Synthesis and evaluation of benzothiazole-Based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 1, 2009, Pages 170-180

  Wang, Xueqing ^a   Sarris, Katerina ^a   Kage, Karen ^a   Zhang, Di ^a   Brown, Scott P ^a   Kolasa, Teodozyi ^a   Surowy, Carol ^a   El Kouhen, Odile F ^a   Muchmore, Steven W ^a   Brioni, Jorge D ^a   Stewart, Andrew O ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTHIAZOLE; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; N [4 (4 METHOXYBENZO[D]THIAZOL 2 YL)PHENYL] 1 (THIOPHEN 2 YLSULFONYL)PIPERIDINE 4 CARBOXAMIDE; UNCLASSIFIED DRUG; AMIDASE; BENZOTHIAZOLE DERIVATIVE; ENZYME INHIBITOR; FATTY-ACID AMIDE HYDROLASE;

ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; ANTIBODY SPECIFICITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; IC 50; METABOLISM; PROTEIN BINDING; SYNTHESIS; TIME; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; ANIMALS; BENZOTHIAZOLES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGAN SPECIFICITY; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 59449100866     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801042a     Document Type: Article

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