Genome-wide epigenetic modifications in cancer

Progress in Drug Research

Volumn 67, Issue , 2011, Pages 25-49

  Park, Yoon Jung ^a   Claus, Rainer ^a   Weichenhan, Dieter ^a   Plass, Christoph ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ARTICLE; CANCER CELL; CANCER GENETICS; CANCER GROWTH; CANCER SCREENING; CHROMOSOMAL INSTABILITY; CHROMOSOME INACTIVATION; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; DRUG MONITORING; EPIGENETICS; GENE CONTROL; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOME IMPRINTING; GENOMIC INSTABILITY; HISTONE MODIFICATION; HUMAN; HUMAN GENOME; MALIGNANT NEOPLASTIC DISEASE; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; X CHROMOSOME; ANIMAL; EARLY DIAGNOSIS; GENETIC EPIGENESIS; GENETICS; NEOPLASM; REVIEW;

ANIMALS; DNA METHYLATION; EARLY DETECTION OF CANCER; EPIGENESIS, GENETIC; GENOMIC IMPRINTING; GENOMIC INSTABILITY; HUMANS; NEOPLASMS;

EID: 79952112864     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7643-8989-5_2     Document Type: Article

References (125)

1. Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69(6):915-926
2. Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3):247-257 (Pubitemid 29519904)
3. Tachibana M, Sugimoto K, Nozaki M et al (2002) G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev 16(14):1779-1791 (Pubitemid 34803894)
4. O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T (2001) The polycomb- group gene Ezh2 is required for early mouse development. Mol Cell Biol 21 (13):4330-4336 (Pubitemid 32565314)
5. Sasaki H, Matsui Y (2008) Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet 9(2):129-140
6. Ooi SK, Bestor TH (2008) The colorful history of active DNA demethylation. Cell 133 (7):1145-1148 (Pubitemid 351852922)
7. Kriaucionis S, Heintz N (2009) The nuclear DNA base 5- hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324(5929):929-930
8. Tahiliani M, Koh KP, Shen Y et al (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324(5929):930-935
9. Suzuki MM, Bird A (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9(6):465-476 (Pubitemid 351693975)
10. Illingworth RS, Bird AP (2009) CpG islands - 'a rough guide'. FEBS Lett 583(11): 1713-1720
11. Kurdistani SK, Tavazoie S, Grunstein M (2004) Mapping global histone acetylation patterns to gene expression. Cell 117(6):721-733 (Pubitemid 38748889)
12. Schotta G, Lachner M, Sarma K et al (2004) A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 18(11):1251-1262 (Pubitemid 38720593)
13. Li B, Carey M, Workman JL (2007) The role of chromatin during transcription. Cell 128 (4):707-719 (Pubitemid 46273570)
14. Heintzman ND, Hon GC, Hawkins RD et al (2009) Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459(7243):108-112
15. Cedar H, Bergman Y (2009) Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 10(5):295-304
16. Gibbons RJ, McDowell TL, Raman S et al (2000) Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat Genet 24 (4):368-371 (Pubitemid 30187434)
17. Knoepfler PS, Eisenman RN (1999) Sin meets NuRD and other tails of repression. Cell 99 (5):447-450
18. Eckhardt F, Lewin J, Cortese R et al (2006) DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet 38(12):1378-1385 (Pubitemid 44837559)
19. Rakyan VK, Down TA, Thorne NP et al (2008) An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res 18(9):1518-1529
20. Yoon B, Herman H, Hu B et al (2005) Rasgrf1 imprinting is regulated by a CTCF-dependent methylation-sensitive enhancer blocker. Mol Cell Biol 25(24):11184-11190 (Pubitemid 41747157)
21. Bell AC, Felsenfeld G (2000) Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene [see comments]. Nature 405(6785):482-485 (Pubitemid 30367427)
22. Illingworth R, Kerr A, Desousa D et al (2008) A novel CpG island set identifies tissuespecific methylation at developmental gene loci. PLoS Biol 6(1):e22
23. Irizarry RA, Ladd-Acosta C, Wen B et al (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 41(2):178-186
24. Bernstein BE, Mikkelsen TS, Xie X et al (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125(2):315-326
25. Mikkelsen TS, Ku M, Jaffe DB et al (2007) Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448(7153):553-560 (Pubitemid 47206934)
26. Fouse SD, Shen Y, Pellegrini M et al (2008) Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2(2):160-169 (Pubitemid 351168712)
27. Surani MA, Durcova-Hills G, Hajkova P, Hayashi K, TeeWW(2008) Germ line, stem cells, and epigenetic reprogramming. Cold Spring Harb Symp Quant Biol 73:9-15
28. Hemberger M, Dean W, Reik W (2009) Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol 10(8):526-537
29. Plass C, Soloway PD (2002) DNA methylation, imprinting and cancer. Eur J Hum Genet 10 (1):6-16 (Pubitemid 34229046)
30. Hark AT, Schoenherr CJ, Katz DJ, Ingram RS, Levorse JM, Tilghman SM (2000) CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus [see comments]. Nature 405(6785):486-489 (Pubitemid 30367428)
31. Umlauf D, Goto Y, Cao R et al (2004) Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet 36(12):1296-1300 (Pubitemid 39577938)
32. Wagschal A, Sutherland HG, Woodfine K et al (2008) G9a histone methyltransferase contributes to imprinting in the mouse placenta. Mol Cell Biol 28(3):1104-1113 (Pubitemid 351160066)
33. Jelinic P, Shaw P (2007) Loss of imprinting and cancer. J Pathol 211(3):261-268 (Pubitemid 46172701)
34. Payer B, Lee JT (2008) X chromosome dosage compensation: how mammals keep the balance. Annu Rev Genet 42:733-772
35. Lee TI, Jenner RG, Boyer LA et al (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125(2):301-313 (Pubitemid 44313811)
36. Goll MG, Bestor TH (2005) Eukaryotic cytosine methyltransferases. Annu Rev Biochem 74:481-514 (Pubitemid 40995515)
37. Lees-Murdock DJ, Frantz DE, Elici M, Walsh CP (2003) Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage. Genomics 82(2):230-237 (Pubitemid 36808623)
38. Bourc'his D, Bestor TH (2004) Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431(7004):96-99 (Pubitemid 39215115)
39. Webster KE, O'Bryan MK, Fletcher S et al (2005) Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci USA 102(11):4068-4073 (Pubitemid 40388556)
40. Kuramochi-Miyagawa S, Watanabe T, Gotoh K et al (2008) DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev 22(7):908-917 (Pubitemid 351482844)
41. Clark SJ, Harrison J, Paul CL, Frommer M (1994) High sensitivity mapping of methylated cytosines. Nucleic Acids Res 22(15):2990-2997 (Pubitemid 24260626)
42. Brena RM, Huang TH, Plass C (2006) Quantitative assessment of DNA methylation: potential applications for disease diagnosis, classification, and prognosis in clinical settings. J Mol Med 84(5):365-377 (Pubitemid 43673611)
43. Kane MF, Loda M, Gaida GM et al (1997) Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57(5):808-811 (Pubitemid 27097998)
44. Herman JG, Umar A, Polyak K et al (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95 (12):6870-6875 (Pubitemid 28278073)
45. Dobrovic A, Simpfendorfer D (1997) Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res 57(16):3347-3350 (Pubitemid 27355472)
46. Rice JC, Massey-Brown KS, Futscher BW (1998) Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells. Oncogene 17(14):1807-1812 (Pubitemid 28482783)
47. Raval A, Tanner SM, Byrd JC et al (2007) Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell 129(5):879-890 (Pubitemid 46813150)
48. Merlo A, Herman JG, Mao L et al (1995) 50 CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers [see comments]. Nat Med 1(7):686-692
49. Bartkova J, Lukas J, Muller H, Strauss M, Gusterson B, Bartek J (1995) Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res 55 (4):949-956
50. Otterson GA, Khleif SN, Chen W, Coxon AB, Kaye FJ (1995) CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 20deoxycytidine. Oncogene 11(6):1211-1216
51. Diala ES, Cheah MS, Rowitch D, Hoffman RM (1983) Extent of DNA methylation in human tumor cells. J Natl Cancer Inst 71(4):755-764 (Pubitemid 14232390)
52. Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE, Feinberg AP (1993) Relaxation of imprinted genes in human cancer. Nature 362(6422):747-749 (Pubitemid 23125977)
53. Ogawa O, Becroft DM, Morison IM et al (1993) Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism. Nat Genet 5 (4):408-412 (Pubitemid 23351315)
54. Huang TH, Perry MR, Laux DE (1999) Methylation profiling of CpG islands in human breast cancer cells. Hum Mol Genet 8(3):459-470 (Pubitemid 29097334)
55. Smiraglia DJ, Plass C (2002) The study of aberrant methylation in cancer via restriction landmark genomic scanning. Oncogene 21(35):5414-5426 (Pubitemid 34983478)
56. Toyota M, Ho C, Ahuja N et al (1999) Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res 59(10):2307-2312 (Pubitemid 29242273)
57. Rush LJ, Dai Z, Smiraglia DJ et al (2001) Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci. Blood 97(10):3226-3233
58. Raval A, Rush LJ, Funchain P et al (2002) Aberrant DNA methylation in chronic lymphocytic leukemia: a role in pathogenesis? Blood 100(11):379a
59. Dai Z, Lakshmanan RR, Zhu WG et al (2001) Global methylation profiling of lung cancer identifies novel methylated genes. Neoplasia 3(4):314-323 (Pubitemid 32801881)
60. Smiraglia DJ, Smith LT, Lang JC et al (2003) Differential targets of CpG island hypermethylation in primary and metastatic head and neck squamous cell carcinoma (HNSCC). J Med Genet 40(1):25-33 (Pubitemid 36115121)
61. Wei SH, Chen CM, Strathdee G et al (2002) Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers. Clin Cancer Res 8:2246-2252 (Pubitemid 34753597)
62. Costello JF, Fruhwald MC, Smiraglia DJ et al (2000) Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nature Genet 24(2):132-138 (Pubitemid 30094712)
63. Plass C, Smiraglia DJ (2006) Genome-wide analysis of DNA methylation changes in human malignancies. Curr Top Microbiol Immunol 310:179-198 (Pubitemid 47400290)
64. Bialik S, Kimchi A (2006) The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem 75:189-210 (Pubitemid 44118031)
65. Liu TX, Becker MW, Jelinek J et al (2007) Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med 13(1):78-83 (Pubitemid 46067389)
66. Smith LT, Lin M, Brena RM et al (2006) Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. Proc Natl Acad Sci USA 103 (4):982-987 (Pubitemid 43212208)
67. Knudson AG Jr (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68(4):820-823
68. Ohm JE, McGarvey KM, Yu X et al (2007) A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 39(2):237-242 (Pubitemid 46184356)
69. Widschwendter M, Fiegl H, Egle D et al (2007) Epigenetic stem cell signature in cancer. Nat Genet 39(2):157-158 (Pubitemid 46184343)
70. Schlesinger Y, Straussman R, Keshet I et al (2007) Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 39 (2):232-236 (Pubitemid 46184355)
71. Fraga MF, Ballestar E, Villar-Garea A et al (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 37(4):391-400
72. Hatada I, Fukasawa M, Kimura M et al (2006) Genome-wide profiling of promoter methylation in human. Oncogene 25(21):3059-3064 (Pubitemid 43780470)
73. Khulan B, Thompson RF, Ye K et al (2006) Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res 16(8):1046-1055 (Pubitemid 44162264)
74. Fazzari MJ, Greally JM (2004) Epigenomics: beyond CpG islands. Nat Rev Genet 5 (6):446-455 (Pubitemid 38915411)
75. Oda M, Glass JL, Thompson RF et al (2009) High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res 37(12):3829-3839
76. Meissner A, Mikkelsen TS, Gu H et al (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454(7205):766-770
77. Weber M, Davies JJ, Wittig D et al (2005) Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 37(8):853-862 (Pubitemid 41077111)
78. Gebhard C, Schwarzfischer L, Pham TH et al (2006) Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia. Cancer Res 66(12):6118-6128
79. Rauch T, Li H, Wu X, Pfeifer GP (2006) MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells. Cancer Res 66(16):7939-7947 (Pubitemid 44299157)
80. Ball MP, Li JB, Gao Y et al (2009) Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol 27(4):361-368
81. Deng J, Shoemaker R, Xie B et al (2009) Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol 27(4):353-360
82. Hodges E, Smith A, Kendall J et al (2009) High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res 19 (9):1593-1605
83. Down TA, Rakyan VK, Turner DJ et al (2008) A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol 26(7):779-785 (Pubitemid 351961453)
84. Pelizzola M, Koga Y, Urban AE et al (2008) MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Res 18(10):1652-1659
85. Chan TL, Yuen ST, Kong CK et al (2006) Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. Nat Genet 38(10):1178-1183 (Pubitemid 44470364)
86. Chen SS, Raval A, Johnson A et al (2009) Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci USA 106(32): 13433-13438
87. Judson H, Stewart A, Leslie A et al (2006) Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas. J Pathol 210(3):344-350 (Pubitemid 44660513)
88. Schulmann K, Sterian A, Berki A et al (2005) Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk. Oncogene 24(25):4138-4148 (Pubitemid 40897058)
89. Banno K, Yanokura M, Susumu N et al (2006) Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer. Oncol Rep 16(6):1189-1196
90. Jeronimo C, Usadel H, Henrique R et al (2001) Quantitation of GSTP1 methylation in nonneoplastic prostatic tissue and organ-confined prostate adenocarcinoma. J Natl Cancer Inst 93(22):1747-1752 (Pubitemid 33130264)
91. Palmisano WA, Divine KK, Saccomanno G et al (2000) Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res 60(21):5954-5958
92. Esteller M, Fraga MF, Guo M et al (2001) DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet 10(26):3001-3007 (Pubitemid 34083486)
93. Moore LE, Pfeiffer RM, Poscablo C et al (2008) Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a casecontrol study. Lancet Oncol 9(4):359-366
94. Jurgens B, Schmitz-Drager BJ, Schulz WA (1996) Hypomethylation of L1 LINE sequences prevailing in human urothelial carcinoma. Cancer Res 56(24):5698-5703 (Pubitemid 26422175)
95. Righini CA, de Fraipont F, Timsit JF et al (2007) Tumor-specific methylation in saliva: a promising biomarker for early detection of head and neck cancer recurrence. Clin Cancer Res 13(4):1179-1185 (Pubitemid 46424058)
96. Esteller M, Gonzalez S, Risques RA et al (2001) K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol 19(2):299-304 (Pubitemid 32112840)
97. Veeck J, Niederacher D, An H et al (2006) Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. Oncogene 25 (24):3479-3488 (Pubitemid 43877051)
98. Widschwendter A, Muller HM, Fiegl H et al (2004) DNA methylation in serum and tumors of cervical cancer patients. Clin Cancer Res 10(2):565-571 (Pubitemid 38173995)
99. Corcoran M, Parker A, Orchard J et al (2005) ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia. Haematologica 90 (8):1078-1088 (Pubitemid 41323507)
100. Hegi ME, Diserens AC, Gorlia T et al (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352(10):997-1003 (Pubitemid 40349502)
101. Strathdee G, MacKean MJ, Illand M, Brown R (1999) A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene 18:2335-2341 (Pubitemid 29192710)
102. Gifford G, Paul J, Vasey PA, Kaye SB, Brown R (2004) The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res 10(13):4420-4426 (Pubitemid 38878884)
103. Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R (2000) Reversal of drug resistance in human tumor xenografts of 20-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res 60:6039-6044
104. Daskalakis M, Nguyen TT, Nguyen C et al (2002) Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-20-deoxycytidine (decitabine) treatment. Blood 100(8):2957-2964
105. Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B et al (2006) Phase I/II study of the combination of 5-aza-20-deoxycytidine with valproic acid in patients with leukemia. Blood 108(10):3271-3279
106. Saunthararajah Y, Hillery CA, Lavelle D et al (2003) Effects of 5-aza-20-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease. Blood 102(12):3865-3870 (Pubitemid 37486964)
107. Laird PW, Jackson-Grusby L, Fazeli A et al (1995) Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81(2):197-205
108. Opavsky R, Wang SH, Trikha P et al (2007) CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet 3(9):1757-1769 (Pubitemid 47510267)
109. Bailey VJ, Easwaran H, Zhang Y et al (2009) MS-qFRET: a quantum dot-based method for analysis of DNA methylation. Genome Res 19(8):1455-1461
110. Nakayama M, Bennett CJ, Hicks JL et al (2003) Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am J Pathol 163(3):923-933 (Pubitemid 37040128)
111. Goessl C, Krause H, Muller M et al (2000) Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids. Cancer Res 60 (21):5941-5945
112. Goessl C, Muller M, Miller K (2000) Methylation-specific PCR (MSP) for detection of tumour DNA in the blood plasma and serum of patients with prostate cancer. Prostate Cancer Prostatic Dis 3(S1):S17
113. Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS (2007) Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large populationbased sample. J Mol Diagn 9(3):305-314 (Pubitemid 47305066)
114. Esteller M, Gaidano G, Goodman SN et al (2002) Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large Bcell lymphoma. J Natl Cancer Inst 94(1):26-32
115. Hibi K, Taguchi M, Nakayama H et al (2001) Molecular detection of p16 promoter methylation in the serum of patients with esophageal squamous cell carcinoma. Clin Cancer Res 7(10):3135-3138 (Pubitemid 32963835)
116. Feng Q, Balasubramanian A, Hawes SE et al (2005) Detection of hypermethylated genes in women with and without cervical neoplasia. J Natl Cancer Inst 97(4):273-282 (Pubitemid 40310275)
117. Brock MV, Hooker CM, Ota-Machida E et al (2008) DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 358(11):1118-1128 (Pubitemid 351398486)
118. Belinsky SA, Palmisano WA, Gilliland FD et al (2002) Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res 62 (8):2370-2377 (Pubitemid 34411720)
119. Wong IH, Lo YM, Zhang J et al (1999) Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res 59(1):71-73 (Pubitemid 29062959)
120. Esteller M, Garcia-Foncillas J, Andion E et al (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343 (19):1350-1354
121. Watanabe H, Okada G, Ohtsubo K et al (2006) Aberrant methylation of secreted apoptosisrelated protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms. Pancreas 32(4):382-389 (Pubitemid 43772194)
122. Friedrich MG, Chandrasoma S, Siegmund KD et al (2005) Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Eur J Cancer 41 (17):2769-2778 (Pubitemid 41607571)
123. Lombaerts M, van Wezel T, Philippo K et al (2006) E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J Cancer 94(5):661-671 (Pubitemid 43361897)
124. Chiles MC, Ai L, Zuo C, Fan CY, Smoller BR (2003) E-cadherin promoter hypermethylation in preneoplastic and neoplastic skin lesions. Mod Pathol 16(10):1014-1018 (Pubitemid 37280817)
125. Richiardi L, Fiano V, Vizzini L et al (2009) Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients. J Clin Oncol 27(19):3161-3168