Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models

NeuroToxicology

Volumn 27, Issue 5, 2006, Pages 807-815

  Sun, Faneng ^a   Anantharam, Vellareddy ^a   Zhang, Danhui ^a   Latchoumycandane, Calivarathan ^a   Kanthasamy, Arthi ^a   Kanthasamy, Anumantha G ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Dopamine; Nigral neurons; Parkinson's disease; Proteasome activity; Ubiquitin; UPS dysfunction

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 3; DNA FRAGMENT; PROTEASOME INHIBITOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL IMMORTALIZATION; CELL LINE; CONSENSUS; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; DOPAMINERGIC ACTIVITY; DOSE RESPONSE; ENZYME ACTIVITY; LOW DRUG DOSE; MESENCEPHALON; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; UBIQUITINATION;

ANALYSIS OF VARIANCE; ANIMALS; CASPASE 3; CASPASES; CELL DEATH; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; IMMUNOHISTOCHEMISTRY; LEUPEPTINS; MESENCEPHALON; MICE; MICE, INBRED C57BL; NERVE DEGENERATION; NEURONS; NEUROTRANSMITTER AGENTS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; TYROSINE 3-MONOOXYGENASE;

ANIMALIA;

EID: 33747165263     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2006.06.006     Document Type: Article

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