Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk

Oncogene

Volumn 24, Issue 25, 2005, Pages 4138-4148

  Schulmann, Karsten ^a,b   Sterian, Anca ^a   Berki, Agnes ^a   Yin, Jing ^a   Sato, Fumiaki ^a,c   Xu, Yan ^a   Olaru, Andreea ^a   Wang, Suna ^a   Mori, Yuriko ^a,c   Deacu, Elena ^a   Hamilton, James ^a   Kan, Takatsugu ^a   Krasna, Mark J ^a,c   Beer, David G ^d   Pepe, Margaret S ^e   Abraham, John M ^a   Feng, Ziding ^e   Schmiegel, Wolff ^b   Greenwald, Bruce D ^a,c   Meltzer, Stephen J ^a,c,f  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^d UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

^f BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

Barrett's esophagus; Cancer biomarkers; Early cancer detection; Esophageal cancer; Hypermethylation; Neoplastic progression

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; APC PROTEIN; CELLULAR RETINOL BINDING PROTEIN 1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN 3 OST 2; PROTEIN HPP1; PROTEIN P14; PROTEIN P16; PROTEIN RIZ1; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSCRIPTION FACTOR RUNX3; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; BARRETT ESOPHAGUS; CONTROLLED STUDY; DYSPLASIA; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGOSCOPY; FEMALE; GENE INACTIVATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; KAPLAN MEIER METHOD; LONGITUDINAL STUDY; MALE; MALIGNANT TRANSFORMATION; METHYLATION; MULTIVARIATE ANALYSIS; NONBIOLOGICAL MODEL; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; RISK FACTOR; ROC CURVE; SENSITIVITY AND SPECIFICITY;

ADENOCARCINOMA; BARRETT ESOPHAGUS; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 3 SUBUNIT; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; DNA METHYLATION; DNA, NEOPLASM; DNA-BINDING PROTEINS; ESOPHAGEAL NEOPLASMS; HUMANS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, NEOPLASM; TRANSCRIPTION FACTORS;

EID: 21244467485     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208598     Document Type: Article

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