Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: Orally active, long-acting analgesics

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2805-2822

  Ezzili, Cyrine ^a   Mileni, Mauro ^a   McGlinchey, Nicholas ^b   Long, Jonathan Z ^a   Kinsey, Steven G ^c   Hochstatter, Dustin G ^a   Stevens, Raymond C ^a   Lichtman, Aron H ^c   Cravatt, Benjamin F ^a   Bilsky, Edward J ^b   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NEW ENGLAND   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(6 PHENOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YL)[5 (PYRIDIN 2 YL)OXAZOL 2 YL]METHANONE; 6 [2 (6 PHENOXY 1,2,3,4 TETRAHYDRONAPHTHALENE 2 CARBONYL)OXAZOL 5 YL]PICOLINIC ACID; 7 PHENYL 1 [5 (2 PYRIDINYL) 2 OXAZOLYL] 1 HEPTANONE; ANALGESIC AGENT; ANANDAMIDE; FATTY ACID AMIDASE INHIBITOR; HETEROCYCLIC KETONE; LONG ACTING DRUG; MORPHINE; N OLEOYLETHANOLAMINE; PALMIDROL; SERINE; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENANTIOMER; HYPERALGESIA; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN;

ADMINISTRATION, ORAL; AMIDOHYDROLASES; ANALGESICS; ANIMALS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RATS;

EID: 79955383220     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101597x     Document Type: Article

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