Paradoxical stimulatory effects of the "standard" histamine H4-receptor antagonist JNJ7777120: The H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity

Molecular Pharmacology

Volumn 79, Issue 4, 2011, Pages 631-638

  Seifert, Roland ^a   Schneider, Erich H ^b   Dove, Stefan ^b   Brunskole, Irena ^b   Neumann, Detlef ^a   Strasser, Andrea ^b   Buschauer, Armin ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; 2 CYANO 1 [ 4 (1H IMIDAZOL 4 YL)BUTYL] 3 [( 2 PHENYLTHIO)ETHYL]GUANIDINE; 4 METHYLHISTAMINE; BETA ARRESTIN; GUANIDINE DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTAMINE; HISTAMINE AGONIST; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; MEMBRANE PROTEIN; N1 [ 3 (1H IMIDAZOL 4 YL)PROPYL] N2 PROPIONYLGUANIDINE; RETINA S ANTIGEN; THIOPERAMIDE; TRANSMEMBRANE DOMAIN RECEPTOR; UNCLASSIFIED DRUG; URPI 294; URPI 376;

ANTIINFLAMMATORY ACTIVITY; CELL LINE; DRUG ANTAGONISM; DRUG BINDING; DRUG EFFECT; DRUG INHIBITION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; HUMAN; IC 50; IN VIVO STUDY; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ARRESTINS; HISTAMINE ANTAGONISTS; HUMANS; INDOLES; MEMBRANE PROTEINS; PIPERAZINES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE;

EID: 79953019023     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.071266     Document Type: Review

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