Methyl arachidonyl fluorophosphonate: A potent irreversible inhibitor of anandamide amidase

Biochemical Pharmacology

Volumn 53, Issue 3, 1997, Pages 255-260

  Deutsch, Dale G ^a   Omeir, Romelda ^a   Arreaza, Gladys ^a   Salehani, David ^a   Prestwich, Glenn D ^a   Huang, Zheng ^b   Howlett, Allyn ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amidohydrolase; anandamide; anandamide amidase; cannabinoid receptor; methyl arachidonyl fluorophosphonate; sleep inducing factor

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; AMIDASE; ANANDAMIDE; ANANDAMIDE AMIDASE; ARACHIDONYL TRIFLUOROMETHYL KETONE; BENZYLSULFONYL FLUORIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; CHYMOTRYPSIN; DEACETYLLEVONANTRADOL; METHYL ARACHIDONYL FLUOROPHOSPHONATE; RADIOLIGAND; REAGENT; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BRAIN HOMOGENATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME ACTIVE SITE; HYDROLYSIS; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

AMIDOHYDROLASES; ANIMALS; ARACHIDONIC ACIDS; BINDING SITES; CYCLOHEXANOLS; ENZYME INHIBITORS; PHOSPHONIC ACIDS; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0031048819     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00830-1     Document Type: Article

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