Loop 5-directed compounds inhibit chimeric Kinesin-5 motors: Implications for conserved allosteric mechanisms

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6201-6210

  Liu, Liqiong ^a   Parameswaran, Sreeja ^a   Liu, Jing ^a   Kim, Sunyoung ^a   Wojcik, Edward J ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC COMMUNICATION; ALLOSTERIC INHIBITION; ALLOSTERIC MECHANISMS; BINDING AFFINITIES; DRUG BINDING; DRUG SENSITIVITY; EFFECTOR BINDING; INTRAMOLECULAR COMMUNICATION; ISOTHERMAL TITRATION CALORIMETRY; KINESINS; L-CYSTEINE; LIGAND-BINDING SITES; MONASTROL; MOTOR DOMAIN;

AMINO ACIDS; BINDING ENERGY; BIOCHEMISTRY;

BINDING SITES;

ADENOSINE TRIPHOSPHATASE INHIBITOR; KINESIN 5; MONASTROL; PROTEIN KLP61F; TRITYLCYSTEINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME INHIBITION; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN;

ALLOSTERIC REGULATION; ANIMALS; CYSTEINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; KINESIN; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; RECOMBINANT FUSION PROTEINS; THIONES;

EID: 79953167875     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.154989     Document Type: Article

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