-
1
-
-
14844361989
-
NMR studies of protein structure and dynamics
-
Kay, L.E. NMR studies of protein structure and dynamics. J. Magn. Reson. 173, 193-207 (2005).
-
(2005)
J. Magn. Reson
, vol.173
, pp. 193-207
-
-
Kay, L.E.1
-
2
-
-
0346220393
-
The role of dynamics in allosteric regulation
-
Kern, D. & Zuiderweg, E.R. The role of dynamics in allosteric regulation. Curr. Opin. Struct. Biol. 13, 748-757 (2003).
-
(2003)
Curr. Opin. Struct. Biol
, vol.13
, pp. 748-757
-
-
Kern, D.1
Zuiderweg, E.R.2
-
3
-
-
0034919305
-
Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules
-
Palmer, A.G. III, Kroenke, C.D. & Loria, J.P. Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules. Methods Enzymol. 339, 204-238 (2001).
-
(2001)
Methods Enzymol
, vol.339
, pp. 204-238
-
-
Palmer III, A.G.1
Kroenke, C.D.2
Loria, J.P.3
-
4
-
-
0141757323
-
Reprogramming control of an allosteric signaling switch through modular recombination
-
Dueber, J.E., Yeh, B.J., Chak, K. & Lim, W.A. Reprogramming control of an allosteric signaling switch through modular recombination. Science 301, 1904-1908 (2003).
-
(2003)
Science
, vol.301
, pp. 1904-1908
-
-
Dueber, J.E.1
Yeh, B.J.2
Chak, K.3
Lim, W.A.4
-
5
-
-
0036441510
-
Autoinhibitory domains: Modular effectors of cellular regulation
-
Pufall, M.A. & Graves, B.J. Autoinhibitory domains: modular effectors of cellular regulation. Annu. Rev. Cell Dev. Biol. 18, 421-462 (2002).
-
(2002)
Annu. Rev. Cell Dev. Biol
, vol.18
, pp. 421-462
-
-
Pufall, M.A.1
Graves, B.J.2
-
6
-
-
0035473464
-
Vav proteins, adaptors and cell signaling
-
Bustelo, X.R. Vav proteins, adaptors and cell signaling. Oncogene 20, 6372-6381 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 6372-6381
-
-
Bustelo, X.R.1
-
7
-
-
0036631548
-
VAV proteins as signal integrators for multi-subunit immune-recognition receptors
-
Turner, M. & Billadeau, D.D. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat. Rev. Immunol. 2, 476-486 (2002).
-
(2002)
Nat. Rev. Immunol
, vol.2
, pp. 476-486
-
-
Turner, M.1
Billadeau, D.D.2
-
8
-
-
18844449626
-
Vav-family proteins in T-cell signalling
-
Tybulewicz, V.L. Vav-family proteins in T-cell signalling. Curr. Opin. Immunol. 17, 267-274 (2005).
-
(2005)
Curr. Opin. Immunol
, vol.17
, pp. 267-274
-
-
Tybulewicz, V.L.1
-
9
-
-
0032724649
-
-
Abe, K., Whitehead, I.P., O'Bryan, J.P. & Der, C.J. Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity. J. Biol. Chem. 274, 30410-30418 (1999).
-
Abe, K., Whitehead, I.P., O'Bryan, J.P. & Der, C.J. Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity. J. Biol. Chem. 274, 30410-30418 (1999).
-
-
-
-
10
-
-
17844367099
-
Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors
-
Heo, J., Thapar, R. & Campbell, S.L. Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors. Biochemistry 44, 6573-6585 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 6573-6585
-
-
Heo, J.1
Thapar, R.2
Campbell, S.L.3
-
11
-
-
0034269240
-
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
-
Aghazadeh, B., Lowry, W.E., Huang, X.Y. & Rosen, M.K. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell 102, 625-633 (2000).
-
(2000)
Cell
, vol.102
, pp. 625-633
-
-
Aghazadeh, B.1
Lowry, W.E.2
Huang, X.Y.3
Rosen, M.K.4
-
12
-
-
0037894847
-
Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav
-
Lopez-Lago, M., Lee, H., Cruz, C., Movilla, N. & Bustelo, X.R. Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav. Mol. Cell. Biol. 20, 1678-1691 (2000).
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 1678-1691
-
-
Lopez-Lago, M.1
Lee, H.2
Cruz, C.3
Movilla, N.4
Bustelo, X.R.5
-
13
-
-
0032696592
-
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
-
Movilla, N. & Bustelo, X.R. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol. Cell. Biol. 19, 7870-7885 (1999).
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 7870-7885
-
-
Movilla, N.1
Bustelo, X.R.2
-
14
-
-
27944475226
-
Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 dbl homology domain
-
Amarasinghe, G.K. & Rosen, M.K. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 dbl homology domain. Biochemistry 44, 15257-15268 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 15257-15268
-
-
Amarasinghe, G.K.1
Rosen, M.K.2
-
15
-
-
34248530027
-
A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity
-
Lundstrom, P., Vallurupalli, P., Religa, T.L., Dahlquist, F.W. & Kay, L.E. A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity. J. Biomol. NMR 38, 79-88 (2007).
-
(2007)
J. Biomol. NMR
, vol.38
, pp. 79-88
-
-
Lundstrom, P.1
Vallurupalli, P.2
Religa, T.L.3
Dahlquist, F.W.4
Kay, L.E.5
-
16
-
-
3242880292
-
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR
-
Korzhnev, D.M. et al. Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR. Nature 430, 586-590 (2004).
-
(2004)
Nature
, vol.430
, pp. 586-590
-
-
Korzhnev, D.M.1
-
17
-
-
27644432794
-
Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: An application to the folding of a Fyn SH3 domain mutant
-
Korzhnev, D.M., Neudecker, P., Mittermaier, A., Orekhov, V.Y. & Kay, L.E. Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant. J. Am. Chem. Soc. 127, 15602-15611 (2005).
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 15602-15611
-
-
Korzhnev, D.M.1
Neudecker, P.2
Mittermaier, A.3
Orekhov, V.Y.4
Kay, L.E.5
-
18
-
-
0035937443
-
Two-state allosteric behavior in a single-domain signaling protein
-
Volkman, B.F., Lipson, D., Wemmer, D.E. & Kern, D. Two-state allosteric behavior in a single-domain signaling protein. Science 291, 2429-2433 (2001).
-
(2001)
Science
, vol.291
, pp. 2429-2433
-
-
Volkman, B.F.1
Lipson, D.2
Wemmer, D.E.3
Kern, D.4
-
19
-
-
0033923367
-
Rational design of faster associating and tighter binding protein complexes
-
Selzer, T., Albeck, S. & Schreiber, G. Rational design of faster associating and tighter binding protein complexes. Nat. Struct. Biol. 7, 537-541 (2000).
-
(2000)
Nat. Struct. Biol
, vol.7
, pp. 537-541
-
-
Selzer, T.1
Albeck, S.2
Schreiber, G.3
-
20
-
-
17844400362
-
Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3
-
Llorca, O., Arias-Palomo, E., Zugaza, J.L. & Bustelo, X.R. Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3. EMBO J. 24, 1330-1340 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 1330-1340
-
-
Llorca, O.1
Arias-Palomo, E.2
Zugaza, J.L.3
Bustelo, X.R.4
-
21
-
-
0024433697
-
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
-
Katzav, S., Martin-Zanca, D. & Barbacid, M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8, 2283-2290 (1989).
-
(1989)
EMBO J
, vol.8
, pp. 2283-2290
-
-
Katzav, S.1
Martin-Zanca, D.2
Barbacid, M.3
-
22
-
-
0026031054
-
Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential
-
Katzav, S., Cleveland, J.L., Heslop, H.E. & Pulido, D. Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential. Mol. Cell. Biol. 11, 1912-1920 (1991).
-
(1991)
Mol. Cell. Biol
, vol.11
, pp. 1912-1920
-
-
Katzav, S.1
Cleveland, J.L.2
Heslop, H.E.3
Pulido, D.4
-
23
-
-
0037160051
-
Structural determinants for the biological activity of Vav proteins
-
Zugaza, J.L. et al. Structural determinants for the biological activity of Vav proteins. J. Biol. Chem. 277, 45377-45392 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 45377-45392
-
-
Zugaza, J.L.1
-
24
-
-
0036468436
-
The modular logic of signaling proteins: Building allosteric switches from simple binding domains
-
Lim, W.A. The modular logic of signaling proteins: building allosteric switches from simple binding domains. Curr. Opin. Struct. Biol. 12, 61-68 (2002).
-
(2002)
Curr. Opin. Struct. Biol
, vol.12
, pp. 61-68
-
-
Lim, W.A.1
-
25
-
-
0842346438
-
Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems
-
Pawson, T. Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell 116, 191-203 (2004).
-
(2004)
Cell
, vol.116
, pp. 191-203
-
-
Pawson, T.1
-
26
-
-
1642416319
-
Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: Application to a 723-residue enzyme
-
Korzhnev, D.M., Kloiber, K., Kanelis, V., Tugarinov, V. & Kay, L.E. Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme. J. Am. Chem. Soc. 126, 3964-3973 (2004).
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 3964-3973
-
-
Korzhnev, D.M.1
Kloiber, K.2
Kanelis, V.3
Tugarinov, V.4
Kay, L.E.5
-
27
-
-
0035930026
-
Slow dynamics in folded and unfolded states of an SH3 domain
-
Tollinger, M., Skrynnikov, N.R., Mulder, F.A., Forman-Kay, J.D. & Kay, L.E. Slow dynamics in folded and unfolded states of an SH3 domain. J. Am. Chem. Soc. 123, 11341-11352 (2001).
-
(2001)
J. Am. Chem. Soc
, vol.123
, pp. 11341-11352
-
-
Tollinger, M.1
Skrynnikov, N.R.2
Mulder, F.A.3
Forman-Kay, J.D.4
Kay, L.E.5
-
28
-
-
0037138654
-
Slow internal dynamics in proteins: Application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme
-
Mulder, F.A., Hon, B., Mittermaier, A., Dahlquist, F.W. & Kay, L.E. Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme. J. Am. Chem. Soc. 124, 1443-1451 (2002).
-
(2002)
J. Am. Chem. Soc
, vol.124
, pp. 1443-1451
-
-
Mulder, F.A.1
Hon, B.2
Mittermaier, A.3
Dahlquist, F.W.4
Kay, L.E.5
|