Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning

Science

Volumn 319, Issue 5867, 2008, Pages 1260-1264

  Nakashiba, Toshiaki ^a   Young, Jennie Z ^a   McHugh, Thomas J ^a   Buhl, Derek L ^a   Tonegawa, Susumu ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TETANUS TOXIN;

LEARNING; MEMORY; RODENT;

ARTICLE; BRAIN FUNCTION; DENTATE GYRUS; ENTORHINAL CORTEX; HIPPOCAMPUS; IMMUNOREACTIVITY; IN VIVO STUDY; LEARNING; MEMORY; MONOSYNAPTIC PATHWAY; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; CROSSES, GENETIC; DENTATE GYRUS; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HIPPOCAMPUS; INTERNEURONS; MALE; MAZE LEARNING; MENTAL RECALL; METALLOENDOPEPTIDASES; MICE; MICE, TRANSGENIC; NEURAL PATHWAYS; PYRAMIDAL CELLS; SYNAPTIC TRANSMISSION; TETANUS TOXIN;

MUS MUSCULUS;

EID: 39449107305     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1151120     Document Type: Article

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35. We thank F. Bushard, C. Carr, X. Zhou, J. Derwin, A. Ogawa, C. Lovett, and M. Ragion for technical assistance; N. Arzoumanian for her help in manuscript preparation; and A. Govindarajan, S. Itohara, M. Remondes, M. Wilson, and members of the Tonegawa lab for advice and discussion. Supported by NIH grants R01-MH078821 and P50-MH58880 to S.T.