메뉴 건너뛰기




Volumn 10, Issue 2, 2011, Pages 227-251

Novel adjuvants and delivery systems for enhancing immune responses induced by immunogens

Author keywords

adjuvant; immunogen; MF59; MPL; nanoemulsions; PAMPs; PLG microparticles; PRR; SMIP

Indexed keywords

ADJUVANT; ALPHA INTERFERON; ANTIGEN; CHOLERA TOXIN; CPG OLIGODEOXYNUCLEOTIDE; DNA VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPATITIS A VACCINE; HEPATITIS C VACCINE; IMMUNOPOTENTIATING RECONSTITUTED INFLUENZA VIROSOME; INFLUENZA VACCINE; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 7; LIPOSOME; MALARIA VACCINE; MELAN A; MUMPS VACCINE; MURAMYL DIPEPTIDE; MURAMYL TRIPEPTIDE; PHOSPHORYL LIPID A; RECOMBINANT HEPATITIS B VACCINE; SAPONIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIROSOME; VIROSOME VACCINE; WART VIRUS VACCINE;

EID: 79951991406     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/erv.10.142     Document Type: Review
Times cited : (54)

References (278)
  • 1
    • 0002678757 scopus 로고
    • Sur la toxine et surranatoxine diphtheriques
    • Ramon G. Sur la toxine et surranatoxine diphtheriques. Ann. Inst. Pasteur 38, 1-7 (1924)
    • (1924) Ann. Inst. Pasteur , vol.38 , pp. 1-7
    • Ramon, G.1
  • 2
    • 0029200883 scopus 로고
    • A compendium of vaccine adjuvants and excipients
    • Powell MF, Newman MJ (Eds) Plenum Press, NY, USA
    • Vogel FR, Powell MF. A compendium of vaccine adjuvants and excipients. In: Vaccine Design: The Subunit and Adjuvant Approach. Powell MF, Newman MJ (Eds). Plenum Press, NY, USA, 141-228 (1995)
    • (1995) Vaccine Design: The Subunit and Adjuvant Approach , pp. 141-228
    • Vogel, F.R.1    Powell, M.F.2
  • 3
    • 0002767893 scopus 로고    scopus 로고
    • Adjuvants for the future
    • Levine MM, Woodrow GC, Kaper JB, Cobon GS (Eds). Marcel Dekker Inc., NY, USA
    • Edelman R. Adjuvants for the future. In: New Generation Vaccines. Levine MM, Woodrow GC, Kaper JB, Cobon GS (Eds). Marcel Dekker Inc., NY, USA, 173-192 (1997)
    • (1997) New Generation Vaccines , pp. 173-192
    • Edelman, R.1
  • 4
    • 7044274793 scopus 로고    scopus 로고
    • Aluminium compounds for use in vaccines
    • DOI 10.1111/j.0818-9641.2004.01286.x
    • Lindblad EB. Aluminium comp (Pubitemid 39421059)
    • (2004) Immunology and Cell Biology , vol.82 , Issue.5 , pp. 497-505
    • Lindblad, E.B.1
  • 5
    • 4243187214 scopus 로고    scopus 로고
    • Aluminium adjuvant - In retrospect and prospect
    • Lindblad EB. Aluminium adjuvant - in retrospect and prospect. Vaccine 22(27-28), 3658-3668 (2004)
    • (2004) Vaccine , vol.22 , Issue.27-28 , pp. 3658-3668
    • Lindblad, E.B.1
  • 6
    • 35349019722 scopus 로고    scopus 로고
    • MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection
    • O'Hagan DT. MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection. Expert Rev. Vaccines 6(5), 699-710 (2007)
    • (2007) Expert Rev. Vaccines , vol.6 , Issue.5 , pp. 699-710
    • O'Hagan, D.T.1
  • 7
    • 53749098101 scopus 로고    scopus 로고
    • Antigenically distinct MF59- adjuvanted vaccine to boost immunity to H5N1
    • Stephenson I, Nicholson KG, Hoschler K, et al. Antigenically distinct MF59- adjuvanted vaccine to boost immunity to H5N1. N. Engl. J. Med. 359(15), 1631-1633 (2008)
    • (2008) N. Engl. J. Med. , vol.359 , Issue.15 , pp. 1631-1633
    • Stephenson, I.1    Nicholson, K.G.2    Hoschler, K.3
  • 8
    • 57649198020 scopus 로고    scopus 로고
    • Immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04- adjuvanted vaccine in healthy boys aged 10-18 years
    • Petaja T, Keranen H, Karppa T, et al. Immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04- adjuvanted vaccine in healthy boys aged 10-18 years. J. Adolesc. Health 44(1), 33-40 (2009)
    • (2009) J. Adolesc. Health , vol.44 , Issue.1 , pp. 33-40
    • Petaja, T.1    Keranen, H.2    Karppa, T.3
  • 9
    • 0032755036 scopus 로고    scopus 로고
    • Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines
    • DOI 10.1006/meth.1999.0834
    • Baldridge JR, Crane RT. Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines. Methods 19(1), 103-107 (1999) (Pubitemid 29497759)
    • (1999) Methods: A Companion to Methods in Enzymology , vol.19 , Issue.1 , pp. 103-107
    • Baldridge, J.R.1    Crane, R.T.2
  • 11
    • 0033426879 scopus 로고    scopus 로고
    • Archaeobacterial ether lipid liposomes (archaeosomes) as novel vaccine and drug delivery systems
    • Patel GB, Sprott GD. Archaeobacterial ether lipid liposomes (archaeosomes) as novel vaccine and drug delivery systems. Crit. Rev. Biotechnol. 19(4), 317-357 (1999) (Pubitemid 30036089)
    • (1999) Critical Reviews in Biotechnology , vol.19 , Issue.4 , pp. 317-357
    • Patel, G.B.1    Sprott, G.D.2
  • 12
    • 1942475301 scopus 로고    scopus 로고
    • Archaeosomes as self-adjuvanting delivery systems for cancer vaccines
    • DOI 10.1080/10611860410001670044, Strategies for Vaccine Delivery
    • Krishnan L, Dennis Sprott G. Archaeosomes as self-adjuvanting delivery systems for cancer vaccines. J. Drug Target. 11(8-10), 515-524 (2003) (Pubitemid 38519161)
    • (2003) Journal of Drug Targeting , vol.11 , Issue.8-10 , pp. 515-524
    • Krishnan, L.1    Sprott, G.D.2
  • 13
    • 0033957435 scopus 로고    scopus 로고
    • Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: Comparison to conventional liposomes and alum
    • Krishnan L, Dicaire CJ, Patel GB, Sprott GD. Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum. Infect. Immun. 68(1), 54-63 (2000) (Pubitemid 30016677)
    • (2000) Infection and Immunity , vol.68 , Issue.1 , pp. 54-63
    • Krishnan, L.1    Dicaire, C.J.2    Patel, G.B.3    Sprott, G.D.4
  • 14
    • 77951553269 scopus 로고    scopus 로고
    • Recent advances in mucosal delivery of vaccines: Role of mucoadhesive/biodegradable polymeric carriers
    • Mishra N, Goyal AK, Tiwari S, et al. Recent advances in mucosal delivery of vaccines: role of mucoadhesive/biodegradable polymeric carriers. Expert Opin. Ther. Pat. 20(5), 661-679 (2010)
    • (2010) Expert Opin. Ther. Pat. , vol.20 , Issue.5 , pp. 661-679
    • Mishra, N.1    Goyal, A.K.2    Tiwari, S.3
  • 16
    • 36048962961 scopus 로고    scopus 로고
    • How do adjuvants work? Important considerations for new generation adjuvants
    • DOI 10.1016/j.immuni.2007.11.003, PII S1074761307004980
    • McKee AS, Munks MW, Marrack P. How do adjuvants work? Important considerations for new generation adjuvants. Immunity 27(5), 687-690 (2007) (Pubitemid 350102263)
    • (2007) Immunity , vol.27 , Issue.5 , pp. 687-690
    • McKee, A.S.1    Munks, M.W.2    Marrack, P.3
  • 17
    • 0030975532 scopus 로고    scopus 로고
    • Antigen localisation regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity
    • Zinkernagel RM, Ehl S, Aichele P, Oehen S, Kundig T, Hengartner H. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156, 199-209 (1997) (Pubitemid 27197203)
    • (1997) Immunological Reviews , vol.156 , pp. 199-209
    • Zinkernagel, R.M.1    Ehl, S.2    Aichele, P.3    Oehen, S.4    Kundig, T.5    Hengartner, H.6
  • 19
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila toll protein signals activation of adaptive immunity
    • DOI 10.1038/41131
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [see comments]. Nature 388(6640), 394-397 (1997) (Pubitemid 27334820)
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 20
    • 0030831201 scopus 로고    scopus 로고
    • Seeking wisdom in innate immunity
    • DOI 10.1038/40967
    • Fearon DT. Seeking wisdom in innate immunity. Nature 388(6640), 323-324 (1997) (Pubitemid 27334792)
    • (1997) Nature , vol.388 , Issue.6640 , pp. 323-324
    • Fearon, D.T.1
  • 21
    • 0029987839 scopus 로고    scopus 로고
    • The instructive role of innate immunity in the acquired immune response
    • Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 272(5258), 50-53 (1996)
    • (1996) Science , vol.272 , Issue.5258 , pp. 50-53
    • Fearon, D.T.1    Locksley, R.M.2
  • 23
    • 0020056981 scopus 로고
    • Preparation and antitumor activity of nontoxic lipid A
    • Ribi E, Amano K, Cantrell JL, Schwartzman S, Parker R, Takayama K. Preparation and antitumor activity of nontoxic lipid A. Cancer Immunol. Immunother. 12, 91-96 (1982) (Pubitemid 12192020)
    • (1982) Cancer Immunology, Immunotherapy , vol.12 , Issue.2 , pp. 91-96
    • Ribi, E.1    Amano, K.2    Cantrell, J.3
  • 24
    • 0020367633 scopus 로고
    • Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium
    • Qureshi N, Takayama K, Ribi E. Purification and structural determination of nontoxic lipid A obtained form the lipopolysaccharide of Salmonella typhimurium. J. Biol. Chem. 257(19), 11808-11815 (1982) (Pubitemid 13218648)
    • (1982) Journal of Biological Chemistry , vol.257 , Issue.19 , pp. 11808-11815
    • Qureshi, N.1    Takayama, K.2    Ribi, E.3
  • 27
    • 0027205150 scopus 로고
    • Abrogation of suppression of delayed hypersensitivity induced by Candida albicans-derived mannan by treatment with monophosphoryl lipid A
    • Domer JE, Human LG, Andersen GB, Rudbach JA, Asherson GL. Abrogation of suppression of delayed hypersensitivity induced by Candida albicans-derived mannan by treatment with monophosphoryl lipid A. Infect. Immun. 61(5), 2122-2130 (1993) (Pubitemid 23145922)
    • (1993) Infection and Immunity , vol.61 , Issue.5 , pp. 2122-2130
    • Domer, J.E.1    Human, L.G.2    Andersen, G.B.3    Rudbach, J.A.4    Asherson, G.L.5
  • 28
    • 0026703432 scopus 로고
    • Bacterial cell wall products as adjuvants: Early interferon g as a marker for adjuvants that enhance protective immunity
    • Gustafson GL, Rhodes MJ. Bacterial cell wall products as adjuvants: early interferon g as a marker for adjuvants that enhance protective immunity. Res. Immunol. 143(5), 483-488 (1992)
    • (1992) Res. Immunol. , vol.143 , Issue.5 , pp. 483-488
    • Gustafson, G.L.1    Rhodes, M.J.2
  • 29
    • 0025939042 scopus 로고
    • Evaluation of monophosphoryl lipid A (MPL) as an adjuvant. Enhancement of the serum antibody response in mice to polysaccharide-protein conjugates by concurrent injection with MPL
    • Schneerson R, Fattom A, Szu SC, et al. Evaluation of monophosphoryl lipid A (MPL) as an adjuvant. Enhancement of the serum antibody response in mice to polysaccharide-protein conjugates by concurrent injection with MPL. J. Immunol. 147(7), 2136-2140 (1991)
    • (1991) J. Immunol. , vol.147 , Issue.7 , pp. 2136-2140
    • Schneerson, R.1    Fattom, A.2    Szu, S.C.3
  • 30
    • 0026773798 scopus 로고
    • Immune responses of systemic and mucosal lymphoid organs to Pnu-Imune vaccine as a function of age and the efficacy of monophosphoryl lipid A as an adjuvant
    • Garg M, Subbarao B. Immune responses of systemic and mucosal lymphoid organs to Pnu-Imune vaccine as a function of age and the efficacy of monophosphoryl lipid A as an adjuvant. Infect. Immun. 60(6), 2329-2336 (1992)
    • (1992) Infect. Immun. , vol.60 , Issue.6 , pp. 2329-2336
    • Garg, M.1    Subbarao, B.2
  • 32
    • 0026571596 scopus 로고
    • Liposomal malaria vaccine in humans: A safe and potent adjuvant strategy
    • Fries LF, Gordon DM, Richards RL, et al. Liposomal malaria vaccine in humans: a safe and potent adjuvant strategy. Proc. Natl Acad. Sci. USA 89(1), 358-362 (1992)
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , Issue.1 , pp. 358-362
    • Fries, L.F.1    Gordon, D.M.2    Richards, R.L.3
  • 36
    • 0023744752 scopus 로고
    • Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Methods used and chemicals evaluated
    • Mitchell AD, Myhr BC, Rudd CJ, Caspary WJ, Dunkel VC. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: methods used and chemicals evaluated. Environ. Mol. Mutagen. 12(Suppl. 13), 1-18 (1988)
    • (1988) Environ. Mol. Mutagen. , vol.12 , Issue.SUPPL. 13 , pp. 1-18
    • Mitchell, A.D.1    Myhr, B.C.2    Rudd, C.J.3    Caspary, W.J.4    Dunkel, V.C.5
  • 37
    • 0023686538 scopus 로고
    • Active specific immunotherapy for melanoma: Phase i trial of allogeneic lysates and a novel adjuvant
    • Mitchell MS, Kan-Mitchell J, Kempf RA, Harel W, Shau HY, Lind S. Active specific immunotherapy for melanoma: Phase I trial of allogeneic lysates and a novel adjuvant. Cancer Res. 48(20), 5883-5893 (1988)
    • (1988) Cancer Res. , vol.48 , Issue.20 , pp. 5883-5893
    • Mitchell, M.S.1    Kan-Mitchell, J.2    Kempf, R.A.3    Harel, W.4    Shau, H.Y.5    Lind, S.6
  • 38
    • 0026596442 scopus 로고
    • Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen- Friedenreich) determinant using a synthetic carbohydrate antigen
    • MacLean GD, Bowen-Yacyshyn MB, Samuel J, et al. Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen- Friedenreich) determinant using a synthetic carbohydrate antigen. J. Immunother. 11(4), 292-305 (1992)
    • (1992) J. Immunother. , vol.11 , Issue.4 , pp. 292-305
    • MacLean, G.D.1    Bowen-Yacyshyn, M.B.2    Samuel, J.3
  • 40
    • 0025756798 scopus 로고
    • Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine
    • Rickman LS, Gordon DM, Wistar R Jr, et al. Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine. Lancet 337(8748), 998-1001 (1991)
    • (1991) Lancet , vol.337 , Issue.8748 , pp. 998-1001
    • Rickman, L.S.1    Gordon, D.M.2    Wistar, Jr.R.3
  • 41
    • 0029057169 scopus 로고
    • Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein- hepatitis B surface antigen subunit vaccine
    • Gordon DM, McGovern TW, Krzych U, et al. Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein- hepatitis B surface antigen subunit vaccine. J. Infect. Dis. 171(6), 1576-1585 (1995)
    • (1995) J. Infect. Dis. , vol.171 , Issue.6 , pp. 1576-1585
    • Gordon, D.M.1    McGovern, T.W.2    Krzych, U.3
  • 42
    • 0034995781 scopus 로고    scopus 로고
    • A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections
    • DOI 10.1034/j.1398-9995.2001.056006498.x
    • Drachenberg KJ, Wheeler AW, Stuebner P, Horak F. A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Allergy 56(6), 498-505 (2001) (Pubitemid 32521429)
    • (2001) Allergy: European Journal of Allergy and Clinical Immunology , vol.56 , Issue.6 , pp. 498-505
    • Drachenberg, K.J.1    Wheeler, A.W.2    Stuebner, P.3    Horak, F.4
  • 43
    • 33845874634 scopus 로고    scopus 로고
    • Pollinex® Quattro: A novel and well-tolerated, ultra short-course allergy vaccine
    • DOI 10.1586/14760584.5.5.617
    • Patel P, Salapatek AM. Pollinex Quattro: a novel and well-tolerated, ultra short-course allergy vaccine. Expert Rev. Vaccines 5(5), 617-629 (2006) (Pubitemid 46021044)
    • (2006) Expert Review of Vaccines , vol.5 , Issue.5 , pp. 617-629
    • Patel, P.1    Salapatek, A.M.F.2
  • 44
    • 0028941862 scopus 로고
    • Immunopharmacological activities and clinical development of muramyl peptides with particular emphasis on murabutide
    • Bahr GM, Darcissac E, Bevec D, Dukor P, Chedid L. Immunopharmacological activities and clinical development of muramyl peptides with particular emphasis on murabutide. Int. J. Immunopharmacol. 17(2), 117-131 (1995)
    • (1995) Int. J. Immunopharmacol. , vol.17 , Issue.2 , pp. 117-131
    • Bahr, G.M.1    Darcissac, E.2    Bevec, D.3    Dukor, P.4    Chedid, L.5
  • 45
    • 8044245915 scopus 로고    scopus 로고
    • Adjuvancy and reactogenicity of N-acetylglucosaminyl-N-acetylmuramyl- dipeptide (GMDP) orally administered just prior to trivalent influenza subunit vaccine
    • Palache AM, Beyer WE, Hendriksen E, et al. Adjuvancy and reactogenicity of N-acetylglucosaminyl-N-acetylmuramyl-dipeptide (GMDP) orally administered just prior to trivalent influenza subunit vaccine. A double-blind placebo-controlled study in nursing home residents. Vaccine 14(14), 1327-1330 (1996)
    • (1996) A Double-blind Placebo-controlled Study in Nursing Home Residents. Vaccine , vol.14 , Issue.14 , pp. 1327-1330
    • Palache, A.M.1    Beyer, W.E.2    Hendriksen, E.3
  • 47
    • 0026322202 scopus 로고
    • Immunization against anthrax with Bacillus anthracis protective antigen combined with adjuvants
    • Ivins BE, Welkos SL, Little SF, Crumrine MH, Nelson GO. Immunization against anthrax with Bacillus anthracis protective antigen combined with adjuvants. Infect. Immun. 60(2), 662-668 (1992)
    • (1992) Infect. Immun. , vol.60 , Issue.2 , pp. 662-668
    • Ivins, B.E.1    Welkos, S.L.2    Little, S.F.3    Crumrine, M.H.4    Nelson, G.O.5
  • 48
    • 0027988552 scopus 로고
    • Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gp120 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers
    • Kahn JO, Sinangil F, Baenziger J, et al. Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gp120 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers. J. Infect. Dis. 170(5), 1288-1291 (1994)
    • (1994) J. Infect. Dis. , vol.170 , Issue.5 , pp. 1288-1291
    • Kahn, J.O.1    Sinangil, F.2    Baenziger, J.3
  • 49
    • 0030581386 scopus 로고    scopus 로고
    • Oral application of romurtide, a synthetic muramyl dipeptide derivative, stimulates nonspecific resistance to microbial infections and hematopoiesis in mice
    • DOI 10.1016/0264-410X(96)00015-1
    • Namba K, Nakajima R, Otani T, Azuma I. Oral application of romurtide, a synthetic muramyl dipeptide derivative, stimulates nonspecific resistance to microbial infections and hematopoiesis in mice. Vaccine 14(12), 1149-1153 (1996) (Pubitemid 26348834)
    • (1996) Vaccine , vol.14 , Issue.12 , pp. 1149-1153
    • Namba, K.1    Nakajima, R.2    Otani, T.3    Azuma, I.4
  • 50
    • 0030266150 scopus 로고    scopus 로고
    • Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model
    • DOI 10.1016/S0264-410X(96)00064-3, PII S0264410X96000643
    • Namba K, Nitanai H, Otani T, Azuma I. Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model. Vaccine 14(14), 1322-1326 (1996) (Pubitemid 27008192)
    • (1996) Vaccine , vol.14 , Issue.14 , pp. 1322-1326
    • Namba, K.1    Nitanai, H.2    Otani, T.3    Azuma, I.4
  • 51
    • 0026695583 scopus 로고
    • Phase 1 clinical tests of influenza MDP-virosome vaccine (KD-5382)
    • Kaji M, Kaji Y, Kaji M, et al. Phase 1 clinical tests of influenza MDP-virosome vaccine (KD-5382). Vaccine 10(10), 663-667 (1992)
    • (1992) Vaccine , vol.10 , Issue.10 , pp. 663-667
    • Kaji, M.1    Kaji, Y.2    Kaji, M.3
  • 54
    • 0026458260 scopus 로고
    • Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin
    • Spangler BD. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 56(4), 622-647 (1992)
    • (1992) Microbiol. Rev. , vol.56 , Issue.4 , pp. 622-647
    • Spangler, B.D.1
  • 55
    • 0028985871 scopus 로고
    • Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity
    • Dickinson BL, Clements JD. Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity. Infect. Immun. 63(5), 1617-1623 (1995)
    • (1995) Infect. Immun. , vol.63 , Issue.5 , pp. 1617-1623
    • Dickinson, B.L.1    Clements, J.D.2
  • 56
    • 0030940814 scopus 로고    scopus 로고
    • Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin
    • Douce G, Fontana M, Pizza M, Rappuoli R, Dougan G. Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin. Infect. Immun. 65(7), 2821-2828 (1997) (Pubitemid 27264113)
    • (1997) Infection and Immunity , vol.65 , Issue.7 , pp. 2821-2828
    • Douce, G.1    Fontana, M.2    Pizza, M.3    Rappuoli, R.4    Dougan, G.5
  • 59
    • 0031027336 scopus 로고    scopus 로고
    • Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop
    • Giannelli V, Fontana MR, Giuliani MM, Guangcai D, Rappuoli R, Pizza M. Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop. Infect. Immun. 65(1), 331-334 (1997) (Pubitemid 27008943)
    • (1997) Infection and Immunity , vol.65 , Issue.1 , pp. 331-334
    • Giannelli, V.1    Fontana, M.R.2    Giuliani, M.M.3    Guangcai, D.4    Rappuoli, R.5    Pizza, M.6
  • 60
    • 0032489830 scopus 로고    scopus 로고
    • Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP- ribosyltransferase activity
    • DOI 10.1084/jem.187.7.1123
    • Giuliani MM, Del Giudice G, Giannelli V, et al. Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity. J. Exp. Med. 187, 1123-1132 (1998) (Pubitemid 28176412)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.7 , pp. 1123-1132
    • Giuliani, M.M.1    Del Giudice, G.2    Giannelli, V.3    Dougan, G.4    Douce, G.5    Rappuoli, R.6    Pizza, M.7
  • 61
    • 0033605094 scopus 로고    scopus 로고
    • The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice
    • DOI 10.1016/S0264-410X(98)00252-7, PII S0264410X98002527
    • Barchfeld GL, Hessler AL, Chen M, Pizza M, Rappuoli R, Van Nest GA. The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice. Vaccine 17(7-8), 695-704 (1999) (Pubitemid 29074723)
    • (1999) Vaccine , vol.17 , Issue.7-8 , pp. 695-704
    • Barchfeld, G.L.1    Hessler, A.L.2    Chen, M.3    Pizza, M.4    Rappuoli, R.5    Van Nest, G.A.6
  • 64
    • 64549126021 scopus 로고    scopus 로고
    • Prolonged protection against Intranasal challenge with influenza virus following systemic immunization or combinations of mucosal and systemic immunizations with a heat-labile toxin mutant
    • Zhou F, Goodsell A, Uematsu Y, Vajdy M. Prolonged protection against Intranasal challenge with influenza virus following systemic immunization or combinations of mucosal and systemic immunizations with a heat-labile toxin mutant. Clin. Vaccine Immunol. 16(4), 471-478 (2009)
    • (2009) Clin. Vaccine Immunol. , vol.16 , Issue.4 , pp. 471-478
    • Zhou, F.1    Goodsell, A.2    Uematsu, Y.3    Vajdy, M.4
  • 65
    • 34247174923 scopus 로고    scopus 로고
    • A vaccination strategy to enhance mucosal and systemic antibody and T cell responses against influenza
    • DOI 10.1016/j.clim.2007.01.009, PII S1521661607000332
    • Vajdy M, Baudner B, Del Giudice G, O'Hagan D. A vaccination strategy to enhance mucosal and systemic antibody and T cell responses against influenza. Clin. Immunol. 123(2), 166-175 (2007) (Pubitemid 46590074)
    • (2007) Clinical Immunology , vol.123 , Issue.2 , pp. 166-175
    • Vajdy, M.1    Baudner, B.2    Del Giudice, G.3    O'Hagan, D.4
  • 67
    • 56349094315 scopus 로고    scopus 로고
    • Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge
    • Bogers WM, Davis D, Baak I, et al. Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge. Virology 382(2), 217-225 (2008)
    • (2008) Virology , vol.382 , Issue.2 , pp. 217-225
    • Bogers, W.M.1    Davis, D.2    Baak, I.3
  • 68
    • 38149096202 scopus 로고    scopus 로고
    • Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope
    • Barnett SW, Srivastava IK, Kan E, et al. Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope. AIDS 22(3), 339-348 (2008)
    • (2008) AIDS , vol.22 , Issue.3 , pp. 339-348
    • Barnett, S.W.1    Srivastava, I.K.2    Kan, E.3
  • 69
    • 0032568114 scopus 로고    scopus 로고
    • Skin immunization made possible by cholera toxin [3]
    • DOI 10.1038/36014
    • Glenn GM, Rao M, Matyas GR, Alving CR. Skin immunization made possible by cholera toxin. Nature 391(6670), 851 (1998) (Pubitemid 28157653)
    • (1998) Nature , vol.391 , Issue.6670 , pp. 851
    • Glenn, G.M.1    Rao, M.2    Matyas, G.R.3    Alving, C.R.4
  • 70
    • 0034528538 scopus 로고    scopus 로고
    • Transcutaneous immunization: A human vaccine delivery strategy using a patch
    • DOI 10.1038/82225
    • Glenn GM, Taylor DN, Li X, Frankel S, Montemarano A, Alving CR. Transcutaneous immunization: a human vaccine delivery strategy using a patch. Nat. Med. 6(12), 1403-1406 (2000) (Pubitemid 32001027)
    • (2000) Nature Medicine , vol.6 , Issue.12 , pp. 1403-1406
    • Glenn, G.M.1    Taylor, D.N.2    Li, X.3    Frankel, S.4    Montemarano, A.5    Alving, C.R.6
  • 71
    • 0035015363 scopus 로고    scopus 로고
    • Oral administration of influenza vaccine in combination with the adjuvants LT-K63 and LT-R72 induces potent immune responses comparable to or stronger than traditional intramuscular immunization
    • DOI 10.1128/CDLI.8.3.652-657.2001
    • Barackman JD, Ott G, Pine S, O'Hagan DT. Oral administration of influenza vaccine in combination with the adjuvants LT-K63 and LT-R72 induces potent immune responses comparable to or stronger than traditional intramuscular immunization. Clin. Diagn. Lab. Immunol. 8(3), 652-657 (2001) (Pubitemid 32428899)
    • (2001) Clinical and Diagnostic Laboratory Immunology , vol.8 , Issue.3 , pp. 652-657
    • Barackman, J.D.1    Ott, G.2    Pine, S.3    O'Hagan, D.T.4
  • 72
    • 0032728547 scopus 로고    scopus 로고
    • Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: Differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells
    • Ryan EJ, McNeela E, Murphy GA, et al. Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells. Infect. Immun. 67(12), 6270-6280 (1999)
    • (1999) Infect. Immun. , vol.67 , Issue.12 , pp. 6270-6280
    • Ryan, E.J.1    McNeela, E.2    Murphy, G.A.3
  • 73
    • 0032755492 scopus 로고    scopus 로고
    • Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections
    • Jakobsen H, Schulz D, Pizza M, Rappuoli R, Jonsdottir I. Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections. Infect. Immun. 67(11), 5892-5897 (1999) (Pubitemid 29508115)
    • (1999) Infection and Immunity , vol.67 , Issue.11 , pp. 5892-5897
    • Jakobsen, H.1    Schulz, D.2    Pizza, M.3    Rappuoli, R.4    Jonsdottir, I.5
  • 74
    • 0034601242 scopus 로고    scopus 로고
    • Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1
    • DOI 10.1016/S0168-3659(00)00226-1, PII S0168365900002261
    • Kazzaz J, Neidleman J, Singh M, Ott G, O'Hagan DT. Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1. J. Control Release 67(2-3), 347-356 (2000) (Pubitemid 30303847)
    • (2000) Journal of Controlled Release , vol.67 , Issue.2-3 , pp. 347-356
    • Kazzaz, J.1    Neidleman, J.2    Singh, M.3    Ott, G.4    O'Hagan, D.T.5
  • 76
    • 0035851379 scopus 로고    scopus 로고
    • Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity
    • DOI 10.1016/S0264-410X(01)00321-8, PII S0264410X01003218
    • Singh M, Vajdy M, Gardner J, Briones M, O'Hagan D. Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity. Vaccine 20(3-4), 594-602 (2001) (Pubitemid 32973805)
    • (2001) Vaccine , vol.20 , Issue.3-4 , pp. 594-602
    • Singh, M.1    Vajdy, M.2    Gardner, J.3    Briones, M.4    O'Hagan, D.5
  • 77
    • 0026006734 scopus 로고
    • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
    • Messina JP, Gilkeson GS, Pisetsky DS. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147(6), 1759-1764 (1991)
    • (1991) J. Immunol. , vol.147 , Issue.6 , pp. 1759-1764
    • Messina, J.P.1    Gilkeson, G.S.2    Pisetsky, D.S.3
  • 78
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
    • Tokunaga T, Yamamoto H, Shimada S, et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl Cancer Inst. 72(4), 955-962 (1984) (Pubitemid 14131740)
    • (1984) Journal of the National Cancer Institute , vol.72 , Issue.4 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3
  • 79
    • 0029565353 scopus 로고
    • Phosphorothioate oligodeoxynucleotides: Antisense or anti-protein?
    • Krieg AM, Stein CA. Phosphorothioate oligodeoxynucleotides: antisense or anti-protein? Antisense Res. Dev. 5(4), 241 (1995) (Pubitemid 26041389)
    • (1995) Antisense Research and Development , vol.5 , Issue.4 , pp. 241
    • Krieg, A.M.1    Stein, C.A.2
  • 80
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374(6522), 546-549 (1995)
    • (1995) Nature , vol.374 , Issue.6522 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 82
    • 0030028722 scopus 로고    scopus 로고
    • Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α
    • DOI 10.1006/cimm.1996.0009
    • Halpern MD, Kurlander RJ, Pisetsky DS. Bacterial-DNA induces murine interferon-g production by stimulation of interleukin-12 and tumor-necrosis-factor-a. Cell. Immunol. 167(1), 72-78 (1996) (Pubitemid 26048848)
    • (1996) Cellular Immunology , vol.167 , Issue.1 , pp. 72-78
    • Halpern, M.D.1    Kurlander, R.J.2    Pisetsky, D.S.3
  • 83
    • 0029670726 scopus 로고    scopus 로고
    • IFN-g promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides
    • Yi AK, Chace JH, Cowdery JS, Krieg AM. IFN-g promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J. Immunol. 156(2), 558-564 (1996)
    • (1996) J. Immunol. , vol.156 , Issue.2 , pp. 558-564
    • Yi, A.K.1    Chace, J.H.2    Cowdery, J.S.3    Krieg, A.M.4
  • 84
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • DOI 10.1126/science.1076071
    • Bernasconi NL, Traggiai E, Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298(5601), 2199-2202 (2002) (Pubitemid 35471246)
    • (2002) Science , vol.298 , Issue.5601 , pp. 2199-2202
    • Bernasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 85
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 406(6797), 782-787 (2000)
    • (2000) Nature , vol.406 , Issue.6797 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 86
    • 67549104694 scopus 로고    scopus 로고
    • Co-administration of a CpG adjuvant (VaxImmune, CPG 7909) with CETP vaccines increased immunogenicity in rabbits and mice
    • Thomas LJ, Hammond RA, Forsberg EM, et al. Co-administration of a CpG adjuvant (VaxImmune, CPG 7909) with CETP vaccines increased immunogenicity in rabbits and mice. Hum. Vaccin. 5(2), 79-84 (2009)
    • (2009) Hum. Vaccin. , vol.5 , Issue.2 , pp. 79-84
    • Thomas, L.J.1    Hammond, R.A.2    Forsberg, E.M.3
  • 87
    • 49049086136 scopus 로고    scopus 로고
    • CpG oligonucleotides enhance proliferative and effector responses of B cells in HIV-infected individuals
    • Malaspina A, Moir S, DiPoto AC, et al. CpG oligonucleotides enhance proliferative and effector responses of B cells in HIV-infected individuals. J. Immunol. 181(2), 1199-1206 (2008)
    • (2008) J. Immunol. , vol.181 , Issue.2 , pp. 1199-1206
    • Malaspina, A.1    Moir, S.2    Dipoto, A.C.3
  • 88
    • 36348945135 scopus 로고    scopus 로고
    • Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation
    • Jurk M, Vollmer J. Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation. BioDrugs 21(6), 387-401 (2007) (Pubitemid 350145447)
    • (2007) BioDrugs , vol.21 , Issue.6 , pp. 387-401
    • Jurk, M.1    Vollmer, J.2
  • 91
    • 0037056040 scopus 로고    scopus 로고
    • Comparative study of immune responses induced after immunization with plasmids encoding the HIV-1 Nef protein under the control of the CMV-IE or the muscle-specific desmin promoter
    • DOI 10.1016/S0264-410X(02)00310-9, PII S0264410X02003109
    • Cazeaux N, Bennasser Y, Vidal PL, Li Z, Paulin D, Bahraoui E. Comparative study of immune responses induced after immunization with plasmids encoding the HIV-1 Nef protein under the control of the CMV-IE or the muscle-specific desmin promoter. Vaccine 20(27-28), 3322-3331 (2002) (Pubitemid 35245816)
    • (2002) Vaccine , vol.20 , Issue.27-28 , pp. 3322-3331
    • Cazeaux, N.1    Bennasser, Y.2    Vidal, P.-L.3    Li, Z.4    Paulin, D.5    Bahraoui, E.6
  • 92
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman DM, Yamshchikov G, Ishigatsubo Y. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol. 158(8), 3635-3639 (1997) (Pubitemid 127488716)
    • (1997) Journal of Immunology , vol.158 , Issue.8 , pp. 3635-3639
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 95
    • 0031948647 scopus 로고    scopus 로고
    • Therapeutic applications of CpG-containing oligodeoxynucleotides
    • Klinman DM. Therapeutic applications of CpG-containing oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev. 8(2), 181-184 (1998) (Pubitemid 28223342)
    • (1998) Antisense and Nucleic Acid Drug Development , vol.8 , Issue.2 , pp. 181-184
    • Klinman, D.M.1
  • 96
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg AM, Love-Homan L, Yi AK, Harty JT. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161(5), 2428-2434 (1998) (Pubitemid 28397058)
    • (1998) Journal of Immunology , vol.161 , Issue.5 , pp. 2428-2434
    • Krieg, A.M.1    Love-Homan, L.2    Yi, A.-K.3    Harty, J.T.4
  • 97
    • 0029162013 scopus 로고
    • Human immune responses to influenza virus vaccines administered by systemic or mucosal routes
    • Moldoveanu Z, Clements ML, Prince SJ, Murphy BR, Mestecky J. Human immune responses to influenza virus vaccines administered by systemic or mucosal routes. Vaccine 13(11), 1006-1012 (1995)
    • (1995) Vaccine , vol.13 , Issue.11 , pp. 1006-1012
    • Moldoveanu, Z.1    Clements, M.L.2    Prince, S.J.3    Murphy, B.R.4    Mestecky, J.5
  • 98
    • 0033082499 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    • Kovarik J, Bozzotti P, Love-Homan L, et al. CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming. J. Immunol. 162(3), 1611-1617 (1999) (Pubitemid 29307036)
    • (1999) Journal of Immunology , vol.162 , Issue.3 , pp. 1611-1617
    • Kovarik, J.1    Bozzotti, P.2    Love-Homan, L.3    Pihlgren, M.4    Davis, H.L.5    Lambert, P.-H.6    Krieg, A.M.7    Siegrist, C.-A.8
  • 99
    • 0032209286 scopus 로고    scopus 로고
    • Cutting edge: CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
    • McCluskie MJ, Davis HL. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. J. Immunol. 161(9), 4463-4466 (1998) (Pubitemid 28492011)
    • (1998) Journal of Immunology , vol.161 , Issue.9 , pp. 4463-4466
    • McCluskie, M.J.1    Davis, H.L.2
  • 101
    • 0035825599 scopus 로고    scopus 로고
    • Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid
    • DOI 10.1016/S0264-410X(00)00422-9, PII S0264410X00004229
    • Eastcott JW, Holmberg CJ, Dewhirst FE, Esch TR, Smith DJ, Taubman MA. Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid. Vaccine 19(13-14), 1636-1642 (2001) (Pubitemid 32175723)
    • (2001) Vaccine , vol.19 , Issue.13-14 , pp. 1636-1642
    • Eastcott, J.W.1    Holmberg, C.J.2    Dewhirst, F.E.3    Esch, T.R.4    Smith, D.J.5    Taubman, M.A.6
  • 103
    • 0034668209 scopus 로고    scopus 로고
    • Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants
    • McCluskie MJ, Davis HL. Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants. Vaccine 19(4-5), 413-422 (2000)
    • (2000) Vaccine , vol.19 , Issue.4-5 , pp. 413-422
    • McCluskie, M.J.1    Davis, H.L.2
  • 104
    • 0032889105 scopus 로고    scopus 로고
    • CpG motifs as immune adjuvants
    • DOI 10.1016/S0264-410X(98)00151-0, PII S0264410X98001510
    • Klinman DM, Barnhart KM, Conover J. CpG motifs as immune adjuvants. Vaccine 17(1), 19-25 (1999) (Pubitemid 28470728)
    • (1999) Vaccine , vol.17 , Issue.1 , pp. 19-25
    • Klinman, D.M.1    Barnhart, K.M.2    Conover, J.3
  • 106
    • 63549137349 scopus 로고    scopus 로고
    • Neutralizing antibody responses to subtype B and C adjuvanted HIV envelope protein vaccination in rabbits
    • Burke B, Gomez-Roman VR, Lian Y, et al. Neutralizing antibody responses to subtype B and C adjuvanted HIV envelope protein vaccination in rabbits. Virology 387(1), 147-156 (2009)
    • (2009) Virology , vol.387 , Issue.1 , pp. 147-156
    • Burke, B.1    Gomez-Roman, V.R.2    Lian, Y.3
  • 107
    • 0026033441 scopus 로고
    • Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
    • Kensil CR, Patel U, Lennick M, Marciani D. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J. Immunol. 146(2), 431-437 (1991)
    • (1991) J. Immunol. , vol.146 , Issue.2 , pp. 431-437
    • Kensil, C.R.1    Patel, U.2    Lennick, M.3    Marciani, D.4
  • 108
    • 37049052069 scopus 로고
    • Action of saponins on biological membranes
    • Glaueri AM, Dingle JT, Lucy JA. Action of saponins on biological membranes. Nature 196, 953 (1962)
    • (1962) Nature , vol.196 , pp. 953
    • Glaueri, A.M.1    Dingle, J.T.2    Lucy, J.A.3
  • 109
    • 0029061265 scopus 로고
    • Immunogenicity and HIV-1 virus neutralization of MN recombinant glycoprotein 120/HIV-1 QS21 vaccine in baboons
    • May
    • Powell MF, Cleland JL, Eastman DJ, et al. Immunogenicity and HIV-1 virus neutralization of MN recombinant glycoprotein 120/HIV-1 QS21 vaccine in baboons [published erratum appears in AIDS Res. Hum. Retroviruses 1995 May; 11(5), 661]. AIDS Res. Hum. Retroviruses 10(Suppl. 2), S105-S108 (1994)
    • (1995) AIDS Res. Hum. Retroviruses , vol.11 , Issue.5 , pp. 661
    • Powell, M.F.1    Cleland, J.L.2    Eastman, D.J.3
  • 110
    • 0026334359 scopus 로고
    • Development of a genetically engineered vaccine against feline leukemia virus infection
    • Kensil CR, Barrett C, Kushner N, et al. Development of a genetically engineered vaccine against feline leukemia virus infection. J. Am. Vet. Med. Assoc. 199(10), 1423-1427 (1991)
    • (1991) J. Am. Vet. Med. Assoc. , vol.199 , Issue.10 , pp. 1423-1427
    • Kensil, C.R.1    Barrett, C.2    Kushner, N.3
  • 111
    • 61349084783 scopus 로고    scopus 로고
    • Advances in saponin-based adjuvants
    • Sun HX, Xie Y, Ye YP. Advances in saponin-based adjuvants. Vaccine 27(12), 1787-1796 (2009)
    • (2009) Vaccine , vol.27 , Issue.12 , pp. 1787-1796
    • Sun, H.X.1    Xie, Y.2    Ye, Y.P.3
  • 112
    • 33344479308 scopus 로고    scopus 로고
    • Immunization of Rhesus monkeys with the conjugate vaccine IGN402 induces an IgG immune response against carbohydrate and protein antigens, and cancer cells
    • DOI 10.1016/j.vaccine.2005.11.059, PII S0264410X05012028
    • Kircheis R, Vondru P, Zinocker I, et al. Immunization of Rhesus monkeys with the conjugate vaccine IGN402 induces an IgG immune response against carbohydrate and protein antigens, and cancer cells. Vaccine 24(13), 2349-2357 (2006) (Pubitemid 43290417)
    • (2006) Vaccine , vol.24 , Issue.13 , pp. 2349-2357
    • Kircheis, R.1    Vondru, P.2    Zinocker, I.3    Haring, D.4    Nechansky, A.5    Loibner, H.6    Mudde, G.C.7
  • 113
    • 35349028297 scopus 로고    scopus 로고
    • GlaxoSmithKline Adjuvant Systems in vaccines: Concepts, achievements and perspectives
    • DOI 10.1586/14760584.6.5.723
    • Garcon N, Chomez P, Van Mechelen M. GlaxoSmithKline adjuvant systems in vaccines: concepts, achievements and perspectives. Expert Rev. Vaccines 6(5), 723-739 (2007) (Pubitemid 47607848)
    • (2007) Expert Review of Vaccines , vol.6 , Issue.5 , pp. 723-739
    • Garcon, N.1    Chomez, P.2    Van Mechelen, M.3
  • 115
    • 77952540334 scopus 로고    scopus 로고
    • Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: Clinical results
    • Cluff CW. Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv. Exp. Med. Biol. 667, 111-123 (2010)
    • (2010) Adv. Exp. Med. Biol. , vol.667 , pp. 111-123
    • Cluff, C.W.1
  • 116
    • 0021255985 scopus 로고
    • Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses
    • Morein B, Sundquist B, Hoglund S, Dalsgaard K, Osterhaus A. Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 308(5958), 457-460 (1984) (Pubitemid 14130919)
    • (1984) Nature , vol.308 , Issue.5958 , pp. 457-460
    • Morein, B.1    Sundquist, B.2    Hoglund, S.3
  • 117
    • 0035850965 scopus 로고    scopus 로고
    • A single dose of an ISCOM influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect Cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses
    • DOI 10.1016/S0264-410X(01)00262-6, PII S0264410X01002626
    • Rimmelzwaan GF, Baars M, van Amerongen G, van Beek R, Osterhaus AD. A single dose of an ISCOM influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect Cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses. Vaccine 20(1-2), 158-163 (2001) (Pubitemid 32905328)
    • (2001) Vaccine , vol.20 , Issue.1-2 , pp. 158-163
    • Rimmelzwaan, G.F.1    Baars, M.2    Van Amerongen, G.3    Van Beek, R.4    Osterhaus, A.D.M.E.5
  • 118
    • 0033577349 scopus 로고    scopus 로고
    • ISCOM vaccine induced protection against a lethal challenge with a human H5N1 influenza virus
    • DOI 10.1016/S0264-410X(98)00390-9, PII S0264410X98003909
    • Rimmelzwaan GF, Claas EC, van Amerongen G, de Jong JC, Osterhaus AD. ISCOM vaccine induced protection against a lethal challenge with a human H5N1 influenza virus. Vaccine 17(11-12), 1355-1358 (1999) (Pubitemid 29138801)
    • (1999) Vaccine , vol.17 , Issue.11-12 , pp. 1355-1358
    • Rimmelzwaan, G.F.1    Claas, E.C.J.2    Van Amerongen, G.3    De Jong, J.C.4    Osterhaus, A.D.M.E.5
  • 121
    • 0023766593 scopus 로고
    • The serum antibody response distributed in subclasses and isotypes after intranasal and subcutaneous immunization with influenza virus immunostimulating complexes
    • Lovgren K. The serum antibody response distributed in subclasses and isotypes after intranasal and subcutaneous immunization with influenza virus immunostimulating complexes. Scand. J. Immunol. 27(2), 241-245 (1988)
    • (1988) Scand. J. Immunol. , vol.27 , Issue.2 , pp. 241-245
    • Lovgren, K.1
  • 122
    • 0033047039 scopus 로고    scopus 로고
    • Investigation of protein-surfactant interactions by analytical ultracentrifugation and electron paramagnetic resonance: The use of recombinant human tissue factor as an example
    • DOI 10.1023/A:1018809632395
    • Jones LS, Cipolla D, Liu J, Shire SJ, Randolph TW. Investigation of protein- surfactant interactions by analytical ultracentrifugation and electron paramagnetic resonance: the use of recombinant human tissue factor as an example. Pharm. Res. 16(6), 808-812 (1999) (Pubitemid 29284189)
    • (1999) Pharmaceutical Research , vol.16 , Issue.6 , pp. 808-812
    • Jones, L.S.1    Cipolla, D.2    Liu, J.3    Shire, S.J.4    Randolph, T.W.5
  • 123
    • 0026027127 scopus 로고
    • Secretory immune responses in the mouse vagina after parenteral or intravaginal immunization with an immunostimulating complex (ISCOM)
    • Thaparr MA, Parr EL, Bozzola JJ, Parr MB. Secretory immune responses in the mouse vagina after parenteral or intravaginal immunization with an immunostimulating complex (ISCOM). Vaccine 9(2), 129-133 (1991)
    • (1991) Vaccine , vol.9 , Issue.2 , pp. 129-133
    • Thaparr, M.A.1    Parr, E.L.2    Bozzola, J.J.3    Parr, M.B.4
  • 124
    • 0029085519 scopus 로고
    • Cytotoxic T-lymphocyte memory - Role in cross-protective immunity against influenza
    • Rimmelzwaan GF, Osterhaus A. Cytotoxic T-lymphocyte memory - role in cross-protective immunity against influenza. Vaccine 13(8), 703-705 (1995)
    • (1995) Vaccine , vol.13 , Issue.8 , pp. 703-705
    • Rimmelzwaan, G.F.1    Osterhaus, A.2
  • 125
    • 0028856624 scopus 로고
    • Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM matrix
    • Ronnberg B, Fekadu M, Morein B. Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM matrix. Vaccine 13(14), 1375-1382 (1995)
    • (1995) Vaccine , vol.13 , Issue.14 , pp. 1375-1382
    • Ronnberg, B.1    Fekadu, M.2    Morein, B.3
  • 126
    • 0023834354 scopus 로고
    • Influenza virus ISCOMs: Antibody response in animals
    • Sundquist B, Lovgren K, Morein B. Influenza virus ISCOMs: antibody response in animals. Vaccine 6(1), 49-53 (1988) (Pubitemid 18042684)
    • (1988) Vaccine , vol.6 , Issue.1 , pp. 49-53
    • Sundquist, B.1    Lovgren, K.2    Morein, B.3
  • 127
    • 0029177785 scopus 로고
    • Development of vaccines based on formulations containing nonionic block copolymers
    • Brey RN. Development of vaccines based on formulations containing nonionic block copolymers. Pharm. Biotechnol. 6, 297-311 (1995)
    • (1995) Pharm. Biotechnol. , vol.6 , pp. 297-311
    • Brey, R.N.1
  • 128
    • 0026730230 scopus 로고
    • A comparison of commercially available adjuvants for use in research
    • Bennett B, Check IJ, Olsen MR, Hunter RL. A comparison of commercially available adjuvants for use in research. J. Immunol. Methods 153(1-2), 31-40 (1992)
    • (1992) J. Immunol. Methods , vol.153 , Issue.1-2 , pp. 31-40
    • Bennett, B.1    Check, I.J.2    Olsen, M.R.3    Hunter, R.L.4
  • 129
    • 0025357678 scopus 로고
    • Induction of macrophage Ia expression in vivo by a synthetic block copolymer, L81
    • Howerton DA, Hunter RL, Ziegler HK, Check IJ. Induction of macrophage Ia expression in vivo by a synthetic block copolymer, L81. J. Immunol. 144(5), 1578-1584 (1990) (Pubitemid 20093983)
    • (1990) Journal of Immunology , vol.144 , Issue.5 , pp. 1578-1584
    • Howerton, D.A.1    Hunter, R.L.2    Ziegler, H.K.3    Check, I.J.4
  • 131
    • 0031863732 scopus 로고    scopus 로고
    • Use of cellular and cytokine adjuvants in the immunotherapy of cancer
    • DOI 10.1002/(SICI)1096-9098(199806)68:2<122::AID-JSO10>3.0.CO;2-4
    • Salgaller ML, Lodge PA. Use of cellular and cytokine adjuvants in the immunotherapy of cancer. J. Surg. Oncol. 68(2), 122-138 (1998) (Pubitemid 28269982)
    • (1998) Journal of Surgical Oncology , vol.68 , Issue.2 , pp. 122-138
    • Salgaller, M.L.1    Lodge, P.A.2
  • 133
    • 0034660885 scopus 로고    scopus 로고
    • In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: Induction of tumor regression and potent antitumor immunity
    • Egilmez NK, Jong YS, Sabel MS, Jacob JS, Mathiowitz E, Bankert RB. In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity. Cancer Res. 60(14), 3832-3837 (2000) (Pubitemid 32204575)
    • (2000) Cancer Research , vol.60 , Issue.14 , pp. 3832-3837
    • Egilmez, N.K.1    Jong, Y.S.2    Sabel, M.S.3    Jacob, J.S.4    Mathiowitz, E.5    Bankert, R.B.6
  • 134
    • 17644416719 scopus 로고    scopus 로고
    • Targeting the innate immune response with improved vaccine adjuvants
    • DOI 10.1038/nm1210
    • Pashine A, Valiante NM, Ulmer JB. Targeting the innate immune response with improved vaccine adjuvants. Nat. Med. 11(4 Suppl.), S63-S68 (2005) (Pubitemid 40562305)
    • (2005) Nature Medicine , vol.11 , Issue.4 SUPPL.
    • Pashine, A.1    Valiante, N.M.2    Ulmer, J.B.3
  • 135
  • 137
    • 0346059383 scopus 로고    scopus 로고
    • Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum
    • Hengge UR, Cusini M. Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum. Br. J. Dermatol. 149(Suppl. 66), 15-19 (2003) (Pubitemid 38064508)
    • (2003) British Journal of Dermatology, Supplement , vol.149 , Issue.66 , pp. 15-19
    • Hengge, U.R.1    Cusini, M.2
  • 139
    • 0035184263 scopus 로고    scopus 로고
    • Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2
    • DOI 10.1128/IAI.69.12.7387-7395.2001
    • Asai Y, Ohyama Y, Gen K, Ogawa T. Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect. Immun. 69(12), 7387-7395 (2001) (Pubitemid 33086563)
    • (2001) Infection and Immunity , vol.69 , Issue.12 , pp. 7387-7395
    • Asai, Y.1    Ohyama, Y.2    Gen, K.3    Ogawa, T.4
  • 140
    • 0036789872 scopus 로고    scopus 로고
    • Antiviral and antitumor peptides from insects
    • Chernysh S, Kim SI, Bekker G, et al. Antiviral and antitumor peptides from insects. Proc. Natl Acad. Sci. USA 99(20), 12628-12632 (2002)
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.20 , pp. 12628-12632
    • Chernysh, S.1    Kim, S.I.2    Bekker, G.3
  • 141
    • 0022854034 scopus 로고
    • An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity
    • DOI 10.1016/0022-1759(86)90402-3
    • Allison AC, Byars NE. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity. J. Immunol. Methods 95(2), 157-168 (1986) (Pubitemid 17229409)
    • (1986) Journal of Immunological Methods , vol.95 , Issue.2 , pp. 157-168
    • Allison, A.C.1    Byars, N.E.2
  • 143
    • 21044452592 scopus 로고    scopus 로고
    • Escaping from the use of Freund's complete adjuvant
    • Balls M, van Zeller A-M, Halder ME (Eds). Elsevier Science, Amsterdam, The Netherlands
    • Lindblad EB, Hau J. Escaping from the use of Freund's complete adjuvant. In: Progress in the Reduction Refinement and Replacement of Animal Experimentation. Balls M, van Zeller A-M, Halder ME (Eds). Elsevier Science, Amsterdam, The Netherlands, 1681-1685 (2000)
    • (2000) Progress in the Reduction Refinement and Replacement of Animal Experimentation , pp. 1681-1685
    • Lindblad, E.B.1    Hau, J.2
  • 144
    • 0038330442 scopus 로고    scopus 로고
    • MF59-adjuvanted vaccines: Increased immunogenicity with an optimal safety profile
    • Podda A, Del Giudice G. MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. Expert Rev. Vaccines 2(2), 197-203 (2003)
    • (2003) Expert Rev. Vaccines , vol.2 , Issue.2 , pp. 197-203
    • Podda, A.1    Del Giudice, G.2
  • 146
    • 0030012890 scopus 로고    scopus 로고
    • MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice
    • Higgins DA, Carlson JR, Van Nest G. MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. Vaccine 14(6), 478-484 (1996)
    • (1996) Vaccine , vol.14 , Issue.6 , pp. 478-484
    • Higgins, D.A.1    Carlson, J.R.2    Van Nest, G.3
  • 147
    • 0034657718 scopus 로고    scopus 로고
    • Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery
    • DOI 10.1016/S0168-3659(99)00275-8, PII S0168365999002758
    • Tinsley-Bown AM, Fretwell R, Dowsett AB, Davis SL, Farrar GH. Formulation of poly(d,l-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery. J. Control. Release 66(2-3), 229-241 (2000) (Pubitemid 30160860)
    • (2000) Journal of Controlled Release , vol.66 , Issue.2-3 , pp. 229-241
    • Tinsley-Bown, A.M.1    Fretwell, R.2    Dowsett, A.B.3    Davis, S.L.4    Farrar, G.H.5
  • 150
    • 0032804298 scopus 로고    scopus 로고
    • Influenza vaccines: Antibody responses to split virus and MF59- adjuvanted subunit virus in an adult population
    • DOI 10.1023/A:1007594911541
    • Menegon T, Baldo V, Bonello C, Dalla CD, Di Tommaso A, Trivello R. Influenza vaccines: antibody responses to split virus and MF59-adjuvanted subunit virus in an adult population. Eur. J. Epidemiol. 15(6), 573-576 (1999) (Pubitemid 29400033)
    • (1999) European Journal of Epidemiology , vol.15 , Issue.6 , pp. 573-576
    • Menegon, T.1    Baldo, V.2    Bonello, C.3    Dalla Costa, D.4    Di Tommaso, A.5    Trivello, R.6
  • 152
    • 0035865873 scopus 로고    scopus 로고
    • Cellular and humoral immune responses to a canarypox vaccine containing human immunodeficiency virus type 1 Env, Gag, and Pro in combination with rgp120
    • AIDS Vaccine Evaluation Group 022 Protocol Team
    • AIDS Vaccine Evaluation Group 022 Protocol Team. Cellular and humoral immune responses to a canarypox vaccine containing human immunodeficiency virus type 1 Env, Gag, and Pro in combination with rgp120. J. Infect. Dis. 183(4), 563-570 (2001)
    • (2001) J. Infect. Dis. , vol.183 , Issue.4 , pp. 563-570
  • 153
    • 51649091684 scopus 로고    scopus 로고
    • Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine
    • Makidon PE, Bielinska AU, Nigavekar SS, et al. Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine. PLoS One 3(8), e2954 (2008)
    • (2008) PLoS One , vol.3 , Issue.8
    • Makidon, P.E.1    Bielinska, A.U.2    Nigavekar, S.S.3
  • 154
    • 77957005783 scopus 로고    scopus 로고
    • Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model
    • DOI: 10.4161/hv.6.7.11818 Epub ahead of print
    • Hamouda T, Chepurnov A, Mank N, et al. Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine model. Hum. Vaccin. DOI: 10.4161/hv.6.7.11818 (2010) (Epub ahead of print)
    • Hum. Vaccin. , vol.2010
    • Hamouda, T.1    Chepurnov, A.2    Mank, N.3
  • 156
    • 34547613366 scopus 로고    scopus 로고
    • Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge
    • DOI 10.1128/IAI.00070-07
    • Bielinska AU, Janczak KW, Landers JJ, et al. Mucosal immunization with a novel nanoemulsion-based recombinant anthrax protective antigen vaccine protects against Bacillus anthracis spore challenge. Infect. Immun. 75(8), 4020-4029 (2007) (Pubitemid 47206301)
    • (2007) Infection and Immunity , vol.75 , Issue.8 , pp. 4020-4029
    • Bielinska, A.U.1    Janczak, K.W.2    Landers, J.J.3    Makidon, P.4    Sower, L.E.5    Peterson, J.W.6    Baker Jr., J.R.7
  • 157
    • 39549118132 scopus 로고    scopus 로고
    • Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates
    • DOI 10.1089/aid.2007.0148
    • Bielinska AU, Janczak KW, Landers JJ, Markovitz DM, Montefiori DC, Baker JR Jr. Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates. AIDS Res. Hum. Retroviruses 24(2), 271-281 (2008) (Pubitemid 351282102)
    • (2008) AIDS Research and Human Retroviruses , vol.24 , Issue.2 , pp. 271-281
    • Bielinska, A.U.1    Janczak, K.W.2    Landers, J.J.3    Markovitz, D.M.4    Montefiori, D.C.5    Baker Jr., J.R.6
  • 158
    • 77951019450 scopus 로고    scopus 로고
    • Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant
    • Bielinska AU, Gerber M, Blanco LP, et al. Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant. Crit. Rev. Immunol. 30(2), 189-199 (2010)
    • (2010) Crit. Rev. Immunol. , vol.30 , Issue.2 , pp. 189-199
    • Bielinska, A.U.1    Gerber, M.2    Blanco, L.P.3
  • 160
    • 2642677624 scopus 로고    scopus 로고
    • Improving protein therapeutics with sustained-release formulations
    • [published erratum Nat. Biotechnol. 16(5), 478 (1998)](2), 153-157 (1998)
    • Putney SD, Burke PA. Improving protein therapeutics with sustained-release formulations. Nat. Biotechnol. 16 [published erratum appears in Nat. Biotechnol. 16(5), 478 (1998)](2), 153-157 (1998)
    • Nat. Biotechnol. , pp. 16
    • Putney, S.D.1    Burke, P.A.2
  • 161
    • 0025834747 scopus 로고
    • Biodegradable and biocompatible poly(dl-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies
    • Eldridge JH, Staas JK, Meulbroek JA, Tice TR, Gilley RM. Biodegradable and biocompatible poly(dl-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect. Immun. 59(9), 2978-2986 (1991)
    • (1991) Infect. Immun. , vol.59 , Issue.9 , pp. 2978-2986
    • Eldridge, J.H.1    Staas, J.K.2    Meulbroek, J.A.3    Tice, T.R.4    Gilley, R.M.5
  • 162
    • 0025845823 scopus 로고
    • HIV and mucosal immunity
    • O'Hagan DT. HIV and mucosal immunity. Lancet 337(8752), 1289 (1991)
    • (1991) Lancet , vol.337 , Issue.8752 , pp. 1289
    • O'Hagan, D.T.1
  • 163
    • 0028049676 scopus 로고
    • Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles
    • Maloy KJ, Donachie AM, O'Hagan DT, Mowat AM. Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. Immunology 81(4), 661-667 (1994) (Pubitemid 24246520)
    • (1994) Immunology , vol.81 , Issue.4 , pp. 661-667
    • Maloy, K.J.1    Donachie, A.M.2    O'Hagan, D.T.3    Mowat, A.M.4
  • 164
    • 0029558085 scopus 로고
    • + Th1 cells
    • DOI 10.1016/0264-410X(95)00184-3
    • Moore A, McGuirk P, Adams S, et al. Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells. Vaccine 13(18), 1741-1749 (1995) (Pubitemid 26013110)
    • (1995) Vaccine , vol.13 , Issue.18 , pp. 1741-1749
    • Moore, A.1    McGuirk, P.2    Adams, S.3    Jones, W.C.4    McGee, J.P.5    O'Hagan, D.T.6    Mills, K.H.G.7
  • 166
    • 0023748061 scopus 로고
    • Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage
    • Tabata Y, Ikada Y. Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage. Biomaterials 9(4), 356-362 (1988)
    • (1988) Biomaterials , vol.9 , Issue.4 , pp. 356-362
    • Tabata, Y.1    Ikada, Y.2
  • 167
    • 0024094796 scopus 로고
    • Macrophage phagocytosis of biodegradable microspheres composed of l-lactic acid/glycolic acid homo- and copolymers
    • Tabata Y, Ikada Y. Macrophage phagocytosis of biodegradable microspheres composed of l-lactic acid/glycolic acid homo- and copolymers. J. Biomed. Mater. Res. 22(10), 837-858 (1988)
    • (1988) J. Biomed. Mater. Res. , vol.22 , Issue.10 , pp. 837-858
    • Tabata, Y.1    Ikada, Y.2
  • 168
    • 0033403066 scopus 로고    scopus 로고
    • Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
    • Randolph GJ, Inaba K, Robbiani DF, Steinman RM, Muller WA. Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity 11(6), 753-761 (1999) (Pubitemid 30030714)
    • (1999) Immunity , vol.11 , Issue.6 , pp. 753-761
    • Randolph, G.J.1    Inaba, K.2    Robbiani, D.F.3    Steinman, R.M.4    Muller, W.A.5
  • 169
    • 0036805438 scopus 로고    scopus 로고
    • Analysis of poly(D,L-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro
    • DOI 10.1023/A:1020452531828
    • Lutsiak ME, Robinson DR, Coester C, Kwon GS, Samuel J. Analysis of poly(d,l-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro. Pharm. Res. 19(10), 1480-1487 (2002) (Pubitemid 35266552)
    • (2002) Pharmaceutical Research , vol.19 , Issue.10 , pp. 1480-1487
    • Lutsiak, M.E.C.1    Robinson, D.R.2    Coester, C.3    Kwon, G.S.4    Samuel, J.5
  • 170
    • 0037024108 scopus 로고    scopus 로고
    • Uptake of poly(d,l-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo
    • Newman KD, Elamanchili P, Kwon GS, Samuel J. Uptake of poly(d,l-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo. J. Biomed. Mater. Res. 60(3), 480-486 (2002)
    • (2002) J. Biomed. Mater. Res. , vol.60 , Issue.3 , pp. 480-486
    • Newman, K.D.1    Elamanchili, P.2    Kwon, G.S.3    Samuel, J.4
  • 171
    • 0034950338 scopus 로고    scopus 로고
    • Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): Evaluation of antibody response after oral and nasal application in mice
    • DOI 10.1023/A:1011063232257
    • Jung T, Kamm W, Breitenbach A, Hungerer KD, Hundt E, Kissel T. Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft- poly(lactide-co-glycolide), evaluation of antibody response after oral and nasal application in mice. Pharm. Res. 18(3), 352-360 (2001) (Pubitemid 32595824)
    • (2001) Pharmaceutical Research , vol.18 , Issue.3 , pp. 352-360
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3    Hungerer, K.-D.4    Hundt, E.5    Kissel, T.6
  • 172
    • 0033595134 scopus 로고    scopus 로고
    • DNA vaccines - Designer vaccines for the 21st
    • Seder RA, Gurunathan S. DNA vaccines - designer vaccines for the 21st Century. N. Engl. J. Med. 341(4), 277-278 (1999)
    • (1999) Century. N. Engl. J. Med. , vol.341 , Issue.4 , pp. 277-278
    • Seder, R.A.1    Gurunathan, S.2
  • 173
  • 176
    • 0034735774 scopus 로고    scopus 로고
    • Development of a preventive vaccine for Ebola virus infection in primates
    • Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ. Development of a preventive vaccine for Ebola virus infection in primates. Nature 408(6812), 605-609 (2000)
    • (2000) Nature , vol.408 , Issue.6812 , pp. 605-609
    • Sullivan, N.J.1    Sanchez, A.2    Rollin, P.E.3    Yang, Z.Y.4    Nabel, G.J.5
  • 177
    • 0031915963 scopus 로고    scopus 로고
    • Microspheres containing plasmid-encoded antigens elicit cytotoxic T- cell responses
    • DOI 10.1038/nm0398-365
    • Hedley ML, Curley J, Urban R. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses. Nat. Med. 4, 365-368 (1998) (Pubitemid 28144100)
    • (1998) Nature Medicine , vol.4 , Issue.3 , pp. 365-368
    • Hedley, M.L.1    Curley, J.2    Urban, R.3
  • 178
    • 0032949618 scopus 로고    scopus 로고
    • PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization
    • DOI 10.1021/js9801687
    • Ando S, Putnam D, Pack DW, Langer R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J. Pharm. Sci. 88(1), 126-130 (1999) (Pubitemid 29037379)
    • (1999) Journal of Pharmaceutical Sciences , vol.88 , Issue.1 , pp. 126-130
    • Ando, S.1    Putnam, D.2    Pack, D.W.3    Langer, R.4
  • 179
    • 0032855232 scopus 로고    scopus 로고
    • Microencapsulation of DNA using poly(DL-lactide-co-glycolide): Stability issues and release characteristics
    • DOI 10.1016/S0168-3659(99)00151-0, PII S0168365999001510
    • Walter E, Moelling K, Pavlovic J, Merkle HP. Microencapsulation of DNA using poly(dl-lactide-co-glycolide), stability issues and release characteristics. J. Control. Release 61(3), 361-374 (1999) (Pubitemid 29413030)
    • (1999) Journal of Controlled Release , vol.61 , Issue.3 , pp. 361-374
    • Walter, E.1    Moelling, K.2    Pavlovic, J.3    Merkle, H.P.4
  • 182
    • 0037056053 scopus 로고    scopus 로고
    • Synergistic adjuvant activity of immunostimulatory DNA and oil/water emulsions for immunization with HIV p55 gag antigen
    • DOI 10.1016/S0264-410X(02)00272-4, PII S0264410X02002724
    • O'Hagan DT, Singh M, Kazzaz J, et al. Synergistic adjuvant activity of immunostimulatory DNA and oil/water emulsions for immunization with HIV p55 gag antigen. Vaccine 20(27-28), 3389-3398 (2002) (Pubitemid 35245822)
    • (2002) Vaccine , vol.20 , Issue.27-28 , pp. 3389-3398
    • O'Hagan, D.T.1    Singh, M.2    Kazzaz, J.3    Ugozzoli, M.4    Briones, M.5    Donnelly, J.6    Ott, G.7
  • 183
    • 0001058063 scopus 로고
    • Macrophage activation through phagocytosis of muramyl dipeptide encapsulated in gelatin microspheres
    • Tabata Y, Ikada Y. Macrophage activation through phagocytosis of muramyl dipeptide encapsulated in gelatin microspheres. J. Pharm. Pharmacol. 39(9), 698-704 (1987) (Pubitemid 18015453)
    • (1987) Journal of Pharmacy and Pharmacology , vol.39 , Issue.9 , pp. 698-704
    • Tabata, Y.1    Ikada, Y.2
  • 184
    • 0034601836 scopus 로고    scopus 로고
    • Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres. II. in vivo investigation
    • Puri N, Sinko PJ. Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres. II. In vivo investigation. J. Control. Release 69(1), 69-80 (2000)
    • (2000) J. Control. Release , vol.69 , Issue.1 , pp. 69-80
    • Puri, N.1    Sinko, P.J.2
  • 186
    • 0032210993 scopus 로고    scopus 로고
    • A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2
    • DOI 10.1016/S0264-410X(98)00179-0, PII S0264410X98001790
    • Singh M, Carlson JR, Briones M, et al. A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2. Vaccine 16(19), 1822-1827 (1998) (Pubitemid 28473922)
    • (1998) Vaccine , vol.16 , Issue.19 , pp. 1822-1827
    • Singh, M.1    Carlson, J.R.2    Briones, M.3    Ugozzoli, M.4    Kazzaz, J.5    Barackman, J.6    Ott, G.7    O'Hagan, D.8
  • 187
    • 0030928864 scopus 로고    scopus 로고
    • Controlled release microparticles as a single dose hepatitis B vaccine: Evaluation of immunogenicity in mice
    • DOI 10.1016/S0264-410X(97)00225-9, PII S0264410X97002253
    • Singh M, Li XM, McGee JP, et al. Controlled release microparticles as a single dose hepatitis B vaccine: evaluation of immunogenicity in mice. Vaccine 15(5), 475-481 (1997) (Pubitemid 27188615)
    • (1997) Vaccine , vol.15 , Issue.5 , pp. 475-481
    • Singh, M.1    Li, X.-M.2    McGee, J.P.3    Zamb, T.4    Koff, W.5    Wang, C.Y.6    O'Hagan, D.T.7
  • 188
    • 0026654831 scopus 로고
    • Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen
    • Challacombe SJ, Rahman D, Jeffery H, Davis SS, O'Hagan DT. Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunology 76(1), 164-168 (1992)
    • (1992) Immunology , vol.76 , Issue.1 , pp. 164-168
    • Challacombe, S.J.1    Rahman, D.2    Jeffery, H.3    Davis, S.S.4    O'Hagan, D.T.5
  • 189
    • 0031081681 scopus 로고    scopus 로고
    • Salivary, gut, vaginal and nasal antibody responses after oral immunization with biodegradable microparticles
    • DOI 10.1016/S0264-410X(96)00159-4, PII S0264410X96001594
    • Challacombe SJ, Rahman D, O'Hagan DT. Salivary, gut, vaginal and nasal antibody responses after oral immunization with biodegradable microparticles. Vaccine 15(2), 169-175 (1997) (Pubitemid 27091247)
    • (1997) Vaccine , vol.15 , Issue.2 , pp. 169-175
    • Challacombe, S.J.1    Rahman, D.2    O'Hagan, D.T.3
  • 190
    • 0025069886 scopus 로고
    • Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches
    • Eldridge JH, Hammond CJ, Meulbroek JA, Staas JK, Gilley RM, Tice TR. Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches. J. Control. Release 11, 205-214 (1990) (Pubitemid 20070098)
    • (1990) Journal of Controlled Release , vol.11 , Issue.1-3 , pp. 205-214
    • Eldridge, J.H.1    Hammond, C.J.2    Meulbroek, J.A.3    Staas, J.K.4    Gilley, R.M.5    Tice, T.R.6
  • 191
    • 0035961506 scopus 로고    scopus 로고
    • Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: Effect of formulation and route of immunization on induction of Th1 and Th2 cells
    • DOI 10.1016/S0264-410X(00)00433-3, PII S0264410X00004333
    • Conway MA, Madrigal-Estebas L, McClean S, Brayden DJ, Mills KH. Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells. Vaccine 19(15-16), 1940-1950 (2001) (Pubitemid 32178342)
    • (2001) Vaccine , vol.19 , Issue.15-16 , pp. 1940-1950
    • Conway, M.A.1    Madrigal-Estebas, L.2    McClean, S.3    Brayden, D.J.4    Mills, K.H.G.5
  • 192
    • 0028962946 scopus 로고
    • Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(dl-lactide-co-glycolide) microspheres
    • Shahin R, Leef M, Eldridge J, Hudson M, Gilley R. Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(dl-lactide-co-glycolide) microspheres. Infect. Immun. 63(4), 1195-1200 (1995)
    • (1995) Infect. Immun. , vol.63 , Issue.4 , pp. 1195-1200
    • Shahin, R.1    Leef, M.2    Eldridge, J.3    Hudson, M.4    Gilley, R.5
  • 193
    • 0029797560 scopus 로고    scopus 로고
    • Oral immunization with an anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection
    • DOI 10.1038/nm1096-1116
    • Whittum-Hudson JA, An LL, Saltzman WM, Prendergast RA, MacDonald AB. Oral immunization with an anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection. Nat. Med. 2(10), 1116-1121 (1996) (Pubitemid 26338631)
    • (1996) Nature Medicine , vol.2 , Issue.10 , pp. 1116-1121
    • Whittum-Hudson, J.A.1    An, L-L.2    Saltzman, W.M.3    Prendergast, R.A.4    Macdonald, A.B.5
  • 194
    • 0031036212 scopus 로고    scopus 로고
    • Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-lactide-co- glycolide) microspheres
    • Allaoui-Attarki K, Pecquet S, Fattal E, et al. Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(dl-lactide-co-glycolide) microspheres. Infect. Immun. 65(3), 853-857 (1997) (Pubitemid 27087981)
    • (1997) Infection and Immunity , vol.65 , Issue.3 , pp. 853-857
    • Allaoui-Attarki, K.1    Pecquet, S.2    Fattal, E.3    Trolle, S.4    Chachaty, E.5    Couvreur, P.6    Andremont, A.7
  • 195
    • 0036176042 scopus 로고    scopus 로고
    • Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin A encapsulated in microspheres
    • DOI 10.1128/IAI.70.3.1143-1149.2002
    • Seo JY, Seong SY, Ahn BY, Kwon IC, Chung H, Jeong SY. Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin encapsulated in microspheres. Infect. Immun. 70(3), 1143-1149 (2002) (Pubitemid 34163385)
    • (2002) Infection and Immunity , vol.70 , Issue.3 , pp. 1143-1149
    • Seo, J.-Y.1    Seong, S.Y.2    Ahn, B.-Y.3    Kwon, I.C.4    Chung, H.5    Jeong, S.Y.6
  • 196
    • 0037154847 scopus 로고    scopus 로고
    • Oral immunization of mice with ricin toxoid vaccine encapsulated in polymeric microspheres against aerosol challenge
    • DOI 10.1016/S0264-410X(01)00484-4, PII S0264410X01004844
    • Kende M, Yan C, Hewetson J, Frick MA, Rill WL, Tammariello R. Oral immunization of mice with ricin toxoid vaccine encapsulated in polymeric microspheres against aerosol challenge. Vaccine 20(11-12), 1681-1691 (2002) (Pubitemid 34169812)
    • (2002) Vaccine , vol.20 , Issue.11-12 , pp. 1681-1691
    • Kende, M.1    Yan, C.2    Hewetson, J.3    Frick, M.A.4    Rill, W.L.5    Tammariello, R.6
  • 198
    • 0029154974 scopus 로고
    • Humoral immunity to aerosolized staphylococcal enterotoxin B (SEB), a superantigen, in monkeys vaccinated with SEB toxoid-containing microspheres
    • Tseng J, Komisar JL, Trout RN, et al. Humoral immunity to aerosolized staphylococcal enterotoxin B (SEB), a superantigen, in monkeys vaccinated with SEB toxoid-containing microspheres. Infect. Immun. 63(8), 2880-2885 (1995)
    • (1995) Infect. Immun. , vol.63 , Issue.8 , pp. 2880-2885
    • Tseng, J.1    Komisar, J.L.2    Trout, R.N.3
  • 200
    • 0034996176 scopus 로고    scopus 로고
    • Tissue distribution of radioactivity following intranasal administration of radioactive microspheres
    • DOI 10.1211/0022357011775929
    • Eyles JE, Spiers ID, Williamson ED, Alpar HO. Tissue distribution of radioactivity following intranasal administration of radioactive microspheres. J. Pharm. Pharmacol. 53(5), 601-607 (2001) (Pubitemid 32457810)
    • (2001) Journal of Pharmacy and Pharmacology , vol.53 , Issue.5 , pp. 601-607
    • Eyles, J.E.1    Spiers, I.D.2    Williamson, E.D.3    Alpar, H.O.4
  • 201
    • 0035972026 scopus 로고    scopus 로고
    • A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects
    • DOI 10.1016/S0264-410X(01)00051-2, PII S0264410X01000512
    • Lambert JS, Keefer M, Mulligan MJ, et al. A Phase I safety and immunogenicity trial of UBI microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. Vaccine 19(23-24), 3033-3042 (2001) (Pubitemid 32324030)
    • (2001) Vaccine , vol.19 , Issue.23-24 , pp. 3033-3042
    • Lambert, J.S.1    Keefer, M.2    Mulligan, M.J.3    Schwartz, D.4    Mestecky, J.5    Weinhold, K.6    Smith, C.7    Hsieh, R.8    Moldoveanu, Z.9    Fast, P.10    Forrest, B.11    Koff, W.12
  • 202
    • 0141676777 scopus 로고    scopus 로고
    • Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers
    • DOI 10.1016/S1521-6616(03)00120-7
    • Tacket CO, Sztein MB, Losonsky GA, Wasserman SS, Estes MK. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin. Immunol. 108(3), 241-247 (2003) (Pubitemid 37117370)
    • (2003) Clinical Immunology , vol.108 , Issue.3 , pp. 241-247
    • Tacket, C.O.1    Sztein, M.B.2    Losonsky, G.A.3    Wasserman, S.S.4    Estes, M.K.5
  • 203
    • 0034822710 scopus 로고    scopus 로고
    • Oral vaccination in man using antigens in particles: Current status
    • DOI 10.1016/S0928-0987(01)00175-0, PII S0928098701001750
    • Brayden DJ. Oral vaccination in man using antigens in particles: current status. Eur. J. Pharm. Sci. 14(3), 183-189 (2001) (Pubitemid 32884313)
    • (2001) European Journal of Pharmaceutical Sciences , vol.14 , Issue.3 , pp. 183-189
    • Brayden, D.J.1
  • 205
    • 22144483806 scopus 로고    scopus 로고
    • Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers
    • DOI 10.1586/14760584.4.3.249
    • North S, Butts C. Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers. Expert Rev. Vaccines 4(3), 249-257 (2005) (Pubitemid 40978689)
    • (2005) Expert Review of Vaccines , vol.4 , Issue.3 , pp. 249-257
    • North, S.1    Butts, C.2
  • 206
    • 36048986266 scopus 로고    scopus 로고
    • L-BLP25: A MUC1-targeted peptide vaccine therapy in prostate cancer
    • DOI 10.1517/14712598.7.11.1723
    • Sangha R, North S. L-BLP25: a MUC1- targeted peptide vaccine therapy in prostate cancer. Expert Opin. Biol. Ther. 7(11), 1723-1730 (2007) (Pubitemid 350157497)
    • (2007) Expert Opinion on Biological Therapy , vol.7 , Issue.11 , pp. 1723-1730
    • Sangha, R.1    North, S.2
  • 207
    • 0016328268 scopus 로고
    • Liposomes as immunological adjuvants
    • Allison AG, Gregoriadis G. Liposomes as immunological adjuvants. Nature 252(5480), 252 (1974)
    • (1974) Nature , vol.252 , Issue.5480 , pp. 252
    • Allison, A.G.1    Gregoriadis, G.2
  • 208
    • 0016246083 scopus 로고
    • Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats
    • Gregoriadis G, Putman D, Louis L, Neerunjun D. Comparative effect and fate of non-entrapped and liposome-entrapped neuraminidase injected into rats. Biochem. J. 140(2), 323-330 (1974)
    • (1974) Biochem. J. , vol.140 , Issue.2 , pp. 323-330
    • Gregoriadis, G.1    Putman, D.2    Louis, L.3    Neerunjun, D.4
  • 209
    • 0025854178 scopus 로고
    • Liposomes as carriers of antigens and adjuvants
    • Alving CR. Liposomes as carriers of antigens and adjuvants. J. Immunol. Methods 140(1), 1-13 (1991)
    • (1991) J. Immunol. Methods , vol.140 , Issue.1 , pp. 1-13
    • Alving, C.R.1
  • 210
    • 0027173808 scopus 로고
    • Lipopolysaccharide, lipid a, and liposomes containing lipid a as immunologic adjuvants
    • Alving CR. Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants. Immunobiology 187(3-5), 430-446 (1993) (Pubitemid 23150783)
    • (1993) Immunobiology , vol.187 , Issue.3-5 , pp. 430-446
    • Alving, C.R.1
  • 211
    • 0018924864 scopus 로고
    • Liposomes in immunology: Evidence that their adjuvant effect results from surface exposition of the antigens
    • DOI 10.1016/0008-8749(80)90043-X
    • van Rooijen N, van Nieuwmegen R. Liposomes in immunology: evidence that their adjuvant effect results from surface exposition of the antigens. Cell. Immunol. 49(2), 402-407 (1980) (Pubitemid 10214929)
    • (1980) Cellular Immunology , vol.49 , Issue.2 , pp. 402-407
    • Van Rooijen, N.1    Van Nieuwmegen, R.2
  • 212
    • 0027793810 scopus 로고
    • Liposomes, a tale of drug targeting
    • Gregoriadis G. Liposomes, a tale of drug targeting. J. Drug Target 1(1), 3-6 (1993)
    • (1993) J. Drug Target , vol.1 , Issue.1 , pp. 3-6
    • Gregoriadis, G.1
  • 213
    • 0025783606 scopus 로고
    • Rouse BT. pH sensitive liposomes provide an efficient means of sensitizing target cells to class i restricted CTL recognition of a soluble protein
    • Reddy R, Zhou F, Huang L, Carbone F, Bevan M, Rouse BT. pH sensitive liposomes provide an efficient means of sensitizing target cells to class I restricted CTL recognition of a soluble protein. J. Immunol. Methods 141(2), 157-163 (1991)
    • (1991) J. Immunol. Methods , vol.141 , Issue.2 , pp. 157-163
    • Reddy, R.1    Zhou, F.2    Huang, L.3    Carbone, F.4    Bevan, M.5
  • 214
    • 0021182456 scopus 로고
    • Comparison of immune responses induced by rat RT-1 antigens presented as inserts into liposomes, as protein micelles and as intact cells
    • Hedlund G, Jansson B, Sjogren HO. Comparison of immune responses induced by rat RT-1 antigens presented as inserts into liposomes, as protein micelles and as intact cells. Immunology 53(1), 69-78 (1984) (Pubitemid 14057692)
    • (1984) Immunology , vol.53 , Issue.1 , pp. 69-78
    • Hedlund, G.1    Jansson, B.2    Sjogren, H.O.3
  • 215
    • 0023187851 scopus 로고
    • Liposomes as immunological adjuvants: Antigen incorporation studies
    • DOI 10.1016/0264-410X(87)90063-6
    • Gregoriadis G, Davis D, Davies A. Liposomes as immunological adjuvants: antigen incorporation studies. Vaccine 5(2), 145-151 (1987) (Pubitemid 17092721)
    • (1987) Vaccine , vol.5 , Issue.2 , pp. 145-151
    • Gregoriadis, G.1    Davis, D.2    Davies, A.3
  • 216
    • 0024253062 scopus 로고
    • Liposomes as a drug delivery system: Optimization studies
    • Gregoriadis G. Liposomes as a drug delivery system: optimization studies. Adv. Exp. Med. Biol. 238, 151-159 (1988)
    • (1988) Adv. Exp. Med. Biol. , vol.238 , pp. 151-159
    • Gregoriadis, G.1
  • 217
    • 0023154977 scopus 로고
    • Liposomes as adjuvants with immunopurified tetanus toxoid: The immune response
    • DOI 10.1016/0165-2478(87)90016-2
    • Davis D, Davies A, Gregoriadis G. Liposomes as adjuvants with immunopurified tetanus toxoid: the immune response. Immunol. Lett. 14(4), 341-348 (1987) (Pubitemid 17055205)
    • (1987) Immunology Letters , vol.14 , Issue.4 , pp. 341-348
    • Davis, D.1    Davies, A.2    Gregoriadis, G.3
  • 218
    • 0027756880 scopus 로고
    • Liposomes as vaccine carriers. Incorporation of soluble and particulate antigens in giant vesicles
    • Antimisiaris SG, Jayasekera P, Gregoriadis G. Liposomes as vaccine carriers. Incorporation of soluble and particulate antigens in giant vesicles. J. Immunol. Methods 166(2), 271-280 (1993)
    • (1993) J. Immunol. Methods , vol.166 , Issue.2 , pp. 271-280
    • Antimisiaris, S.G.1    Jayasekera, P.2    Gregoriadis, G.3
  • 219
    • 33748778266 scopus 로고    scopus 로고
    • Liposomal vaccines-targeting the delivery of antigen
    • DOI 10.1016/j.ymeth.2006.05.027, PII S1046202306001605
    • Altin JG, Parish CR. Liposomal vaccines - targeting the delivery of antigen. Methods 40(1), 39-52 (2006) (Pubitemid 44415497)
    • (2006) Methods , vol.40 , Issue.1 , pp. 39-52
    • Altin, J.G.1    Parish, C.R.2
  • 220
    • 9244234954 scopus 로고    scopus 로고
    • Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs
    • DOI 10.1016/j.copbio.2004.10.005, PII S0958166904001430
    • Felnerova D, Viret JF, Gluck R, et al. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr. Opin. Biotechnol. 15, 518-529 (2004) (Pubitemid 39551004)
    • (2004) Current Opinion in Biotechnology , vol.15 , Issue.6 , pp. 518-529
    • Felnerova, D.1    Viret, J.-F.2    Gluck, R.3    Moser, C.4
  • 222
    • 0027080416 scopus 로고
    • Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A
    • Gluck R, Mischler R, Brantschen S, Just M, Althaus B, Cryz SJ Jr. Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis A. J. Clin. Invest. 90(6), 2491-2495 (1992) (Pubitemid 23010069)
    • (1992) Journal of Clinical Investigation , vol.90 , Issue.6 , pp. 2491-2495
    • Gluck, R.1    Mischler, R.2    Brantschen, S.3    Just, M.4    Althaus, B.5    Cryz Jr., S.J.6
  • 223
    • 0037146938 scopus 로고    scopus 로고
    • New technology platforms in the development of vaccines for the future
    • DOI 10.1016/S0264-410X(02)00513-3, PII S0264410X02005133
    • Gluck R, Metcalfe IC. New technology platforms in the development of vaccines for the future. Vaccine 20(Suppl. 5), B10-B16 (2002) (Pubitemid 35435391)
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 5
    • Gluck, R.1    Metcalfe, I.C.2
  • 224
    • 0038439355 scopus 로고    scopus 로고
    • Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs)
    • DOI 10.1016/S0264-410X(98)00440-X, PII S0264410X9800440X
    • Gluck R. Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs). Vaccine 17(13-14), 1782-1787 (1999) (Pubitemid 29138918)
    • (1999) Vaccine , vol.17 , Issue.13-14 , pp. 1782-1787
    • Gluck, R.1
  • 225
    • 0037146955 scopus 로고    scopus 로고
    • Inflexal®V a trivalent virosome subunit influenza vaccine: Production
    • DOI 10.1016/S0264-410X(02)00512-1, PII S0264410X02005121
    • Mischler R, Metcalfe IC. Inflexal V a trivalent virosome subunit influenza vaccine: production. Vaccine 20(Suppl. 5), B17-B23 (2002) (Pubitemid 35435392)
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 5
    • Mischler, R.1    Metcalfe, I.C.2
  • 226
    • 0029023980 scopus 로고
    • Liposomal vaccines: Clinical status and immunological presentation for humoral and cellular immunity
    • Alving CR. Liposomal vaccines: clinical status and immunological presentation for humoral and cellular immunity. Ann NY Acad. Sci. 754, 143-152 (1995)
    • (1995) Ann NY Acad. Sci. , vol.754 , pp. 143-152
    • Alving, C.R.1
  • 227
    • 0037472438 scopus 로고    scopus 로고
    • Novel approaches in the development of immunopotentiating reconstituted influenza virosomes as efficient antigen carrier systems
    • DOI 10.1016/S0264-410X(02)00567-4, PII S0264410X02005674
    • Gluck R, Metcalfe IC. Novel approaches in the development of immunopotentiating reconstituted influenza virosomes as efficient antigen carrier systems. Vaccine 21(7-8), 611-615 (2003) (Pubitemid 36091969)
    • (2003) Vaccine , vol.21 , Issue.7-8 , pp. 611-615
    • Gluck, R.1    Metcalfe, I.C.2
  • 228
    • 0023082135 scopus 로고
    • The structure and function of the hemagglutinin membrane glycoprotein of influenza virus
    • Wiley DC, Skehel JJ. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu. Rev. Biochem. 56, 365-394 (1987)
    • (1987) Annu. Rev. Biochem. , vol.56 , pp. 365-394
    • Wiley, D.C.1    Skehel, J.J.2
  • 229
    • 0025974482 scopus 로고
    • Three antibody molecules can bind simultaneously to each monomer of the tetramer of influenza virus neuraminidase and the trimer of influenza virus hemagglutinin
    • Jackson DC, Crabb BS, Poumbourios P, Tulip WR, Laver WG. Three antibody molecules can bind simultaneously to each monomer of the tetramer of influenza virus neuraminidase and the trimer of influenza virus hemagglutinin. Arch. Virol. 116(1-4), 45-56 (1991)
    • (1991) Arch. Virol. , vol.116 , Issue.1-4 , pp. 45-56
    • Jackson, D.C.1    Crabb, B.S.2    Poumbourios, P.3    Tulip, W.R.4    Laver, W.G.5
  • 230
    • 0023860096 scopus 로고
    • Peptides bound to proteosomes via hydrophobic feet become highly immunogenic without adjuvants
    • Lowell GH, Smith LF, Seid RC, Zollinger WD. Peptides bound to proteosomes via hydrophobic feet become highly immunogenic without adjuvants. J. Exp. Med. 167(2), 658-663 (1988) (Pubitemid 18073663)
    • (1988) Journal of Experimental Medicine , vol.167 , Issue.2 , pp. 658-663
    • Lowell, G.H.1    Smith, L.F.2    Seid, R.C.3    Zollinger, W.D.4
  • 231
    • 0024380946 scopus 로고
    • Poly(butyl-2-cyanoacrylate) particles as adjuvants for oral immunization
    • O'Hagan DT, Palin KJ, Davis SS. Poly(butyl-2-cyanoacrylate) particles as adjuvants for oral immunization. Vaccine 7(3), 213-216 (1989) (Pubitemid 19174455)
    • (1989) Vaccine , vol.7 , Issue.3 , pp. 213-216
    • O'Hagan, D.T.1    Palin, K.J.2    Davis, S.S.3
  • 232
    • 77049248972 scopus 로고
    • The mode of action of immunologic adjuvants
    • Freund J. The mode of action of immunologic adjuvants. Bibl. Tuberc. 10, 130-148 (1956)
    • (1956) Bibl. Tuberc. , vol.10 , pp. 130-148
    • Freund, J.1
  • 233
    • 24644505322 scopus 로고    scopus 로고
    • Adjuvant and antigen delivery properties of virosomes
    • DOI 10.2174/156720105774370302
    • Gluck R, Burri KG, Metcalfe I. Adjuvant and antigen delivery properties of virosomes. Curr. Drug Deliv. 2(4), 395-400 (2005) (Pubitemid 41277771)
    • (2005) Current Drug Delivery , vol.2 , Issue.4 , pp. 395-400
    • Gluck, R.1    Burri, K.G.2    Metcalfe, I.3
  • 234
    • 3142657967 scopus 로고    scopus 로고
    • Influenza virosomes as an efficient system for adjuvanted vaccine delivery
    • DOI 10.1517/14712598.4.7.1139
    • Gluck R, Moser C, Metcalfe IC. Influenza virosomes as an efficient system for adjuvanted vaccine delivery. Expert Opin. Biol. Ther. 4(7), 1139-1145 (2004) (Pubitemid 38937555)
    • (2004) Expert Opinion on Biological Therapy , vol.4 , Issue.7 , pp. 1139-1145
    • Gluck, R.1    Moser, C.2    Metcalfe, I.C.3
  • 235
    • 33748794562 scopus 로고    scopus 로고
    • Virus-like particles: Passport to immune recognition
    • DOI 10.1016/j.ymeth.2006.07.018, PII S1046202306001629
    • Grgacic EV, Anderson DA. Virus-like particles: passport to immune recognition. Methods 40(1), 60-65 (2006) (Pubitemid 44415499)
    • (2006) Methods , vol.40 , Issue.1 , pp. 60-65
    • Grgacic, E.V.L.1    Anderson, D.A.2
  • 236
    • 22544484231 scopus 로고    scopus 로고
    • The virosome concept for influenza vaccines
    • Huckriede A, Bungener L, Stegmann T, et al. The virosome concept for influenza vaccines. Vaccine 23(Suppl. 1), S26-S38 (2005)
    • (2005) Vaccine , vol.23 , Issue.SUPPL. 1
    • Huckriede, A.1    Bungener, L.2    Stegmann, T.3
  • 237
    • 0028172936 scopus 로고
    • Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines
    • Shouval D, Ilan Y, Adler R, et al. Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines. Vaccine 12(15), 1453-1459 (1994)
    • (1994) Vaccine , vol.12 , Issue.15 , pp. 1453-1459
    • Shouval, D.1    Ilan, Y.2    Adler, R.3
  • 238
    • 0026549999 scopus 로고
    • Recombinant DNA hepatitis B vaccine containing pre-S components of the coat protein - A preliminary study on immunogenicity
    • Yap I, Guan R, Chan SH. Recombinant DNA hepatitis B vaccine containing pre-S components of the coat protein - a preliminary study on immunogenicity. Vaccine 10(7), 439-442 (1992)
    • (1992) Vaccine , vol.10 , Issue.7 , pp. 439-442
    • Yap, I.1    Guan, R.2    Chan, S.H.3
  • 239
    • 0031906229 scopus 로고    scopus 로고
    • Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice
    • Ball JM, Hardy ME, Atmar RL, Conner ME, Estes MK. Oral immunization with recombinant Norwalk virus-like particles induces a systemic and mucosal immune response in mice. J. Virol. 72(2), 1345-1353 (1998) (Pubitemid 28116920)
    • (1998) Journal of Virology , vol.72 , Issue.2 , pp. 1345-1353
    • Ball, J.M.1    Hardy, M.E.2    Atmar, R.L.3    Conner, M.E.4    Estes, M.K.5
  • 244
    • 0022032982 scopus 로고
    • The stabilization of proteins by osmolytes
    • Arakawa T, Timasheff SN. The stabilization of proteins by osmolytes. Biophys. J. 47(3), 411-414 (1985)
    • (1985) Biophys. J. , vol.47 , Issue.3 , pp. 411-414
    • Arakawa, T.1    Timasheff, S.N.2
  • 245
    • 0031734018 scopus 로고    scopus 로고
    • Advances in the delivery of pharmaceuticals
    • Middaugh CR. Advances in the delivery of pharmaceuticals. J. Pharm. Sci. 87(11), 1265-1266 (1998) (Pubitemid 28514125)
    • (1998) Journal of Pharmaceutical Sciences , vol.87 , Issue.11 , pp. 1265-1266
    • Middaugh, C.R.1
  • 246
    • 0031708329 scopus 로고    scopus 로고
    • Recent advances in our understanding of protein conformational stability from a pharmaceutical perspective
    • Middaugh CR, Edwards KL. Recent advances in our understanding of protein conformational stability from a pharmaceutical perspective. Expert Opin. Investig. Drugs 7(9), 1493-1500 (1998)
    • (1998) Expert Opin. Investig. Drugs , vol.7 , Issue.9 , pp. 1493-1500
    • Middaugh, C.R.1    Edwards, K.L.2
  • 248
    • 0030823347 scopus 로고    scopus 로고
    • HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti- interferon-γ antibody
    • Toda S, Ishii N, Okada E, et al. HIV-1- specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-g antibody. Immunology 92(1), 111-117 (1997) (Pubitemid 27380889)
    • (1997) Immunology , vol.92 , Issue.1 , pp. 111-117
    • Toda, S.1    Ishii, N.2    Okada, E.3    Kusakabe, K.-I.4    Arai, H.5    Hamajima, K.6    Gorai, I.7    Nishioka, K.8    Okuda, K.9
  • 249
    • 0030879822 scopus 로고    scopus 로고
    • Targeted delivery of antigen to hamster nasal lymphoid tissue with M- cell-directed lectins
    • Giannasca PJ, Boden JA, Monath TP. Targeted delivery of antigen to hamster nasal lymphoid tissue with M-cell-directed lectins. Infect. Immun. 65(10), 4288-4298 (1997) (Pubitemid 27422090)
    • (1997) Infection and Immunity , vol.65 , Issue.10 , pp. 4288-4298
    • Giannasca, P.J.1    Boden, J.A.2    Monath, T.P.3
  • 250
    • 0032033578 scopus 로고    scopus 로고
    • Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo
    • DOI 10.1016/S0264-410X(97)00222-3, PII S0264410X97002223
    • Foster N, Clark MA, Jepson MA, Hirst BH. Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo. Vaccine 16(5), 536-541 (1998) (Pubitemid 28044172)
    • (1998) Vaccine , vol.16 , Issue.5 , pp. 536-541
    • Foster, N.1    Clark, M.A.2    Jepson, M.A.3    Hirst, B.H.4
  • 251
    • 0030952669 scopus 로고    scopus 로고
    • Enhanced oral uptake of tomato Lectin-Conjugated nanoparticles in the rat
    • DOI 10.1023/A:1012153011884
    • Hussain N, Jani PU, Florence AT. Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat. Pharm. Res. 14(5), 613-618 (1997) (Pubitemid 27220279)
    • (1997) Pharmaceutical Research , vol.14 , Issue.5 , pp. 613-618
    • Hussain, N.1    Jani, P.U.2    Florence, A.T.3
  • 253
    • 0034660136 scopus 로고    scopus 로고
    • The ADP-ribosylating CTA1-DD adjuvant enhances T cell-dependent and independent responses by direct action on B cells involving anti-apoptotic Bcl-2- and germinal center-promoting effects
    • Agren L, Sverremark E, Ekman L, et al. The ADP-ribosylating CTA1-DD adjuvant enhances T cell-dependent and independent responses by direct action on B cells involving anti-apoptotic Bcl-2- and germinal center-promoting effects. J. Immunol. 164(12), 6276-6286 (2000) (Pubitemid 30408808)
    • (2000) Journal of Immunology , vol.164 , Issue.12 , pp. 6276-6286
    • Agren, L.1    Sverremark, E.2    Ekman, L.3    Schon, K.4    Lowenadler, B.5    Fernandez, C.6    Lycke, N.7
  • 254
    • 0031569528 scopus 로고    scopus 로고
    • Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit
    • Agren LC, Ekman L, Lowenadler B, Lycke NY. Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit. J. Immunol. 158(8), 3936-3946 (1997) (Pubitemid 127488754)
    • (1997) Journal of Immunology , vol.158 , Issue.8 , pp. 3936-3946
    • Agren, L.C.1    Ekman, L.2    Lowenadler, B.3    Lycke, N.Y.4
  • 255
    • 0033557754 scopus 로고    scopus 로고
    • Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1- DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity
    • Agren LC, Ekman L, Lowenadler B, Nedrud JG, Lycke NY. Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity. J. Immunol. 162(4), 2432-2440 (1999) (Pubitemid 29288873)
    • (1999) Journal of Immunology , vol.162 , Issue.4 , pp. 2432-2440
    • Agren, L.C.1    Ekman, L.2    Lowenadler, B.3    Nedrud, J.G.4    Lycke, N.Y.5
  • 257
    • 74149091711 scopus 로고    scopus 로고
    • The expanding vaccine development pipeline
    • Davis MM, Butchart AT, Coleman MS, et al. The expanding vaccine development pipeline, 1995-2008. Vaccine 28(5), 1353-1356 (2010)
    • (2010) Vaccine , vol.28 , Issue.5 , pp. 1353-1356
    • Davis, M.M.1    Butchart, A.T.2    Coleman, M.S.3
  • 258
    • 0037223760 scopus 로고    scopus 로고
    • Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine
    • DOI 10.1128/JVI.77.2.1049-1058.2003
    • Voss G, Manson K, Montefiori D, et al. Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine. J. Virol. 77(2), 1049-1058 (2003) (Pubitemid 36055526)
    • (2003) Journal of Virology , vol.77 , Issue.2 , pp. 1049-1058
    • Voss, G.1    Manson, K.2    Montefiori, D.3    Watkins, D.I.4    Heeney, J.5    Wyand, M.6    Cohen, J.7    Bruck, C.8
  • 261
    • 0030872511 scopus 로고    scopus 로고
    • Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit
    • DOI 10.1016/S0264-410X(96)00264-2, PII S0264410X96002642
    • Barnett SW, Rajasekar S, Legg H, et al. Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. Vaccine 15(8), 869-873 (1997) (Pubitemid 27287978)
    • (1997) Vaccine , vol.15 , Issue.8 , pp. 869-873
    • Barnett, S.W.1    Rajasekar, S.2    Legg, H.3    Doe, B.4    Fuller, D.H.5    Haynes, J.R.6    Walker, C.M.7    Steimer, K.S.8
  • 262
    • 0029852624 scopus 로고    scopus 로고
    • MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates
    • Traquina P, Morandi M, Contorni M, Van Nest G. MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. J. Infect. Dis. 174(6), 1168-1175 (1996) (Pubitemid 26393893)
    • (1996) Journal of Infectious Diseases , vol.174 , Issue.6 , pp. 1168-1175
    • Traquina, P.1    Morandi, M.2    Contorni, M.3    Van Nest, G.4
  • 263
    • 33750601327 scopus 로고    scopus 로고
    • Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
    • DOI 10.1097/QAD.0b013e32801086ee, PII 0000203020061114000003
    • Peng B, Voltan R, Cristillo AD, et al. Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity. AIDS 20(17), 2149-2157 (2006) (Pubitemid 44684705)
    • (2006) AIDS , vol.20 , Issue.17 , pp. 2149-2157
    • Peng, B.1    Voltan, R.2    Cristillo, A.D.3    Alvord, W.G.4    Davis-Warren, A.5    Zhou, Q.6    Murthy, K.K.7    Robert-Guroff, M.8
  • 264
    • 33645058168 scopus 로고    scopus 로고
    • An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine
    • Del Giudice G, Hilbert AK, Bugarini R, et al. An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine. Vaccine 24(16), 3063-3065 (2006)
    • (2006) Vaccine , vol.24 , Issue.16 , pp. 3063-3065
    • Del Giudice, G.1    Hilbert, A.K.2    Bugarini, R.3
  • 265
    • 34247215969 scopus 로고    scopus 로고
    • MF59-adjuvanted influenza vaccine confers superior immunogenicity in adult subjects (18-60 years of age) with chronic diseases who are at risk of post-influenza complications
    • DOI 10.1016/j.vaccine.2007.02.045, PII S0264410X07002204
    • Baldo V, Baldovin T, Floreani A, Carraro AM, Trivello R. MF59- adjuvanted influenza vaccine confers superior immunogenicity in adult subjects (18-60 years of age) with chronic diseases who are at risk of post-influenza complications. Vaccine 25(20), 3955-3961 (2007) (Pubitemid 46616991)
    • (2007) Vaccine , vol.25 , Issue.20 , pp. 3955-3961
    • Baldo, V.1    Baldovin, T.2    Floreani, A.3    Carraro, A.M.4    Trivello, R.5
  • 267
    • 0037654801 scopus 로고    scopus 로고
    • Survey of human-use adjuvants
    • DOI 10.1586/14760584.2.2.167
    • Keeney RT, Edelman R. Survey of human-use adjuvants. Expert Rev. Vaccines 2, 167-188 (2003) (Pubitemid 36559923)
    • (2003) Expert Review of Vaccines , vol.2 , Issue.2 , pp. 167-188
    • Kenney, R.T.1    Edelman, R.2
  • 268
    • 0038330442 scopus 로고    scopus 로고
    • MF59- adjuvanted vaccines: Increased immunogenicity with an optimal safety profile
    • Podda A, Del Giudice G. MF59- adjuvanted vaccines: increased immunogenicity with an optimal safety profile. Expert Rev. Vaccines 2, 197-203 (2003)
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 197-203
    • Podda, A.1    Del Giudice, G.2
  • 269
    • 0028822890 scopus 로고
    • Virosomes as carriers for combined vaccines
    • Mengiardi B, Berger R, Just M, et al. Virosomes as carriers for combined vaccines. Vaccines 13, 1306-1315 (1995)
    • (1995) Vaccines , vol.13 , pp. 1306-1315
    • Mengiardi, B.1    Berger, R.2    Just, M.3
  • 272
    • 0037019885 scopus 로고    scopus 로고
    • Influenza virosomes are an efficient delivery system for respiratory syncytial virus-F antigen inducing humoral and cell-mediated immunity
    • DOI 10.1016/S0264-410X(02)00353-5, PII S0264410X02003535
    • Cusi MG, Zubriggen R, Correale P, et al. Influenza virosomes are an efficient delivery system for respiratory syncytial virus- F antigen inducing humoral and cell-mediated immunity. Vaccine 20, 3436-3442 (2002) (Pubitemid 35248067)
    • (2002) Vaccine , vol.20 , Issue.29-30 , pp. 3436-3442
    • Cusi, M.G.1    Zurbriggen, R.2    Correale, P.3    Valassina, M.4    Terrosi, C.5    Pergola, L.6    Valensin, P.E.7    Gluck, R.8
  • 273
    • 0034634304 scopus 로고    scopus 로고
    • Intranasal immunization with Mumps virus DNA vaccine delivered by influenza virosomes elicits mucosal and systemic immunity
    • Cusi MG, Zubriggen R, Valassina M, et al. Intranasal immunization with Mumps virus DNA vaccine delivered by influenza virosomes elicits mucosal and systemic immunity. Virology 277, 111-118 (2000)
    • (2000) Virology , vol.277 , pp. 111-118
    • Cusi, M.G.1    Zubriggen, R.2    Valassina, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.