A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2714-2726

  Cai, Qian ^a,c   Sun, Haiying ^a   Peng, Yuefeng ^a,d   Lu, Jianfeng ^a   Nikolovska Coleska, Zaneta ^a   McEachern, Donna ^a   Liu, Liu ^a   Qiu, Su ^a   Yang, Chao Yie ^a   Miller, Rebecca ^a   Yi, Han ^a   Zhang, Tao ^a   Sun, Duxin ^a   Kang, Sanmao ^b   Guo, Ming ^b   Leopold, Lance ^b   Yang, Dajun ^b   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Ascenta Therapeutics   (United States)

^c GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AT 406; DOCETAXEL; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; SM 406; SM 428; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

AREA UNDER THE CURVE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER THERAPY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROTEIN DEGRADATION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AREA UNDER CURVE; AZOCINES; BENZHYDRYL COMPOUNDS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MODELS, MOLECULAR; NEOPLASMS;

EID: 79954504195     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101505d     Document Type: Article

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