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Volumn 9, Issue 1, 2003, Pages 76-81

Modulation of anxiety through blockade of anandamide hydrolysis

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; BENZODIAZEPINE DERIVATIVE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; ENZYME INHIBITOR; FATTY ACID AMIDASE; UNCLASSIFIED DRUG; URB 532;

EID: 0037234363     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm803     Document Type: Article
Times cited : (1274)

References (45)
  • 1
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane, W.A. et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992).
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1
  • 2
    • 0028589390 scopus 로고
    • Formation and inactivation of endogenous cannabinoid anandamide in central neurons
    • Di Marzo, V. et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372, 686-691 (1994).
    • (1994) Nature , vol.372 , pp. 686-691
    • Di Marzo, V.1
  • 3
    • 0033362973 scopus 로고    scopus 로고
    • Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
    • Giuffrida, A. et al. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nature Neurosci. 2, 358-363 (1999).
    • (1999) Nature Neurosci. , vol.2 , pp. 358-363
    • Giuffrida, A.1
  • 4
    • 0030865871 scopus 로고    scopus 로고
    • Functional role of high-affinity anandamide transport, as revealed by selective inhibition
    • Beltramo, M. et al. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277, 1094-1097 (1997).
    • (1997) Science , vol.277 , pp. 1094-1097
    • Beltramo, M.1
  • 5
    • 0029904838 scopus 로고    scopus 로고
    • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
    • Cravatt, B.F. et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384, 83-87 (1996).
    • (1996) Nature , vol.384 , pp. 83-87
    • Cravatt, B.F.1
  • 6
    • 0033520099 scopus 로고    scopus 로고
    • Chemical and mutagenic investigations of fatty acid amide hydrolase: Evidence for a family of serine hydrolases with distinct catalytic properties
    • Patricelli, M.P., Lovato, M.A. & Cravatt, B.F. Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties. Biochemistry 38, 9804-9812 (1999).
    • (1999) Biochemistry , vol.38 , pp. 9804-9812
    • Patricelli, M.P.1    Lovato, M.A.2    Cravatt, B.F.3
  • 7
    • 0035829625 scopus 로고    scopus 로고
    • An anorexic lipid mediator regulated by feeding
    • Rodríguez de Fonseca, F. et al. An anorexic lipid mediator regulated by feeding. Nature 414, 209-212 (2001).
    • (2001) Nature , vol.414 , pp. 209-212
    • Rodríguez de Fonseca, F.1
  • 8
    • 0032537734 scopus 로고    scopus 로고
    • Control of pain initiation by endogenous cannabinoids
    • Calignano, A., La Rana, G., Giuffrida, A. & Piomelli, D. Control of pain initiation by endogenous cannabinoids. Nature 394, 277-281 (1998).
    • (1998) Nature , vol.394 , pp. 277-281
    • Calignano, A.1    La Rana, G.2    Giuffrida, A.3    Piomelli, D.4
  • 9
    • 0035979244 scopus 로고    scopus 로고
    • Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
    • Cravatt, B.F. et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc. Natl. Acad. Sci. USA 98, 9371-9376(2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9371-9376
    • Cravatt, B.F.1
  • 10
    • 0032517566 scopus 로고    scopus 로고
    • Adverse effects of cannabis
    • Hall, W. & Solowij, N. Adverse effects of cannabis. Lancet 352, 1611-1616 (1998).
    • (1998) Lancet , vol.352 , pp. 1611-1616
    • Hall, W.1    Solowij, N.2
  • 11
    • 1642602474 scopus 로고    scopus 로고
    • Behavioral effects of cannabinoid agents in animals
    • Chaperon, F. & Thiébot, M.H. Behavioral effects of cannabinoid agents in animals. Crit. Rev. Neurobiol. 13, 243-281 (1999).
    • (1999) Crit. Rev. Neurobiol. , vol.13 , pp. 243-281
    • Chaperon, F.1    Thiébot, M.H.2
  • 12
    • 0028108312 scopus 로고
    • Inhibitors of arachidonoyl ethanolamide hydrolysis
    • Koutek, B. et al. Inhibitors of arachidonoyl ethanolamide hydrolysis. J. Biol. Chem. 269, 22937-22940 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 22937-22940
    • Koutek, B.1
  • 13
    • 0031040788 scopus 로고    scopus 로고
    • Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one
    • Beltramo, M., di Tomaso, E. & Piomelli, D. Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one. FEBS Lett. 403, 263-267 (1997).
    • (1997) FEBS Lett. , vol.403 , pp. 263-267
    • Beltramo, M.1    Di Tomaso, E.2    Piomelli, D.3
  • 14
    • 0031550564 scopus 로고    scopus 로고
    • Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase
    • De Petrocellis, L. et al. Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase. Biochem. Biophys. Res. Commun. 231, 82-88 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.231 , pp. 82-88
    • De Petrocellis, L.1
  • 15
    • 0031550548 scopus 로고    scopus 로고
    • Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor
    • Deutsch, D.G. et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem. Biophys. Res. Commun. 231, 217-221 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.231 , pp. 217-221
    • Deutsch, D.G.1
  • 16
    • 12944277105 scopus 로고    scopus 로고
    • Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
    • Boger, D.L. et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proc. Natl. Acad. Sci. USA 97, 5044-5049 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5044-5049
    • Boger, D.L.1
  • 17
    • 0036678094 scopus 로고    scopus 로고
    • Brain monoglyceride lipase participating in endocannabinoid inactivation
    • Dinh, T.P. et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc. Natl. Acad. Sci. USA 99, 10819-10824 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10819-10824
    • Dinh, T.P.1
  • 18
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam, R. et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50, 83-90 (1995).
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 83-90
    • Mechoulam, R.1
  • 19
    • 0028970517 scopus 로고
    • 2-Arachidonoylglycerol; a possible endogenous cannabinoid receptor ligand in brain
    • Sugiura, T. et al. 2-Arachidonoylglycerol; a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. 215, 89-97 (1995).
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 89-97
    • Sugiura, T.1
  • 20
    • 0030870722 scopus 로고    scopus 로고
    • A second endogenous cannabinoid that modulates long-term potentiation
    • Stella, N., Schweitzer, P. & Piomelli, D. A second endogenous cannabinoid that modulates long-term potentiation. Nature 388, 773-778 (1997).
    • (1997) Nature , vol.388 , pp. 773-778
    • Stella, N.1    Schweitzer, P.2    Piomelli, D.3
  • 21
    • 0025236913 scopus 로고
    • Cannabinoid receptor localization in brain
    • Herkenham, M. et al. Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. USA 87, 1932-1936 (1990).
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 1932-1936
    • Herkenham, M.1
  • 22
    • 0031047273 scopus 로고    scopus 로고
    • Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain
    • Glass, M., Dragunow, M. & Faull, R.L. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 77, 299-318 (1997).
    • (1997) Neuroscience , vol.77 , pp. 299-318
    • Glass, M.1    Dragunow, M.2    Faull, R.L.3
  • 23
    • 0035576023 scopus 로고    scopus 로고
    • Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission
    • Katona, I. et al. Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission. J. Neurosci. 21, 9506-9518, (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 9506-9518
    • Katona, I.1
  • 24
    • 0035135376 scopus 로고    scopus 로고
    • Therapeutic aspects of cannabis and cannabinoids
    • Robson, P. Therapeutic aspects of cannabis and cannabinoids. Br. J. Psychiatry 178, 107-115 (2001).
    • (2001) Br. J. Psychiatry , vol.178 , pp. 107-115
    • Robson, P.1
  • 25
    • 0039534405 scopus 로고    scopus 로고
    • Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal
    • Rodríguez de Fonseca, F., Carrera, M.R.A., Navarro, M., Koob, G.F. & Weiss, F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science 276, 2050-2054 (1997).
    • (1997) Science , vol.276 , pp. 2050-2054
    • Rodríguez de Fonseca, F.1    Carrera, M.R.A.2    Navarro, M.3    Koob, G.F.4    Weiss, F.5
  • 26
    • 0034866872 scopus 로고    scopus 로고
    • Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters
    • Arévalo, C., de Miguel, R. & Hernández-Tristán, R. Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters. Pharmacol. Biochem. Behav. 70, 123-131 (2001).
    • (2001) Pharmacol. Biochem. Behav. , vol.70 , pp. 123-131
    • Arévalo, C.1    De Miguel, R.2    Hernández-Tristán, R.3
  • 28
    • 0028555890 scopus 로고
    • The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze
    • Bickerdike, M.J., Marsden, C.A., Dourish, C.T. & Fletcher, A. The influence of 5-hydroxytryptamine re-uptake blockade on CCK receptor antagonist effects in the rat elevated zero-maze. Eur. J. Pharmacol. 271, 403-411 (1994).
    • (1994) Eur. J. Pharmacol. , vol.271 , pp. 403-411
    • Bickerdike, M.J.1    Marsden, C.A.2    Dourish, C.T.3    Fletcher, A.4
  • 29
    • 0028075302 scopus 로고
    • Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety
    • Shepherd, J.K., Grewal, S.S., Fletcher, A., Bill, D.J. & Dourish, C.T. Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety. Psychopharmacology 116, 56-64 (1994).
    • (1994) Psychopharmacology , vol.116 , pp. 56-64
    • Shepherd, J.K.1    Grewal, S.S.2    Fletcher, A.3    Bill, D.J.4    Dourish, C.T.5
  • 30
    • 0022501316 scopus 로고
    • Rat pup ultrasonic isolation calls: Possible mediation by the benzodiazepine receptor complex
    • Insel, T.R., Hill, J.L. & Mayor, R.B. Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex. Pharmacol. Biochem. Behav. 24, 1263-1267 (1986).
    • (1986) Pharmacol. Biochem. Behav. , vol.24 , pp. 1263-1267
    • Insel, T.R.1    Hill, J.L.2    Mayor, R.B.3
  • 33
    • 0032125414 scopus 로고    scopus 로고
    • Mechanisms of emotional arousal and lasting declarative memory
    • Cahill, L. & McGaugh, I.L. Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci. 21, 294-299 (1998).
    • (1998) Trends Neurosci. , vol.21 , pp. 294-299
    • Cahill, L.1    McGaugh, I.L.2
  • 34
    • 0035965676 scopus 로고    scopus 로고
    • Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: High concentrations in a subpopulation of cholecystokinin-containing interneurons
    • McDonald, A.J. & Mascagni, F. Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons. Neuroscience 107, 641-652 (2001).
    • (2001) Neuroscience , vol.107 , pp. 641-652
    • McDonald, A.J.1    Mascagni, F.2
  • 35
    • 0031730754 scopus 로고    scopus 로고
    • Major biological actions of CCK: A critical evaluation of research findings
    • Fink, H., Rex, A., Voits, M. & Voigt, J.P. Major biological actions of CCK: a critical evaluation of research findings. Exp. Brain Res. 123, 77-83 (1998).
    • (1998) Exp. Brain Res. , vol.123 , pp. 77-83
    • Fink, H.1    Rex, A.2    Voits, M.3    Voigt, J.P.4
  • 36
    • 0035937647 scopus 로고    scopus 로고
    • Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids
    • Beinfeld, M.C. & Connolly, K. Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids. Neurosci. Lett. 301, 69-71 (2001).
    • (2001) Neurosci. Lett. , vol.301 , pp. 69-71
    • Beinfeld, M.C.1    Connolly, K.2
  • 37
    • 0036462447 scopus 로고    scopus 로고
    • Cannabinoids: A real prospect for pain relief?
    • Iversen, L. & Chapman, V. Cannabinoids: a real prospect for pain relief? Curr. Opin. Pharmacol. 2, 50-55 (2002).
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 50-55
    • Iversen, L.1    Chapman, V.2
  • 38
    • 0035902918 scopus 로고    scopus 로고
    • Receptor-dependent formation of endogenous cannabinoids in cortical neurons
    • Stella, N. & Piomelli, D. Receptor-dependent formation of endogenous cannabinoids in cortical neurons. Eur. J. Pharmacol. 425, 189-196 (2001).
    • (2001) Eur. J. Pharmacol. , vol.425 , pp. 189-196
    • Stella, N.1    Piomelli, D.2
  • 39
    • 0342368911 scopus 로고    scopus 로고
    • Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry
    • Giuffrida, A., Rodríguez de Fonseca, F. & Piomelli, D. Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. Anal. Biochem. 280, 87-93 (2000).
    • (2000) Anal. Biochem. , vol.280 , pp. 87-93
    • Giuffrida, A.1    Rodríguez de Fonseca, F.2    Piomelli, D.3
  • 40
    • 0033545991 scopus 로고    scopus 로고
    • Structural determinants for recognition and translocation by the anandamide transporter
    • Piomelli, D. et al. Structural determinants for recognition and translocation by the anandamide transporter. Proc. Natl. Acad. Sci. USA 96, 5802-5807 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5802-5807
    • Piomelli, D.1
  • 41
    • 0035955393 scopus 로고    scopus 로고
    • Sex differences in antinociceptive and motoric effects of cannabinoids
    • Tseng, A.H. & Craft, R.M. Sex differences in antinociceptive and motoric effects of cannabinoids. Eur. J. Pharmacol. 430, 41-47 (2001).
    • (2001) Eur. J. Pharmacol. , vol.430 , pp. 41-47
    • Tseng, A.H.1    Craft, R.M.2
  • 42
    • 0034697213 scopus 로고    scopus 로고
    • Locomotor and learning deficits in adult rats exposed to monosodium-L-glutamate during early life
    • Ali, M.M., Bawari, M., Misra, U.K. & Babu, G.N. Locomotor and learning deficits in adult rats exposed to monosodium-L-glutamate during early life. Neurosci. Lett. 284, 57-60 (2000).
    • (2000) Neurosci. Lett. , vol.284 , pp. 57-60
    • Ali, M.M.1    Bawari, M.2    Misra, U.K.3    Babu, G.N.4
  • 43
    • 0343278972 scopus 로고    scopus 로고
    • WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801
    • Wedzony, K. et al. WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801. Neuropsychopharmacology 23, 547-559 (2000).
    • (2000) Neuropsychopharmacology , vol.23 , pp. 547-559
    • Wedzony, K.1
  • 44
    • 0023253725 scopus 로고
    • Ultrasonic vocalization in rat pups: Effects of early postnatal exposure to SCH 23390 (a DA1-receptor antagonist) and sulpiride (a DA2-receptor antagonist)
    • Cuomo, V., Cagiano, R., Renna, G., De Salvia, M.A. & Racagni, G. Ultrasonic vocalization in rat pups: effects of early postnatal exposure to SCH 23390 (a DA1-receptor antagonist) and sulpiride (a DA2-receptor antagonist). Neuropharmacology 26, 701-705 (1987).
    • (1987) Neuropharmacology , vol.26 , pp. 701-705
    • Cuomo, V.1    Cagiano, R.2    Renna, G.3    De Salvia, M.A.4    Racagni, G.5
  • 45
    • 85056020252 scopus 로고    scopus 로고
    • The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety
    • in the press
    • Haller, J., Bakus, N., Szirmay, M., Ledent, C. & Freund, T.F. The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. Eur. J. Neurosci. (in the press).
    • Eur. J. Neurosci.
    • Haller, J.1    Bakus, N.2    Szirmay, M.3    Ledent, C.4    Freund, T.F.5


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