Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3601-3605

  Di Fiore, Anna ^a   Monti, Simona Maria ^a   Innocenti, Alessio ^b   Winum, Jean Yves ^c   De Simone, Giuseppina ^a   Supuran, Claudiu T ^b  

^a CNR   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c INSTITUT CHARLES GERHARDT   (France)

Author keywords

Carbonic anhydrase; Dioxaborolan; Sulfamide; Sulfonamide; X ray crystallography

Indexed keywords

4 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)PHENYLSULFAMIDE; BORON; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; GLUTAMINE; ISOENZYME; ISOLEUCINE; LEUCINE; PHENYLALANINE; SUGAR; SULFAMIDE DERIVATIVE; SULFANILAMIDE; THREONINE; UNCLASSIFIED DRUG; VALINE; ZINC;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; INTROSPECTION; MAMMAL; NONHUMAN;

AMIDES; BORON; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROCARBONS, AROMATIC; PROTEIN BINDING; PROTEIN ISOFORMS; SOLUTIONS; SULFONIC ACIDS; ZINC;

MAMMALIA;

EID: 77954213812     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.114     Document Type: Article

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