Adjuvancy and reactogenicity of N-acetylglucosaminyl-N-acetylmuramyl-dipeptide (GMDP) orally administered just prior to trivalent influenza subunit vaccine. A double-blind placebo-controlled study in nursing home residents

Vaccine

Volumn 14, Issue 14, 1996, Pages 1327-1330

  Palache, A M ^a   Beyer, W E P ^a   Hendriksen, E ^b   Gerez, L ^b   Aston, R ^c   Ledger, P W ^c   De Regt, V ^d   Kerstens, R ^d   Rothbarth, Ph H ^a   Osterhaus, A D M E ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b Nursing Home Den Ooiman   (Netherlands)

^c Peptech   (United Kingdom)

^d Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

Adjuvant; GDMP; Influenza vaccine

Indexed keywords

INFLUENZA VACCINE; MURAMYL DIPEPTIDE DERIVATIVE; N ACETYLGLUCOSAMINYL N ACETYLMURAMYLDIPEPTIDE; PLACEBO; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEVER; HUMAN; INFLUENZA; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALAISE; MORTALITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANTIBODIES, VIRAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLUENZA VACCINES; MALE; NURSING HOMES; PLACEBOS;

EID: 8044245915     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00075-8     Document Type: Article

References (4)

1. 1 Andronova, T. and Ivanov, I. The structure and immunomodulating function of glucosaminmuramyl dipeptides. Sov. Med. Rev. D. Immun. 1991, 4, 1-63
2. 2 Palache, A.M., Beyer, W.E.P., Sprenger, M.J.W, et al. Antibody response after influenza immunization with various vaccine doses: a double-blind, placebo-controlled, multi-centre, dose-response study in elderly nursing-home residents and young adults. Vaccine 1993, 11, 3-9
3. 3 WHO Recommended composition of influenza virus vaccines for use in the 1994-1995 season. Wkly Epidemiol. Rec. 1994, 69, 53-60
4. 4 Masurel, N., Ophof, P. and De Jong, P. Antibody response to immunization with influenza A/USSR/77 (H1N1) virus in young individuals primed or unprimed for A/New Jersey/76 (H1N1) virus. J. Hyg. (Camb.) 1981, 87, 201-209