Defective signal transduction in B lymphocytes lacking presenilin proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 3, 2008, Pages 979-984

  Yagi, Tomohito ^a,e   Giallourakis, Cosmas ^b   Mohanty, Subhasis ^a   Scheidig, Christina ^a   Shen, Jie ^c   Zheng, Hui ^d   Xavier, Ramnik J ^b   Shaw, Albert C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

B cell; B cell antigen receptor (BCR); Computational biology; Gene targeting; Toll like receptor

Indexed keywords

B LYMPHOCYTE ANTIGEN; CD19 ANTIGEN; IMMUNOGLOBULIN M ANTIBODY; LIPOPOLYSACCHARIDE; PRESENILIN 1; PRESENILIN 2; RNA; TOLL LIKE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ALLELE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE INACTIVATION; GENE SEQUENCE; GENOME; IMMUNE SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGY; CYTOLOGY; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT;

MAMMALIA; MUS;

ANIMALS; B-LYMPHOCYTES; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENOME; MICE; MICE, KNOCKOUT; PRESENILIN-1; PRESENILIN-2; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 38949176817     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0707755105     Document Type: Article

References (32)

1. Vetrivel KS, Zhang YW, Xu H, Thinakaran G (2006) Mol Neurodegener 1:4.
2. Selkoe D, Kopan R (2003) Annu Rev Neurosci 26:565-597.
3. LaFerla FM (2002) Nat Rev Neurosci 3:862-872.
4. Mattson MP, Chan SL, Camandola S (2001) Bioessays 23:733-744.
5. Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I (2006) Cell 126:981-993.
6. Donoviel DB, Hadjantonakis AK, Ikeda M, Zheng H, Hyslop PS, Bernstein A (1999) Genes Dev 13:2801-2810.
7. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Cell 89:629-639.
8. Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS (1997) Nature 387:288-292.
9. Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H (2004) Biochemistry 43:5352-5359.
10. Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, Saftig P, Craessaerts K, De Strooper B, Hartmann D (2004) Hum Mol Genet 13:1321-1331.
11. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, et al. (2003) Nat Genet 34:267-273.
12. Tomlins SA, Mehra R, Rhodes DR, Cao X, Wang L, Dhanasekaran SM, Kalyana-Sundaram S, Wei JT, Rubin MA, Pienta KJ, et al. (2007) Nat Genet 39:41-51.
13. Levine DM, Haynor DR, Castle JC, Stepaniants SB, Pellegrini M, Mao M, Johnson JM (2006) Genome Biol 7:R93.
14. Hyatt G, Melamed R, Park R, Seguritan R, Laplace C, Poirot L, Zucchelli S, Obst R, Matos M, Venanzi E, et al. (2006) Nat Immunol 7:686-691.
15. Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CA, Taylor MS, Engstrom PG, Frith MC, et al. (2006) Nat Genet 38:626-635.
16. Stuart JM, Segal E, Koller D, Kim SK (2003) Science 302:249-255.
17. Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Xu F, et al. (2003) Proc Natl Acad Sci USA 100:605-610.
18. Giallourakis C, Cao Z, Green T, Wachtel H, Xie X, Lopez-Illasaca M, Daly M, Rioux J, Xavier R (2006) Genome Res 16:1056-1072.
19. Hosack DA, Dennis G, Jr, Sherman BT, Lane HC, Lempicki RA (2003) Genome Biol 4:R70.
20. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, et al. (2004) Proc Natl Acad Sci USA 101:6062-6067.
21. Li SH, Lam S, Cheng AL, Li XJ (2000) Hum Mol Genet 9:2859-2867.
22. Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, et al. (1999) Nature 399:263-267.
23. Khoshnan A, Ko J, Watkin EE, Paige LA, Reinhart PH, Patterson PH (2004) J Neurosci 24:7999-8008.
24. Ogura Y, Sutterwala FS, Flavell RA (2006) Cell 126:659-662.
25. Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Miller MW, Ware CB, Martin GM, et al. (2001) Neuron 32:911-926.
26. Rickert RC, Roes J, Rajewsky K (1997) Nucleic Acids Res 25:1317-1318.
27. Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, et al. (2003) Immunity 18:675-685.
28. Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, Kuroda K, Suzuki A, Nakano T, Honjo T (2002) Nat Immunol 3:443-450.
29. Witt CM, Won WJ, Hurez V, Klug CA (2003) J Immunol 171:2783-2788.
30. Dennis G, Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA (2003) Genome Biol 4:P3.
31. Schadt EE, Li C, Ellis B, Wong WH (2001) J Cell Biochem Suppl 37:120-125.
32. Laky K, Fowlkes BJ (2007) J Exp Med 204:2115-2129.