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Volumn 1, Issue , 2009, Pages 87-110

Pharmacological tools in endocannabinoid neurobiology

Author keywords

Anandamide Transport; FAAH inhibitors; MGL inhibitors; NAAA inhibitors

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR; ENDOCANNABINOID; ENZYME INHIBITOR; LIGAND;

EID: 79952115220     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/978-3-540-88955-7_4     Document Type: Article
Times cited : (4)

References (127)
  • 1
    • 36048978697 scopus 로고    scopus 로고
    • Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity
    • Ahn K, Johnson DS, Fitzgerald LR et al. (2007) Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46:13019-13030
    • (2007) Biochemistry , vol.46 , pp. 13019-13030
    • Ahn, K.1    Johnson, D.S.2    Fitzgerald, L.R.3
  • 2
    • 27744466783 scopus 로고    scopus 로고
    • Mechanism of carbamate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes
    • Alexander JP, Cravatt BF (2005) Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol 12:1179-1187
    • (2005) Chem Biol , vol.12 , pp. 1179-1187
    • Alexander, J.P.1    Cravatt, B.F.2
  • 3
    • 33646068357 scopus 로고    scopus 로고
    • New insights into endocannabinoid degradation and its therapeutic potential
    • Bari M, Battista N, Fezza F et al. (2006) New insights into endocannabinoid degradation and its therapeutic potential. Mini Rev Med Chem 6:257-268
    • (2006) Mini Rev Med Chem , vol.6 , pp. 257-268
    • Bari, M.1    Battista, N.2    Fezza, F.3
  • 4
    • 84950164702 scopus 로고    scopus 로고
    • 9-Tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase
    • 9-Tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase. J Biol Chem 27:19902-19905
    • (1996) J Biol Chem , vol.27 , pp. 19902-19905
    • Bayewitch, M.1    Rhee, M-H.2    Avidor-Reiss, T.3
  • 5
    • 0030865871 scopus 로고    scopus 로고
    • Functional role of high-affinity anandamide transport, as revealed by selective inhibition
    • Beltramo M, Stella N, Calignano A et al. (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277:1094-1097
    • (1997) Science , vol.277 , pp. 1094-1097
    • Beltramo, M.1    Stella, N.2    Calignano, A.3
  • 7
    • 10744229235 scopus 로고    scopus 로고
    • Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
    • Bisogno T, Howell F, Williams G et al. (2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol 163:463-468
    • (2003) J Cell Biol , vol.163 , pp. 463-468
    • Bisogno, T.1    Howell, F.2    Williams, G.3
  • 8
    • 33646472897 scopus 로고    scopus 로고
    • Development of the first potent and specific inhibitors of endocannabinoid biosynthesis
    • Bisogno T, Cascio MG, Saha B et al. (2006) Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochim Biophys Acta 1761:205-212
    • (2006) Biochim Biophys Acta , vol.1761 , pp. 205-212
    • Bisogno, T.1    Cascio, M.G.2    Saha, B.3
  • 9
    • 12944277105 scopus 로고    scopus 로고
    • Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
    • Boger DL, Sato H, Lerner AE et al. (2000) Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proc Natl Acad Sci USA 97:5044-5049
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5044-5049
    • Boger, D.L.1    Sato, H.2    Lerner, A.E.3
  • 10
    • 20144377098 scopus 로고    scopus 로고
    • Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics
    • Boger DL, Miyauchi H, Du W et al. (2005) Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. J Med Chem 48:1849-1856
    • (2005) J Med Chem , vol.48 , pp. 1849-1856
    • Boger, D.L.1    Miyauchi, H.2    Du, W.3
  • 11
    • 34250786050 scopus 로고    scopus 로고
    • Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress
    • Bortolato M, Mangieri RA, Fu J et al. (2007) Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry 62:1103-1110
    • (2007) Biol Psychiatry , vol.62 , pp. 1103-1110
    • Bortolato, M.1    Mangieri, R.A.2    Fu, J.3
  • 12
    • 35748973885 scopus 로고    scopus 로고
    • Novel cannabinoid receptors
    • Brown AJ (2007) Novel cannabinoid receptors. Br J Pharmacol 152:567-575
    • (2007) Br J Pharmacol , vol.152 , pp. 567-575
    • Brown, A.J.1
  • 13
    • 0031550564 scopus 로고    scopus 로고
    • Novel inhibitors of brain neuronal and basophilic anandamide amidohydrolase
    • De Petrocellis L, Melck D, Ueda N et al. (1997) Novel inhibitors of brain neuronal and basophilic anandamide amidohydrolase. Biochem Biophys Res Commun 231:82-88
    • (1997) Biochem Biophys Res Commun , vol.231 , pp. 82-88
    • de Petrocellis, L.1    Melck, D.2    Ueda, N.3
  • 14
    • 0027180394 scopus 로고
    • Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist
    • Deutsch DG, Chin SA (1993) Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem Pharmacol 46:791-796
    • (1993) Biochem Pharmacol , vol.46 , pp. 791-796
    • Deutsch, D.G.1    Chin, S.A.2
  • 15
    • 0031550548 scopus 로고    scopus 로고
    • Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor
    • Deutsch DG, Lin S, Hill WA et al. (1997) Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun 3:217-221
    • (1997) Biochem Biophys Res Commun , vol.3 , pp. 217-221
    • Deutsch, D.G.1    Lin, S.2    Hill, W.A.3
  • 16
    • 0024263922 scopus 로고
    • Determination and characterization of a cannabinoid receptor in rat brain
    • Devane WA, Dysarz FA III, Johnson MR et al. (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605-613
    • (1988) Mol Pharmacol , vol.34 , pp. 605-613
    • Devane, W.A.1    Dysarz III, F.A.2    Johnson, M.R.3
  • 17
    • 0029756752 scopus 로고    scopus 로고
    • Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells
    • Di Marzo V, De Petrocellis L, Sepe N et al. (1996) Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. Biochem J 316:977-984
    • (1996) Biochem J , vol.316 , pp. 977-984
    • Di Marzo, V.1    de Petrocellis, L.2    Sepe, N.3
  • 18
    • 0033567190 scopus 로고    scopus 로고
    • Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
    • Di Marzo V, Bisogno T, De Petrocellis L et al. (1999) Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur J Biochem 264:258-267
    • (1999) Eur J Biochem , vol.264 , pp. 258-267
    • Di Marzo, V.1    Bisogno, T.2    de Petrocellis, L.3
  • 19
    • 0034808060 scopus 로고    scopus 로고
    • Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands
    • Di Marzo V, Bisogno T, De Petrocellis L et al. (2001) Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands. Biochem Biophys Res Commun 281:444-451
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 444-451
    • Di Marzo, V.1    Bisogno, T.2    de Petrocellis, L.3
  • 20
    • 0036678094 scopus 로고    scopus 로고
    • Brain monoglyceride lipase participating in endocannabinoid inactivation
    • Dinh TP, Carpenter D, Leslie FM et al. (2002a) Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci USA 99:10819-10824
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10819-10824
    • Dinh, T.P.1    Carpenter, D.2    Leslie, F.M.3
  • 21
    • 0037207088 scopus 로고    scopus 로고
    • A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation
    • Dinh TP, Freund TF, Piomelli D (2002b) A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids 31:149-158
    • (2002) Chem Phys Lipids , vol.31 , pp. 149-158
    • Dinh, T.P.1    Freund, T.F.2    Piomelli, D.3
  • 24
    • 2942525207 scopus 로고    scopus 로고
    • Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
    • Fegley D, Kathuria S, Mercier R et al. (2004) Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci USA 101:8756-8761
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8756-8761
    • Fegley, D.1    Kathuria, S.2    Mercier, R.3
  • 26
    • 34248532300 scopus 로고    scopus 로고
    • Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S, 2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[5-(trifluoromethyl) pyridin-2-yl]oxy]propanamide (MK-0364), in rodents
    • Fong TM, Guan XM, Marsh DJ et al. (2007) Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S, 2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[5-(trifluoromethyl) pyridin-2-yl]oxy]propanamide (MK-0364), in rodents. J Pharmacol Exp Ther 321:1013-1022
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1013-1022
    • Fong, T.M.1    Guan, X.M.2    Marsh, D.J.3
  • 27
    • 2442595984 scopus 로고    scopus 로고
    • Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis: A difficult issue to handle
    • Fowler CJ, Tiger G, Ligresti A et al. (2004) Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis: a difficult issue to handle. Eur J Pharmacol 492:1-11
    • (2004) Eur J Pharmacol , vol.492 , pp. 1-11
    • Fowler, C.J.1    Tiger, G.2    Ligresti, A.3
  • 28
    • 20444458379 scopus 로고    scopus 로고
    • The endocannabinoid signaling system: Pharmacological and therapeutic aspects
    • Fowler CJ, Holt S, Nilsson O et al. (2005) The endocannabinoid signaling system: pharmacological and therapeutic aspects. Pharmacol Biochem Behav 81:248-262
    • (2005) Pharmacol Biochem Behav , vol.81 , pp. 248-262
    • Fowler, C.J.1    Holt, S.2    Nilsson, O.3
  • 29
    • 0041321275 scopus 로고    scopus 로고
    • Oleoylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
    • Fu J, Gaetani S, Oveisi F et al. (2003) Oleoylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425:90-93
    • (2003) Nature , vol.425 , pp. 90-93
    • Fu, J.1    Gaetani, S.2    Oveisi, F.3
  • 30
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • Gaoni Y, Mechoulam R (1964) Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 86:1646-1647
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 31
    • 29844447996 scopus 로고    scopus 로고
    • Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'
    • Gardner A, Mallet PE (2006) Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'. Eur J Pharmacol 530:103-106
    • (2006) Eur J Pharmacol , vol.530 , pp. 103-106
    • Gardner, A.1    Mallet, P.E.2
  • 33
    • 10044228562 scopus 로고    scopus 로고
    • Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol
    • Ghafouri N, Tiger G, Razdan RK et al. (2004) Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol 143:774-784
    • (2004) Br J Pharmacol , vol.143 , pp. 774-784
    • Ghafouri, N.1    Tiger, G.2    Razdan, R.K.3
  • 34
    • 34250202493 scopus 로고    scopus 로고
    • Discovery of 2-[(2, 4-dichlorophenyl) amino]-N-[(tetrahydro-2H-pyran-4-yl) methyl]-4-trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain
    • Giblin GM, O'Shaughnessy CT, Naylor A et al. (2007) Discovery of 2-[(2, 4-dichlorophenyl) amino]-N-[(tetrahydro-2H-pyran-4-yl) methyl]-4-trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem 50:2597-2600
    • (2007) J Med Chem , vol.50 , pp. 2597-2600
    • Giblin, G.M.1    O'Shaughnessy, C.T.2    Naylor, A.3
  • 35
    • 0037389484 scopus 로고    scopus 로고
    • Evidence against the presence of an anandamide transporter
    • Glaser S, Abumrad N, Fatade F et al. (2003) Evidence against the presence of an anandamide transporter. Proc Natl Acad Sci USA 100:4269-4274
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4269-4274
    • Glaser, S.1    Abumrad, N.2    Fatade, F.3
  • 36
    • 29444460231 scopus 로고    scopus 로고
    • Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
    • Gobbi G, Bambico FR, Mangieri et al. (2005) Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci USA 102:18620-18625
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18620-18625
    • Gobbi, G.1    Bambico, F.R.2    Mangieri3
  • 39
    • 0034058250 scopus 로고    scopus 로고
    • Endocannabinoid 2-AG is a full agonist through human type 2 cannabinoid receptor: Antagonism by anandamide
    • Gonsorek W, Lunn C, Fan X et al. (2000) Endocannabinoid 2-AG is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. Mol Pharmacol 57:1045-1050
    • (2000) Mol Pharmacol , vol.57 , pp. 1045-1050
    • Gonsorek, W.1    Lunn, C.2    Fan, X.3
  • 40
    • 38349119715 scopus 로고    scopus 로고
    • 2receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain
    • 2receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain. Br J Pharmacol 153:319-334
    • (2008) Br J Pharmacol , vol.153 , pp. 319-334
    • Guindon, J.1    Hohmann, A.G.2
  • 44
    • 35348851360 scopus 로고    scopus 로고
    • Studies of anandamide accumulation inhibitors in cerebellar granule neurons: Comparison to inhibition of fatty acid amide hydrolase
    • Hillard CJ, Shi L, Tuniki VR et al. (2007) Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase. J Mol Neurosci 33:18-24
    • (2007) J Mol Neurosci , vol.33 , pp. 18-24
    • Hillard, C.J.1    Shi, L.2    Tuniki, V.R.3
  • 45
    • 27644514002 scopus 로고    scopus 로고
    • Modulators of endocannabinoid enzymic hydrolysis and membrane transport
    • In: Pertwee RG (ed) Cannabinoids. Springer, Heidelberg
    • Ho W-SV, Hillard CJ (2005) Modulators of endocannabinoid enzymic hydrolysis and membrane transport. In: Pertwee RG (ed) Cannabinoids. Handbook of experimental pharmacology. Springer, Heidelberg
    • (2005) Handbook of experimental pharmacology
    • Ho, W-S.V.1    Hillard, C.J.2
  • 46
    • 21344444379 scopus 로고    scopus 로고
    • An endocannabinoid mechanism for stressinduced analgesia
    • Hohmann AG, Suplita RL, Bolton NM et al. (2005) An endocannabinoid mechanism for stressinduced analgesia. Nature 435:1108-1112
    • (2005) Nature , vol.435 , pp. 1108-1112
    • Hohmann, A.G.1    Suplita, R.L.2    Bolton, N.M.3
  • 48
    • 18444376760 scopus 로고    scopus 로고
    • International union of pharmacology. XXVII. Classification of cannabinoid receptors
    • Howlett AC, Barth F, Bonner TI et al. (2002) International union of pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202
    • (2002) Pharmacol Rev , vol.54 , pp. 161-202
    • Howlett, A.C.1    Barth, F.2    Bonner, T.I.3
  • 49
    • 0033381793 scopus 로고    scopus 로고
    • 3-(10, 10-Dimethylbutyl)-1-deoxy-D8-THC and related compounds: Synthesis of selective ligands for the CB2 receptor
    • Huffman JW, Liddle J, Yu S et al. (1999) 3-(10, 10-Dimethylbutyl)-1-deoxy-D8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. BioorgMed Chem 7:2905-2914
    • (1999) BioorgMed Chem , vol.7 , pp. 2905-2914
    • Huffman, J.W.1    Liddle, J.2    Yu, S.3
  • 51
    • 40349113029 scopus 로고    scopus 로고
    • 1cannabinoid antagonists: Structureactivity relationships and potential therapeutic applications
    • 1cannabinoid antagonists: structureactivity relationships and potential therapeutic applications. Curr Top Med Chem 8:205-230
    • (2008) Curr Top Med Chem , vol.8 , pp. 205-230
    • Jagerovic, N.1    Fernandez-Fernandez, C.2    Goya, P.3
  • 52
    • 0034070409 scopus 로고    scopus 로고
    • Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter
    • Jarrahian A, Manna S, Edgemond WS et al. (2000) Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. J Neurochem 74:2597-2606
    • (2000) J Neurochem , vol.74 , pp. 2597-2606
    • Jarrahian, A.1    Manna, S.2    Edgemond, W.S.3
  • 53
    • 32244432341 scopus 로고    scopus 로고
    • Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models
    • Jayamanne A, Greenwood R, Mitchell VA et al. (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol 147:281-288
    • (2006) Br J Pharmacol , vol.147 , pp. 281-288
    • Jayamanne, A.1    Greenwood, R.2    Mitchell, V.A.3
  • 54
    • 28944438774 scopus 로고    scopus 로고
    • 2receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of b-hexosaminidase from skin slices in vitro
    • 2receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of b-hexosaminidase from skin slices in vitro. Life Sci 78:598-606
    • (2006) Life Sci , vol.78 , pp. 598-606
    • Jonsson, K.O.1    Persson, E.2    Fowler, C.J.3
  • 55
    • 0030767295 scopus 로고    scopus 로고
    • cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases
    • Karlsson M, Contreras JA, Hellman U et al. (1997) cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem 272:27218-27223
    • (1997) J Biol Chem , vol.272 , pp. 27218-27223
    • Karlsson, M.1    Contreras, J.A.2    Hellman, U.3
  • 56
    • 0037234363 scopus 로고    scopus 로고
    • Modulation of anxiety through blockade of anandamide hydrolysis
    • Kathuria S, Gaetani S, Fegley et al. (2003) Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81
    • (2003) Nat Med , vol.9 , pp. 76-81
    • Kathuria, S.1    Gaetani, S.2    Fegley3
  • 57
    • 37349115572 scopus 로고    scopus 로고
    • Cannabilactones: A novel class of CB2 selective agonists with peripheral analgesic activity
    • Khanolkar AD, Lu D, Ibrahim M et al. (2007) Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem 50:6493-6500
    • (2007) J Med Chem , vol.50 , pp. 6493-6500
    • Khanolkar, A.D.1    Lu, D.2    Ibrahim, M.3
  • 58
    • 40549088536 scopus 로고    scopus 로고
    • 2) ligand, PF-03550096, in vitro and in vivo by using a rat model of visceral hypersensitivity
    • 2) ligand, PF-03550096, in vitro and in vivo by using a rat model of visceral hypersensitivity. J Pharmacol Sci 106:219-224
    • (2008) J Pharmacol Sci , vol.106 , pp. 219-224
    • Kikuchi, A.1    Ohashi, K.2    Sugie, Y.3
  • 59
    • 37149011506 scopus 로고    scopus 로고
    • URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices
    • King AR, Duranti A, Tontini A et al. (2007) URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol 14:1357-1365
    • (2007) Chem Biol , vol.14 , pp. 1357-1365
    • King, A.R.1    Duranti, A.2    Tontini, A.3
  • 60
    • 0028108312 scopus 로고
    • Inhibitors of arachidonoyl ethanolamide hydrolysis
    • Koutek B, Prestwich GD, Howlett AC et al. (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J Biol Chem 269:22937-22940
    • (1994) J Biol Chem , vol.269 , pp. 22937-22940
    • Koutek, B.1    Prestwich, G.D.2    Howlett, A.C.3
  • 61
    • 0027379769 scopus 로고
    • Aminoalkylindole binding in rat cerebellum: Selective displacement by natural and synthetic cannabinoids
    • Kuster JE, Stevenson JI, Ward SJ et al. (1993) Aminoalkylindole binding in rat cerebellum: selective displacement by natural and synthetic cannabinoids. J Pharmacol Exp Ther 264:1352-1363
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 1352-1363
    • Kuster, J.E.1    Stevenson, J.I.2    Ward, S.J.3
  • 62
    • 34548504316 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase: From characterization to therapeutics
    • Labar G, Michaux C (2007) Fatty acid amide hydrolase: from characterization to therapeutics. Chem Biodivers 4:1882-1902
    • (2007) Chem Biodivers , vol.4 , pp. 1882-1902
    • Labar, G.1    Michaux, C.2
  • 63
    • 34547483026 scopus 로고    scopus 로고
    • Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling
    • Labar G, Bauvois C, Muccioli GG et al. (2007) Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. Chembiochem 23:1293-1297
    • (2007) Chembiochem , vol.23 , pp. 1293-1297
    • Labar, G.1    Bauvois, C.2    Muccioli, G.G.3
  • 64
    • 23444432920 scopus 로고    scopus 로고
    • The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
    • Lambert D, Fowler CJ (2005) The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 48:1-29
    • (2005) J Med Chem , vol.48 , pp. 1-29
    • Lambert, D.1    Fowler, C.J.2
  • 65
    • 4644354869 scopus 로고    scopus 로고
    • Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: Evidence for an unprecedented combination of potency and selectivity
    • Lichtman AH, Leung D, Shelton C et al. (2004) Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther 311:441-448
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 441-448
    • Lichtman, A.H.1    Leung, D.2    Shelton, C.3
  • 66
    • 11244328917 scopus 로고    scopus 로고
    • The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    • Lo Verme J, Fu J, Astarita G et al. (2005) The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol 67:15-19
    • (2005) Mol Pharmacol , vol.67 , pp. 15-19
    • Lo Verme, J.1    Fu, J.2    Astarita, G.3
  • 67
    • 25444523794 scopus 로고    scopus 로고
    • QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation
    • Lodola A, Mor M, Hermann JC et al. (2005) QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation. Chem Commun (Camb) 35:4399-4401
    • (2005) Chem Commun (Camb) , vol.35 , pp. 4399-4401
    • Lodola, A.1    Mor, M.2    Hermann, J.C.3
  • 68
    • 37349122437 scopus 로고    scopus 로고
    • Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling
    • Lodola A, Mor M, Rivara S et al. (2008) Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling. Chem Commun (Camb) 2:214-216
    • (2008) Chem Commun (Camb) , vol.2 , pp. 214-216
    • Lodola, A.1    Mor, M.2    Rivara, S.3
  • 69
    • 0242585423 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: Comparison with effects on fatty acid amidohydrolase
    • Lopez-Rodrguez ML, Viso A, Ortega-Gutierrez S et al. (2003) Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. J Med Chem 46:1512-1522
    • (2003) J Med Chem , vol.46 , pp. 1512-1522
    • Lopez-Rodrguez, M.L.1    Viso, A.2    Ortega-Gutierrez, S.3
  • 70
    • 31144468211 scopus 로고    scopus 로고
    • A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo
    • Lunn CA, Fine JS, Rojas-Triana A et al. (2006) A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther 316:780-788
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 780-788
    • Lunn, C.A.1    Fine, J.S.2    Rojas-Triana, A.3
  • 71
    • 33745997333 scopus 로고    scopus 로고
    • 2receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis
    • 2receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur J Pharmacol 542:179-183
    • (2006) Eur J Pharmacol , vol.542 , pp. 179-183
    • Maekawa, T.1    Nojima, H.2    Kuraishi, Y.3
  • 72
    • 33947319316 scopus 로고    scopus 로고
    • Analgesic actions of N-arachidonoylserotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors
    • Maione S, De Petrocellis L, de Novellis V et al. (2007) Analgesic actions of N-arachidonoylserotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br J Pharmacol 150:766-781
    • (2007) Br J Pharmacol , vol.150 , pp. 766-781
    • Maione, S.1    de Petrocellis, L.2    de Novellis, V.3
  • 73
    • 25844440525 scopus 로고    scopus 로고
    • Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
    • Makara JK, Mor M, Fegley D et al. (2005) Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci 8:1139-1141
    • (2005) Nat Neurosci , vol.8 , pp. 1139-1141
    • Makara, J.K.1    Mor, M.2    Fegley, D.3
  • 74
    • 33845880380 scopus 로고    scopus 로고
    • Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
    • Makara JK, Mor M, Fegley D et al. (2007) Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci 10:134
    • (2007) Nat Neurosci , vol.10 , pp. 134
    • Makara, J.K.1    Mor, M.2    Fegley, D.3
  • 75
    • 33749236407 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of new 1, 8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists
    • Manera C, Benetti V, Castelli MP et al. (2006) Design, synthesis, and biological evaluation of new 1, 8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists. J Med Chem 49:5947-5957
    • (2006) J Med Chem , vol.49 , pp. 5947-5957
    • Manera, C.1    Benetti, V.2    Castelli, M.P.3
  • 76
    • 33747615483 scopus 로고    scopus 로고
    • Pharmacological characterization of novel watersoluble cannabinoids
    • Martin BR, Wiley JL, Beletskaya I et al. (2006) Pharmacological characterization of novel watersoluble cannabinoids. J Pharmacol Exp Ther 318:1230-1239
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1230-1239
    • Martin, B.R.1    Wiley, J.L.2    Beletskaya, I.3
  • 77
    • 22244484464 scopus 로고    scopus 로고
    • Structure and function of fatty acid amide hydrolase
    • McKinney MK, Cravat BF (2005) Structure and function of fatty acid amide hydrolase. Annu Rev Biochem 74:411-432
    • (2005) Annu Rev Biochem , vol.74 , pp. 411-432
    • McKinney, M.K.1    Cravat, B.F.2
  • 78
    • 28444487445 scopus 로고    scopus 로고
    • Plant cannabinoids: A neglected pharmacological treasure trove
    • Mechoulam R (2005) Plant cannabinoids: a neglected pharmacological treasure trove. Br J Pharmacol 146:913-915
    • (2005) Br J Pharmacol , vol.146 , pp. 913-915
    • Mechoulam, R.1
  • 80
    • 4744354729 scopus 로고    scopus 로고
    • Cyclohexylcarbamic acid 3'-or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structure-activity relationships, and molecular modelling studies
    • Mor M, Rivara S, Lodola A et al. (2004) Cyclohexylcarbamic acid 3'-or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modelling studies. J Med Chem 47:4998-5008
    • (2004) J Med Chem , vol.47 , pp. 4998-5008
    • Mor, M.1    Rivara, S.2    Lodola, A.3
  • 81
    • 34548515486 scopus 로고    scopus 로고
    • Blocking the cannabinoid receptors: Drug candidates and therapeutic promises
    • Muccioli GG (2007) Blocking the cannabinoid receptors: drug candidates and therapeutic promises. Chem Biodivers 4:1805-1827
    • (2007) Chem Biodivers , vol.4 , pp. 1805-1827
    • Muccioli, G.G.1
  • 82
    • 33947330328 scopus 로고    scopus 로고
    • Identification of a novel endocannabinoid-hydrolysing enzyme expressed by microglial cells
    • Muccioli GG, Xu C, Odah E et al. (2007) Identification of a novel endocannabinoid-hydrolysing enzyme expressed by microglial cells. J Neurosci 27:2883-2889
    • (2007) J Neurosci , vol.27 , pp. 2883-2889
    • Muccioli, G.G.1    Xu, C.2    Odah, E.3
  • 83
    • 33845496711 scopus 로고    scopus 로고
    • Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3 carboxamide
    • Murineddu G, Lazzari P, Ruiu S et al. (2006) Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3 carboxamide. J Med Chem 49:7502-7512
    • (2006) J Med Chem , vol.49 , pp. 7502-7512
    • Murineddu, G.1    Lazzari, P.2    Ruiu, S.3
  • 85
    • 34548512479 scopus 로고    scopus 로고
    • Biosynthetic pathways of the endocannabinoid anandamide
    • Okamoto Y, Wang J, Morishita J et al. (2007) Biosynthetic pathways of the endocannabinoid anandamide. Chem Biodivers 4:1842-1857
    • (2007) Chem Biodivers , vol.4 , pp. 1842-1857
    • Okamoto, Y.1    Wang, J.2    Morishita, J.3
  • 86
    • 0037542450 scopus 로고    scopus 로고
    • Novel selective and metabolically stable inhibitors of anandamide cellular uptake
    • Ortar G, Ligresti A, De Petrocellis L et al. (2003) Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol 65:1473-1481
    • (2003) Biochem Pharmacol , vol.65 , pp. 1473-1481
    • Ortar, G.1    Ligresti, A.2    de Petrocellis, L.3
  • 87
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Batkay S, Kunos G (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58:390-462
    • (2006) Pharmacol Rev , vol.58 , pp. 390-462
    • Pacher, P.1    Batkay, S.2    Kunos, G.3
  • 88
    • 33746110406 scopus 로고    scopus 로고
    • Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole-LH 21
    • Pavon FJ, Bilbao A, Hernández-Folgado L et al. (2006) Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole-LH 21. Neuropharmacology 51:358-366
    • (2006) Neuropharmacology , vol.51 , pp. 358-366
    • Pavon, F.J.1    Bilbao, A.2    Hernández-Folgado, L.3
  • 89
    • 12744258029 scopus 로고    scopus 로고
    • 1receptors
    • 1receptors. Life Sci 76:1307-1324
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 90
    • 26044476776 scopus 로고    scopus 로고
    • Pharmacological action of cannabinoid
    • In: Pertwee RG (ed) Cannabinoids. Springer, Heidelberg
    • Pertwee RG (2005b) Pharmacological action of cannabinoid. In: Pertwee RG (ed) Cannabinoids. Handbook of experimental pharmacology. Springer, Heidelberg
    • (2005) Handbook of experimental pharmacology
    • Pertwee, R.G.1
  • 91
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873-884
    • (2003) Nat Rev Neurosci , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 92
    • 21344432777 scopus 로고    scopus 로고
    • The endocannabinoid system: A drug discovery perspective
    • Piomelli D (2005) The endocannabinoid system: a drug discovery perspective. Curr Opin Investig Drugs 6:672-679
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 672-679
    • Piomelli, D.1
  • 93
    • 33746474287 scopus 로고    scopus 로고
    • Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597)
    • Piomelli D, Tarzia G, Duranti A et al. (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev 12:21-38
    • (2006) CNS Drug Rev , vol.12 , pp. 21-38
    • Piomelli, D.1    Tarzia, G.2    Duranti, A.3
  • 96
    • 0028129936 scopus 로고
    • SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
    • Rinaldi-Carmona M, Barth F, Heaulme M et al. (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240-244
    • (1994) FEBS Lett , vol.350 , pp. 240-244
    • Rinaldi-Carmona, M.1    Barth, F.2    Heaulme, M.3
  • 100
    • 34250750792 scopus 로고    scopus 로고
    • The fatty-acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neurophatic pain after oral administration
    • Russo R, Lo Verme J, La Rana G et al. (2007) The fatty-acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neurophatic pain after oral administration. J Pharmacol Exp Ther 322:236-242
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 236-242
    • Russo, R.1    Lo Verme, J.2    La Rana, G.3
  • 101
    • 35649015179 scopus 로고    scopus 로고
    • The orphan receptor GPR55 is a novel cannabinoid receptor
    • Ryberg E, Larsson N, Sjögren S et al. (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152:1092-1101
    • (2007) Br J Pharmacol , vol.152 , pp. 1092-1101
    • Ryberg, E.1    Larsson, N.2    Sjögren, S.3
  • 102
    • 34548514198 scopus 로고    scopus 로고
    • Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol
    • Saario SM, Laitinen JT (2007a) Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol. Chem Biodivers 4:1903-1913
    • (2007) Chem Biodivers , vol.4 , pp. 1903-1913
    • Saario, S.M.1    Laitinen, J.T.2
  • 103
    • 34848863139 scopus 로고    scopus 로고
    • Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors
    • Saario SM, Laitinen JT (2007b) Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors. Basic Clin Pharmacol Toxicol 101:287-293
    • (2007) Basic Clin Pharmacol Toxicol , vol.101 , pp. 287-293
    • Saario, S.M.1    Laitinen, J.T.2
  • 104
    • 1542346866 scopus 로고    scopus 로고
    • Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes
    • Saario SM, Savinainen JR, Laitinen JT et al. (2004) Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. Biochem Pharmacol 67:1381-1387
    • (2004) Biochem Pharmacol , vol.67 , pp. 1381-1387
    • Saario, S.M.1    Savinainen, J.R.2    Laitinen, J.T.3
  • 105
    • 24944508307 scopus 로고    scopus 로고
    • Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes
    • Saario SM, Salo OM, Nevalainen T et al. (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem Biol 12:649-656
    • (2005) Chem Biol , vol.12 , pp. 649-656
    • Saario, S.M.1    Salo, O.M.2    Nevalainen, T.3
  • 106
    • 39149110920 scopus 로고    scopus 로고
    • The novel cannabinoid CB(1) receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats
    • Sink KS, McLaughlin PJ, Wood JA et al. (2008) The novel cannabinoid CB(1) receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 33:946-955
    • (2008) Neuropsychopharmacology , vol.33 , pp. 946-955
    • Sink, K.S.1    McLaughlin, P.J.2    Wood, J.A.3
  • 107
    • 0029866824 scopus 로고    scopus 로고
    • A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2
    • Song ZH, Bonner TI (1996) A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2. Mol Pharmacol 49:891-896
    • (1996) Mol Pharmacol , vol.49 , pp. 891-896
    • Song, Z.H.1    Bonner, T.I.2
  • 108
    • 33745195042 scopus 로고    scopus 로고
    • Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
    • Sugiura T, Kishimoto S, Oka S et al. (2006) Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog Lipid Res 45:405-446
    • (2006) Prog Lipid Res , vol.45 , pp. 405-446
    • Sugiura, T.1    Kishimoto, S.2    Oka, S.3
  • 109
    • 31844433721 scopus 로고    scopus 로고
    • Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia
    • Suplita RL 2nd, Gutierrez T, Fegley D et al. (2006) Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacology 50:372-379
    • (2006) Neuropharmacology , vol.50 , pp. 372-379
    • Suplita II, R.L.1    Gutierrez, T.2    Fegley, D.3
  • 112
    • 33947604827 scopus 로고    scopus 로고
    • 1cannabinoid receptor as determined through the use of conformationally constrained analogs
    • 1cannabinoid receptor as determined through the use of conformationally constrained analogs. AAPS J 8:E665-E671
    • (2006) AAPS J , vol.8
    • Thomas, B.1    Zhang, Y.2    Brackeen, M.3
  • 113
    • 33750005593 scopus 로고    scopus 로고
    • On the formation of [H3C-S-S-CH3]+* ions from the bis(dimethylthio) mercury molecular ion
    • Tonidandel L, Tarzia G, Antonietti F et al. (2006) On the formation of [H3C-S-S-CH3]+* ions from the bis(dimethylthio) mercury molecular ion. Rapid Commun Mass Spectrom 20:3154-3158
    • (2006) Rapid Commun Mass Spectrom , vol.20 , pp. 3154-3158
    • Tonidandel, L.1    Tarzia, G.2    Antonietti, F.3
  • 114
    • 1842833388 scopus 로고    scopus 로고
    • N-cyclohexanecarbonylpentadecylamine: A selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase
    • Tsuboi K, Hilligsmann C, Vandevoorde S et al. (2004) N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem J 379(Pt 1):99-106
    • (2004) Biochem J , vol.379 , Issue.PART 1 , pp. 99-106
    • Tsuboi, K.1    Hilligsmann, C.2    Vandevoorde, S.3
  • 115
    • 15744378565 scopus 로고    scopus 로고
    • Molecular characterization of N-acylethanolaminehydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase
    • Tsuboi K, Sun YX, Okamoto Y et al. (2005) Molecular characterization of N-acylethanolaminehydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem 280:11082-11092
    • (2005) J Biol Chem , vol.280 , pp. 11082-11092
    • Tsuboi, K.1    Sun, Y.X.2    Okamoto, Y.3
  • 116
    • 34548513526 scopus 로고    scopus 로고
    • The N-acylethanolamine-hydrolyzing acid amidase (NAAA)
    • Tsuboi K, Takezaki N, Ueda N (2007) The N-acylethanolamine-hydrolyzing acid amidase (NAAA). Chem Biodivers 4:1914-1925
    • (2007) Chem Biodivers , vol.4 , pp. 1914-1925
    • Tsuboi, K.1    Takezaki, N.2    Ueda, N.3
  • 117
    • 0032974478 scopus 로고    scopus 로고
    • An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors
    • Ueda N, Yamanaka K, Terasawa Y et al. (1999) An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors. FEBS Lett 454:267-270
    • (1999) FEBS Lett , vol.454 , pp. 267-270
    • Ueda, N.1    Yamanaka, K.2    Terasawa, Y.3
  • 118
    • 0035929564 scopus 로고    scopus 로고
    • Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance
    • Ueda N, Yamanaka K, Yamamoto S (2001) Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. J Biol Chem 276:35552-35557
    • (2001) J Biol Chem , vol.276 , pp. 35552-35557
    • Ueda, N.1    Yamanaka, K.2    Yamamoto, S.3
  • 119
    • 20144388149 scopus 로고    scopus 로고
    • Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
    • Valenzano KJ, Tafesse L, Lee G et al. (2005) Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology 48:658-672
    • (2005) Neuropharmacology , vol.48 , pp. 658-672
    • Valenzano, K.J.1    Tafesse, L.2    Lee, G.3
  • 120
    • 40349114245 scopus 로고    scopus 로고
    • Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors
    • Vandevoorde S (2008) Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors. Curr Top Med Chem 8:247-267
    • (2008) Curr Top Med Chem , vol.8 , pp. 247-267
    • Vandevoorde, S.1
  • 121
    • 23744501056 scopus 로고    scopus 로고
    • Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: Evidence that VDM11 acts as an FAAH substrate
    • Vandevoorde S, Fowler CJ (2005) Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. Br J Pharmacol 145:885-893
    • (2005) Br J Pharmacol , vol.145 , pp. 885-893
    • Vandevoorde, S.1    Fowler, C.J.2
  • 122
    • 33744962965 scopus 로고    scopus 로고
    • Functional analysis of the purified anandamidegenerating phospholipase D as a member of the metallo-beta-lactamase family
    • Wang J, Okamoto Y, Morishita J et al. (2006) Functional analysis of the purified anandamidegenerating phospholipase D as a member of the metallo-beta-lactamase family. J Biol Chem 281:12325-12335
    • (2006) J Biol Chem , vol.281 , pp. 12325-12335
    • Wang, J.1    Okamoto, Y.2    Morishita, J.3
  • 123
    • 33845981826 scopus 로고    scopus 로고
    • A second fatty acid amide hydrolase with variable distribution among placental mammals
    • Wei BQ, Mikkelsen TS, McKinney MK et al. (2006) A second fatty acid amide hydrolase with variable distribution among placental mammals. J Biol Chem 281:36569-36578
    • (2006) J Biol Chem , vol.281 , pp. 36569-36578
    • Wei, B.Q.1    Mikkelsen, T.S.2    McKinney, M.K.3
  • 125
    • 38449088457 scopus 로고    scopus 로고
    • The endocannabinoid system: Novel pathway for cardiometabolic Risk-factor reduction
    • Woods SC (2007) The endocannabinoid system: novel pathway for cardiometabolic Risk-factor reduction. JAAPA 20(Suppl Endocannabinoid):7-10
    • (2007) JAAPA , vol.20 , Issue.SUPPL. , pp. 7-10
    • Woods, S.C.1
  • 126
    • 38349177841 scopus 로고    scopus 로고
    • 2receptor agonist exhibiting analgesic activity in rodent pain models
    • 2receptor agonist exhibiting analgesic activity in rodent pain models. Br J Pharmacol 153:390-401
    • (2008) Br J Pharmacol , vol.153 , pp. 390-401
    • Yao, B.B.1    Hsieh, G.C.2    Frost, J.M.3
  • 127
    • 33847283286 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets
    • Zhang D, Saraf A, Kolasa T et al. (2007) Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology 52:1095-1105
    • (2007) Neuropharmacology , vol.52 , pp. 1095-1105
    • Zhang, D.1    Saraf, A.2    Kolasa, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.