Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42

Journal of Biological Chemistry

Volumn 274, Issue 47, 1999, Pages 33587-33593

  Reid, Tim ^a,c   Bathoorn, Anja ^a   Ahmadian, Mohammad Reza ^b   Collard, John G ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c ExonHit Therapeutics   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL CYCLE PROTEIN; COMPLEMENTARY DNA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PLECKSTRIN; RHO FACTOR;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; FIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CDC42 GTP-BINDING PROTEIN; COS CELLS; DNA PRIMERS; EGG PROTEINS; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; ASCIDIA;

EID: 0033584865     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.47.33587     Document Type: Article

References (51)

1. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., and Hall, A. (1992) Cell 70, 401-410
2. Ridley, A. J., and Hall, A. (1992) Cell 70, 389-399
3. Mackay, D. J., and Hall, A. (1998) J. Biol. Chem. 273, 20685-20688
4. Whitehead, I. P., Campbell, S., Rossman, K. L., and Der, C. J. (1997) Biochim. Biophys. Acta 1332, F1-F23
5. Leeuwen, F. N., Kain, H. E., van der Kammen, R. A., Michiels, F., Kranenburg, O. W., and Collard, J. G. (1997) J. Cell Biol. 139, 797-807
6. Kozma, R., Sarner, S., Ahmed, S., and L. Lim. (1997) Mol. Cell. Biol. 17, 1201-1211
7. van Leeuwen, F. N., van Delft, S., Kain, H. E., van der Kammen, R. A., and Collard, J. G. (1999) Nat. Cell Biol. 1, 242-248
8. Hart, M. J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W. D., Gilman, A. G., Sternweis, P. C., and Bollag, G. (1998) Science 280, 2112-2114
9. Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., and Sternweis, P. C. (1998) Science 280, 2109-2111
10. Rubino, D., Driggers P., Arbit D., Kemp L., Miller B., Coso O., Pagliai K., Gray, K., Gutkind, S., and Segare, J. (1998) Oncogens 16, 2513-2526
11. Fischer, K. D., Kong, Y. Y., Nishina, H., Tedford, K., Marengere, L. E., Kozieradzki, I., Sasaki, T., Starr, M., Chan, G., Gardener, S., Nghiem, M. P., Bouchard, D., Barbacid M., Bernstein, A., and Penninger, J. M. (1998) Curr. Biol. 8, 554-562
12. Holsinger, L. J., Graef, I. A., Swat, W., Chi, T., Bautista, D. M., Davidson, L., Lewis, R. S., Alt, F. W., and Crabtree, G. R. (1998) Curr. Biol. 8, 563-572
13. Nern, A., and Arkowitz, R. A. (1998) Nature 381, 195-198
14. Steven, R., Kubiseski, T. J., Zheng, H., Kulkarni, S., Mancillas, J., Ruiz Morales, A., Hogue, C. W., Pawson, T., and Culotti, J. (1998) Cell 92, 785-795
15. Michiels, F., Stam, J. C., Hordijk, P. L., van der Kammen, R. A., Ruuls-Van Stalle, L., Feltkamp, C. A., and Collard, J. G. (1997) J. Cell Biol. 137, 387-398
16. Whitehead, I., Kirk, H., Tognon, C., Trigo-Gonzalez, G., and Kay, R. (1995) J. Biol. Chem. 270, 18388-18395
17. Soisson S. M., Nimnual, A. S., Uy M., Bar-Sagi, D., and Kuriyan, J. (1998) Cell 96, 259-268
18. Aghazadeh, B., Zhu, K, Kubiseski, T. J., Liu G. A., Pawson, T., Zheng, Y., and Rosen, M. K. (1998) Nat. Struct. Biol. 5, 1098-1107
19. Liu, X, Wang, H., Eberstadt, M., Schnuchel, A., Olejniczak, E. T., Meadows, R. P., Schkeryantz, J. M., Janowick, D. A., Harlan, J. E., Harris, E. A., Staunton, D. E., and Fesik, S. W. (1998) Cell 96, 269-277
20. Habets, G. G., Scholtes, E. H., Zuydgeest, D., van der Kammen, R. A., Stam, J. C., Berns, A., and Collard, J. G. (1994) Cell 77, 537-549
21. Hordijk, P. L., ten Klooster, J. P., van der Kammen, R. A., Michiels, F., Oomen, L. C., and Collard, J. G. (1997) Science 278, 1464-1466
22. Michiels, F., Habets, G. G., Stam, J. C., van der Kammen, R. A., and Collard, J. G. (1995) Nature 375, 338-340
23. Hunter, T., and Plowman, G. D. (1997) Trends Biochem. Sci. 22, 18-22
24. Johnson, L. N., Lowe, E. D., Noble, M. E., and Owen, D. J. (1998) FEBS Lett. 430, 1-11
25. Barford, D., Das, A. K., and Egloff, M. P. (1998) Annu. Rev. Biophys. Biomol. Struct. 27, 133-164
26. Satou, Y., and Satoh, N. (1997) Dev. Biol. 192, 467-481
27. Sander, E. E., van Delft, S., ten Klooster J. P., Reid T., van der Kammen R. A., Michiels F., and Collard J. G. (1998) J. Cell Biol. 143, 1385-1398
28. Reid, T., Furuyashiki, T., Ishizaki, T., Watanabe, G., Watanabe, N., Fujisawa, K., Morii, N., Madaule, P., and Narumiya, S. (1996) J. Biol. Chem. 271, 13556-13560
29. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
30. Ahmadian, M. R., Mittal, R., Hall, A., and Wittinghofer, A (1997) FEBS Lett. 408, 315-318
31. Herrmann, C., Martin, G. A., and Wittinghofer, A. (1995) J. Biol. Chem. 270, 2901-2905
32. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res. 25, 4876-4882
33. Page, R. D. M. (1996) Comput. Appl. Biosci. 12, 357-358
34. Stam, J. C., and Collard, J. G. (1999) Prog. Mol. Subcell. Biol. 22, 51-83
35. Wolthuis, R. M., Franke, B., van Triest, M., Bauer, B., Cool, R. H., Camonis, J. H., Akkerman, J. W., and Bos, J. L. (1998) Mol. Cell. Biol. 18, 2486-2491
36. Franke, B., Akkerman, J. W., and Bos, J. L. (1997) EMBO J. 16, 252-259
37. de Rooij, J., and Bos, J. L. (1997) Oncogene 14, 623-625
38. Ren, X. D., Kiosses, W. B., and Schwartz, M. A. (1999) EMBO J. 18, 678-585
39. Zhou, K., Wang Y., Gorski J. L., Nomura N., Collard J., and Bokoch G. M. (1998) J. Biol. Chem. 273, 16782-16786
40. Glaven, J. A., Whitehead, I., Bagrodia, S., Kay, R., and Cerione, R. A. (1999) J. Biol. Chem. 274, 2279-2285
41. Crespo, P., Schuebel K. E., Ostrom A. A., Gutkind J. S., and Bustelo, X. R. (1997) Nature 388, 169-172
42. Hart M. J., Eva, A., Zangrilli, D., Aaronson, S. A., Evans, T., Cerione, R. A., and Zheng, Y. (1994) J. Biol. Chem. 269, 62-65
43. Nimnual A. S., Yatsula, B. A., and Bar-Sagi, D. (1998) Science 279, 560-563
44. Manser, E., Loo, T. H., Koh, C. G., Zhao, Z. S., Chen, X. Q., Tan, L., Tan, I., Leung, T., and Lim, L. (1998) Mol. Cell 1, 183-192
45. Clayton, L., Hall, A., and Johnson, M. H. (1999) Dev. Biol. 205, 322-331
46. Nobes, C. D., and Hall, A. (1999) J. Cell Biol. 144, 1235-1244
47. Allen, W. E., Zicha, D., Ridley, A. J., and Jones, G. E. (1998) J. Cell Biol. 141, 1147-1157
48. Adams, A. E., Johnson, D. I., Longnecker, R. M., Sloat, B. F., and Pringle, J. R. (1990) J. Cell Biol. 111, 131-142
49. Stowers, L., Yelon, D., Berg, L. J., and Chant, J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 5027-5031
50. Daniels, R. H., Hall, P. S., and Bokoch, G. M. (1998) EMBO J. 17, 754-764
51. Threadgill, R., Bobb, K., and Ghosh, A. (1997) Neuron 19, 625-634