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Volumn 120, Issue 8, 2010, Pages 531-537

Animal models of alzheimer's disease: An understanding of pathology and therapeutic avenues

Author keywords

Alzheimer's disease; Animal model; Therapeutic strategies

Indexed keywords

1 3 N BUTYLPHTHALIDE; 3 BUTYLPHTHALIDE; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; ANGIOTENSIN II [3-8]; BAFILOMYCIN; CURCUMIN; DNA VACCINE; DONEPEZIL; GANSTIGMINE; GLOXAZONE; GLYCOGEN SYNTHASE KINASE 3; IBUPROFEN; NEUTRALIZING ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; POLYPHENOL; RESVERATROL; SOMATOMEDIN C; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 77954478325     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207451003760080     Document Type: Review
Times cited : (25)

References (72)
  • 1
    • 30444437033 scopus 로고    scopus 로고
    • Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: Implications for clinical outcome
    • Abrahamson, E. E., Ikonomovic, M. D., Ciallella, J. R.,Hope, C. E., Paljug, W. R., Isanski, B. A., et al. (2006). Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: Implications for clinical outcome. Experimental Neurology, 197(2), 437-450.
    • (2006) Experimental Neurology , vol.197 , Issue.2 , pp. 437-450
    • Abrahamson, E.E.1    Ikonomovic, M.D.2    Ciallella, J.R.3    Hope, C.E.4    Paljug, W.R.5    Isanski, B.A.6
  • 2
    • 36148960495 scopus 로고    scopus 로고
    • Generation of a transgenic zebrafish model of tauopathy using a novel promoter element derived from the zebrafish eno2 gene
    • Bai, Q., Garver, J. A., Hukriede, N. A., & Burton, E. A. (2007). Generation of a transgenic zebrafish model of tauopathy using a novel promoter element derived from the zebrafish eno2 gene. Nucleic Acids Research, 35(19), 6501-6516.
    • (2007) Nucleic Acids Research , vol.35 , Issue.19 , pp. 6501-6516
    • Bai, Q.1    Garver, J.A.2    Hukriede, N.A.3    Burton, E.A.4
  • 3
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F., Cannon, C., Barbour, R., Burke, R. L., Games, D., Grajeda, H., et al. (2000). Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Medicine, 6(8), 916-919.
    • (2000) Nature Medicine , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6
  • 4
    • 0033739282 scopus 로고    scopus 로고
    • Apoptosis and Alzheimer's disease
    • Behl, C. (2000). Apoptosis and Alzheimer's disease. Journal of Neural Transmission, 107(11), 1325-1344.
    • (2000) Journal of Neural Transmission , vol.107 , Issue.11 , pp. 1325-1344
    • Behl, C.1
  • 5
    • 70350029602 scopus 로고    scopus 로고
    • A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease
    • Bennett, S. P., Boyd, T., Norden, M., Padmanabhan, J., Neame, P., Wefes, I., et al. (2009). A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease. Journal of Neuroscience Methods, 184(2), 320-326.
    • (2009) Journal of Neuroscience Methods , vol.184 , Issue.2 , pp. 320-326
    • Bennett, S.P.1    Boyd, T.2    Norden, M.3    Padmanabhan, J.4    Neame, P.5    Wefes, I.6
  • 6
    • 33748696860 scopus 로고    scopus 로고
    • A new insight into Al-maltolate treated aged rabbit brain as Alzheimer's animal model
    • Bharathi, Shama Sundar, N. M., Rao, T. S. S., Ravid, R., & Rao, K. S. J. (2006). A new insight into Al-maltolate treated aged rabbit brain as Alzheimer's animal model. Brain Research Reviews, 52(2), 275-292.
    • (2006) Brain Research Reviews , vol.52 , Issue.2 , pp. 275-292
    • Bharathi1    Shama Sundar, N.M.2    Rao, T.S.S.3    Ravid, R.4    Rao, K.S.J.5
  • 7
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005). Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron, 45(5), 675-688.
    • (2005) Neuron , vol.45 , Issue.5 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    Laferla, F.M.5
  • 9
    • 39049192182 scopus 로고    scopus 로고
    • On the molecular basis linking nerve growth factor (NGF) to Alzheimer's disease
    • Capsoni, S., & Cattaneo, A. (2006). On the molecular basis linking nerve growth factor (NGF) to Alzheimer's disease. Cell and Molecular Neurobiology, 26(4-6), 619-633.
    • (2006) Cell and Molecular Neurobiology , vol.26 , Issue.4-6 , pp. 619-633
    • Capsoni, S.1    Cattaneo, A.2
  • 10
    • 0036828769 scopus 로고    scopus 로고
    • Alzheimer's disease: Treatments in discovery and development
    • Citron, M. (2002). Alzheimer's disease: treatments in discovery and development. Nature Neuroscience, 5(Suppl), 1055-1057.
    • (2002) Nature Neuroscience , vol.5 , Issue.SUPPL. , pp. 1055-1057
    • Citron, M.1
  • 11
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C., Paul, S. M., & Holtzman, D. M. (2001). Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proceedings of National Academy of Sciences USA, 98(15), 8850-8855.
    • (2001) Proceedings of National Academy of Sciences USA , vol.98 , Issue.15 , pp. 8850-8855
    • Demattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 13
    • 85047693458 scopus 로고    scopus 로고
    • Apoptoticmechanisms in Alzheimer neurofibrillary degeneration: Cause or effect?
    • Dickson,D.W. (2004). Apoptoticmechanisms in Alzheimer neurofibrillary degeneration: Cause or effect? Journal of Clinical Investigation, 114(1), 23-27.
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.1 , pp. 23-27
    • Dickson, D.W.1
  • 14
    • 66249148382 scopus 로고    scopus 로고
    • The common inhalational anesthetic sevoflurane induces apoptosis and increases β-amyloid protein levels
    • Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Xia, W., Marcantonio, E. R., et al. (2009). The common inhalational anesthetic sevoflurane induces apoptosis and increases β-amyloid protein levels. Archives of Neurology, 66(5), 620-631.
    • (2009) Archives of Neurology , vol.66 , Issue.5 , pp. 620-631
    • Dong, Y.1    Zhang, G.2    Zhang, B.3    Moir, R.D.4    Xia, W.5    Marcantonio, E.R.6
  • 15
    • 65849162974 scopus 로고    scopus 로고
    • Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease
    • Du, J., Sun, B., Chen, K., Zhang, L., Liu, S., Gu, Q., et al. (2009). Metabolites of cerebellar neurons and hippocampal neurons play opposite roles in pathogenesis of Alzheimer's disease. PLoSONE, 4(5), e5530.
    • (2009) PLoSONE , vol.4 , Issue.5
    • Du, J.1    Sun, B.2    Chen, K.3    Zhang, L.4    Liu, S.5    Gu, Q.6
  • 16
    • 71249124418 scopus 로고    scopus 로고
    • Resveratrol inh'ibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation
    • Feng, Y., Wang, X. P., Yang, S. G., Wang, Y. J., Zhang, X., Du, X. T., et al. (2009). Resveratrol inh'ibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation. Neurotoxicology, 30(6), 986-995.
    • (2009) Neurotoxicology , vol.30 , Issue.6 , pp. 986-995
    • Feng, Y.1    Wang, X.P.2    Yang, S.G.3    Wang, Y.J.4    Zhang, X.5    Du, X.T.6
  • 20
    • 0036696549 scopus 로고    scopus 로고
    • Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)
    • Gerhard, G. S., Kauffman, E. J., Wang, X., Stewart, R., Moore, J. L., Kasales, et al. (2002). Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio). Experimental Gerontology, 37(8-9), 1055-1068.
    • (2002) Experimental Gerontology , vol.37 , Issue.8-9 , pp. 1055-1068
    • Gerhard, G.S.1    Kauffman, E.J.2    Wang, X.3    Stewart, R.4    Kasales, L.M.J.5
  • 21
  • 22
    • 0035827093 scopus 로고    scopus 로고
    • Coinvolvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: Changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits
    • Ghribi,O., DeWitt,D. A., Forbes, M. S.,Herman, M. M., &Savory, J. (2001). Coinvolvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits. Brain Research, 903(1-2), 66-73.
    • (2001) Brain Research , vol.903 , Issue.1-2 , pp. 66-73
    • Ghribi, O.1    De Witt, D.A.2    Forbes, M.S.3    Herman, M.M.4    Savory, J.5
  • 23
    • 0035976761 scopus 로고    scopus 로고
    • Abeta(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of GADD 153 and NF-kappaB
    • Ghribi, O., Herman, M. M., DeWitt, D. A., Forbes, M. S., & Savory, J. (2001). Abeta(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of GADD 153 and NF-kappaB. Brain Research Molecular Brain Research, 96(1-2), 30-38.
    • (2001) Brain Research Molecular Brain Research , vol.96 , Issue.1-2 , pp. 30-38
    • Ghribi, O.1    Herman, M.M.2    De Witt, D.A.3    Forbes, M.S.4    Savory, J.5
  • 24
    • 0035173536 scopus 로고    scopus 로고
    • GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation
    • Ghribi, O., Herman, M. M., Forbes, M. S., DeWitt, D. A., & Savory, J. (2001). GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation. Neurobiology of Disease, 8(5), 764-773.
    • (2001) Neurobiology of Disease , vol.8 , Issue.5 , pp. 764-773
    • Ghribi, O.1    Herman, M.M.2    Forbes, M.S.3    De Witt, D.A.4    Savory, J.5
  • 25
    • 0037166054 scopus 로고    scopus 로고
    • The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus
    • Ghribi, O., Herman, M. M., & Savory, J. (2002). The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus. Neuroscience Letters, 324(3), 217-221.
    • (2002) Neuroscience Letters , vol.324 , Issue.3 , pp. 217-221
    • Ghribi, O.1    Herman, M.M.2    Savory, J.3
  • 27
    • 43149100823 scopus 로고    scopus 로고
    • Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedishmutant, beta-secretase site of the amyloid precursor protein
    • Hook, V. Y., Kindy, M., & Hook, G. (2008). Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedishmutant, beta-secretase site of the amyloid precursor protein. Journal of Biological Chemistry, 283(12), 7745-7753.
    • (2008) Journal of Biological Chemistry , vol.283 , Issue.12 , pp. 7745-7753
    • Hook, V.Y.1    Kindy, M.2    Hook, G.3
  • 28
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5′-splicesite mutations in tau with the inherited dementia FTDP-17
    • Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., et al. (1998). Association of missense and 5′-splicesite mutations in tau with the inherited dementia FTDP-17. Nature, 393(6686), 702-705.
    • (1998) Nature , vol.393 , Issue.6686 , pp. 702-705
    • Hutton, M.1    Lendon, C.L.2    Rizzu, P.3    Baker, M.4    Froelich, S.5    Houlden, H.6
  • 29
    • 10044278300 scopus 로고    scopus 로고
    • In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent
    • Jack, C. R., Jr., Garwood, M., Wengenack, T. M., Borowski, B., Curran, G. L., Lin, J., et al. (2004). In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. Magnetic Resonance in Medicine, 52(6), 1263-1271.
    • (2004) Magnetic Resonance in Medicine , vol.52 , Issue.6 , pp. 1263-1271
    • Jack Jr., C.R.1    Garwood, M.2    Wengenack, T.M.3    Borowski, B.4    Curran, G.L.5    Lin, J.6
  • 30
    • 33845995054 scopus 로고    scopus 로고
    • Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: A new tool in Alzheimer's disease research
    • Jack, C. R., Jr., Marjanska,M.,Wengenack, T. M., Reyes, D. A., Curran, G. L., Lin, J., et al. (2007). Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research. Neuroscientist, 13(1), 38-48.
    • (2007) Neuroscientist , vol.13 , Issue.1 , pp. 38-48
    • Jack Jr., C.R.1    Marjanska, M.2    Wengenack, T.M.3    Reyes, D.A.4    Curran, G.L.5    Lin, J.6
  • 31
    • 27344439224 scopus 로고    scopus 로고
    • In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice
    • Jack, C. R., Jr., Wengenack, T. M., Reyes, D. A., Garwood, M., Curran, G. L., Borowski, B. J., et al. (2005). In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice. Journal of Neuroscience, 25(43), 10041-10048.
    • (2005) Journal of Neuroscience , vol.25 , Issue.43 , pp. 10041-10048
    • Jack Jr., C.R.1    Wengenack, T.M.2    Reyes, D.A.3    Garwood, M.4    Curran, G.L.5    Borowski, B.J.6
  • 32
    • 0037088914 scopus 로고    scopus 로고
    • Microglial activation and betaamyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
    • Jantzen, P. T., Connor, K. E., DiCarlo, G., Wenk, G. L., Wallace, J. L., Rojiani, A. M., et al. (2002). Microglial activation and betaamyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. Journal of Neuroscience, 22(6), 2246-2254.
    • (2002) Journal of Neuroscience , vol.22 , Issue.6 , pp. 2246-2254
    • Jantzen, P.T.1    Connor, K.E.2    Dicarlo, G.3    Wenk, G.L.4    Wallace, J.L.5    Rojiani, A.M.6
  • 33
    • 40749095640 scopus 로고    scopus 로고
    • Functional and developmental analysis of the blood-brain barrier in zebrafish
    • Jeong, J. Y., Kwon, H. B., Ahn, J. C., Kang, D., Kwon, S. H., Park, J. A., et al. (2008). Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Research Bulletin, 75(5), 619-628.
    • (2008) Brain Research Bulletin , vol.75 , Issue.5 , pp. 619-628
    • Jeong, J.Y.1    Kwon, H.B.2    Ahn, J.C.3    Kang, D.4    Kwon, S.H.5    Park, J.A.6
  • 34
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim, G. P., Chu, T., Yang, F. S., Beech, W., Frautschy, S. A., & Cole, G. M. (2001). The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience, 21(21), 8370-8377.
    • (2001) Journal of Neuroscience , vol.21 , Issue.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.S.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 35
    • 0034254924 scopus 로고    scopus 로고
    • Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
    • Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W., Teter, B., et al. (2000). Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. Journal of Neuroscience, 20(15), 5709-5714.
    • (2000) Journal of Neuroscience , vol.20 , Issue.15 , pp. 5709-5714
    • Lim, G.P.1    Yang, F.2    Chu, T.3    Chen, P.4    Beech, W.5    Teter, B.6
  • 36
    • 0035691115 scopus 로고    scopus 로고
    • Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
    • Lim, G. P., Yang, F., Chu, T., Gahtan, E., Ubeda, O., Beech,W., et al. (2001). Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiology of Aging, 22(6), 983-991.
    • (2001) Neurobiology of Aging , vol.22 , Issue.6 , pp. 983-991
    • Lim, G.P.1    Yang, F.2    Chu, T.3    Gahtan, E.4    Ubeda, O.5    Beech, W.6
  • 37
    • 71049118151 scopus 로고    scopus 로고
    • Sustained Activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity
    • Price, K. A., Caragounis, A., Paterson, B. M., Filiz, G., Volitakis, I., Masters, C. L., et al. (2009). Sustained Activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity. Journal of Medicinal Chemistry, 52(21), 6606-6620.
    • (2009) Journal of Medicinal Chemistry , vol.52 , Issue.21 , pp. 6606-6620
    • Price, K.A.1    Caragounis, A.2    Paterson, B.M.3    Filiz, G.4    Volitakis, I.5    Masters, C.L.6
  • 38
  • 39
    • 70649097387 scopus 로고    scopus 로고
    • RNAi applications in therapy development for neurodegenerative disease
    • Maxwell, M. M. (2009). RNAi applications in therapy development for neurodegenerative disease. Current Pharmaceutical Design, 15(34), 3977-3991.
    • (2009) Current Pharmaceutical Design , vol.15 , Issue.34 , pp. 3977-3991
    • Maxwell, M.M.1
  • 41
    • 66149090377 scopus 로고    scopus 로고
    • Magnetic resonance imaging and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
    • Meadowcroft, M. D., Connor, J. R., Smith, M. B., & Yang, Q. X. (2009). Magnetic resonance imaging and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice. Journal of Magnetic Resonance and Imaging, 29(5), 997-1007.
    • (2009) Journal of Magnetic Resonance and Imaging , vol.29 , Issue.5 , pp. 997-1007
    • Meadowcroft, M.D.1    Connor, J.R.2    Smith, M.B.3    Yang, Q.X.4
  • 42
    • 77952096057 scopus 로고    scopus 로고
    • Neuroprotective effects of IGF-I following kainic acid-induced hippocampal degeneration in the rat
    • in press
    • Miltiadous, P., Stamatakis, A., & Stylianopoulou, F. (in press). Neuroprotective effects of IGF-I following kainic acid-induced hippocampal degeneration in the rat. Cell and Molecular Neurobiology.
    • Cell and Molecular Neurobiology
    • Miltiadous, P.1    Stamatakis, A.2    Stylianopoulou, F.3
  • 43
    • 47749107621 scopus 로고    scopus 로고
    • Reducing ADlike pathology in 3xTg-AD mouse model by DNA epitope vaccine-A novel immunotherapeutic strategy
    • Movsesyan, N., Ghochikyan, A., Mkrtichyan, M., Petrushina, I., Davtyan, H., Olkhanud, P. B., et al. (2008). Reducing ADlike pathology in 3xTg-AD mouse model by DNA epitope vaccine-A novel immunotherapeutic strategy. PLoS ONE, 3(5), e2124.
    • (2008) PLoS ONE , vol.3 , Issue.5
    • Movsesyan, N.1    Ghochikyan, A.2    Mkrtichyan, M.3    Petrushina, I.4    Davtyan, H.5    Olkhanud, P.B.6
  • 44
    • 75149136696 scopus 로고    scopus 로고
    • Alzheimer's disease and the amyloid-beta peptide
    • Murphy, M. P., & Levine, H. (2010). Alzheimer's disease and the amyloid-beta peptide. Journal of Alzheimers Disease, 19(1), 311-323.
    • (2010) Journal of Alzheimers Disease , vol.19 , Issue.1 , pp. 311-323
    • Murphy, M.P.1    Levine, H.2
  • 45
    • 77954477360 scopus 로고    scopus 로고
    • Studies on genomic DNA stability in aluminium-maltolate treated aged New Zealand rabbit: Relevance to the Alzheimer's animal model
    • Obulesu, M., Rao, D. M., & Shama Sundar, N. M. (2009). Studies on genomic DNA stability in aluminium-maltolate treated aged New Zealand rabbit: Relevance to the Alzheimer's animal model. Journal of Clinical Medicine and Research, 1(4), 212-218.
    • (2009) Journal of Clinical Medicine and Research , vol.1 , Issue.4 , pp. 212-218
    • Obulesu, M.1    Rao, D.M.2    Shama Sundar, N.M.3
  • 46
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., & LaFerla, F. M. (2004). Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron, 43(3), 321-332.
    • (2004) Neuron , vol.43 , Issue.3 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    Laferla, F.M.5
  • 47
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo, S.,Caccamo,A., Shepherd, J. D.,Murphy,M. P.,Golde,T.E., Kayed, R., et al. (2003). Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction. Neuron, 39(3), 409-421.
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6
  • 48
    • 33846015514 scopus 로고    scopus 로고
    • Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    • Oddo, S., Vasilevko, V., Caccamo, A., Kitazawa,M., Cribbs, D. H., & LaFerla, F. M. (2006). Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. Journal of Biological Chemistry, 281(51), 39413-39423.
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.51 , pp. 39413-39423
    • Oddo, S.1    Vasilevko, V.2    Caccamo, A.3    Kitazawa, M.4    Cribbs, D.H.5    Laferla, F.M.6
  • 49
    • 66449115032 scopus 로고    scopus 로고
    • A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
    • Paquet, D., Bhat, R., Sydow, A., Mandelkow, E. M., Berg, S., Hellberg, S., et al. (2009). A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. Journal of Clinical Investigation, 119(5), 1382-1395.
    • (2009) Journal of Clinical Investigation , vol.119 , Issue.5 , pp. 1382-1395
    • Paquet, D.1    Bhat, R.2    Sydow, A.3    Mandelkow, E.M.4    Berg, S.5    Hellberg, S.6
  • 50
    • 70349617912 scopus 로고    scopus 로고
    • L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloidbeta peptide in rats
    • Peng, Y., Xing, C., Xu, S., Lemere, C. A., Chen, G., Liu, B., et al. (2009). l-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloidbeta peptide in rats. European Journal of Pharmacology, 621(1-3), 38-45.
    • (2009) European Journal of Pharmacology , vol.621 , Issue.1-3 , pp. 38-45
    • Peng, Y.1    Xing, C.2    Xu, S.3    Lemere, C.A.4    Chen, G.5    Liu, B.6
  • 51
    • 69449093036 scopus 로고    scopus 로고
    • Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
    • Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E., & Davies, P. (2009). Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. Journal of Neuroscience, 29(34), 10741-10749.
    • (2009) Journal of Neuroscience , vol.29 , Issue.34 , pp. 10741-10749
    • Polydoro, M.1    Acker, C.M.2    Duff, K.3    Castillo, P.E.4    Davies, P.5
  • 53
    • 13244266322 scopus 로고    scopus 로고
    • Aluminium induced neurodegeneration in hippocampus of aged rabbits mimics AD
    • Rao, K. S. J., Anitha, S., & Latha, K. S. (2000). Aluminium induced neurodegeneration in hippocampus of aged rabbits mimics AD. Alzheimer's Reports, 3, 83-88.
    • (2000) Alzheimer's Reports , vol.3 , pp. 83-88
    • Rao, K.S.J.1    Anitha, S.2    Latha, K.S.3
  • 54
    • 41149176407 scopus 로고    scopus 로고
    • Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the antiapoptotic protein bcl-2
    • Rohn, T. T., Vyas, V., Hernandez-estrada, T., Nichol, K. E., Christie, L. A., & Head, E. (2008). Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the antiapoptotic protein bcl-2. Journal of Neuroscience, 28(12), 3051-3059.
    • (2008) Journal of Neuroscience , vol.28 , Issue.12 , pp. 3051-3059
    • Rohn, T.T.1    Vyas, V.2    Hernandez-Estrada, T.3    Nichol, K.E.4    Christie, L.A.5    Head, E.6
  • 55
    • 84966168931 scopus 로고
    • The lifetime growth and reproduction of selected strains of mice
    • Roberts, R. C. (1961). The lifetime growth and reproduction of selected strains of mice. Heredity, 16, 369-381.
    • (1961) Heredity , vol.16 , pp. 369-381
    • Roberts, R.C.1
  • 56
    • 0034175581 scopus 로고    scopus 로고
    • Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen and skeletal muscle dystrophy
    • Ruberti, F., Capsoni, S., Comparini, A., Di Daniel, E., Franzot, J., Gonfloni, S., et al. (2000). Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen and skeletal muscle dystrophy. Journal of Neuroscience, 20(7), 2589-2601.
    • (2000) Journal of Neuroscience , vol.20 , Issue.7 , pp. 2589-2601
    • Ruberti, F.1    Capsoni, S.2    Comparini, A.3    Di Daniel, E.4    Franzot, J.5    Gonfloni, S.6
  • 57
    • 0032733813 scopus 로고    scopus 로고
    • Age-related hippocampal changes in Bcl3-2: Bax Ratio, Oxidative Stress, Redox-Active iron and apoptosis associated with Al induced neurodegeneration: Increased susceptibility with aging
    • Savory, J., Jagannatha, K. S. Rao., Yue, H., Philip, R., Ledata, et al. (1999). Age-related hippocampal changes in Bcl3-2: Bax Ratio, Oxidative Stress, Redox-Active iron and apoptosis associated with Al induced neurodegeneration: Increased susceptibility with aging. Neurotoxicology, 20(5), 805-818.
    • (1999) Neurotoxicology , vol.20 , Issue.5 , pp. 805-818
    • Savory, J.1    Jagannatha, K.S.R.2    Yue, H.3    Philip, R.4    Ledata5
  • 58
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk, D., Barbour, R., Dunn,W., Gordon, G., Grajeda, H., Guido, T., et al. (1999). Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature, 400, 173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6
  • 59
    • 0034018813 scopus 로고    scopus 로고
    • Apoptosis in Alzheimer's disease-An update
    • Shimohama, S. (2000). Apoptosis in Alzheimer's disease-An update. Apoptosis, 5(1), 9-16.
    • (2000) Apoptosis , vol.5 , Issue.1 , pp. 9-16
    • Shimohama, S.1
  • 60
    • 37349049243 scopus 로고    scopus 로고
    • Oxidative stress and transcriptional regulation in Alzheimer disease
    • Shi, Q., & Gibson, G. E. (2007). Oxidative stress and transcriptional regulation in Alzheimer disease. Alzheimer Disease and Associated Disorders, 21(4), 276-291.
    • (2007) Alzheimer Disease and Associated Disorders , vol.21 , Issue.4 , pp. 276-291
    • Shi, Q.1    Gibson, G.E.2
  • 61
    • 0030801772 scopus 로고    scopus 로고
    • Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society
    • Small, G. W., Rabins, P. V., Barry, P. P. Buckholtz, N. S., DeKosky, S. T., Ferris, S. H., et al. (1997). Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. The Journal of the American Medical Association, 278(16), 1363-1371.
    • (1997) The Journal of the American Medical Association , vol.278 , Issue.16 , pp. 1363-1371
    • Small, G.W.1    Rabins, P.V.2    Barry, P.P.3    Buckholtz, N.S.4    Dekosky, S.T.5    Ferris, S.H.6
  • 62
    • 73949137867 scopus 로고    scopus 로고
    • Agents complexing copper as a therapeutic strategy for the treatment of Alzheimer's disease
    • Squitti, R., & Salustri, C. (2009). Agents complexing copper as a therapeutic strategy for the treatment of Alzheimer's disease. Current Alzheimer's Research, 6(6), 476-487.
    • (2009) Current Alzheimer's Research , vol.6 , Issue.6 , pp. 476-487
    • Squitti, R.1    Salustri, C.2
  • 63
    • 70349518598 scopus 로고    scopus 로고
    • Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models
    • Sugama, S., Takenouchi, T., Cho, B. P., Joh, T. H., Hashimoto, M., & Kitani, H. (2009). Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models. Inflammation and Allergy Drug Targets, 8, 277-284.
    • (2009) Inflammation and Allergy Drug Targets , vol.8 , pp. 277-284
    • Sugama, S.1    Takenouchi, T.2    Cho, B.P.3    Joh, T.H.4    Hashimoto, M.5    Kitani, H.6
  • 64
    • 67649641916 scopus 로고    scopus 로고
    • Alternative Aβimmunotherapy approaches for Alzheimer's disease
    • Terrence Town
    • Terrence Town. (2009). Alternative Aβimmunotherapy approaches for Alzheimer's disease.CNS and Neurological Desorders Drug Targets, 8(4), 144-1127
    • (2009) CNS and Neurological Desorders Drug Targets , vol.8 , Issue.4 , pp. 144-1127
  • 66
    • 48749089723 scopus 로고    scopus 로고
    • Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
    • Trinchese, F., Fa, M., Liu, S., Zhang, H., Hidalgo, A., Schmidt, S. D., et al. (2008). Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. Journal of Clinical Investigation, 118(8), 2796-2807.
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.8 , pp. 2796-2807
    • Trinchese, F.1    Fa, M.2    Liu, S.3    Zhang, H.4    Hidalgo, A.5    Schmidt, S.D.6
  • 67
    • 14744298662 scopus 로고    scopus 로고
    • Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease
    • Vanhoutte, G., Dewachter, I., Borghgraef, P., Van Leuven, F., & Van Der Linden, A. (2005). Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magnetic Resonance in Medicine, 53(3), 607-613.
    • (2005) Magnetic Resonance in Medicine , vol.53 , Issue.3 , pp. 607-613
    • Vanhoutte, G.1    Dewachter, I.2    Borghgraef, P.3    Van Leuven, F.4    Van Der Linden, A.5
  • 68
    • 33747153860 scopus 로고    scopus 로고
    • Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice
    • van Groen, T., Kiliaan, A. J., & Kadish, I. (2006). Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. Neurobiology of Disease, 23(3), 653-662.
    • (2006) Neurobiology of Disease , vol.23 , Issue.3 , pp. 653-662
    • Van Groen, T.1    Kiliaan, A.J.2    Kadish, I.3
  • 69
    • 28044458281 scopus 로고    scopus 로고
    • Energy inhibition elevates betasecretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer's disease pathogenesis
    • Velliquette, R. A., O'Connor, T., & Vassar, R. (2005). Energy inhibition elevates betasecretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer's disease pathogenesis. Journal of Neuroscience, 25(47), 10874-10883.
    • (2005) Journal of Neuroscience , vol.25 , Issue.47 , pp. 10874-10883
    • Velliquette, R.A.1    O'Connor, T.2    Vassar, R.3
  • 70
    • 0034736182 scopus 로고    scopus 로고
    • Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain
    • Wengenack, T. M.,Whelan, S., Curran,G. L.,Duff, K. E., & Poduslo, J. F. (2000). Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain. Neuroscience, 101(4), 939-944.
    • (2000) Neuroscience , vol.101 , Issue.4 , pp. 939-944
    • Wengenack, T.M.1    Whelan, S.2    Curran, G.L.3    Duff, K.E.4    Poduslo, J.F.5
  • 72
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • Zon, L. I., & Peterson, R. T.,(2005). In vivo drug discovery in the zebrafish. Nature Reviews Drug Discovery, 4(1), 35-44.
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.1 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2


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