Learning induces long-term potentiation in the hippocampus

Science

Volumn 313, Issue 5790, 2006, Pages 1093-1097

  Whitlock, Jonathan R ^a,b   Heynen, Arnold J ^a   Shuler, Marshall G ^a   Bear, Mark F ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; LEARNING SYSTEMS; NATURAL FREQUENCIES; PROTEINS;

HIGH-FREQUENCY STIMULATION (HFS); HIPPOCAMPAL GLUTAMATE RECEPTORS; LONG-TERM POTENTIATION (LTP);

BIOMEDICAL ENGINEERING;

AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

BRAIN; INHIBITION; LEARNING; RODENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DEPHOSPHORYLATION; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; IMMUNOBLOTTING; IN VIVO STUDY; LEARNING; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MEMORY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SHOCK; SYNAPTIC TRANSMISSION;

ANIMALS; AVOIDANCE LEARNING; CONDITIONING (PSYCHOLOGY); ELECTRIC STIMULATION; ELECTRODES, IMPLANTED; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MEMORY; PHOSPHORYLATION; PHOSPHOSERINE; RATS; RATS, LONG-EVANS; RECEPTORS, AMPA; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 33748060215     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1128134     Document Type: Article

References (38)

1. T. Lomo, Philos. Trans. R. Soc. London Ser. B 358, 617 (2003).
2. T. V. Bliss, T. Lomo, J. Physiol. 232, 331 (1973).
3. S. J. Martin, P. D. Grimwood, R. G. Morris, Annu. Rev. Neurosci. 23, 649 (2000).
4. M. F. Bear, Proc. Natl. Acad. Sci. USA 93, 13453 (1996).
5. S. Impey et al., Nat. Neurosci. 1, 595 (1998).
6. S. M. Taubenfeld, K. A. Wiig, M. F. Bear, C. M. Alberini, Nat. Neurosci. 2, 309 (1999).
7. S. M. Taubenfeld et al., J. Neurosci. 21, 84 (2001).
8. H. K. Lee, M. Barbarosie, K. Kameyama, M. F. Bear, R. L. Huganir, Nature 405, 955 (2000).
9. H. K. Lee, K. Kameyama, R. L. Huganir, M. F. Bear, Neuron 21, 1151 (1998).
10. A. J. Heynen, E. M. Quinlan, D. C. Bae, M. F. Bear, Neuron 28, 527 (2000).
11. R. L. Isaacon, W. O. Wickelgren, Science 138, 1104 (1962).
12. I. Izquierdo et al., Behav. Neural Biol. 58, 16 (1992).
13. C. A. Lorenzini, E. Baldi, C. Bucherelli, B. Sacchetti, G. Tassoni, Brain Res. 730, 32 (1996).
14. Materials and methods available as supporting online material.
15. M. S. Fanselow, Learn. Motiv. 17, 16 (1986).
16. M. S. Fanselow, Anim. Learn. Behav. 18, 264 (1990).
17. K. Louie, M. A. Wilson, Neuron 29, 145 (2001).
18. D. Marr, Philos. Trans. R. Soc London Ser. B 262, 23 (1971).
19. E. I. Moser, Behav. Brain Res. 71, 11 (1995).
20. B. L. McNaughton, R. M. Douglas, G. V. Goddard, Brain Res. 157, 277 (1978).
21. T. V. Bliss, G. L. Collingridge, Nature 361, 31 (1993).
22. T. V. Bliss, G. L. Collingridge, R. G. Morris, Philos. Trans. R. Soc. London Ser. B 358, 607 (2003).
23. R. G. Morris et al., Philos. Trans. R. Soc. London Ser. B 358, 773 (2003).
24. W. C. Abraham, J. M. Williams, Neuroscientist 9, 463 (2003).
25. M. Cammarota et al., Neurobiol. Learn. Mem. 64, 257 (1995).
26. M. Cammarota, R. Bernabeu, I. Izquierdo, J. H. Medina, Neurobiol. Learn. Mem. 66, 85 (1996).
27. M. Cammarota, R. Bernabeu, M. Levi De Stein, I. Izquierdo, J. H. Medina, Eur. J. Neurosci. 10, 2669 (1998).
28. L. R. Bevilaqua, J. H. Medina, I. Izquierdo, M. Cammarota, Neuroscience 136, 397 (2005).
29. D. J. Weisz, G. A. Clark, R. F. Thompson, Behav. Brain Res. 12, 145 (1984).
30. P. E. Sharp, B. L. McNaughton, C. A. Barnes, Brain Res. 339, 361 (1985).
31. B. L. McNaughton, C. A. Barnes, G. Rao, J. Baldwin, M. Rasmussen, J. Neurosci. 6, 563 (1986).
32. E. J. Green, B. L. McNaughton, C. A. Barnes, J. Neurosci. 10, 1455 (1990).
33. A. Gruart, M. D. Munoz, J. M. Delgado-Garcia, J. Neurosci. 26, 1077 (2006).
34. E. Moser, I. Mathiesen, P. Andersen, Science 259, 1324 (1993).
35. C. A. Erickson, B. L. McNaughton, C. A. Barnes, Brain Res. 615, 275 (1993).
36. P. Andersen, E. I. Moser, Hippocampus 5, 491 (1995).
37. B. Sacchetti et al., Eur. J. Neurosci. 15, 143 (2002).
38. This project was supported by the Howard Hughes Medical Institute and the National Institute of Mental Health. We thank E. Sklar, K. Clayton, K. Miller, M. Linden, and S. Meagher for assistance and M. Wilson for helpful discussion.