메뉴 건너뛰기




Volumn 20, Issue 6, 2010, Pages 795-806

Carbonic anhydrase inhibition as a cancer therapy: A review of patent literature, 2007 - 2009

Author keywords

Cancer; Carbonic anhydrase; Carbonic anhydrase inhibitor; Click chemistry; Hypoxia; Nitric oxide; Radiopharmaceutical; Sulfamate; Sulfonamide

Indexed keywords

ACETAZOLAMIDE; BRINZOLAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; DICLOFENAMIDE; ETHOXZOLAMIDE; HYPOXIA INDUCIBLE FACTOR; MONOCLONAL ANTIBODY G250; SHORT HAIRPIN RNA; SULFONAMIDE; TOPIRAMATE;

EID: 77952571665     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.2010.484803     Document Type: Review
Times cited : (47)

References (38)
  • 1
    • 42149143745 scopus 로고    scopus 로고
    • Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein- ligand binding
    • Krishnamurthy VM, Kaufman GK, Urbach AR, et al. Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein- ligand binding. Chem Rev 2008;108:946-1051
    • (2008) Chem Rev , vol.108 , pp. 946-1051
    • Krishnamurthy, V.M.1    Kaufman, G.K.2    Urbach, A.R.3
  • 2
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008;7:168-181
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 4
    • 0034671307 scopus 로고    scopus 로고
    • Hypoxia-inducible expression of tumor-associated carbonic anhydrases
    • Wykoff CC,Beasley NJ,Watson PH,et al.Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000 ,60: 7075--83
    • (2000) Cancer Res , vol.60 , pp. 70-83
    • Wykoff, C.C.1    Beasley, N.J.2    Watson, P.H.3
  • 5
    • 0042847064 scopus 로고    scopus 로고
    • Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
    • Potter CPS, Harris AL. Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br J Cancer 2003;89:2-7
    • (2003) Br J Cancer , vol.89 , pp. 2-7
    • Potter, C.P.S.1    Harris, A.L.2
  • 6
    • 62749124795 scopus 로고    scopus 로고
    • Transcriptional control of the tumorand hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?
    • Kaluz S, Kaluzova M, Liao S-Y, et al. Transcriptional control of the tumorand hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show? Biochim Biophys Acta Rev Cancer 2009;1795:162-172
    • (2009) Biochim Biophys Acta Rev Cancer , vol.1795 , pp. 162-172
    • Kaluz, S.1    Kaluzova, M.2    Liao, S.-Y.3
  • 7
    • 0029975564 scopus 로고    scopus 로고
    • Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
    • Opavský R, Pastoreková S, Zeln?́k V, et al. Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. Genomics 1996;33:480-487
    • (1996) Genomics , vol.33 , pp. 480-487
    • Opavský, R.1    Pastoreková, S.2    Zelńk, V.3
  • 8
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J, Ilc K, Laferrière J, et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 2009;69:358-368
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferrière, J.3
  • 10
    • 0029982979 scopus 로고    scopus 로고
    • Acidic pH enhances the invasive behavior of human melanoma cells
    • Martinez-Zaguilan R, Seftor EA, Seftor RE, et al. Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis 1996;14:176-186
    • (1996) Clin Exp Metastasis , vol.14 , pp. 176-186
    • Martinez-Zaguilan, R.1    Seftor, E.A.2    Seftor, R.E.3
  • 11
    • 50649105780 scopus 로고    scopus 로고
    • Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths
    • Swietach P, Wigfield S, Cobden P, et al. Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. J Biol Chem 2008;283:20473-20483
    • (2008) J Biol Chem , vol.283 , pp. 20473-20483
    • Swietach, P.1    Wigfield, S.2    Cobden, P.3
  • 12
    • 67749145635 scopus 로고    scopus 로고
    • The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths
    • Swietach P, Patiar S, Supuran CT, et al. The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths. J Biol Chem 2009;284:20299-20310
    • (2009) J Biol Chem , vol.284 , pp. 20299-20310
    • Swietach, P.1    Patiar, S.2    Supuran, C.T.3
  • 13
    • 8844249356 scopus 로고    scopus 로고
    • Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
    • Svastova E, Hulikova A, Rafajova M, et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004;577:439-445
    • (2004) FEBS Lett , vol.577 , pp. 439-445
    • Svastova, E.1    Hulikova, A.2    Rafajova, M.3
  • 14
    • 0031724558 scopus 로고    scopus 로고
    • Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma
    • Divgi CR, Bander NH, Scott AM, et al. Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma. Clin Cancer Res 1998;4:2729-2739
    • (1998) Clin Cancer Res , vol.4 , pp. 2729-2739
    • Divgi, C.R.1    Bander, N.H.2    Scott, A.M.3
  • 15
    • 0034099829 scopus 로고    scopus 로고
    • Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250
    • Grabmaier K, Vissers JL, De Weijert MC, et al. Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250. Int J Cancer 2000;85:865-870
    • (2000) Int J Cancer , vol.85 , pp. 865-870
    • Grabmaier, K.1    Vissers, J.L.2    De Weijert, M.C.3
  • 16
    • 77950563961 scopus 로고    scopus 로고
    • Sulfonamide linked neoglycoconjugates -- A new class of inhibitors for cancer-associated carbonic anhydrases
    • Lopez M, Bornaghi LF, Innocenti A, et al. Sulfonamide linked neoglycoconjugates -- a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem 2010;53:2913-2926
    • (2010) J Med Chem , vol.53 , pp. 2913-2926
    • Lopez, M.1    Bornaghi, L.F.2    Innocenti, A.3
  • 17
    • 70350072336 scopus 로고    scopus 로고
    • S-glycosyl primary sulfonamides -- A new structural class for selective inhibition of cancer-associated carbonic anhydrases
    • Lopez M, Paul B, Hofmann A, et al. S-glycosyl primary sulfonamides -- A new structural class for selective inhibition of cancer-associated carbonic anhydrases. J Med Chem 2009;52:6421-6432
    • (2009) J Med Chem , vol.52 , pp. 6421-6432
    • Lopez, M.1    Paul, B.2    Hofmann, A.3
  • 18
    • 77952579283 scopus 로고    scopus 로고
    • Sulfonamide carbonic anhydrase IX-specific inhibitors for the treatment of preneoplastic and neoplastic diseases
    • Supuran C, Scozzafava A, Pastorekova S, Pastorek J. Sulfonamide carbonic anhydrase IX-specific inhibitors for the treatment of preneoplastic and neoplastic diseases. WO048544; 2004
    • (2004) WO048544
    • Supuran, C.1    Scozzafava, A.2    Pastorekova, S.3    Pastorek, J.4
  • 19
    • 66149131065 scopus 로고    scopus 로고
    • Therapeutic applications of glycosidic carbonic anhydrase inhibitors
    • Winum J-Y, Poulsen S-A, Supuran CT. Therapeutic applications of glycosidic carbonic anhydrase inhibitors. Med Res Rev 2009;29:419-435
    • (2009) Med Res Rev , vol.29 , pp. 419-435
    • Winum, J.-Y.1    Poulsen, S.-A.2    Supuran, C.T.3
  • 20
    • 42549148009 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: A new druggable target for the design of antitumor agents
    • Winum J-Y, Rami M, Scozzafava A, et al. Carbonic anhydrase IX: a new druggable target for the design of antitumor agents. Med Res Rev 2008;28:445-463
    • (2008) Med Res Rev , vol.28 , pp. 445-463
    • Winum, J.-Y.1    Rami, M.2    Scozzafava, A.3
  • 21
    • 57149100954 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes i and II
    • Stiti M, Cecchi A, Rami M, et al. Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II. J Am Chem Soc 2008;130:16130-16131
    • (2008) J Am Chem Soc , vol.130 , pp. 16130-16131
    • Stiti, M.1    Cecchi, A.2    Rami, M.3
  • 22
    • 77952572188 scopus 로고    scopus 로고
    • Nitrate esters of carbonic anhydrase inhibitors
    • Nicox SA. Nitrate esters of carbonic anhydrase inhibitors. WO071421; 2008
    • (2008) WO071421
    • Nicox, S.A.1
  • 23
    • 77952570551 scopus 로고    scopus 로고
    • Novel sulfamate compounds for medical use
    • Solvay Pharmaceuticals GMBH
    • Solvay Pharmaceuticals GMBH. Novel sulfamate compounds for medical use. WO050252; 2009
    • (2009) WO050252
  • 24
    • 66749096587 scopus 로고    scopus 로고
    • Pharmaceutical "gold" from neurostabilizing agents: Topiramate and successor molecules
    • Maryanoff BE. Pharmaceutical "gold" from neurostabilizing agents: Topiramate and successor molecules. J Med Chem 2009;52:3431-3440
    • (2009) J Med Chem , vol.52 , pp. 3431-3440
    • Maryanoff, B.E.1
  • 25
    • 0344193512 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV
    • Casini A, Antel J, Abbate F, et al. Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV. Bioorg Med Chem Lett 2003;13:841-845
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 841-845
    • Casini, A.1    Antel, J.2    Abbate, F.3
  • 27
    • 0034596449 scopus 로고    scopus 로고
    • Efficient general method for sulfamoylation of a hydroxyl group
    • Okada M, Iwashita S, Koizumi N. Efficient general method for sulfamoylation of a hydroxyl group. Tetrahedron Lett 2000;41:7047-7051
    • (2000) Tetrahedron Lett , vol.41 , pp. 7047-7051
    • Okada, M.1    Iwashita, S.2    Koizumi, N.3
  • 28
    • 77952563815 scopus 로고    scopus 로고
    • Benzimidazo [ 1,2,-c][ 1,2,3]thiadiazol-7-sulfonamides as CA inhibitors
    • Biotechnologijos Institutas
    • Biotechnologijos Institutas. Benzimidazo [1,2,-c][1,2,3]thiadiazol-7- sulfonamides as CA inhibitors. WO016288; 2008
    • (2008) WO016288
  • 29
    • 34249685537 scopus 로고    scopus 로고
    • Benzimidazo[1,2-c][1,2,3] thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase
    • Dudutiene V, Baranauskiene L, Matulis D. Benzimidazo[1,2-c][1,2,3] thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase. Bioorg Med Chem Lett 2007;17:3335-3338
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 3335-3338
    • Dudutiene, V.1    Baranauskiene, L.2    Matulis, D.3
  • 30
    • 77952578510 scopus 로고    scopus 로고
    • The development of molecular imaging probes for carbonic anhydrase-IX using click chemistry
    • Siemens Medical Solutions USA, Inc
    • Siemens Medical Solutions USA, Inc. The development of molecular imaging probes for carbonic anhydrase-IX using click chemistry. WO124703; 2008
    • (2008) WO124703
  • 31
    • 0033566151 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: Is the tail more important than the ring?
    • DOI 10.1021/jm9900523
    • Scozzafava A, Menabuoni L, Mincione L, et al. Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: Is the tail more important than the ring? J Med Chem 1999:42:2641-2650 (Pubitemid 29344304)
    • (1999) Journal of Medicinal Chemistry , vol.42 , Issue.14 , pp. 2641-2650
    • Scozzafava, A.1    Menabuoni, L.2    Mincione, F.3    Briganti, F.4    Mincione, G.5    Supuran, C.T.6
  • 32
    • 33750471952 scopus 로고    scopus 로고
    • A novel class of carbonic anhydrase inhibitors: Glycoconjugate benzene sulfonamides prepared by "click-tailing"
    • Wilkinson BL, Bornaghi LF, Houston TA, et al. A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem 2006;49:6539-6548
    • (2006) J Med Chem , vol.49 , pp. 6539-6548
    • Wilkinson, B.L.1    Bornaghi, L.F.2    Houston, T.A.3
  • 33
    • 33645852593 scopus 로고    scopus 로고
    • Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilising alkene cross metathesis
    • Poulsen S-A, Bornaghi LF. Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilising alkene cross metathesis. Bioorg Med Chem 2006;14:3275-3284
    • (2006) Bioorg Med Chem , vol.14 , pp. 3275-3284
    • Poulsen, S.-A.1    Bornaghi, L.F.2
  • 35
    • 77952562194 scopus 로고    scopus 로고
    • Inhibitors of carbonic anhydrase IX
    • Molecular Insight Pharmaceuticals Inc
    • Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase IX. WO089383; 2009
    • (2009) WO089383
  • 36
    • 70350450778 scopus 로고    scopus 로고
    • Perspectives on the development of imatinib and the future of cancer research
    • Druker BJ. Perspectives on the development of imatinib and the future of cancer research. Nat Med 2009;15:1149-1152
    • (2009) Nat Med , vol.15 , pp. 1149-1152
    • Druker, B.J.1
  • 37
    • 75949085017 scopus 로고    scopus 로고
    • 2009 FDA drug approvals
    • Hughes B. 2009 FDA drug approvals. Nat Rev Drug Discov 2010;9:89-92
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 89-92
    • Hughes, B.1
  • 38
    • 33751106653 scopus 로고    scopus 로고
    • New approaches to molecular cancer therapeutics
    • Collins I, Workman P. New approaches to molecular cancer therapeutics. Nat Chem Biol 2006;2:689-700
    • (2006) Nat Chem Biol , vol.2 , pp. 689-700
    • Collins, I.1    Workman, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.