Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

Nature Biotechnology

Volumn 21, Issue 6, 2003, Pages 687-691

  Leung, Donmienne ^a   Hardouin, Christophe ^a   Boger, Dale L ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE; ENZYME INHIBITION; SYNTHESIS (CHEMICAL);

CHEMICAL PROBES;

BIOTECHNOLOGY;

CANNABINOID; FATTY ACID AMIDASE; PROTEOME; SERINE DEHYDRATASE; TRIACYLGLYCEROL LIPASE;

ARTICLE; CELL STRAIN COS7; ENZYME INHIBITION; GENETIC TRANSFECTION; GENOMICS; IC 50; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN TARGETING;

AMIDOHYDROLASES; ANIMALS; BINDING, COMPETITIVE; ENDOCANNABINOIDS; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROLASES; LIPASE; MICE; PEPTIDE LIBRARY; PROTEIN ARRAY ANALYSIS; PROTEOME; PROTEOMICS;

EID: 0038361307     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt826     Document Type: Article

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