Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat

European Journal of Pharmacology

Volumn 522, Issue 1-3, 2005, Pages 130-138

  Varga, Csaba ^b   Horvath, Krisztina ^b   Berko, Aniko ^b   Thurmond, Robin L ^c   Dunford, Paul J ^c   Whittle, Brendan J R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF SZEGED   (Hungary)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Colitis; Histamine H4 receptor antagonist; Inflammatory bowel disease; JNJ 10191584; JNJ 7777120; Neutrophil; Tumour necrosis factor

Indexed keywords

ANTIHISTAMINIC AGENT; HISTAMINE H4 RECEPTOR; JNJ 10191584; JNJ 7777120; MYELOPEROXIDASE; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; DRUG EFFECT; INTESTINE INJURY; INTESTINE MUCOSA; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ACUTE DISEASE; ANIMALS; BENZIMIDAZOLES; BODY WEIGHT; COLITIS; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; MALE; ORGAN SIZE; PEROXIDASE; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 26844504964     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.08.045     Document Type: Article

References (58)

1. C.K. Ameho, A.A. Adjei, E.K. Harrison, K. Takeshita, T. Morioka, Y. Arakaki, E. Ito, I. Suzuki, A.D. Kulkarni, A. Kawajiri, and S. Yamamoto Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis Gut 41 1997 487 493
2. F. Barreau, L. Ferrier, J. Fioramonti, and L. Bueno Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats Gut 53 2004 501 506
3. S.C. Bischoff, J. Wedemeyer, A. Herrmann, P.N. Meier, C. Trautwein, Y. Cetin, H. Maschek, M. Stolte, M. Gebel, and M.P. Manns Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease Histopathology 28 1996 1 13
4. S.C. Bischoff, A. Lorentz, S. Schwengberg, G. Weier, R. Raab, and M.P. Manns Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinal tissue Gut 44 1999 643 652
5. C. Bobin-Dubigeon, X. Collin, N. Grimaud, J.M. Robert, G. Le Baut, and J.Y. Petit Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis Eur. J. Pharmacol. 431 2001 103 110
6. N.K. Boughton-Smith, J.L. Wallace, G.P. Morris, and B.J.R. Whittle The effect of anti-inflammatory drugs on eicosanoid formation in a chronic model of inflammatory bowel disease in the rat Br. J. Pharmacol. 94 1988 65 72
7. N.K. Boughton-Smith, J.L. Wallace, and B.J.R. Whittle Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease Agents Actions 25 1988 115 123
8. K.F. Buckland, T.J. Williams, and D.M. Conroy Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor Br. J. Pharmacol. 140 2003 1117 1127
9. F. Coge, S.P. Guenin, H. Rique, J.A. Boutin, and J.P. Galizzi Structure and expression of the human histamine H4-receptor gene Biochem. Biophys. Res. Commun. 284 2001 301 309
10. I.J. De Esch, R.L. Thurmond, A. Jongejan, and R. Leurs The histamine H(4) receptor as a new therapeutic target for inflammation Trends Pharmacol. Sci. 26 2005 462 469
11. 4 receptor antagonist-the new antihistamines? Curr. Opin. Investig. Drugs 5 2004 1174 1183
12. J. Galvez, M. Garrido, M. Merlos, M.I. Torres, and A. Zarzuelo Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat Br. J. Pharmacol. 130 2000 1949 1959
13. 2 receptors control histamine-induced interleukin-16 release from human CD8+ T cells J. Pharmacol. Exp. Ther. 303 2002 300 307
14. X. Guo, W.P. Wang, J.K. Ko, and C.H. Cho Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on inflammatory bowel disease in rats Gastroenterology 117 1999 884 892
15. P. Hoffmann, J.M. Zeeh, J. Lakshmanan, V.S. Wu, F. Procaccino, M. Reinshagen, J.A. McRoberts, and V.E. Eysselein Increased expression of transforming growth factor alpha precursors in acute experimental colitis in rats Gut 41 1997 195 202
16. 4 receptor mediates chemotaxis and calcium mobilization of mast cells J. Pharmacol. Exp. Ther. 305 2003 1212 1221
17. S.P. Hogan, and M.E. Rothenberg Review article: the eosinophil as a therapeutic target in gastrointestinal disease Aliment. Pharmacol. Ther. 20 2004 1231 1240
18. 4 receptor antagonists J. Med. Chem. 46 2003 3957 3960
19. 4 receptor ligands and their potential therapeutic uses Mini Rev. Med. Chem. 4 2004 993 1000
20. J. Kiss, D. Lamarque, J.C. Delchier, and B.J.R. Whittle Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats Eur. J. Pharmacol. 336 1997 219 224
21. G. Kristjansson, P. Venge, A. Wanders, L. Loof, and R. Hallgren Clinical and subclinical intestinal inflammation assessed by the mucosal patch technique: studies of mucosal neutrophil and eosinophil activation in inflammatory bowel diseases and irritable bowel syndrome Gut 53 2004 1806 1812
22. M. Lampinen, M. Carlson, P. Sangfelt, Y. Taha, M. Thorn, L. Loof, Y. Raab, and P. Venge IL-5 and TNF-alpha participate in recruitment of eosinophils to intestinal mucosa in ulcerative colitis Dig. Dis. Sci. 46 2001 2004 2009
23. M. Lampinen, M. Carlson, L.D. Hakansson, and P. Venge Cytokine-regulated accumulation of eosinophils in inflammatory disease Allergy 59 2004 793 805
24. P. Ling, K. Ngo, S. Nguyen, R.L. Thurmond, J.P. Edwards, L. Karlsson, and W.P. Fung-Leung Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation Br. J. Pharmacol. 142 2004 161 171 (Erratum in: Br J Pharmacol. 2004,142,1052)
25. 4) expressed in bone marrow Mol. Pharmacol. 59 2001 420 426
26. 4 receptors reveals substantial pharmacological species variation J. Pharmacol. Exp. Ther. 299 2001 121 130
27. K.L. Morse, J. Behan, T.M. Laz, R.E. West Jr., S.A. Greenfeder, J.C. Anthes, S. Umland, Y. Wan, R.W. Hipkin, W. Gonsiorek, N. Shin, E.L. Gustafson, X. Qiao, S. Wang, J.A. Hedrick, J. Greene, M. Bayne, and F.J. Monsma Jr. Cloning and characterization of a novel human histamine receptor J. Pharmacol. Exp. Ther. 296 2001 1058 1066
28. G.P. Morris, P.L. Beck, M.S. Herridge, W.T. Depew, M.R. Szewzcuk, and J.L. Wallace Hapten-induced model of chronic inflammation and ulceration in the rat colon Gastroenterology 96 1989 795 803
29. T. Nakamura, H. Itadani, Y. Hidaka, M. Ohta, and K. Tanaka Molecular cloning and characterization of a new human histamine receptor, HH4R Biochem. Biophys. Res. Commun. 279 2000 615 620
30. M. Neurath, I. Fuss, and W. Strober TNBS-colitis Int. Rev. Immunol. 19 2000 51 62
31. T. Nguyen, D.A. Shapiro, S.R. George, V. Setola, D.K. Lee, R. Cheng, L. Rauser, S.P. Lee, K.R. Lynch, B.L. Roth, and B.F. O'Dowd Discovery of a novel member of the histamine receptor family Mol. Pharmacol. 59 2001 427 433
32. T. Oda, N. Morikawa, Y. Saito, Y. Masuho, and S.-I. Matsumoto Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes J. Biol. Chem. 275 2000 36781 36786
33. 4 receptor on human eosinophils-role in eosinophil chemotaxis J. Recept. Signal Transduct. Res. 22 2002 431 448
34. K.A. Papadakis, and S.R. Targan Role of cytokines in the pathogenesis of inflammatory bowel disease Annu. Rev. Med. 51 2000 289 298
35. Y. Raab, B. Gerdin, S. Ahlstedt, and R. Hallgren Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis Gut 34 1993 1203 1206
36. Y. Raab, K. Fredens, B. Gerdin, and R. Hallgren Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents Dig. Dis. Sci. 43 1998 1061 1070
37. D. Rachmilewitz, P.L. Simon, L.W. Schwartz, D.E. Griswold, J.D. Fondacaro, and M.A. Wasserman Inflammatory mediators of experimental colitis in rats Gastroenterology 97 1989 326 337
38. B.K. Reuter, S. Asfaha, A. Buret, K.A. Sharkey, and J.L. Wallace Exacerbation of inflammation-associated colonic injury through inhibition of cyclooxygenase-2 J. Clin. Invest. 98 1996 2076 2085
39. K.A. Ribbons, J.H. Thompson, X. Liu, K. Pennline, D.A. Clark, and M.J. Miller Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis Eur. J. Pharmacol. 323 1997 245 254
40. P. Rutgeerts, G. Van Assche, and S. Vermeire Optimizing anti-TNF treatment in inflammatory bowel disease Gastroenterology 126 2004 1593 1610
41. J. Stein, J. Ries, and K.E. Barrett Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells Am. J. Physiol. 274 1998 G203 G209
42. F.F. Sun, P.S. Lai, G. Yue, K. Yin, R.G. Nagele, D.M. Tong, R.F. Krzesicki, J.E. Chin, and P.Y. Wong Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat Inflammation 25 2001 33 45
43. A.P. Sykes, R. Bhogal, C. Brampton, C. Chander, C. Whelan, M.E. Parsons, and J. Bird The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease Aliment. Pharmacol. Ther. 13 1999 1535 1542
44. K. Takeshita, K. Sakai, K.B. Bacon, and F. Gantner Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo J. Pharmacol. Exp. Ther. 307 2003 1072 1078
45. K. Takeshita, K.B. Bacon, and F. Gantner Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan J. Pharmacol. Exp. Ther. 310 2004 272 280
46. T. Ten Hove, A. Corbaz, H. Amitai, S. Aloni, I. Belzer, P. Graber, P. Drillenburg, S.J. van Deventer, Y. Chvatchko, and A.A. Te Velde Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice Gastroenterology 121 2001 1372 1379
47. N. Terzioglu, R.M. van Rijn, R.A. Bakker, I.J. De Esch, and R. Leurs Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists Bioorg. Med. Chem. Lett. 14 2004 5251 5256
48. 4 receptor antagonist with anti-inflammatory properties J. Pharmacol. Exp. Ther. 309 2004 404 413
49. M.I. Torres, M. Garcia-Martin, M.I. Fernandez, N. Nieto, A. Gil, and A. Rios Experimental colitis induced by trinitrobenzenesulfonic acid: an ultrastructural and histochemical study Dig. Dis. Sci. 44 1999 2523 2529
50. 4 antagonists. J. Med. Chem.
51. I. Villegas, C. La Casa, A. Orjales, and C. Alarcon de la Lastra Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats Eur. J. Pharmacol. 460 2003 209 218
52. J.L. Wallace, W.K. MacNaughton, G.P. Morris, and P.L. Beck Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease Gastroenterology 96 1989 29 36
53. S. Winterkamp, M. Weidenhiller, P. Otte, J. Stolper, D. Schwab, E.G. Hahn, and M. Raithel Urinary excretion of N-methylhistamine as a marker of disease activity in inflammatory bowel disease Am. J. Gastroenterol. 97 2002 3071 3077
54. B.J.R. Whittle, M. Cavicchi, and D. Lamarque Assessment of anticolitic drugs in the trinitrobenzene sulfonic acid (TNBS) rat model of inflammatory bowel disease P.G. Winyard D.A. Willoughby Inflammation Protocols: Methods in Molecular Biology vol. 225 2003 Humana Press New Jersey 209 222
55. T.M. Woodruff, T.V. Arumugam, I.A. Shiels, R.C. Reid, D.P. Fairlie, and S.M. Taylor A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease J. Immunol. 171 2003 5514 5520
56. X. Xu, S. Weskler-Zangen, A. Pikarsky, O. Pappo, D. Wengrower, S.C. Bischoff, M. Pines, A. Rivkind, E. Goldin, and F. Levi-Schaffer Mast cells involvement in the inflammation and fibrosis development of the TNBS-induced rat model of colitis Scand. J. Gastroenterol. 37 2002 330 337
57. Y. Yamada, S. Marshall, R.D. Specian, and M.B. Grisham A comparative analysis of two models of colitis in rats Gastroenterology 102 1992 524 534
58. Y. Zhu, D. Michalovich, H.-L. Wu, K.B. Tan, G.M. Dytko, I.J. Mannan, R. Boyce, J. Alston, L.A. Tierney, and X. Li Cloning, expression and pharmacological characterization of a novel human histamine receptor Mol. Pharmacol. 59 2001 434 441