Potent bivalent smac mimetics: Effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity

Journal of Medicinal Chemistry

Volumn 54, Issue 9, 2011, Pages 3306-3318

  Sun, Haiying ^a   Liu, Liu ^a   Lu, Jianfeng ^a   Bai, Longchuan ^a   Li, Xiaoqin ^a   Nikolovska Coleska, Zaneta ^a   McEachern, Donna ^a   Yang, Chao Yie ^a   Qiu, Su ^a   Yi, Han ^a   Sun, Duxin ^a   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; DOCETAXEL; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; N,N' [[1,1' [1,4 PHENYLENEBIS(DECANE 1,10 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [1,4 PHENYLENEBIS(DODECANE 1,12 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [1,4 PHENYLENEBIS(ETHANE 2,1 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [1,4 PHENYLENEBIS(HEXANE 6,1 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [1,4 PHENYLENEBIS(OCTANE 8,1 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [1,4 PHENYLENEBIS(PROPANE 3,1 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [[BUTANE 1,4 DIYLBIS(OXY)]BIS(ETHANE 2,1 DIYL)] BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [[CARBONYLBIS(AZANEDIYL)]BIS(BUTANE 4,1 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; N,N' [[1,1' [OXYBIS(PENTANE 5,1 DIYL)]BIS(1H 1,2,3 TRIAZOLE 4,1 DIYL)]BIS(PHENYLMETHYLENE)]BIS[6 [2 (METHYLAMINO)PROPANAMIDO] 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE]; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN INHIBITOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE MIMETIC; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; X LINKED INHIBITOR OF APOPTOSIS ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER SIZE; CELL GROWTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; FEMALE; IC 50; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZOCINES; CELL LINE, TUMOR; CELL PROLIFERATION; DIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MITOCHONDRIAL PROTEINS; MOLECULAR MIMICRY; NEOPLASM TRANSPLANTATION; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 79955876177     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101651b     Document Type: Article

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