Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)

Journal of Biological Chemistry

Volumn 286, Issue 20, 2011, Pages 18202-18212

  Jaiswal, Mamta ^a   Gremer, Lothar ^a   Dvorsky, Radovan ^a,b   Haeusler, Lars Christian ^b,c   Cirstea, Ion C ^a   Uhlenbrock, Katharina ^b   Ahmadian, Mohammad Reza ^a  

^a Department of Orthopedic Surgery   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CATALYTIC ACTIVITY; COMPARATIVE STUDIES; DETAILED KINETICS; G PROTEIN; GDP/GTP EXCHANGE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; ISOFORMS; MULTI-MODULAR; NUCLEOTIDE EXCHANGE; PLECKSTRIN HOMOLOGY DOMAINS; REGULATORY ELEMENTS; REGULATORY REGIONS; RHO FAMILY; RHO PROTEINS;

CATALYST ACTIVITY; CHEMICAL REACTIONS; DISEASES; POSITIVE IONS; PROTEINS; SIGNALING;

NUCLEOTIDES;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; LEUKEMIA ASSOCIATED RHOGEF; PROTEIN P115; PROTEIN P190; PROTEIN PDZ RHOGEF; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

CATALYSIS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; RHOA GTP-BINDING PROTEIN;

BACTERIA (MICROORGANISMS);

EID: 79955968406     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.226431     Document Type: Article

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