Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins

Journal of Medicinal Chemistry

Volumn 53, Issue 17, 2010, Pages 6361-6367

  Sun, Haiying ^a   Lu, Jianfeng ^a   Liu, Liu ^a   Yi, Han ^a   Qiu, Su ^a   Yang, Chao Yie ^a   Deschamps, Jeffrey R ^b   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 2 (METHYLAMINO)PROPANAMIDO) 5 OXO 9 (2 PHENYLACETAMIDO) N ( 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)DECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE; ANTINEOPLASTIC AGENT; BENZYL 6 [(TERT BUTOXYCARBONYL)AMINO] 5,9 DIOXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXYLATE (12) AND BENZYL 6 [(TERT BUTOXYCARBONYL)AMINO] 5,8 DIOXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXYLATE; BENZYL 6 [(TERT BUTOXYCARBONYL)AMINO] 9 HYDROXY 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXYLATE; CASPASE 9; INHIBITOR OF APOPTOTIC PROTEIN 1; INHIBITOR OF APOPTOTIC PROTEIN 2; N BENZHYDRYL 6 ( 2 (METHYLAMINO) PROPANAMIDO) 5 OXO 9 (2 PHENYLACETAMIDO)DECAHYDROPYRROLO [1,2 A]AZOCINE 3 CARBOXAMIDE; N BENZHYDRYL 9 HYDROXY 6 ( 2 (METHYLAMINO)PROPANAMIDO) 5 OXODECAHYDROPYRROLO[1,2 A]AZOCINE 3 CARBOXAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REGULATOR PROTEIN; TERT BUTYL ( 9 AZIDO 3 (BENZHYDRYLCARBAMOYL) 5 OXODECAHYDROPYRROLO[1,2 A]AZOCIN 6 YL)CARBAMATE; TERT BUTYL ( 9 AZIDO 5 OXO 3 [( 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)CARBAMOYL)DECAHYDROPYRROLO[1,2 A] AZOCIN 6 YL)CARBAMATE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION;

ALANINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BICYCLO COMPOUNDS, HETEROCYCLIC; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MOLECULAR STRUCTURE; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 77956302209     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100487z     Document Type: Article

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