메뉴 건너뛰기




Volumn 121, Issue 5, 2011, Pages 229-236

Genetics of alzheimer's disease: An insight into presenilins and apolipoprotein e instigated neurodegeneration

Author keywords

Alzheimer's disease; apolipoprotein E; presenilin 1; presenilin 2

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; CYSTATIN C; PRESENILIN; PRESENILIN 1; PRESENILIN 2;

EID: 79955866845     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2010.551432     Document Type: Article
Times cited : (19)

References (88)
  • 2
    • 73349135640 scopus 로고    scopus 로고
    • Caspase-6 activation in familial Alzheimer disease brains carrying amyloid precursor protein or presenilin i or pre-senilin II mutations
    • Albrecht, S., Bogdanovic, N., Ghetti, B., Winblad, B., & LeBlanc, A. C. (2009). Caspase-6 activation in familial Alzheimer disease brains carrying amyloid precursor protein or presenilin I or pre-senilin II mutations. Journal of Neuropatholology and Experimental Neurology, 68(12), 1282-1293.
    • (2009) Journal of Neuropatholology and Experimental Neurology , vol.68 , Issue.12 , pp. 1282-1293
    • Albrecht, S.1    Bogdanovic, N.2    Ghetti, B.3    Winblad, B.4    Leblanc, A.C.5
  • 3
    • 77955921493 scopus 로고    scopus 로고
    • Brain lipid metabolism, apolipoprotein e and the pathophysiology of Alzheimer's disease
    • Bales, K. R. (2010). Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease. Neuropharmacology, 59(4-5), 295-302.
    • (2010) Neuropharmacology , vol.59 , Issue.4-5 , pp. 295-302
    • Bales, K.R.1
  • 4
    • 77955922499 scopus 로고    scopus 로고
    • Apolipoprotein E-isoform dependent decrease in brain ï-amyloid following treatment of PDAPP transgenic mice with a LXR agonist
    • Bales, K. R., Liu, F., Koger, D., Wu, S., Mabry, T., Christie, M., et al. (2008). Apolipoprotein E-isoform dependent decrease in brain brain ï-amyloid following treatment of PDAPP transgenic mice with a LXR agonist.Society of Neuroscience Abstracts, 45, 14.
    • (2008) Society of Neuroscience Abstracts , vol.45 , pp. 14
    • Bales, K.R.1    Liu, F.2    Koger, D.3    Wu, S.4    Mabry, T.5    Christie, M.6
  • 5
    • 66149181776 scopus 로고    scopus 로고
    • Human APOE isoform-dependent effects on brain beta amyloid levels in PDAPP transgenic mice
    • Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, K., DeLong, C, et al. (2009). Human APOE isoform-dependent effects on brain beta amyloid levels in PDAPP transgenic mice. The Journal of Neuroscience, 29(21), 6771-6779.
    • (2009) The Journal of Neuroscience , vol.29 , Issue.21 , pp. 6771-6779
    • Bales, K.R.1    Liu, F.2    Wu, S.3    Lin, S.4    Koger, K.5    Delong, C.6
  • 7
    • 0031278270 scopus 로고    scopus 로고
    • Lack of apolipoprotein e dramatically reduces amyloid beta-peptide deposition
    • Bales, K. R., Verina, T., Dodel, R. C, Du, Y, Altsteil, L., Bender, M., et al. (1997). Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nature Genetics, 17(3), 263-264.
    • (1997) Nature Genetics , vol.17 , Issue.3 , pp. 263-264
    • Bales, K.R.1    Verina, T.2    Dodel, R.C.3    Du, Y.4    Altsteil, L.5    Bender, M.6
  • 8
    • 76449085569 scopus 로고    scopus 로고
    • Gamma-secretases: From cell biology to therapeutic strategies
    • Bergmans, B. A., & De Strooper, B. (2010). Gamma-secretases: From cell biology to therapeutic strategies. The Lancet Neurology, 9(2), 215-226.
    • (2010) The Lancet Neurology , vol.9 , Issue.2 , pp. 215-226
    • Bergmans, B.A.1    De Strooper, B.2
  • 9
    • 77953886784 scopus 로고    scopus 로고
    • Current status on Alzheimer disease molecular genetics: From past, to present, to future
    • Bettens, K., Sleegers, K., & Van Broeckhoven, C. (2010). Current status on Alzheimer disease molecular genetics: From past, to present, to future. Human Molecular Genetics, 19(R1), R4-R11.
    • (2010) Human Molecular Genetics , vol.19 , Issue.R1
    • Bettens, K.1    Sleegers, K.2    Van Broeckhoven, C.3
  • 10
    • 0022350033 scopus 로고
    • Apolipoprotein e associated with astrocytic glia of the central nervous system and with nonmylinating glia of the peripheral nervous system
    • Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W, & Taylor, J. M. (1995). Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmylinating glia of the peripheral nervous system. The Journal of Clinical Investigation, 76(4), 1501-1513.
    • (1995) The Journal of Clinical Investigation , vol.76 , Issue.4 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 11
    • 77955773912 scopus 로고    scopus 로고
    • Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease
    • Bruno, E., Quattrocchi, G., Nicoletti, A., Le Pira, F., Maci, T., Mos-tile, G., et al. (2010). Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease. Neuroscience Letters, 482(2), 112-116.
    • (2010) Neuroscience Letters , vol.482 , Issue.2 , pp. 112-116
    • Bruno, E.1    Quattrocchi, G.2    Nicoletti, A.3    Le Pira, F.4    MacI, T.5    Mos-Tile, G.6
  • 12
    • 4344632844 scopus 로고    scopus 로고
    • Functional implications of the presenilin dimerization: Reconstitution of y-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins
    • DOI 10.1074/jbc.M404832200
    • Cervantes, S., Saura, C. A., Pomares, E., Gonzalez-Duarte, R., & Marfany, G. (2004). Functional implications of the presenilin dimerization: Reconstitution of y-secretase activity by assembly of a catalytic site at the dimer interface of two catalyti-cally inactive presenilins. Journal of Biological Chemistry, 279(35), 36519-36529. (Pubitemid 39128993)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.35 , pp. 36519-36529
    • Cervantes, S.1    Saura, C.A.2    Pomares, E.3    Gonzalez-Duarte, R.4    Marfany, G.5
  • 14
    • 77956884129 scopus 로고    scopus 로고
    • Presenilin-1 regulates induction of hypoxia inducible factor1es: Altered activation by a mutation associated with familial Alzheimer's disease
    • De Gasperi, R., Sosa, M. A., Dracheva, S., & Elder, G. A. (2010). Presenilin-1 regulates induction of hypoxia inducible factor1es: Altered activation by a mutation associated with familial Alzheimer's disease. Molecular Neurodegeneration, 5, 38.
    • (2010) Molecular Neurodegeneration , vol.5 , pp. 38
    • De Gasperi, R.1    Sosa, M.A.2    Dracheva, S.3    Elder, G.A.4
  • 15
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active y-Secretase complex
    • DOI 10.1016/S0896-6273(03)00205-8
    • De Strooper, B. (2003). Aph-1, pen-2, and nicastrin with presenilin generate an active y-secretase complex. Neuron, 38(1), 9-12. (Pubitemid 36423348)
    • (2003) Neuron , vol.38 , Issue.1 , pp. 9-12
    • De Strooper, B.1
  • 20
    • 73949119034 scopus 로고    scopus 로고
    • Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations
    • Gama Sosa, M. A., Gasperi, R. D., Rocher, A. B., Wang, A. C., Janssen, W. G., Flores, T., et al. (2010). Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations. American Journal of Pathology, 176(1), 353-368.
    • (2010) American Journal of Pathology , vol.176 , Issue.1 , pp. 353-368
    • Gama Sosa, M.A.1    Gasperi, R.D.2    Rocher, A.B.3    Wang, A.C.4    Janssen, W.G.5    Flores, T.6
  • 22
    • 78149368167 scopus 로고    scopus 로고
    • Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease
    • in press
    • Ghidoni, R., Paterlini, A., Albertini, V., Glionna, M., Monti, E., Schi-affonati, L., et al. (2009). Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease. Neurobiology of Aging, in press.
    • (2009) Neurobiology of Aging
    • Ghidoni, R.1    Paterlini, A.2    Albertini, V.3    Glionna, M.4    Monti, E.5    Schi-Affonati, L.6
  • 23
    • 46249123354 scopus 로고    scopus 로고
    • SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production
    • DOI 10.1083/jcb.200706171
    • Green, K. N., Demuro, A., Akbari, Y., Hitt, B. D., Smith, I. F., Parker, I., et al. (2008). SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. Journal of Cell Biology, 181(7), 1107-1116. (Pubitemid 351915486)
    • (2008) Journal of Cell Biology , vol.181 , Issue.7 , pp. 1107-1116
    • Green, K.N.1    Demuro, A.2    Akbari, Y.3    Hitt, B.D.4    Smith, I.F.5    Parker, I.6    LaFerla, F.M.7
  • 24
    • 78049427912 scopus 로고    scopus 로고
    • Progression of cerebral amyloid load is associated with the apolipoprotein e epsilon4 genotype in Alzheimer's disease
    • Grimmer, T., Tholen, S., Yousef, B. H., Alexopoulos, P., Forschler, A., Forstl, H., et al. (2010). Progression of cerebral amyloid load is associated with the apolipoprotein E epsilon4 genotype in Alzheimer's disease. Biological Psychiatry, 68(10), 879-884.
    • (2010) Biological Psychiatry , vol.68 , Issue.10 , pp. 879-884
    • Grimmer, T.1    Tholen, S.2    Yousef, B.H.3    Alexopoulos, P.4    Forschler, A.5    Forstl, H.6
  • 26
    • 0026894414 scopus 로고
    • Framing β-amyloid
    • Hardy, J. (1992). Framing β-amyloid. Nature Genetics, 1(4), 233-234.
    • (1992) Nature Genetics , vol.1 , Issue.4 , pp. 233-234
    • Hardy, J.1
  • 27
    • 70349558522 scopus 로고    scopus 로고
    • Genome-wide association study identifes variants at CLU and PICALM associated with Alzheimer's disease
    • Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., et al. (2009). Genome-wide association study identifes variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics, 41(10), 1088-1093.
    • (2009) Nature Genetics , vol.41 , Issue.10 , pp. 1088-1093
    • Harold, D.1    Abraham, R.2    Hollingworth, P.3    Sims, R.4    Gerrish, A.5    Hamshere, M.L.6
  • 28
    • 0036488129 scopus 로고    scopus 로고
    • Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: Involvement of NO synthase via a novel pertussis toxin target
    • DOI 10.1046/j.0022-3042.2001.00722.x
    • Hashimoto, Y., Ito, Y., Arakawa, E., Kita, Y., Terashita, K., Ni-ikura, T., et al. (2002). Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: Involvement of NO synthase via a novel pertussis toxin target. Journal of Neurochemistry, 80(3), 426-437. (Pubitemid 36383026)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.3 , pp. 426-437
    • Hashimoto, Y.1    Ito, Y.2    Arakawa, E.3    Kita, Y.4    Terashita, K.5    Niikura, T.6    Nishimoto, I.7
  • 29
    • 0034602331 scopus 로고    scopus 로고
    • Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein
    • Hashimoto, Y., Niikura, T., Ito, Y., & Nishimoto, I. (2000). Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein. The Journal of Biological Chemistry, 275(44), 34541-34551.
    • (2000) The Journal of Biological Chemistry , vol.275 , Issue.44 , pp. 34541-34551
    • Hashimoto, Y.1    Niikura, T.2    Ito, Y.3    Nishimoto, I.4
  • 30
    • 0035576106 scopus 로고    scopus 로고
    • Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults
    • Hashimoto, Y., Niikura, T., Ito, Y., Sudo, H., Hata, M., Arakawa, E., et al. (2001). Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. Journal of Neuroscience, 21(23), 9235-9245. (Pubitemid 33096867)
    • (2001) Journal of Neuroscience , vol.21 , Issue.23 , pp. 9235-9245
    • Hashimoto, Y.1    Niikura, T.2    Ito, Y.3    Sudo, H.4    Hata, M.5    Arakawa, E.6    Abe, Y.7    Kita, Y.8    Nishimoto, I.9
  • 32
    • 0028899724 scopus 로고
    • Quantitative analysis of senile plaques in Alzheimer disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein e genotype and trisomy 21 (Down syndrome)
    • Hyman, B. T., West, H. L., Rebeck, G. W., Buldyrev, S. V., Mantegna, R. N., Ukleia, M., et al. (1995). Quantitative analysis of senile plaques in Alzheimer disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proceedings of the National Academy of Sciences, USA, 92(8), 3586-3590.
    • (1995) Proceedings of the National Academy of Sciences USA , vol.92 , Issue.8 , pp. 3586-3590
    • Hyman, B.T.1    West, H.L.2    Rebeck, G.W.3    Buldyrev, S.V.4    Mantegna, R.N.5    Ukleia, M.6
  • 33
    • 47949125010 scopus 로고    scopus 로고
    • Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations
    • Ikeuchi, T., Kaneko, H., Miyashita, A., Nozaki, H., Kasuga, K., Tsukie, T., et al. (2008). Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations. Dementia and Geriatric and Cognitive Disorders, 26(1), 43-49.
    • (2008) Dementia and Geriatric and Cognitive Disorders , vol.26 , Issue.1 , pp. 43-49
    • Ikeuchi, T.1    Kaneko, H.2    Miyashita, A.3    Nozaki, H.4    Kasuga, K.5    Tsukie, T.6
  • 35
    • 34548316144 scopus 로고    scopus 로고
    • NTR processing and signalling by PS2 mutation and γ-secretase inhibition
    • DOI 10.1016/j.nbd.2007.05.002, PII S0969996107001064
    • Ito, Y., Ishii, A., Passmore, A. P., & McIlroy, S. P. (2007). Analysis of alteration of p75NTR processing and signalling by PS2 mutation and gamma-secretase inhibition. Neurobiology of Disease, 27(3), 258-264. (Pubitemid 47334956)
    • (2007) Neurobiology of Disease , vol.27 , Issue.3 , pp. 258-264
    • Ito, Y.1    Ishii, A.2    Passmore, A.P.3    McIlroy, S.P.4
  • 36
    • 77954976544 scopus 로고    scopus 로고
    • The pathological cross talk between apolipoprotein e and amyloid-beta peptide in Alzheimer's disease: Emerging gene-based therapeutic approaches
    • Iurescia, S., Fioretti, D., Mangialasche, F., & Rinaldi, M. (2010). The pathological cross talk between apolipoprotein E and amyloid-beta peptide in Alzheimer's disease: Emerging gene-based therapeutic approaches. Journal of Alzheimers Disease, 21(1), 35-48.
    • (2010) Journal of Alzheimers Disease , vol.21 , Issue.1 , pp. 35-48
    • Iurescia, S.1    Fioretti, D.2    Mangialasche, F.3    Rinaldi, M.4
  • 38
    • 0342601539 scopus 로고    scopus 로고
    • Immunoreactivity of presenilin-1 in human, rat and mouse brain
    • DOI 10.1016/S0006-8993(97)00243-6, PII S0006899397002436
    • Kim, K. S., Wegiel, J., Sapienza, V., Chen, J., Hong, H., & Wisniewski, H. M. (1997). Immunoreactivity of presenilin-1 in human, rat and mouse brain. Brain Research, 757(1), 159-163. (Pubitemid 27244634)
    • (1997) Brain Research , vol.757 , Issue.1 , pp. 159-163
    • Kim, K.S.1    Wegiel, J.2    Sapienza, V.3    Chen, J.4    Hong, H.5    Wisniewski, H.M.6
  • 39
    • 3142512452 scopus 로고    scopus 로고
    • Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
    • DOI 10.1038/nm1065
    • Koo, E. H., & Kopan, R. (2004). Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nature Medicine, (10 Suppl), S26-S33. (Pubitemid 38901864)
    • (2004) Nature Medicine , vol.10 , Issue.SUPPL.
    • Koo, E.H.1    Kopan, R.2
  • 40
    • 59849093899 scopus 로고    scopus 로고
    • Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing
    • Kumar, V. B., Franko, M., Banks, W. A., Kasinadhuni, P., Farr, S. A., Vyas, K., et al. (2009). Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing. Journal of Experimental Biology, 212(4), 494-498.
    • (2009) Journal of Experimental Biology , vol.212 , Issue.4 , pp. 494-498
    • Kumar, V.B.1    Franko, M.2    Banks, W.A.3    Kasinadhuni, P.4    Farr, S.A.5    Vyas, K.6
  • 41
  • 42
    • 34547669095 scopus 로고    scopus 로고
    • Genetic heterogeneity of Alzheimer's disease: Complexity and advances
    • DOI 10.1016/j.psyneuen.2007.05.015, PII S0306453007001333
    • Lambert, J. C., & Amouyel, P. (2007). Genetic heterogeneity of Alzheimer's disease: Complexity and advances.Psychoneuroendocrinology, 32(Suppl 1), S62-S70. (Pubitemid 47211638)
    • (2007) Psychoneuroendocrinology , vol.32 , Issue.SUPPL. 1
    • Lambert, J.-C.1    Amouyel, P.2
  • 43
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifes variants at CLU and CR1 associated with Alzheimer's disease
    • Lambert, J. C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., et al. (2009). Genome-wide association study identifes variants at CLU and CR1 associated with Alzheimer's disease. Nature Genetics, 41(10), 1094-1099.
    • (2009) Nature Genetics , vol.41 , Issue.10 , pp. 1094-1099
    • Lambert, J.C.1    Heath, S.2    Even, G.3    Campion, D.4    Sleegers, K.5    Hiltunen, M.6
  • 44
    • 77950878145 scopus 로고    scopus 로고
    • Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein e epsilon4 allele
    • Langbaum, J. B., Chen, K., Caselli, R. J., Lee, W., Reschke, C., Bandy, D., et al. (2010). Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele. Archives of Neurology, 67(4), 462-468.
    • (2010) Archives of Neurology , vol.67 , Issue.4 , pp. 462-468
    • Langbaum, J.B.1    Chen, K.2    Caselli, R.J.3    Lee, W.4    Reschke, C.5    Bandy, D.6
  • 45
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, H., et al. (1995). Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science, 269(5226), 973-977.
    • (1995) Science , vol.269 , Issue.5226 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3    Romano, D.M.4    Oshima, J.5    Pettingell, H.6
  • 46
    • 38549087358 scopus 로고    scopus 로고
    • A presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity
    • DOI 10.1213/ane.0b013e3181605b71, PII 0000053920080200000021
    • Liang, G., Wang, Q., Li, Y., Kang, B., Eckenhoff, M. F., Eckenhoff, R. G., et al. (2008). A presenilin-1 mutation renders neurons vulnerable to isofurane toxicity. Anesthesia and Analgesia, 106(2), 492-500. (Pubitemid 351156673)
    • (2008) Anesthesia and Analgesia , vol.106 , Issue.2 , pp. 492-500
    • Liang, G.1    Wang, Q.2    Li, Y.3    Kang, B.4    Eckenhoff, M.F.5    Eckenhoff, R.G.6    Wei, H.7
  • 47
    • 39049176043 scopus 로고    scopus 로고
    • Study on expression of PS1 in APP-PS1 double gene stably trans-fected cell lines and its relation to gamma-secretase
    • Liang, P., Pan, Y. X., Zhao, X. M., Du, H. Z., & Zhang, J. M. (2005). Study on expression of PS1 in APP-PS1 double gene stably trans-fected cell lines and its relation to gamma-secretase. Zhonghua Bing Li Xue Za Zhi, 34(5), 297-301.
    • (2005) Zhonghua Bing Li Xue Za Zhi , vol.34 , Issue.5 , pp. 297-301
    • Liang, P.1    Pan, Y.X.2    Zhao, X.M.3    Du, H.Z.4    Zhang, J.M.5
  • 48
    • 0035834416 scopus 로고    scopus 로고
    • CNS synaptogenesis promoted by glia-derived cholesterol
    • DOI 10.1126/science.294.5545.1354
    • Mauch, D. H., Nagler, K., Schumacher, S., Goritz, C., Muller, E. C., Otto, A., et al. (2001). CNS synaptogenesis promoted by glia-derived cholesterol. Science, 294(5545), 1354-1357. (Pubitemid 33063104)
    • (2001) Science , vol.294 , Issue.5545 , pp. 1354-1357
    • Mauch, D.H.1    Nagier, K.2    Schumacher, S.3    Goritz, C.4    Muller, E.-C.5    Otto, A.6    Pfrieger, F.W.7
  • 50
    • 77649314191 scopus 로고    scopus 로고
    • APOE predicts Aβ but not Tau Alzheimer's pathology in cognitively normal aging
    • Morris, J. C., Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., et al. (2009). APOE predicts Aβ but not Tau Alzheimer's pathology in cognitively normal aging. Annals of Neurology, 67(1), 122-131.
    • (2009) Annals of Neurology , vol.67 , Issue.1 , pp. 122-131
    • Morris, J.C.1    Roe, C.M.2    Xiong, C.3    Fagan, A.M.4    Goate, A.M.5    Holtzman, D.M.6
  • 51
    • 48349085043 scopus 로고    scopus 로고
    • The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
    • Muller, T., Meyer, H. E., Egensperger, R., & Marcus, K. (2008). The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Progress in Neurobiology, 85(4), 393-406.
    • (2008) Progress in Neurobiology , vol.85 , Issue.4 , pp. 393-406
    • Muller, T.1    Meyer, H.E.2    Egensperger, R.3    Marcus, K.4
  • 52
    • 77954359268 scopus 로고    scopus 로고
    • Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif
    • Munter, L. M., Botev, A., Richter, L., Hildebrand, P. W., Althoff, V., Weise, C., et al. (2010). Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif. Journal of Biological Chemistry, 285(28), 21636-21643.
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.28 , pp. 21636-21643
    • Munter, L.M.1    Botev, A.2    Richter, L.3    Hildebrand, P.W.4    Althoff, V.5    Weise, C.6
  • 53
    • 73649091064 scopus 로고    scopus 로고
    • CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular traffcking is affected by presenilin-2
    • Nahalkova, J., Volkmann, I., Aoki, M., Winblad, B., Bogdanovic, N., Tjernberg, L. O., et al. (2010). CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular traffcking is affected by presenilin-2. Neurochemistry International, 56(1), 67-76.
    • (2010) Neurochemistry International , vol.56 , Issue.1 , pp. 67-76
    • Nahalkova, J.1    Volkmann, I.2    Aoki, M.3    Winblad, B.4    Bogdanovic, N.5    Tjernberg, L.O.6
  • 54
  • 57
    • 77952813805 scopus 로고    scopus 로고
    • DNA damage and impairment of DNA repair in Alzheimer's Disease
    • Obulesu, M., & Rao, D. M. (2010a). DNA damage and impairment of DNA repair in Alzheimer's Disease. The International Journal of Neuroscience, 120(6), 397-403.
    • (2010) The International Journal of Neuroscience , vol.120 , Issue.6 , pp. 397-403
    • Obulesu, M.1    Rao, D.M.2
  • 58
    • 77954478325 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease: An understanding of pathology and therapeutic avenues
    • Obulesu, M., & Rao, D. M. (2010b). Animal models of Alzheimer's disease: An understanding of pathology and therapeutic avenues. The International Journal of Neuroscience, 120(8), 531-537.
    • (2010) The International Journal of Neuroscience , vol.120 , Issue.8 , pp. 531-537
    • Obulesu, M.1    Rao, D.M.2
  • 59
    • 77954477360 scopus 로고    scopus 로고
    • Studies on genomic DNA stability in aluminium maltolate treated aged New Zealand rabbit: Relevance to the Alzheimer's animal model
    • Obulesu, M., Rao, D. M., & Shamasundar, N. M. (2009). Studies on genomic DNA stability in aluminium maltolate treated aged New Zealand rabbit: Relevance to the Alzheimer's animal model. Journal of Clinical and Medicinal Research, 1(4), 212-218.
    • (2009) Journal of Clinical and Medicinal Research , vol.1 , Issue.4 , pp. 212-218
    • Obulesu, M.1    Rao, D.M.2    Shamasundar, N.M.3
  • 60
    • 77953808196 scopus 로고    scopus 로고
    • Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease
    • Odero, G. L., Oikawa, K., Glazner, K. A., Schapansky, J., Grossman, D., Thiessen, J. D., et al. (2010). Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease. Neuroscience, 169(1), 532-543.
    • (2010) Neuroscience , vol.169 , Issue.1 , pp. 532-543
    • Odero, G.L.1    Oikawa, K.2    Glazner, K.A.3    Schapansky, J.4    Grossman, D.5    Thiessen, J.D.6
  • 61
    • 2542470579 scopus 로고    scopus 로고
    • 2+ homeostasis in type I cortical astrocytes by hypoxia: Evidence for association with Alzheimer's disease
    • DOI 10.1515/BC.2004.023
    • 2+ homeostasis in type I cortical astrocytes by hypoxia: Evidence for association with Alzheimer's disease. Biological Chemistry, 385(3-4), 285-289. (Pubitemid 38679074)
    • (2004) Biological Chemistry , vol.385 , Issue.3-4 , pp. 285-289
    • Peers, C.1    Smith, I.F.2    Boyle, J.P.3    Pearson, H.A.4
  • 62
    • 59149088690 scopus 로고    scopus 로고
    • Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes
    • Placanica, L., Tarassishin, L., Yang, G., Peethumnongsin, E., Kim, S. H., Zheng, H., et al. (2009). Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. The Journal of Biological Chemistry, 284(5), 2967-2977.
    • (2009) The Journal of Biological Chemistry , vol.284 , Issue.5 , pp. 2967-2977
    • Placanica, L.1    Tarassishin, L.2    Yang, G.3    Peethumnongsin, E.4    Kim, S.H.5    Zheng, H.6
  • 63
    • 2942557310 scopus 로고    scopus 로고
    • A-POE 34 allele is associated with reduced cerebrospinal fluid levels of Aβ42
    • Prince, J. A., Zetterberg, H., Andreasen, N., Marcusson, J., & Blennow, K. (2004). APOE 34 allele is associated with reduced cerebrospinal fuid levels of Aβ 42. Neurology, 62(11), 2116-2118. (Pubitemid 38738236)
    • (2004) Neurology , vol.62 , Issue.11 , pp. 2116-2118
    • Prince, J.A.1    Zetterberg, H.2    Andreasen, N.3    Marcusson, J.4    Blennow, K.5
  • 65
    • 0038240721 scopus 로고    scopus 로고
    • Causative and susceptibility genes for Alzheimer's disease: A review
    • DOI 10.1016/S0361-9230(03)00067-4
    • Rocchi, A., Pellegrini, S., Siciliano, G., & Murri, L. (2003). Causative and susceptibility genes for Alzheimer's disease: A review. Brain Research Bulletin, 61(1), 1-24. (Pubitemid 36682979)
    • (2003) Brain Research Bulletin , vol.61 , Issue.1 , pp. 1-24
    • Rocchi, A.1    Pellegrini, S.2    Siciliano, G.3    Murri, L.4
  • 66
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y, et al. (1995). Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature, 376(6543), 775-778.
    • (1995) Nature , vol.376 , Issue.6543 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6
  • 68
    • 79551484106 scopus 로고    scopus 로고
    • Presenilin/y-secretase and infammation
    • Saura, C. A. (2010). Presenilin/y-secretase and infammation. Frontiers of Aging Neuroscience, 2, 16.
    • (2010) Frontiers of Aging Neuroscience , vol.2 , pp. 16
    • Saura, C.A.1
  • 69
    • 0033553564 scopus 로고    scopus 로고
    • Evidence that intramolecular associations between presenilin domains are obligatory for endopro-teolytic processing
    • Saura, C. A., Tomita, T., Davenport, F., Harris, C. L., Iwatsubo, T., & Thinakaran, G. (1999). Evidence that intramolecular associations between presenilin domains are obligatory for endopro-teolytic processing. The Journal of Biological Chemistry, 274(20), 13818-13823.
    • (1999) The Journal of Biological Chemistry , vol.274 , Issue.20 , pp. 13818-13823
    • Saura, C.A.1    Tomita, T.2    Davenport, F.3    Harris, C.L.4    Iwatsubo, T.5    Thinakaran, G.6
  • 71
    • 77956203927 scopus 로고    scopus 로고
    • Is Alzheimer's disease a disorder of mitochondria-associated membranes?
    • Schon, E. A., & Area-Gomez, E. (2010). Is Alzheimer's disease a disorder of mitochondria-associated membranes? Journal of Alzheimers Disease, 20(Suppl 2), S281-S292.
    • (2010) Journal of Alzheimers Disease , vol.20 , Issue.SUPPL. 2
    • Schon, E.A.1    Area-Gomez, E.2
  • 72
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • DOI 10.1126/science.1074069
    • Selkoe, D. J. (2002). Alzheimer's disease is a synaptic failure. Science, 298(5594), 789-791. (Pubitemid 35231524)
    • (2002) Science , vol.298 , Issue.5594 , pp. 789-791
    • Selkoe, D.J.1
  • 73
    • 0029004341 scopus 로고
    • Cloning of novel gene bearing mis-sense mutations in early onset familial Alzheimer's disease
    • Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., et al. (1995). Cloning of novel gene bearing mis-sense mutations in early onset familial Alzheimer's disease. Nature, 375(6534), 754-760.
    • (1995) Nature , vol.375 , Issue.6534 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6
  • 78
    • 52649094417 scopus 로고    scopus 로고
    • Analysis of intrusive errors in a memory test as possible pre-clinical marker of familial Alzheimer disease, in E280A presenilin-1 mutation carrier
    • Tirado, V., Motta, M., Aguirre-Acevedo, D. C, Pineda, D. A., & Lopera, F. (2008). Analysis of intrusive errors in a memory test as possible pre-clinical marker of familial Alzheimer disease, in E280A presenilin-1 mutation carrier. Revista de Neurologia, 47(6), 290-294.
    • (2008) Revista de Neurologia , vol.47 , Issue.6 , pp. 290-294
    • Tirado, V.1    Motta, M.2    Aguirre-Acevedo, D.C.3    Pineda, D.A.4    Lopera, F.5
  • 79
    • 76549103969 scopus 로고    scopus 로고
    • Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogene-sis
    • Veeraraghavalu, K., Choi, S. H., & Sisodia, S. S. (2010). Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogene-sis. Neurodegenerative Diseases, 7(1-3), 46-49.
    • (2010) Neurodegenerative Diseases , vol.7 , Issue.1-3 , pp. 46-49
    • Veeraraghavalu, K.1    Choi, S.H.2    Sisodia, S.S.3
  • 80
    • 77952604395 scopus 로고    scopus 로고
    • Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease
    • Wan, J., Fu, A. K., Ip, F. C, Ng, H. K., Hugon, J., Page, G., et al. (2010). Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease. The Journal of Neuroscience, 30(20), 6873-6881.
    • (2010) The Journal of Neuroscience , vol.30 , Issue.20 , pp. 6873-6881
    • Wan, J.1    Fu, A.K.2    Ip, F.C.3    Ng, H.K.4    Hugon, J.5    Page, G.6
  • 81
    • 77950551338 scopus 로고    scopus 로고
    • The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) profle without affecting Notch processing
    • Wanngren, J., Franberg, J., Svensson, A. I., Laudon, H., Olsson, F, Winblad, B., et al. (2010). The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) profle without affecting Notch processing. The Journal of Biological Chemistry, 285(12), 8527-8536.
    • (2010) The Journal of Biological Chemistry , vol.285 , Issue.12 , pp. 8527-8536
    • Wanngren, J.1    Franberg, J.2    Svensson, A.I.3    Laudon, H.4    Olsson, F.5    Winblad, B.6
  • 82
    • 0032487575 scopus 로고    scopus 로고
    • Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain
    • Weggen, S., Diehlmann, A., Buslei, R., Beyreuther, K., & Bayer, T. A. (1998). Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain. Neuroreport, 9(14), 3279-3283. (Pubitemid 28522349)
    • (1998) NeuroReport , vol.9 , Issue.14 , pp. 3279-3283
    • Weggen, S.1    Diehlmann, A.2    Buslei, R.3    Beyreuther, K.4    Bayer, T.A.5
  • 83
    • 0028303072 scopus 로고
    • Apolipoprotein E: Structure function relationships
    • Weisgraber, K. H. (1994). Apolipoprotein E: Structure function relationships. Advances in Protein Chemistry, 45, 249-302.
    • (1994) Advances in Protein Chemistry , vol.45 , pp. 249-302
    • Weisgraber, K.H.1
  • 84
    • 63449100233 scopus 로고    scopus 로고
    • Genetic aspects of Alzheimer disease
    • Williamson, J., Goldman, J., & Marder, K. S. (2009). Genetic aspects of Alzheimer disease. Neurologist, 15(2), 80-86.
    • (2009) Neurologist , vol.15 , Issue.2 , pp. 80-86
    • Williamson, J.1    Goldman, J.2    Marder, K.S.3
  • 86
    • 34548179335 scopus 로고    scopus 로고
    • γ-secretase substrate concentration modulates the Aβ42/Aβ40 ratio: Implications for Alzheimer disease
    • DOI 10.1074/jbc.M704601200
    • Yin, Y. I., Bassit, B., Zhu, L., Yang, X., Wang, C., & Li, Y. M. (2007). {gamma}-secretase substrate concentration modulates the Abeta42/Abeta40 ratio: Implications for Alzheimer's disease. The Journal of Biological Chemistry, 282(32), 23639-23644. (Pubitemid 47311934)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.32 , pp. 23639-23644
    • Ye, I.Y.1    Bassit, B.2    Zhu, L.3    Yang, X.4    Wang, C.5    Li, Y.-M.6
  • 87
    • 54849428907 scopus 로고    scopus 로고
    • Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2
    • Zhu, M., Gu, F., Shi, J., Hu, J., Hu, Y., & Zhao, Z. (2008). Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2. Free Radical Biology and Medicine, 45(10), 1493-1499.
    • (2008) Free Radical Biology and Medicine , vol.45 , Issue.10 , pp. 1493-1499
    • Zhu, M.1    Gu, F.2    Shi, J.3    Hu, J.4    Hu, Y.5    Zhao, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.