. 182 (2009) 1138-1145
    • (2009) J. Immunol. , vol.182 , pp. 1138-1145
    • Agrawal, A.1
  • 112
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao T., and Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol. 24 (2003) 358-363
    • (2003) Trends Immunol. , vol.24 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.