Further studies on arylpiperazinyl alkyl pyridazinones: Discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain

Journal of Medicinal Chemistry

Volumn 52, Issue 23, 2009, Pages 7397-7409

  Biancalani, Claudio ^a   Giovannoni, Maria Paola ^a   Pieretti, Stefano ^b   Cesari, Nicoletta ^a   Graziano, Alessia ^a   Vergelli, Claudia ^a   Cilibrizzi, Agostino ^a   Di Gianuario, Amalia ^b   Colucci, Mariantonella ^b   Mangano, Giorgina ^c   Garrone, Beatrice ^c   Polenzani, Lorenzo ^c   Dal Piaz, Vittorio ^a  

^a Dipartimento di Scienze Farmaceutiche   (Italy)

^b Department of Therapeutic Research and Medicine Evaluation ^*  (Italy)

^c Università Politecnica delle Marche ACRAF Gruppo Angelini   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIMETHYL 4 [2 (4 4 TOLYLPIPERAZIN 1 YL)ETHYLAMINO] 5 VINYLPYRIDAZIN 3(2H)ONE; 3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINO 2 [2 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 6 METHYL 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 2 [3 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL] 6 METHYL 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 2 [3 [4 (3 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 6 METHYL 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 2 [3 [4 (3 METHYLPHENYL)PIPERAZIN 1 YL]PROPYL] 6 METHYL 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 2 [3 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL] 6 METHYL 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 2 [3 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 6 METHYL 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 5 (2 METHYLTHIAZOL 4 YL) 6 PHENYL 2 [2 (4 4 TOLYLPIPERAZIN 1 YL)ETHYL]PYRIDAZIN 3(2H)ONE; 4 AMINO 5 (2 METHYLTHIAZOL 4 YL) 6 PHENYL 2 [3 (4 4 TOLYLPIPERAZIN 1 YL)PROPYL]PYRIDAZIN 3(2H)ONE; 4 AMINO 6 METHYL 2 [3 (4 4 TOLYLPIPERAZIN 1 YL)PROPYL] 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 6 METHYL 2 [3 (4 METHYLPIPERAZIN 1 YL)PROPYL] 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 6 METHYL 2 [3 (4 METHYLPIPERIDIN 1 YL)PROPYL] 5 VINYLPYRIDAZIN 3(2H)ONE; 4 AMINO 6 METHYL 5 (1H PYRAZOL 3 YL) 2 [2 (4 4 TOLYLPIPERAZIN 1 YL)ETHYL]PYRIDAZIN 3(2H)ONE; 4 METHYL 3 [3 (4 4 TOLYLPIPERAZIN 1 YL)PROPYL] 5 VINYL 3H THIAZOL 2 ONE; 6 METHYL 2 [3 (4 4 TOLYLPIPERAZIN 1 YL)PROPYL]PYRIDAZIN 3(2H)ONE; ANTINOCICEPTIVE AGENT; MECAMYLAMINE; MORPHINE; NALOXONE; PYRIDAZINONE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG; YOHIMBINE;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SYNTHESIS; HOT PLATE TEST; IN VITRO STUDY; LIGAND BINDING; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAIN; TAIL FLICK TEST; THERMAL EXPOSURE;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CELL LINE; DRUG DISCOVERY; HOT TEMPERATURE; HUMANS; MALE; MICE; PAIN; PIPERAZINES; PYRIDAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72249110442     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900458r     Document Type: Article

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