Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse

Journal of Neuroscience Research

Volumn 86, Issue 7, 2008, Pages 1615-1625

  Chen, Qian ^a   Nakajima, Akira ^a   Se, Hoon Choi ^a   Xiong, Xiaoli ^a   Tang, Ya Ping ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b Jules Knapp Medical Center   (United States)

Author keywords

Aging dependent neurodegeneration; Alzheimer's disease; Conditional knockout; Mouse; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN; PRESENILIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN CORTEX; BRAIN VENTRICLE DILATATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; FOREBRAIN; FUNCTIONAL PROTEOMICS; GLIOSIS; HIPPOCAMPUS; KNOCKOUT MOUSE; LEARNING DISORDER; MEMORY DISORDER; MOUSE; NERVE CELL DEGENERATION; NEUROFILAMENT; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEAR; GLIOSIS; MAGNETIC RESONANCE IMAGING; MAZE LEARNING; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; PRESENILIN-1; PRESENILIN-2; PROSENCEPHALON; SILVER STAINING;

EID: 43149088503     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21601     Document Type: Article

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