Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: Activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator

Journal of the American Chemical Society

Volumn 130, Issue 24, 2008, Pages 7584-7591

  Luo, Lusong ^a   Carson, Jeffrey D ^a   Molnar, Kathleen S ^b   Tuske, Steven J ^b   Coales, Stephen J ^b   Hamuro, Yoshitomo ^b   Sung, Chiu Mei ^a   Sudakin, Valery ^a   Auger, Kurt R ^a   Dhanak, Dashyant ^a   Jackson, Jeffrey R ^a   Huang, Pearl S ^a   Tummino, Peter J ^a   Copeland, Robert A ^a  

^a GLAXOSMITHKLINE   (United States)

^b ExSAR Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BINDING ENERGY; BIOCHEMISTRY; CELL DEATH; CELL PROLIFERATION; CELLS; CONFORMATIONS; HYDROLYSIS; MECHANISMS; MICROFLUIDICS; MODULATION; MOLECULAR STRUCTURE; MOLECULES; TELLURIC PROSPECTING; TELLURIUM COMPOUNDS; TISSUE; TUMORS;

AMERICAN CHEMICAL SOCIETY (ACS); ATP HYDROLYSIS; ATP-ASE ACTIVITY; CELL CYCLE ARREST; CELL-CYCLE PROGRESSION; CLINICAL TRIALS; CONFORMATIONAL CHANGES; HUMAN CELLS; IN PHASE (IP); IN-VITRO; KINESIN; KINESINS; KINETIC ANALYSES; MICROTUBULE (MT); MICROTUBULES (MT); MITOTIC SPINDLES; MOTOR DOMAINS; SMALL MOLECULES; TUMOR CELLS;

BINDING SITES;

ADENOSINE TRIPHOSPHATE; DEUTERIUM; HYDROGEN; KINESIN SPINDLE PROTEIN 1; LIGAND; PROTEIN;

ARTICLE; BINDING ASSAY; BINDING COMPETITION; CATALYSIS; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; HUMAN; HUMAN CELL; HYDROLYSIS; KINETICS; MICROTUBULE; PROTEIN DOMAIN; STEADY STATE; TUMOR CELL;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; CELL LINE; CELL PROLIFERATION; DEUTERIUM; HUMANS; HYDROCARBONS, FLUORINATED; HYDROGEN; HYDROLYSIS; KINESIN; LIGANDS; MALEATES; MICROTUBULES; MITOTIC SPINDLE APPARATUS; PYRROLES;

EID: 45249090979     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja710889h     Document Type: Article

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