CD147, a γ-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2

Neurochemistry International

Volumn 56, Issue 1, 2010, Pages 67-76

  Nahalkova, Jarmila ^a   Volkmann, Inga ^a   Aoki, Mikio ^a   Winblad, Bengt ^a   Bogdanovic, Nenad ^a   Tjernberg, Lars O ^a   Behbahani, Homira ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Secretase; Alzheimer's disease; CD147; Human brain; Iodixanol gradient; Presenilin

Indexed keywords

CD147 ANTIGEN; GAMMA SECRETASE; MEMBRANE PROTEIN; NICASTRIN; PRESENILIN 1; PRESENILIN 2;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN TISSUE; CELL FRACTIONATION; CELL MIGRATION; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; FIBROBLAST; FLOW CYTOMETRY; FRONTAL CORTEX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCHEMISTRY; IMMUNOPRECIPITATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THALAMUS; UPREGULATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIGENS, CD147; BRAIN; CELL COMPARTMENTATION; ENDOTHELIAL CELLS; FEMALE; FRONTAL LOBE; HELA CELLS; HUMANS; MALE; MICE; NEURONS; PRESENILIN-2; PROTEIN TRANSPORT; RATS; SUBCELLULAR FRACTIONS; THALAMUS; UP-REGULATION;

RATTUS;

EID: 73649091064     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.09.003     Document Type: Article

References (42)

1. Berditchevski F., Chang S., Bodorova J., and Hemler M.E. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J. Biol. Chem. 272 (1997) 29174-29180
2. Biswas C., Zhang Y., DeCastro R., Guo H., Nakamura T., Kataoka H., and Nabeshima K. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 55 (1995) 434-439
3. Bogdanovic N., and Morris J.H. In: Cruz-Sanchez F.F., et al. (Ed). Diagnostic Criteria for Alzheimer's Disease in Multi-Centre Brain Banking, Biomedical and Health Research Series (1995), IOS Press, Amsterdam 20-29
4. Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82 (1991) 239-259
5. Burggraf D., Martens H.K., Dichgans M., and Hamann G.F. Matrix metalloproteinase (MMP) induction and inhibition at different doses of recombinant tissue plasminogen activator following experimental stroke. Thromb. Haemost. 98 (2007) 963-969
6. Cai D., Netzer W.J., Zhong M., et al. Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 1941-1946
7. Chen F., Hasegawa H., Schmitt-Ulms G., et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 440 (2006) 1208-1212
8. Corder E.H., Woodbury M.A., Volkmann I., Madsen D.K., Bogdanovic N., and Winblad B. Density profiles of Alzheimer disease regional brain pathology for the Huddinge brain bank: pattern recognition emulates and expands upon Braak staging. Exp. Gerontol. 35 (2000) 851-864
9. de la Torre J.C. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol. 3 (2004) 184-190
10. Egawa N., Koshikawa N., Tomari T., Nabeshima K., Isobe T., and Seiki M. Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells. J. Biol. Chem. 281 (2006) 37576-37585
11. Fadool J.M., and Linser P.J. 5A11 antigen is a cell recognition molecule which is involved in neuronal-glial interactions in avian neural retina. Dev. Dynam. 196 (1993) 252-262
12. Fadool J.M., and Linser P.J. Differential glycosylation of the 5A11/HT7 antigen by neural retina and epithelial tissues in the chicken. J. Neurochem. 60 (1993) 1354-1364
13. Fan Q.W., Yuasa S., Kuno N., Senda T., Kobayashi M., Muramatsu T., and Kadomatsu K. Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Neurosci. Res. 30 (1998) 53-63
14. Franberg J., Welander H., Aoki M., Winblad B., Tjernberg L.O., and Frykman S. Rat brain gamma-secretase activity is highly influenced by detergents. Biochemistry 46 (2007) 7647-7654
15. Guo H., Zucker S., Gordon M.K., Toole B.P., and Biswas C. Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells. J. Biol. Chem. 272 (1997) 24-27
16. Huang Y., Jiang J., Dou K., and Chen Z. HAb18G/CD147 enhances the secretion of matrix metalloproteinases (MMP) via cGMP/NO-sensitive capacitative calcium entry (CCE) and accordingly attenuates adhesion ability of fibroblasts. Eur. J. Cell Biol. 84 (2005) 59-73
17. Jia L., Cao J., Wei W., Wang S., Zuo Y., and Zhang J. CD147 depletion down-regulates matrix metalloproteinase-11, vascular endothelial growth factor-A expression and the lymphatic metastasis potential of murine hepatocarcinoma Hca-F cells. Int. J. Biochem. Cell Biol. 39 (2007) 2135-2142
18. Kirschenbaum F., Hsu S.C., Cordell B., and McCarthy J.V. Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels. J. Biol. Chem. 276 (2001) 30701-30707
19. Koch C., Staffler G., Huttinger R., et al. T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density. Int. Immunol. 11 (1999) 777-786
20. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (1984) 939-944
21. Mirra S.S., Heyman A., McKeel D., et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41 (1991) 479-486
22. Miyauchi T., Kanekura T., Yamaoka A., Ozawa M., Miyazawa S., and Muramatsu T. Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the beta-chain of major histocompatibility complex class II antigen. J. Biochem. 107 (1990) 316-323
23. Miyauchi T., Masuzawa Y., and Muramatsu T. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J. Biochem. 110 (1991) 770-774
24. Muramatsu T., and Miyauchi T. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol. Histopathol. 18 (2003) 981-987
25. Nehme C.L., Fayos B.E., and Bartles J.R. Distribution of the integral plasma membrane glycoprotein CE9 (MRC OX-47) among rat tissues and its induction by diverse stimuli of metabolic activation. Biochem. J. 310 Pt 2 (1995) 693-698
26. Ochrietor J.D., Moroz T.P., van Ekeris L., et al. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4086-4096
27. Schlosshauer B., and Herzog K.H. Neurothelin: an inducible cell surface glycoprotein of blood-brain barrier-specific endothelial cells and distinct neurons. J. Cell Biol. 110 (1990) 1261-1274
28. Schulte E.C., Slawik H., Schule R., Gunther T., and Hull M. Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease. Neurochem. Int. (2009) Epub ahead of print
29. Seulberger H., Lottspeich F., and Risau W. The inducible blood-brain barrier-specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein. Embo J. 9 (1990) 2151-2158
30. Siman R., and Salidas S. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain. Neuroscience 129 (2004) 615-628
31. Spring F.A., Holmes C.H., Simpson K.L., Mawby W.J., Mattes M.J., Okubo Y., and Parsons S.F. The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues. Eur J Immunol 27 (1997) 891-897
32. Suh Y.H., and Checler F. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol. Rev. 54 (2002) 469-525
33. Sun J., and Hemler M.E. Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res. 61 (2001) 2276-2281
34. Tang W., Chang S.B., and Hemler M.E. Links between CD147 function, glycosylation, and caveolin-1. Mol. Biol. Cell 15 (2004) 4043-4050
35. Vetrivel K.S., Zhang X., Meckler X., et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. J. Biol. Chem. 283 (2008) 19489-19498
36. Winkler E., Hobson S., Fukumori A., Dumpelfeld B., Luebbers T., Baumann K., Haass C., Hopf C., and Steiner H. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase (dagger). Biochemistry (2009)
37. Yoshida S., Shibata M., Yamamoto S., Hagihara M., Asai N., Takahashi M., Mizutani S., Muramatsu T., and Kadomatsu K. Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Eur. J. Biochem. 267 (2000) 4372-4380
38. Yurchenko V., Zybarth G., O'Connor M., et al. Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J. Biol. Chem. 277 (2002) 22959-22965
39. Zhou S., Zhou H., Walian P.J., and Jap B.K. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 7499-7504
40. Zhou S., Zhou H., Walian P.J., and Jap B.K. The discovery and role of CD147 as a subunit of gamma-secretase complex. Drug News Perspect. 19 (2006) 133-138
41. Zhou S., Zhou H., Walian P.J., and Jap B.K. Regulation of gamma-secretase activity in Alzheimer's disease. Biochemistry 46 (2007) 2553-2563
42. Zhu W., Khachi S., Hao Q., Shen F., Young W.L., Yang G.Y., and Chen Y. Upregulation of EMMPRIN after permanent focal cerebral ischemia. Neurochem. Int. 52 (2008) 1086-1091