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Volumn 5, Issue 2, 2011, Pages 265-277

Organelle dysfunction in hepatitis C virus-associated steatosis: Anything to learn from nonalcoholic steatohepatitis?

Author keywords

hepatitis C; insulin resistance; mitochondria; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; oxidative stress; steatosis

Indexed keywords

ACYL COENZYME A DESATURASE 1; ALPHA TOCOPHEROL; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ATORVASTATIN; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID SYNTHASE; FIBROBLAST GROWTH FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER X RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; MICRORNA; PEGINTERFERON; PIOGLITAZONE; RIBAVIRIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 79954557009     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/egh.11.12     Document Type: Review
Times cited : (2)

References (123)
  • 1
    • 67651146947 scopus 로고    scopus 로고
    • Independent effects of physical activity in patients with nonalcoholic fatty liver disease
    • St George A, Bauman A, Johnston A, Farrell G, Chey T, George J. Independent effects of physical activity in patients with nonalcoholic fatty liver disease. Hepatology 50(1), 68-76 (2009).
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 68-76
    • St George, A.1    Bauman, A.2    Johnston, A.3    Farrell, G.4    Chey, T.5    George, J.6
  • 2
    • 77950614975 scopus 로고    scopus 로고
    • The chicken or the egg: Adipocytes and hepatic insulin resistance
    • Hebbard L, George J. The chicken or the egg: adipocytes and hepatic insulin resistance. Hepatology 51(3), 1076-1079 (2010).
    • (2010) Hepatology , vol.51 , Issue.3 , pp. 1076-1079
    • Hebbard, L.1    George, J.2
  • 3
    • 77954235797 scopus 로고    scopus 로고
    • Fitness versus fatness: Moving beyond weight loss in nonalcoholic fatty liver disease
    • Johnson NA, George J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology 52(1), 370-381 (2010).
    • (2010) Hepatology , vol.52 , Issue.1 , pp. 370-381
    • Johnson, N.A.1    George, J.2
  • 4
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • DOI 10.1053/jhep.2003.50193
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37(5), 1202-1219 (2003). (Pubitemid 36538699)
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 6
    • 0036381117 scopus 로고    scopus 로고
    • Genotype-specifc mechanisms for hepatic steatosis in chronic hepatitis C infection
    • Hui JM, Kench J, Farrell GC et al. Genotype-specifc mechanisms for hepatic steatosis in chronic hepatitis C infection. J. Gastroenterol. Hepatol. 17(8), 873-881 (2002).
    • (2002) J. Gastroenterol. Hepatol. , vol.17 , Issue.8 , pp. 873-881
    • Hui, J.M.1    Kench, J.2    Farrell, G.C.3
  • 8
    • 0345059390 scopus 로고    scopus 로고
    • Insulin Resistance and Tissue Repair: A "Fato-Logical" Phenomenon
    • DOI 10.1053/j.gastro.2003.10.021
    • Sanyal AJ. Insulin resistance and tissue repair: a 'fato-logical' phenomenon. Gastroenterology 125(6), 1886-1889 (2003). (Pubitemid 37500454)
    • (2003) Gastroenterology , vol.125 , Issue.6 , pp. 1886-1889
    • Sanyal, A.J.1
  • 9
    • 0036711553 scopus 로고    scopus 로고
    • New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: A role for the transcription factor sterol regulatory element binding protein-1c
    • DOI 10.1042/BJ20020430
    • Foufelle F, Ferre P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem. J. 366(Pt 2), 377-391 (2002). (Pubitemid 35001682)
    • (2002) Biochemical Journal , vol.366 , Issue.2 , pp. 377-391
    • Foufelle, F.1    Ferre, P.2
  • 10
    • 43649094366 scopus 로고    scopus 로고
    • Carbohydrate responsive element binding protein and lipid homeostasis
    • DOI 10.1097/MOL.0b013e3282ffafaa, PII 0004143320080600000014
    • Denechaud PD, Girard J, Postic C. Carbohydrate responsive element binding protein and lipid homeostasis. Curr. Opin. Lipidol. 19(3), 301-306 (2008). (Pubitemid 351681558)
    • (2008) Current Opinion in Lipidology , vol.19 , Issue.3 , pp. 301-306
    • Denechaud, P.-D.1    Girard, J.2    Postic, C.3
  • 11
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • Anderson N, Borlak J. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol. Rev. 60(3), 311-357 (2008).
    • (2008) Pharmacol. Rev. , vol.60 , Issue.3 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 14
    • 70449122132 scopus 로고    scopus 로고
    • Foxo1 integrates insulin signaling with mitochondrial function in the liver
    • Cheng Z, Guo S, Copps K et al. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 15(11), 1307-1311 (2009).
    • (2009) Nat Med. , vol.15 , Issue.11 , pp. 1307-1311
    • Cheng, Z.1    Guo, S.2    Copps, K.3
  • 17
    • 77951632831 scopus 로고    scopus 로고
    • Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
    • Rector RS, Thyfault JP, Uptergrove GM et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J. Hepatol. 52(5), 727-736 (2010).
    • (2010) J. Hepatol. , vol.52 , Issue.5 , pp. 727-736
    • Rector, R.S.1    Thyfault, J.P.2    Uptergrove, G.M.3
  • 18
    • 68949086361 scopus 로고    scopus 로고
    • Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis
    • Caldwell SH, de Freitas LA, Park SH et al. Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis. Hepatology 49(6), 1888-1895 (2009).
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1888-1895
    • Caldwell, S.H.1    De Freitas, L.A.2    Park, S.H.3
  • 23
    • 77955690182 scopus 로고    scopus 로고
    • Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
    • Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 52(2), 774-788 (2010).
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 774-788
    • Neuschwander-Tetri, B.A.1
  • 24
    • 77956822767 scopus 로고    scopus 로고
    • Mass spectrometric profling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
    • Feldstein AE, Lopez R, Abu-Rajab Tamimi T et al. Mass spectrometric profling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J. Lipid Res. 51 (10), 3046-3054 (2010).
    • (2010) J. Lipid Res. , vol.51 , Issue.10 , pp. 3046-3054
    • Feldstein, A.E.1    Lopez, R.2    Abu-Rajab Tamimi, T.3
  • 25
    • 70449552861 scopus 로고    scopus 로고
    • Insulin resistance is a cellular antioxidant defense mechanism
    • Hoehn KL, Salmon AB, Hohnen-Behrens C et al. Insulin resistance is a cellular antioxidant defense mechanism. Proc. Natl Acad. Sci. USA 106(42), 17787-17792 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.42 , pp. 17787-17792
    • Hoehn, K.L.1    Salmon, A.B.2    Hohnen-Behrens, C.3
  • 26
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • DOI 10.1210/en.2005-0570
    • Wang D, Wei Y, Pagliassotti MJ. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147(2), 943-951 (2006). (Pubitemid 43113013)
    • (2006) Endocrinology , vol.147 , Issue.2 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 27
    • 34548220998 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
    • DOI 10.1016/j.biocel.2007.05.002, PII S1357272507001458
    • Colgan SM, Tang D, Werstuck GH, Austin RC. Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. Int. J. Biochem. Cell Biol. 39(10), 1843-1851 (2007). (Pubitemid 47321345)
    • (2007) International Journal of Biochemistry and Cell Biology , vol.39 , Issue.10 , pp. 1843-1851
    • Colgan, S.M.1    Tang, D.2    Werstuck, G.H.3    Austin, R.C.4
  • 28
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun HL, Chabanon H, Hainault I et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest 119(5), 1201-1215 (2009).
    • (2009) J. Clin. Invest , vol.119 , Issue.5 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3
  • 29
  • 30
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • DOI 10.1002/hep.510270121
    • Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27(1), 128-133 (1998). (Pubitemid 28041545)
    • (1998) Hepatology , vol.27 , Issue.1 , pp. 128-133
    • Weltman, M.D.1    Farrell, G.C.2    Hall, P.3    Ingelman-Sundberg, M.4    Liddle, C.5
  • 33
    • 38649124615 scopus 로고    scopus 로고
    • Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.10.039, PII S0016508507019191
    • Puri P, Mirshahi F, Cheung O et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134(2), 568-576 (2008). (Pubitemid 351173040)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3    Natarajan, R.4    Maher, J.W.5    Kellum, J.M.6    Sanyal, A.J.7
  • 34
    • 57049111040 scopus 로고    scopus 로고
    • UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
    • Rutkowski DT, Wu J, Back SH et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev. Cell 15(6), 829-840 (2008).
    • (2008) Dev. Cell , vol.15 , Issue.6 , pp. 829-840
    • Rutkowski, D.T.1    Wu, J.2    Back, S.H.3
  • 35
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.11.038, PII S0016508507021154
    • Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 134(2), 424-431 (2008). (Pubitemid 351173050)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 36
    • 70349249503 scopus 로고    scopus 로고
    • Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis
    • Fujita K, Nozaki Y, Wada K et al. Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis. Hepatology 50(3), 772-780 (2009).
    • (2009) Hepatology , vol.50 , Issue.3 , pp. 772-780
    • Fujita, K.1    Nozaki, Y.2    Wada, K.3
  • 37
    • 0036207720 scopus 로고    scopus 로고
    • Apolipoprotein synthesis in nonalcoholic steatohepatitis
    • DOI 10.1053/jhep.2002.32527
    • Charlton M, Sreekumar R, Rasmussen D, Lindor K, Nair KS. Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 35(4), 898-904 (2002). (Pubitemid 34258385)
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 898-904
    • Charlton, M.1    Sreekumar, R.2    Rasmussen, D.3    Lindor, K.4    Nair K.Sreekumaran5
  • 38
    • 77952425688 scopus 로고    scopus 로고
    • Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model
    • Shindo N, Fujisawa T, Sugimoto K et al. Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model. J. Hepatol. 52(6), 903-912 (2010).
    • (2010) J. Hepatol. , vol.52 , Issue.6 , pp. 903-912
    • Shindo, N.1    Fujisawa, T.2    Sugimoto, K.3
  • 40
    • 27744458510 scopus 로고    scopus 로고
    • NF-κB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • DOI 10.1053/j.gastro.2005.09.004, PII S0016508505017889
    • Dela Pena A, Leclercq I, Field J, George J, Jones B, Farrell G. NF-κB activation, rather than TNF, mediates hepatic infammation in a murine dietary model of steatohepatitis. Gastroenterology 129(5), 1663-1674 (2005). (Pubitemid 41597405)
    • (2005) Gastroenterology , vol.129 , Issue.5 , pp. 1663-1674
    • Dela Pena, A.1    Leclercq, I.2    Field, J.3    George, J.4    Jones, B.5    Farrell, G.6
  • 42
    • 33646853899 scopus 로고    scopus 로고
    • Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease
    • DOI 10.1111/j.1365-2265.2006.02527.x
    • Targher G, Bertolini L, Rodella S et al. Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease. Clin. Endocrinol. (Oxf) 64(6), 679-683 (2006). (Pubitemid 43775007)
    • (2006) Clinical Endocrinology , vol.64 , Issue.6 , pp. 679-683
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Zoppini, G.4    Scala, L.5    Zenari, L.6    Falezza, G.7
  • 43
    • 67649598622 scopus 로고    scopus 로고
    • Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization
    • Fukushima J, Kamada Y, Matsumoto H et al. Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization. Hepatol. Res. 39(7), 724-738 (2009).
    • (2009) Hepatol. Res. , vol.39 , Issue.7 , pp. 724-738
    • Fukushima, J.1    Kamada, Y.2    Matsumoto, H.3
  • 44
    • 62049083189 scopus 로고    scopus 로고
    • MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease
    • Jin X, Ye YF, Chen SH, Yu CH, Liu J, Li YM. MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease. Dig. Liver Dis. 41(4), 289-297 (2009).
    • (2009) Dig. Liver Dis. , vol.41 , Issue.4 , pp. 289-297
    • Jin, X.1    Ye, Y.F.2    Chen, S.H.3    Yu, C.H.4    Liu, J.5    Li, Y.M.6
  • 45
    • 58149386462 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression
    • Cheung O, Puri P, Eicken C et al. Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression. Hepatology 48(6), 1810-1820 (2008).
    • (2008) Hepatology , vol.48 , Issue.6 , pp. 1810-1820
    • Cheung, O.1    Puri, P.2    Eicken, C.3
  • 46
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Curr. Biol. 19(22), R1046-R1052 (2009).
    • (2009) Curr. Biol. , vol.19 , Issue.22
    • Laplante, M.1    Sabatini, D.M.2
  • 47
    • 34547488563 scopus 로고    scopus 로고
    • A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis
    • DOI 10.1002/hep.21688
    • Calvert VS, Collantes R, Elariny H et al. A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. Hepatology 46(1), 166-172 (2007). (Pubitemid 47171933)
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 166-172
    • Calvert, V.S.1    Collantes, R.2    Elariny, H.3    Afendy, A.4    Baranova, A.5    Mendoza, M.6    Goodman, Z.7    Liotta, L.A.8    Petricoin, E.F.9    Younossi, Z.M.10
  • 48
    • 77957336340 scopus 로고    scopus 로고
    • A role for mammalian target of rapamycin (mTOR) pathway in non alcoholic steatohepatitis related-cirrhosis
    • Kubrusly MS, Correa-Giannella ML, Bellodi-Privato M et al. A role for mammalian target of rapamycin (mTOR) pathway in non alcoholic steatohepatitis related-cirrhosis. Histol. Histopathol. 25(9), 1123-1131 (2010).
    • (2010) Histol. Histopathol. , vol.25 , Issue.9 , pp. 1123-1131
    • Kubrusly, M.S.1    Correa-Giannella, M.L.2    Bellodi-Privato, M.3
  • 49
    • 77951995518 scopus 로고    scopus 로고
    • Thyroid hormone regulates hepatic expression of fbroblast growth factor 21 in a PPARα-dependent manner
    • Adams AC, Astapova I, Fisher FM et al. Thyroid hormone regulates hepatic expression of fbroblast growth factor 21 in a PPARα-dependent manner. J. Biol. Chem. 285(19), 14078-14082 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.19 , pp. 14078-14082
    • Adams, A.C.1    Astapova, I.2    Fisher, F.M.3
  • 50
    • 77955474305 scopus 로고    scopus 로고
    • Increased fbroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • Dushay J, Chui PC, Gopalakrishnan GS et al. Increased fbroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139(2), 456-463 (2010).
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 456-463
    • Dushay, J.1    Chui, P.C.2    Gopalakrishnan, G.S.3
  • 51
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H, Fang Q, Gao F et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J. Hepatol. 53(5), 934-940 (2010).
    • (2010) J. Hepatol. , vol.53 , Issue.5 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3
  • 52
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 40(12), 1461-1465 (2008).
    • (2008) Nat Genet. , vol.40 , Issue.12 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 53
    • 79953321200 scopus 로고    scopus 로고
    • Genetic determinants of hepatic steatosis in man
    • DOI: 10.1194/jlr. R008896 Epub ahead of print
    • Hooper AJ, Adams LA, Burnett JR. Genetic determinants of hepatic steatosis in man. J. Lipid Res. DOI: 10.1194/jlr. R008896 (2011) (Epub ahead of print).
    • J. Lipid Res. , vol.2011
    • Hooper, A.J.1    Adams, L.A.2    Burnett, J.R.3
  • 54
    • 77950202777 scopus 로고    scopus 로고
    • Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    • Petersen KF, Dufour S, Hariri A et al. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N. Engl. J. Med. 362(12), 1082-1089 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , Issue.12 , pp. 1082-1089
    • Petersen, K.F.1    Dufour, S.2    Hariri, A.3
  • 55
    • 77952692915 scopus 로고    scopus 로고
    • Increased fructose consumption is associated with fbrosis severity in patients with nonalcoholic fatty liver disease
    • Abdelmalek MF, Suzuki A, Guy C et al. Increased fructose consumption is associated with fbrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 51(6), 1961-1971 (2010).
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1961-1971
    • Abdelmalek, M.F.1    Suzuki, A.2    Guy, C.3
  • 56
    • 77955500907 scopus 로고    scopus 로고
    • Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model
    • De Meijer VE, Le HD, Meisel JA et al. Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model. Metabolism 59(8), 1092-1105 (2010).
    • (2010) Metabolism , vol.59 , Issue.8 , pp. 1092-1105
    • De Meijer, V.E.1    Le Meisel, H.D.J.A.2
  • 57
    • 77952597452 scopus 로고    scopus 로고
    • Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content
    • Machado RM, Stefano JT, Oliveira CP et al. Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content. J. Nutr. 140(6), 1127-1132 (2010).
    • (2010) J. Nutr. , vol.140 , Issue.6 , pp. 1127-1132
    • MacHado, R.M.1    Stefano, J.T.2    Oliveira, C.P.3
  • 59
    • 1542721931 scopus 로고    scopus 로고
    • Muscle triglyceride and glycogen in endurance exercise: Implications for performance
    • DOI 10.2165/00007256-200434030-00002
    • Johnson NA, Stannard SR, Thompson MW. Muscle triglyceride and glycogen in endurance exercise: implications for performance. Sports Med. 34(3), 151-164 (2004). (Pubitemid 38338720)
    • (2004) Sports Medicine , vol.34 , Issue.3 , pp. 151-164
    • Johnson, N.A.1    Stannard, S.R.2    Thompson, M.W.3
  • 60
    • 68049105042 scopus 로고    scopus 로고
    • Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance
    • Solomon TP, Haus JM, Marchetti CM, Stanley WC, Kirwan JP. Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance. Am. J. Physiol. Endocrinol. Metab. 297(2), E552-E559 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , Issue.2
    • Solomon, T.P.1    Haus, J.M.2    Marchetti, C.M.3    Stanley, W.C.4    Kirwan, J.P.5
  • 61
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L, Valenza V, La Torre G et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49 (6), 1877-1887 (2009).
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3
  • 62
    • 79952702137 scopus 로고    scopus 로고
    • Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver
    • Begriche K, Massart J, Robin MA, Borgne-Sanchez A, Fromenty B. Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver. J. Hepatol. 54(4), 773-794 (2011).
    • (2011) J. Hepatol. , vol.54 , Issue.4 , pp. 773-794
    • Begriche, K.1    Massart, J.2    Robin, M.A.3    Borgne-Sanchez, A.4    Fromenty, B.5
  • 65
    • 79251554394 scopus 로고    scopus 로고
    • Changes in insulin sensitivity and body weight during and after peginterferon and ribavirin therapy for hepatitis C
    • Conjeevaram HS, Wahed AS, Afdhal N, Howell CD, Everhart JE, Hoofnagle JH. Changes in insulin sensitivity and body weight during and after peginterferon and ribavirin therapy for hepatitis C Gastroenterology 140(2), 469-477 (2011).
    • (2011) Gastroenterology , vol.140 , Issue.2 , pp. 469-477
    • Conjeevaram, H.S.1    Wahed, A.S.2    Afdhal, N.3    Howell, C.D.4    Everhart, J.E.5    Hoofnagle, J.H.6
  • 66
    • 72049095072 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in chronic hepatitis C World
    • Douglas MW, George J. Molecular mechanisms of insulin resistance in chronic hepatitis C World J. Gastroenterol. 15(35), 4356-4364 (2009).
    • (2009) J Gastroenterol. , vol.15 , Issue.35 , pp. 4356-4364
    • Douglas, M.W.1    George, J.2
  • 67
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C Virus Infection and Diabetes: Direct Involvement of the Virus in the Development of Insulin Resistance
    • DOI 10.1053/j.gastro.2003.11.056
    • Shintani Y, Fujie H, Miyoshi H et al. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 126(3), 840-848 (2004). (Pubitemid 38298332)
    • (2004) Gastroenterology , vol.126 , Issue.3 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3    Tsutsumi, T.4    Tsukamoto, K.5    Kimura, S.6    Moriya, K.7    Koike, K.8
  • 68
    • 77449150552 scopus 로고    scopus 로고
    • Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance
    • Milner KL, van der Poorten D, Trenell M et al. Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance. Gastroenterology 138(3), 932-941.e1-3 (2010).
    • (2010) Gastroenterology , vol.138 , Issue.3
    • Milner, K.L.1    Van Der Poorten, D.2    Trenell, M.3
  • 70
    • 34248671715 scopus 로고    scopus 로고
    • The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    • DOI 10.1002/hep.21634
    • Pazienza V, Clement S, Pugnale P et al. The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specifc mechanisms. Hepatology 45(5), 1164-1171 (2007). (Pubitemid 46775778)
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1164-1171
    • Pazienza, V.1    Clement, S.2    Pugnale, P.3    Conzelman, S.4    Foti, M.5    Mangia, A.6    Negro, F.7
  • 71
    • 40149089262 scopus 로고    scopus 로고
    • Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream Akt/protein kinase B signaling pathway for insulin resistance
    • DOI 10.1128/JVI.01672-07
    • Banerjee S, Saito K, Ait-Goughoulte M, Meyer K, Ray RB, Ray R. Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream Akt/protein kinase B signaling pathway for insulin resistance. J. Virol. 82(6), 2606-2612 (2008). (Pubitemid 351329151)
    • (2008) Journal of Virology , vol.82 , Issue.6 , pp. 2606-2612
    • Banerjee, S.1    Saito, K.2    Ait-Goughoulte, M.3    Meyer, K.4    Ray, R.B.5    Ray, R.6
  • 72
    • 77952708205 scopus 로고    scopus 로고
    • Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression
    • Banerjee A, Meyer K, Mazumdar B, Ray RB, Ray R. Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression. J. Virol. 84(12), 5936-5946 (2010).
    • (2010) J. Virol. , vol.84 , Issue.12 , pp. 5936-5946
    • Banerjee, A.1    Meyer, K.2    Mazumdar, B.3    Ray, R.B.4    Ray, R.5
  • 73
    • 48449100910 scopus 로고    scopus 로고
    • Virus induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C
    • Bernsmeier C, Duong FH, Christen V et al. Virus induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C J. Hepatol. 49(3), 429-440 (2008).
    • (2008) J Hepatol. , vol.49 , Issue.3 , pp. 429-440
    • Bernsmeier, C.1    Duong, F.H.2    Christen, V.3
  • 74
    • 0346100572 scopus 로고    scopus 로고
    • Hepatitis C Virus Inhibits Interferon Signaling through Up-regulation of Protein Phosphatase 2A
    • DOI 10.1053/j.gastro.2003.10.076
    • Duong FH, Filipowicz M, Tripodi M, La Monica N, Heim MH. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126(1), 263-277 (2004). (Pubitemid 38040741)
    • (2004) Gastroenterology , vol.126 , Issue.SUPPL. 1 , pp. 263-277
    • Duong, F.H.T.1    Filipowicz, M.2    Tripodi, M.3    La Monica, N.4    Heim, M.H.5
  • 75
    • 33746134804 scopus 로고    scopus 로고
    • The protein phosphatase 2A represents a novel cellular target for hepatitis C virus NS5A protein
    • DOI 10.1016/j.biochi.2005.12.003, PII S0300908405002774
    • Georgopoulou U, Tsitoura P, Kalamvoki M, Mavromara P. The protein phosphatase 2A represents a novel cellular target for hepatitis C virus NS5A protein. Biochimie 88(6), 651-662 (2006). (Pubitemid 44081829)
    • (2006) Biochimie , vol.88 , Issue.6 , pp. 651-662
    • Georgopoulou, U.1    Tsitoura, P.2    Kalamvoki, M.3    Mavromara, P.4
  • 76
    • 34548304715 scopus 로고    scopus 로고
    • Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A
    • DOI 10.1002/hep.21611
    • Christen V, Treves S, Duong FH, Heim MH. Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A. Hepatology 46(2), 558-565 (2007). (Pubitemid 47344792)
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 558-565
    • Christen, V.1    Treves, S.2    Duong, F.H.T.3    Heim, M.H.4
  • 78
    • 27844604269 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
    • DOI 10.1074/jbc.M506412200
    • Korenaga M, Wang T, Li Y et al. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J. Biol. Chem. 280(45), 37481-37488 (2005). (Pubitemid 41642356)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.45 , pp. 37481-37488
    • Korenaga, M.1    Wang, T.2    Li, Y.3    Showalter, L.A.4    Chan, T.5    Sun, J.6    Weinman, S.A.7
  • 79
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR et al. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122(2), 366-375 (2002). (Pubitemid 34116988)
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3    Showalter, L.A.4    Scholle, F.5    Lemon, S.M.6    Weinman, S.A.7
  • 81
    • 47649114826 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner
    • DOI 10.1111/j.1600-0854.2008.00767.x
    • Boulant S, Douglas MW, Moody L, Budkowska A, Targett-Adams P, McLauchlan J. Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule-and dynein-dependent manner. Traffc 9(8), 1268-1282 (2008). (Pubitemid 352016286)
    • (2008) Traffic , vol.9 , Issue.8 , pp. 1268-1282
    • Boulant, S.1    Douglas, M.W.2    Moody, L.3    Budkowska, A.4    Targett-Adams, P.5    McLauchlan, J.6
  • 82
    • 17044382863 scopus 로고    scopus 로고
    • An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation
    • Abid K, Pazienza V, de Gottardi A et al. An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation. J. Hepatol. 42(5), 744-751 (2005).
    • (2005) J. Hepatol. , vol.42 , Issue.5 , pp. 744-751
    • Abid, K.1    Pazienza, V.2    De Gottardi, A.3
  • 83
    • 34548130208 scopus 로고    scopus 로고
    • The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model
    • DOI 10.1136/gut.2006.108647
    • Hourioux C, Patient R, Morin A et al. The genotype 3-specifc hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut 56(9), 1302-1308 (2007). (Pubitemid 47300434)
    • (2007) Gut , vol.56 , Issue.9 , pp. 1302-1308
    • Hourioux, C.1    Patient, R.2    Morin, A.3    Blanchard, E.4    Moreau, A.5    Trassard, S.6    Giraudeau, B.7    Roingeard, P.8
  • 84
    • 39149138470 scopus 로고    scopus 로고
    • Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation
    • DOI 10.1086/524846
    • Jhaveri R, McHutchison J, Patel K, Qiang G, Diehl AM. Specifc polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation. J. Infect. Dis., 197(2), 283-291 (2008). (Pubitemid 351263449)
    • (2008) Journal of Infectious Diseases , vol.197 , Issue.2 , pp. 283-291
    • Jhaveri, R.1    McHutchison, J.2    Patel, K.3    Qiang, G.4    Diehl, A.M.5
  • 85
    • 72849151027 scopus 로고    scopus 로고
    • Domain 3 of hepatitis C virus core protein is suffcient for intracellular lipid accumulation
    • Jhaveri R, Qiang G, Diehl AM. Domain 3 of hepatitis C virus core protein is suffcient for intracellular lipid accumulation. J. Infect. Dis., 200(11), 1781-1788 (2009).
    • (2009) J. Infect. Dis. , vol.200 , Issue.11 , pp. 1781-1788
    • Jhaveri, R.1    Qiang, G.2    Diehl, A.M.3
  • 87
    • 34247636649 scopus 로고    scopus 로고
    • Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: Genotype-3a core has a stronger effect than genotype-1b core
    • DOI 10.1016/j.jhep.2006.10.019, PII S0168827806006179
    • Jackel-Cram C, Babiuk LA, Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J. Hepatol. 46(6), 999-1008 (2007). (Pubitemid 46669729)
    • (2007) Journal of Hepatology , vol.46 , Issue.6 , pp. 999-1008
    • Jackel-Cram, C.1    Babiuk, L.A.2    Liu, Q.3
  • 88
    • 77952737082 scopus 로고    scopus 로고
    • Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway J
    • Jackel-Cram C, Qiao L, Xiang Z et al. Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway J. Gen. Virol. 91(Pt 6), 1388-1395 (2010).
    • (2010) Gen. Virol. , vol.91 , Issue.PART 6 , pp. 1388-1395
    • Jackel-Cram, C.1    Qiao, L.2    Xiang, Z.3
  • 89
    • 34547097746 scopus 로고    scopus 로고
    • Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • DOI 10.1128/JVI.00125-07
    • Waris G, Felmlee DJ, Negro F, Siddiqui A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J. Virol. 81(15), 8122-8130 (2007). (Pubitemid 47101498)
    • (2007) Journal of Virology , vol.81 , Issue.15 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.J.2    Negro, F.3    Siddiqui, A.4
  • 91
    • 44649115421 scopus 로고    scopus 로고
    • Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2
    • Oem JK, Jackel-Cram C, Li YP et al. Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2. J. Gen Virol. 89(Pt 5), 1225-1230 (2008).
    • (2008) J. Gen Virol. , vol.89 , Issue.PART 5 , pp. 1225-1230
    • Oem, J.K.1    Jackel-Cram, C.2    Li, Y.P.3
  • 92
    • 66149149803 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway
    • Park CY, Jun HJ, Wakita T, Cheong JH, Hwang SB. Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway. J. Biol. Chem. 284(14), 9237-9246 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.14 , pp. 9237-9246
    • Park, C.Y.1    Jun, H.J.2    Wakita, T.3    Cheong, J.H.4    Hwang, S.B.5
  • 93
    • 77958571316 scopus 로고    scopus 로고
    • Hepatitis C virus induces the cannabinoid receptor 1
    • van der Poorten D, Shahidi M, Tay E et al. Hepatitis C virus induces the cannabinoid receptor 1. PLoS ONE 5(9), e12841 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.9
    • Van Der Poorten, D.1    Shahidi, M.2    Tay, E.3
  • 97
    • 38849184816 scopus 로고    scopus 로고
    • PPARα activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
    • DOI 10.1172/JCI33594
    • Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T PPARα activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J. Clin. Invest. 118(2), 683-694 (2008). (Pubitemid 351206557)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.2 , pp. 683-694
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3    Koike, K.4    Gonzalez, F.J.5    Aoyama, T.6
  • 98
    • 68949196124 scopus 로고    scopus 로고
    • Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein
    • Tsutsumi T, Matsuda M, Aizaki H et al. Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein. Hepatology 50(2), 378-386 (2009).
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 378-386
    • Tsutsumi, T.1    Matsuda, M.2    Aizaki, H.3
  • 101
    • 52149104233 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein (MTP)-493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients
    • Zampino R, Ingrosso D, Durante-Mangoni E et al. Microsomal triglyceride transfer protein (MTP)-493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients. J. Viral Hepat. 15(10), 740-746 (2008).
    • (2008) J. Viral Hepat. , vol.15 , Issue.10 , pp. 740-746
    • Zampino, R.1    Ingrosso, D.2    Durante-Mangoni, E.3
  • 102
    • 62749100684 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C
    • Mirandola S, Osterreicher CH, Marcolongo M et al. Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C Liver Int. 29(4), 557-565 (2009).
    • (2009) Liver Int. , vol.29 , Issue.4 , pp. 557-565
    • Mirandola, S.1    Osterreicher, C.H.2    Marcolongo, M.3
  • 104
    • 34547444610 scopus 로고    scopus 로고
    • Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines
    • DOI 10.1002/hep.21703
    • Cua IH, Hui JM, Bandara P et al. Insulin resistance and liver injury in hepatitis C is not associated with virus-specifc changes in adipocytokines. Hepatology 46 (1), 66-73 (2007). (Pubitemid 47171922)
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 66-73
    • Cua, I.H.Y.1    Hui, J.M.2    Bandara, P.3    Kench, J.G.4    Farrell, G.C.5    McCaughan, G.W.6    George, J.7
  • 105
    • 59149102171 scopus 로고    scopus 로고
    • Regulation of hepatitis C virus by microRNA-122
    • Jopling CL. Regulation of hepatitis C virus by microRNA-122. Biochem. Soc. Trans., 36(Pt 6), 1220-1223 (2008).
    • (2008) Biochem. Soc. Trans. , vol.36 , Issue.PART 6 , pp. 1220-1223
    • Jopling, C.L.1
  • 106
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford RE, Hildebrandt-Eriksen ES, Petri A et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327(5962), 198-201 (2010).
    • (2010) Science , vol.327 , Issue.5962 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3
  • 107
    • 33645075443 scopus 로고    scopus 로고
    • MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
    • Esau C, Davis S, Murray SF et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab., 3(2), 87-98 (2006).
    • (2006) Cell Metab. , vol.3 , Issue.2 , pp. 87-98
    • Esau, C.1    Davis, S.2    Murray, S.F.3
  • 108
    • 76049113205 scopus 로고    scopus 로고
    • Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes
    • Braconi C, Valeri N, Gasparini P et al. Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes. Clin. Cancer. Res. 16(3), 957-966 (2010).
    • (2010) Clin. Cancer. Res. , vol.16 , Issue.3 , pp. 957-966
    • Braconi, C.1    Valeri, N.2    Gasparini, P.3
  • 109
    • 79951624703 scopus 로고    scopus 로고
    • Parallel microRNA and mRNA expression profling of (genotype 1b) human hepatoma cells expressing hepatitis C virus
    • Steuerwald NM, Parsons JC, Bennett K, Bates TC, Bonkovsky HL. Parallel microRNA and mRNA expression profling of (genotype 1b) human hepatoma cells expressing hepatitis C virus. Liver Int. 30(10), 1490-1504 (2010)
    • (2010) Liver Int. , vol.30 , Issue.10 , pp. 1490-1504
    • Steuerwald, N.M.1    Parsons, J.C.2    Bennett, K.3    Bates, T.C.4    Bonkovsky, H.L.5
  • 110
    • 58149333128 scopus 로고    scopus 로고
    • Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
    • Sarasin-Filipowicz M, Krol J, Markiewicz I, Heim MH, Filipowicz W. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med. 15(1), 31-33 (2009).
    • (2009) Nat Med. , vol.15 , Issue.1 , pp. 31-33
    • Sarasin-Filipowicz, M.1    Krol, J.2    Markiewicz, I.3    Heim, M.H.4    Filipowicz, W.5
  • 111
    • 35349009932 scopus 로고    scopus 로고
    • Interferon modulation of cellular microRNAs as an antiviral mechanism
    • DOI 10.1038/nature06205, PII NATURE06205
    • Pedersen IM, Cheng G, Wieland S et al. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 449(7164), 919-922 (2007). (Pubitemid 47598616)
    • (2007) Nature , vol.449 , Issue.7164 , pp. 919-922
    • Pedersen, I.M.1    Cheng, G.2    Wieland, S.3    Volinia, S.4    Croce, C.M.5    Chisari, F.V.6    David, M.7
  • 113
    • 33846114600 scopus 로고    scopus 로고
    • Hepatitis C, metabolic syndrome, and inflammatory markers: Results from the Third National Health and Nutrition Examination Survey [NHANES III]
    • DOI 10.1016/j.diabres.2006.07.008, PII S0168822706003081
    • Shaheen M, Echeverry D, Oblad MG, Montoya MI, Teklehaimanot S, Akhtar AJ. Hepatitis C, metabolic syndrome, and infammatory markers: results from the Third National Health and Nutrition Examination Survey [NHANES III]. Diabetes Res. Clin. Pract. 75(3), 320-326 (2007). (Pubitemid 46074212)
    • (2007) Diabetes Research and Clinical Practice , vol.75 , Issue.3 , pp. 320-326
    • Shaheen, M.1    Echeverry, D.2    Oblad, M.G.3    Montoya, M.I.4    Teklehaimanot, S.5    Akhtar, A.J.6
  • 116
    • 52049096635 scopus 로고    scopus 로고
    • Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease
    • Kawaguchi T, Nagao Y, Matsuoka H, Ide T, Sata M. Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease. Int J. Mol. Med. 22(1), 105-112 (2008).
    • (2008) Int J. Mol. Med. , vol.22 , Issue.1 , pp. 105-112
    • Kawaguchi, T.1    Nagao, Y.2    Matsuoka, H.3    Ide, T.4    Sata, M.5
  • 117
    • 79954523255 scopus 로고    scopus 로고
    • Combination drug treatment in patients with non-alcoholic fatty liver disease
    • Filippatos TD, Elisaf MS. Combination drug treatment in patients with non-alcoholic fatty liver disease. World J. Hepatol. 2(4), 139-142 (2010).
    • (2010) World J. Hepatol. , vol.2 , Issue.4 , pp. 139-142
    • Filippatos, T.D.1    Elisaf, M.S.2
  • 118
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley KV et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl. J. Med. 362(18), 1675-1685 (2010).
    • (2010) N Engl. J. Med. , vol.362 , Issue.18 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 119
    • 77955664397 scopus 로고    scopus 로고
    • Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: Clinical usefulness of AGEs as a biomarker for the attenuation of NASH
    • Kimura Y, Hyogo H, Yamagishi S et al. Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH. J. Gastroenterol. 45(7), 750-757 (2010).
    • (2010) J. Gastroenterol. , vol.45 , Issue.7 , pp. 750-757
    • Kimura, Y.1    Hyogo, H.2    Yamagishi, S.3
  • 120
    • 77954366025 scopus 로고    scopus 로고
    • Effcacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study
    • Yoneda M, Fujita K, Nozaki Y et al. Effcacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: an open-label, pilot study. Hepatol. Res. 40(6), 613-621 (2010).
    • (2010) Hepatol. Res. , vol.40 , Issue.6 , pp. 613-621
    • Yoneda, M.1    Fujita, K.2    Nozaki, Y.3
  • 121
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    • Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 52(1), 79-104 (2010).
    • (2010) Hepatology , vol.52 , Issue.1 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 122
    • 72549104493 scopus 로고    scopus 로고
    • Treatment of insulin resistance with metformin in naive genotype 1 chronic hepatitis C patients receiving PEGinterferon α-2a plus ribavirin
    • Romero-Gomez M, Diago M, Andrade RJ et al. Treatment of insulin resistance with metformin in naive genotype 1 chronic hepatitis C patients receiving PEGinterferon α-2a plus ribavirin. Hepatology 50(6), 1702-1708 (2009).
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1702-1708
    • Romero-Gomez, M.1    Diago, M.2    Andrade, R.J.3
  • 123
    • 77950602195 scopus 로고    scopus 로고
    • Pioglitazone improves virological response to PEGinterferon α-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance
    • Khattab M, Emad M, Abdelaleem A et al. Pioglitazone improves virological response to PEGinterferon α-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance. Liver Int. 30(3), 447-454 (2010).
    • (2010) Liver Int. , vol.30 , Issue.3 , pp. 447-454
    • Khattab, M.1    Emad, M.2    Abdelaleem, A.3


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