Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 4894-4899

  Güzel, Özlen ^a,b   Innocenti, Alessio ^b   Scozzafava, Andrea ^b   Salman, Aydin ^a   Supuran, Claudiu T ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antiobesity; Carbonic anhydrase; Cytosolic isoforms I and II; Isoform selective inhibitor; Mitochondrial isozymes VA and VB; Sulfonamide

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARBAMOYL PHOSPHATE SYNTHASE; CARBAMOYL PHOSPHATE SYNTHASE (GLUTAMINE HYDROLYSING); CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE V; PYRUVATE CARBOXYLASE; SULFONAMIDE;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; FATTY ACID SYNTHESIS; HUMAN; OBESITY;

CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CYTOSOL; HUMANS; MITOCHONDRIA; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 67650046728     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.006     Document Type: Article

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