Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6565-6570

  Steele, Rebecca M ^a   Benedini, Francesca ^a   Biondi, Stefano ^a   Borghi, Valentina ^a   Carzaniga, Laura ^a   Impagnatiello, Francesco ^a   Miglietta, Daniela ^a   Chong, Wesley K M ^b   Rajapakse, Ranjan ^b   Cecchi, Alessandro ^c   Temperini, Claudia ^c   Supuran, Claudiu T ^c  

^a NicOx Research Institute   (Italy)

^b PFIZER INC   (United States)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antiglaucoma drug; Carbonic anhydrase; Dorzolamide; NO donating agent; Sulfonamide; X ray crystallography

Indexed keywords

ANTIGLAUCOMA AGENT; CARBONATE DEHYDRATASE INHIBITOR; DORZOLAMIDE; ISOSORBIDE MONONITRATE; NCX 201; NCX 245; NCX 265; NCX 274; NCX 278; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; INTRAOCULAR PRESSURE; NONHUMAN; OPEN ANGLE GLAUCOMA; RABBIT; VASCULAR RING; X RAY CRYSTALLOGRAPHY;

ANIMALS; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; GLAUCOMA, OPEN-ANGLE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOPHENES;

ORYCTOLAGUS CUNICULUS;

EID: 71749104748     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.036     Document Type: Article

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