-
1
-
-
57749107808
-
Bad bugs, no drugs: NO ESKAPE! An update from the Infectious Diseases Society of America
-
Boucher, H. W.; Talbot, G. H.; Bradley, J. S.; Edwards, J. E., Jr.; Gilbert, D.; Rice, L. B.; Scheld, M.; Spellberg, B.; Bartlett, J. Bad bugs, no drugs: NO ESKAPE! An update from the Infectious Diseases Society of America Clin. Infect. Dis. 2009, 48, 1-12
-
(2009)
Clin. Infect. Dis.
, vol.48
, pp. 1-12
-
-
Boucher, H.W.1
Talbot, G.H.2
Bradley, J.S.3
Edwards, Jr.J.E.4
Gilbert, D.5
Rice, L.B.6
Scheld, M.7
Spellberg, B.8
Bartlett, J.9
-
2
-
-
77951132271
-
-
Technical Report EMEA/576176/2009; EMEA: London.
-
The Bacterial Challenge: Time to React; Technical Report EMEA/576176/2009; EMEA: London, 2009.
-
(2009)
The Bacterial Challenge: Time to React
-
-
-
3
-
-
77957360801
-
The antibacterial lead discovery challenge
-
Jones, D. The antibacterial lead discovery challenge Nat. Rev. Drug Discovery 2010, 9, 751-752
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 751-752
-
-
Jones, D.1
-
4
-
-
4644242447
-
st Century - An industry perspective of the challenges
-
DOI 10.1016/j.mib.2004.08.009, PII S1369527404001031
-
Thomson, C. J.; Power, E.; Ruebsamen-Waigmann, H.; Labischinski, H. Antibacterial research and development in the 21st century-an industry perspective of the challenges Curr. Opin. Microbiol. 2004, 7, 445-450 (Pubitemid 39297123)
-
(2004)
Current Opinion in Microbiology
, vol.7
, Issue.5
, pp. 445-450
-
-
Thomson, C.J.1
Power, E.2
Ruebsamen-Waigmann, H.3
Labischinski, H.4
-
6
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
DOI 10.1038/nrd2201, PII NRD2201
-
Payne, D. J.; Gwynn, M. N.; Holmes, D. J.; Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery Nat. Rev. Drug Discovery 2007, 6, 29-40 (Pubitemid 46020284)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.1
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
7
-
-
43949129098
-
Physicochemical properties of antibacterial compounds: Implications for drug discovery
-
DOI 10.1021/jm700967e
-
O'Shea, R.; Moser, H. E. Physicochemical properties of antibacterial compounds: implications for drug discovery J. Med. Chem. 2008, 51, 2871-2878 (Pubitemid 351706014)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.10
, pp. 2871-2878
-
-
O'Shea, R.1
Moser, H.E.2
-
8
-
-
9744232909
-
Time-related differences in the physical property profiles of oral drugs
-
DOI 10.1021/jm049717d
-
Leeson, P. D.; Davis, A. M. Time-related differences in the physical property profiles of oral drugs J. Med. Chem. 2004, 47, 6338-6348 (Pubitemid 39587257)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.25
, pp. 6338-6348
-
-
Leeson, P.D.1
Davis, A.M.2
-
9
-
-
60549115249
-
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
-
Miller, J. R.; Dunham, S.; Mochalkin, I.; Banotai, C.; Bowman, M.; Buist, S.; Dunkle, B.; Hanna, D.; Harwood, H. J.; Huband, M. D.; Karnovsky, A.; Kuhn, M.; Limberakis, C.; Liu, J. Y.; Mehrens, S.; Mueller, W. T.; Narasimhan, L.; Ogden, A.; Ohren, J.; Vara Prasad, J. V. N.; Shelly, J. A.; Skerlos, L.; Sulavik, M.; Thomas, V. H.; VanderRoest, S.; Wang, L.; Wang, Z.; Whitton, A.; Zhu, T.; Stover, C. K. A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 1737-1742
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 1737-1742
-
-
Miller, J.R.1
Dunham, S.2
Mochalkin, I.3
Banotai, C.4
Bowman, M.5
Buist, S.6
Dunkle, B.7
Hanna, D.8
Harwood, H.J.9
Huband, M.D.10
Karnovsky, A.11
Kuhn, M.12
Limberakis, C.13
Liu, J.Y.14
Mehrens, S.15
Mueller, W.T.16
Narasimhan, L.17
Ogden, A.18
Ohren, J.19
Vara Prasad, J.V.N.20
Shelly, J.A.21
Skerlos, L.22
Sulavik, M.23
Thomas, V.H.24
Vanderroest, S.25
Wang, L.26
Wang, Z.27
Whitton, A.28
Zhu, T.29
Stover, C.K.30
more..
-
10
-
-
0034730616
-
A novel method for measurement of submembrane ATP concentration
-
Gribble, F. M.; Loussouarn, G.; Tucker, S. J.; Zhao, C.; Nichols, C. G.; Ashcroft, F. M. A novel method for measurement of submembrane ATP concentration J. Biol. Chem. 2000, 275, 30046-30049
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30046-30049
-
-
Gribble, F.M.1
Loussouarn, G.2
Tucker, S.J.3
Zhao, C.4
Nichols, C.G.5
Ashcroft, F.M.6
-
11
-
-
70349449239
-
Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators
-
Imamura, H.; Huynh Nhat, K. P.; Togawa, H.; Saito, K.; Iino, R.; Kato-Yamada, Y.; Nagai, T.; Noji, H. Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 15651-15656
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 15651-15656
-
-
Imamura, H.1
Huynh Nhat, K.P.2
Togawa, H.3
Saito, K.4
Iino, R.5
Kato-Yamada, Y.6
Nagai, T.7
Noji, H.8
-
12
-
-
0028143584
-
Physiological concentrations of purines and pyrimidines
-
Traut, T. W. Physiological concentrations of purines and pyrimidines Mol. Cell. Biol. 2004, 140, 1-22
-
(2004)
Mol. Cell. Biol.
, vol.140
, pp. 1-22
-
-
Traut, T.W.1
-
13
-
-
0002124180
-
Use of the firefly bioluminescent reaction for rapid detection and counting of bacteria
-
Chapelle, E. W.; Levin, G. V. Use of the firefly bioluminescent reaction for rapid detection and counting of bacteria Biochem. Med. 1968, 2, 41-52
-
(1968)
Biochem. Med.
, vol.2
, pp. 41-52
-
-
Chapelle, E.W.1
Levin, G.V.2
-
14
-
-
0036527429
-
Protein kinases - The major drug targets of the twenty-first century?
-
Cohen, P. Protein kinases: the major grug targets of the twenty-first century? Nat. Rev. Drug Discovery 2002, 1, 309-315 (Pubitemid 37361447)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.4
, pp. 309-315
-
-
Cohen, P.1
-
15
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman, M. W.; Herrgard, S.; Treiber, D. K.; Gallant, P.; Atteridge, C. E.; Campbell, B. T.; Chan, K. W.; Ciceri, P.; Davis, M. I.; Edeen, P. T.; Faraoni, R.; Floyd, M.; Hunt, J. P.; Lockhart, D. J.; Milanov, Z. V.; Morrison, M. J.; Pallares, G.; Patel, H. K.; Pritchard, S.; Wodicka, L. M.; Zarrinkar, P. P. A quantitative analysis of kinase inhibitor selectivity Nat. Biotechnol. 2008, 26, 127-132
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
Chan, K.W.7
Ciceri, P.8
Davis, M.I.9
Edeen, P.T.10
Faraoni, R.11
Floyd, M.12
Hunt, J.P.13
Lockhart, D.J.14
Milanov, Z.V.15
Morrison, M.J.16
Pallares, G.17
Patel, H.K.18
Pritchard, S.19
Wodicka, L.M.20
Zarrinkar, P.P.21
more..
-
16
-
-
36549040859
-
The selectivity of protein kinase inhibitors: A further update
-
Bain, J.; Plater, L.; Elliott, M.; Shapiro, N.; Hastie, C. J.; McLauchlan, H.; Klevernic, I.; Arthur, J. S.; Alessi, D. R.; Cohen, P. The selectivity of protein kinase inhibitors: a further update Biochem. J. 2007, 408, 297-315
-
(2007)
Biochem. J.
, vol.408
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, M.3
Shapiro, N.4
Hastie, C.J.5
McLauchlan, H.6
Klevernic, I.7
Arthur, J.S.8
Alessi, D.R.9
Cohen, P.10
-
17
-
-
33845894155
-
Multi-targeting by monotherapeutic antibacterials
-
DOI 10.1038/nrd2202, PII NRD2202
-
Silver, L. L. Multi-targeting by monotherapeutic antibacterials Nat. Rev. Drug Discovery 2007, 6, 41-55 (Pubitemid 46020285)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.1
, pp. 41-55
-
-
Silver, L.L.1
-
18
-
-
0032583606
-
Engineering a cell-free murein biosynthetic pathway: Combinatorial enzymology in drug discovery [8]
-
DOI 10.1021/ja983468z
-
Wong, K. K.; Kuo, D. W.; Chabin, R. M.; Fournier, C.; Gregnas, L. D.; Waddell, S. T.; Marsilio, F.; Leiting, B.; Pompliano, D. L. Engeneering a cell-free murein biosynthetic pathway: Combinatorial enzymology in drug discovery J. Am. Chem. Soc. 1998, 120, 13527-13528 (Pubitemid 29025224)
-
(1998)
Journal of the American Chemical Society
, vol.120
, Issue.51
, pp. 13527-13528
-
-
Wong, K.K.1
Kuo, D.W.2
Chabin, R.M.3
Fournier, C.4
Gegnas, L.D.5
Waddell, S.T.6
Marsilio, F.7
Leiting, B.8
Pompliano, D.L.9
-
19
-
-
39149083088
-
Cytoplasmic steps of peptydoglycan biosynthesis
-
Barreteau, H.; Kovač, A.; Boniface, A.; Sova, M.; Gobec, S.; Blanot, D. Cytoplasmic steps of peptydoglycan biosynthesis FEMS Microbiol. Rev. 2008, 32, 168-207
-
(2008)
FEMS Microbiol. Rev.
, vol.32
, pp. 168-207
-
-
Barreteau, H.1
Kovač, A.2
Boniface, A.3
Sova, M.4
Gobec, S.5
Blanot, D.6
-
20
-
-
0033954256
-
The Protein Data Bank
-
Berman, H. M.; Westbrook, J.; Feng, Z.; Gilliland, G.; Bhat, T. N.; Weissig, H.; Shindyalov, I. N.; Bourne, P. E. The Protein Data Bank Nucleic Acids Res. 2000, 28, 235-242 (Pubitemid 30047768)
-
(2000)
Nucleic Acids Research
, vol.28
, Issue.1
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
Weissig, H.6
Shindyalov, I.N.7
Bourne, P.E.8
-
21
-
-
79951822696
-
-
http://www.pdb.org.
-
-
-
-
22
-
-
12844274375
-
Antibiotics: Where did we go wrong?
-
DOI 10.1016/S1359-6446(04)03285-4, PII S1359644604032854
-
Overbye, K. M.; Barrett, J. F. Antibiotics: where did we go wrong? Drug Discovery Today 2005, 10, 45-52 (Pubitemid 40164818)
-
(2005)
Drug Discovery Today
, vol.10
, Issue.1
, pp. 45-52
-
-
Overbye, K.M.1
Barrett, J.F.2
-
23
-
-
0034082239
-
The influence of natural products upon drug discovery
-
Newman, D. J.; Cragg, G. M.; Snader, K. M. The influence of natural products upon drug discovery Nat. Prod. Rep. 2000, 17, 251-234
-
(2000)
Nat. Prod. Rep.
, vol.17
, pp. 251-234
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
24
-
-
0031105464
-
DNA gyrase as a drug target
-
DOI 10.1016/S0966-842X(96)10085-8, PII S0966842X96100858
-
Maxwell, A. DNA gyrase as a drug target Trends Microbiol. 1997, 5, 102-109 (Pubitemid 27139470)
-
(1997)
Trends in Microbiology
, vol.5
, Issue.3
, pp. 102-109
-
-
Maxwell, A.1
-
25
-
-
0017043747
-
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase
-
DOI 10.1073/pnas.73.12.4474
-
Gellert, M.; O'Dea, M. H.; Itoh, T.; Tomizawa, J. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase Proc. Natl. Acad. Sci. U.S.A. 1976, 73, 4474-4478 (Pubitemid 8013922)
-
(1976)
Proceedings of the National Academy of Sciences of the United States of America
, vol.73
, Issue.12
, pp. 4474-4478
-
-
Gellert, M.1
O'Dea, M.H.2
Itoh, T.3
Tomizawa, J.I.4
-
26
-
-
0029978822
-
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography
-
Lewis, R. J.; Singh, O. M. P.; Smith, C. V.; Skarzynski, T.; Maxwell, A.; Wonacott, A. L.; Wigley, D. B. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography EMBO J. 1996, 15, 1412-1420 (Pubitemid 26093794)
-
(1996)
EMBO Journal
, vol.15
, Issue.6
, pp. 1412-1420
-
-
Lewis, R.J.1
Singh, O.M.P.2
Smith, C.V.3
Skarzynski, T.4
Maxwell, A.5
Wonacott, A.J.6
Wigley, D.B.7
-
27
-
-
0026428621
-
Crystal structure of an N-terminal fragment of the DNA gyrase B protein
-
Wigley, D. B.; Davies, G. J.; Dodson, E. J.; Maxwell, A.; Dodson, G. Crystal structure of an N-terminal fragment of the DNA gyrase B protein Nature 1991, 351, 624-629 (Pubitemid 21896650)
-
(1991)
Nature
, vol.351
, Issue.6328
, pp. 624-629
-
-
Wigley, D.B.1
Davies, G.J.2
Dodson, E.J.3
Maxwell, A.4
Dodson, G.5
-
28
-
-
0034737716
-
Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center
-
DOI 10.1074/jbc.275.13.9468
-
Brino, L.; Urzhumtsev, A.; Mousli, M.; Bronner, C.; Mirschler, A.; Oudet, P.; Moras, D. Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center J. Biol. Chem. 2000, 275, 9468-9475 (Pubitemid 30185175)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.13
, pp. 9468-9475
-
-
Brino, L.1
Urzhumtsev, A.2
Mousli, M.3
Bronner, C.4
Mitschler, A.5
Oudet, P.6
Moras, D.7
-
29
-
-
0037166285
-
An open conformation of the Thermus thermophilus gyrase B ATP-binding domain
-
DOI 10.1074/jbc.M111740200
-
Lamour, V.; Hoermann, L.; Jeltsch, J.; Oudett, P.; Moras, D. An open conformation of Thermus thermophilus Gyrase B ATP-binding domain J. Biol. Chem. 2002, 277, 18947-18953 (Pubitemid 34952456)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.21
, pp. 18947-18953
-
-
Lamour, V.1
Hoermann, L.2
Jeltsch, J.-M.3
Oudet, P.4
Moras, D.5
-
30
-
-
0030893658
-
The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin
-
DOI 10.1002/(SICI)1097-0134(199705)28:1<41::AID-PROT4>3.0.CO;2-M
-
Tsai, F. T. F.; Singh, O. M. P.; Skarzynski, T.; Wonacott, A. J.; Weston, S.; Tucker, A.; Pauptit, R. A.; Breeze, A. L.; Poyser, J. P.; O'Brien, R.; Ladbury, J. E.; Wigley, D. B. The high-resolution crystal structure of a 24-kDa Gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin Proteins 1997, 28, 41-52 (Pubitemid 27194017)
-
(1997)
Proteins: Structure, Function and Genetics
, vol.28
, Issue.1
, pp. 41-52
-
-
Tsai, F.T.F.1
Singh, O.M.P.2
Skarzynski, T.3
Wonacott, A.J.4
Weston, S.5
Tucker, A.6
Pauptit, R.A.7
Breeze, A.L.8
Poyser, J.P.9
O'Brien, R.10
Ladbury, J.E.11
Wigley, D.B.12
-
31
-
-
0030758672
-
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: A thermodynamic and crystallographic study
-
DOI 10.1021/bi970294+
-
Holdgate, G. A.; Tunnicliffe, A.; Ward, W. H. J.; Weston, S. A.; Rosenbrock, G.; Barth, P. T.; Taylor, I. W. F.; Paupit, R. A.; Timms, D. The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study Biochemistry 1997, 36, 9663-9673 (Pubitemid 27364677)
-
(1997)
Biochemistry
, vol.36
, Issue.32
, pp. 9663-9673
-
-
Holdgate, G.A.1
Tunnicliffe, A.2
Ward, W.H.J.3
Weston, S.A.4
Rosenbrock, G.5
Barth, P.T.6
Taylor, I.W.F.7
Pauptit, R.A.8
Timms, D.9
-
32
-
-
0012684806
-
The ATP-binding site of type II topoisomerases as a target for antibacterial drugs
-
Maxwell, A.; Lawson, D. M. The ATP-binding site of type II topoisomerases as a target for antibacterial drugs Curr. Top. Med. Chem. 2003, 3, 283-303
-
(2003)
Curr. Top. Med. Chem.
, vol.3
, pp. 283-303
-
-
Maxwell, A.1
Lawson, D.M.2
-
33
-
-
0028363364
-
The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs
-
DOI 10.1111/j.1365-2958.1994.tb01026.x
-
Gilbert, E. J.; Maxwell, A. The 24-kDa N-terminal subdomain of the DNA gyrase B protein coumarin drugs Mol. Microbiol. 1994, 12, 365-373 (Pubitemid 24197493)
-
(1994)
Molecular Microbiology
, vol.12
, Issue.3
, pp. 365-373
-
-
Gilbert, E.J.1
Maxwell, A.2
-
34
-
-
33747872588
-
Molecular complexes at a glance: Automated generation of two-dimensional complex diagrams
-
DOI 10.1093/bioinformatics/btl150
-
Stierand, K.; Maass, P.; Rarey, M. Molecular complexes at a glance: automated generation of two-dimensional complex diagrams Bioinformatics 2006, 22, 1710-1716 (Pubitemid 44288332)
-
(2006)
Bioinformatics
, vol.22
, Issue.14
, pp. 1710-1716
-
-
Stierand, K.1
Maass, P.C.2
Rarey, M.3
-
35
-
-
79951818379
-
-
PoseViewWeb is available at.
-
PoseViewWeb is available at http://poseview.zbh.uni-hamburg.de/poseview.
-
-
-
-
36
-
-
34548628774
-
Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents
-
Oblak, M.; Kotnik, M.; Šolmajer, T. Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents Curr. Med. Chem. 2007, 14, 2033-204
-
(2007)
Curr. Med. Chem.
, vol.14
, pp. 2033-204
-
-
Oblak, M.1
Kotnik, M.2
Šolmajer, T.3
-
37
-
-
0033523720
-
Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose
-
DOI 10.1016/S0960-894X(99)00493-X, PII S0960894X9900493X
-
Ferroud, D.; Collard, J.; Klich, M.; Dupuis-Hamelin, C.; Mauvais, P.; Lassaigne, P.; Bonnefoy, A.; Musicki, B. Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose Bioorg. Med. Chem. Lett. 1999, 9, 2881-2886 (Pubitemid 29481182)
-
(1999)
Bioorganic and Medicinal Chemistry Letters
, vol.9
, Issue.19
, pp. 2881-2886
-
-
Ferroud, D.1
Collard, J.2
Klich, M.3
Dupuis-Hamelin, C.4
Mauvais, P.5
Lassaigne, P.6
Bonnefoy, A.7
Musicki, B.8
-
38
-
-
0034677130
-
Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis
-
Periers, A. M.; Laurin, P.; Ferroud, D.; Haesslein, J. L.; Klich, M.; Dupuis-Hamelin, C.; Mauvais, P.; Lassaigne, P.; Bonnefoy, A.; Musicki, B. Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis Bioorg. Med. Chem. Lett. 2000, 10, 161-165
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 161-165
-
-
Periers, A.M.1
Laurin, P.2
Ferroud, D.3
Haesslein, J.L.4
Klich, M.5
Dupuis-Hamelin, C.6
Mauvais, P.7
Lassaigne, P.8
Bonnefoy, A.9
Musicki, B.10
-
39
-
-
0034618191
-
Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: Biological activity of RU79115
-
DOI 10.1016/S0960-894X(00)00304-8, PII S0960894X00003048
-
Musicki, B.; Periers, A. M.; Laurin, P.; Ferroud, D.; Benedetti, Y.; Lachaud, S.; Chatreaux, F.; Haesslein, J. L.; Iltis, A.; Pierre, C.; Khider, J.; Tessot, N.; Airault, M.; Demassey, J.; Dupuis-Hamelin, C.; Lassaigne, P.; Bonnefoy, A.; Vicat, P.; Klich, M. Improved antibacterial activities of coumarin antibiotics bearing 5′,5′-dialkylnoviose: biological activity of RU79115 Bioorg. Med. Chem. Lett. 2000, 10, 1695-1699 (Pubitemid 30495242)
-
(2000)
Bioorganic and Medicinal Chemistry Letters
, vol.10
, Issue.15
, pp. 1695-1699
-
-
Musicki, B.1
Periers, A.-M.2
Laurin, P.3
Ferroud, D.4
Benedetti, Y.5
Lachaud, S.6
Chatreaux, F.7
Haesslein, J.-L.8
Iltis, A.9
Pierre, C.10
Khider, J.11
Tessot, N.12
Airault, M.13
Demassey, J.14
Dupuis-Hamelin, C.15
Lassaigne, P.16
Bonnefoy, A.17
Vicat, P.18
Klich, M.19
-
40
-
-
2142814314
-
Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): A Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase
-
DOI 10.1128/AAC.48.5.1856-1864.2004
-
Bellon, S.; Parsons, J. D.; Wei, Y.; Hayakawa, K.; Swonson, L. L.; Charifson, P. S.; Lippke, J. A.; Aldape, R.; Gross, C. H. Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase Antimicrob. Agents Chemother. 2004, 48, 1856-1864 (Pubitemid 38544398)
-
(2004)
Antimicrobial Agents and Chemotherapy
, vol.48
, Issue.5
, pp. 1856-1864
-
-
Bellon, S.1
Parsons, J.D.2
Wei, Y.3
Hayakawa, K.4
Swenson, L.L.5
Charifson, P.S.6
Lippke, J.A.7
Aldape, R.8
Gross, C.H.9
-
41
-
-
37849037266
-
Transferred NOE and saturation transfer difference NMR studies of novobiocin binding to EnvZ suggest binding mode similar to DNA gyrase
-
Plesniak, L. A.; Botsch, K.; Leibrand, M.; Kelly, M.; Sem, D.; Adams, J. A.; Jennings, P. Transferred NOE and saturation transfer difference NMR studies of novobiocin binding to EnvZ suggest binding mode similar to DNA gyrase Chem. Biol. Drug Des. 2008, 71, 28-35
-
(2008)
Chem. Biol. Drug Des.
, vol.71
, pp. 28-35
-
-
Plesniak, L.A.1
Botsch, K.2
Leibrand, M.3
Kelly, M.4
Sem, D.5
Adams, J.A.6
Jennings, P.7
-
42
-
-
0034711270
-
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone
-
DOI 10.1074/jbc.M003701200
-
Marcu, M. G.; Chadli, A.; Bouhoche, I.; Catelli, M.; Neckers, L. M. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone J. Biol. Chem. 2000, 275, 37181-37186 (Pubitemid 32002137)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.47
, pp. 37181-37186
-
-
Marcu, M.G.1
Chadli, A.2
Bouhouche, I.3
Catelli, M.4
Neckers, L.M.5
-
43
-
-
0033985080
-
GHKL, an emergent ATPase/kinase superfamily
-
DOI 10.1016/S0968-0004(99)01503-0, PII S0968000499015030
-
Dutta, R.; Inouye, M. GHKL, an emergent ATPase/kinase superfamily Trends Biochem. Sci. 2000, 25, 24-28 (Pubitemid 30060426)
-
(2000)
Trends in Biochemical Sciences
, vol.25
, Issue.1
, pp. 24-28
-
-
Dutta, R.1
Inouye, M.2
-
44
-
-
0032487858
-
NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ
-
DOI 10.1038/23968
-
Tanaka, T.; Saha, S. K.; Tomomori, C.; Ishima, R.; Liu, D.; Tong, K. I.; Park, H.; Dutta, R.; Qin, L.; Swindells, M. B.; Yamazaki, T.; Ono, A. M.; Kainosho, M.; Inouye, M.; Ikura, M. NMR structure of the histidine kinase domain of the E. coli osmosenzor EnvZ Nature 1998, 396, 88-92 (Pubitemid 28520455)
-
(1998)
Nature
, vol.396
, Issue.6706
, pp. 88-92
-
-
Tanaka, T.1
Saha, S.K.2
Tomomori, C.3
Ishima, R.4
Liu, D.5
Tong, K.I.6
Park, H.7
Dutta, R.8
Qin, L.9
Swindells, M.B.10
Yamazaki, T.11
Ono, A.M.12
Kainosho, M.13
Inouye, M.14
Ikura, M.15
-
45
-
-
79951835099
-
Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor
-
Nakada, N.; Gmünder, H.; Hirata, T.; Arisawa, M. Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor Antimicrob. Agents Chemother. 1994, 40, 473-476
-
(1994)
Antimicrob. Agents Chemother.
, vol.40
, pp. 473-476
-
-
Nakada, N.1
Gmünder, H.2
Hirata, T.3
Arisawa, M.4
-
46
-
-
0029978822
-
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography
-
Lewis, R. J.; Singh, O. M. P.; Smith, C. V.; Skarynski, T.; Maxwell, A.; Wonacott, A. J.; Wigley, D. B. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography EMBO J. 1996, 15, 1412-1420 (Pubitemid 26093794)
-
(1996)
EMBO Journal
, vol.15
, Issue.6
, pp. 1412-1420
-
-
Lewis, R.J.1
Singh, O.M.P.2
Smith, C.V.3
Skarzynski, T.4
Maxwell, A.5
Wonacott, A.J.6
Wigley, D.B.7
-
47
-
-
33749129568
-
Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol
-
DOI 10.1093/nar/gkl567
-
Corbett, K. D.; Berger, J. M. Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol Nucleic Acids Res. 2006, 34, 4269-4277 (Pubitemid 44542206)
-
(2006)
Nucleic Acids Research
, vol.34
, Issue.15
, pp. 4269-4277
-
-
Corbett, K.D.1
Berger, J.M.2
-
48
-
-
0036073440
-
Inhibition of branched-chain α-keto acid dehydrogenase kinase and, Sln1 yeast histidine kinase by the antifungal antibiotic radicicol
-
DOI 10.1124/mol.62.2.289
-
Besant, P. G.; Lasker, M. V.; Bui, C. D.; Turck, C. W. Inhibition of branched-chain α-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol Mol. Pharmacol. 2002, 62, 289-296 (Pubitemid 34804108)
-
(2002)
Molecular Pharmacology
, vol.62
, Issue.2
, pp. 289-296
-
-
Besant, P.G.1
Lasker, M.V.2
Bui, C.D.3
Turck, C.W.4
-
49
-
-
42749090538
-
The Hsp90 inhibitor radicolol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ
-
Guarnieri, M. T.; Zhang, L.; Shen, J.; Zhao, R. The Hsp90 inhibitor radicolol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ J. Mol. Biol. 2008, 379, 82-93
-
(2008)
J. Mol. Biol.
, vol.379
, pp. 82-93
-
-
Guarnieri, M.T.1
Zhang, L.2
Shen, J.3
Zhao, R.4
-
50
-
-
0033305209
-
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones
-
Schulte, T. W.; Akinaga, S.; Murakata, T.; Agatsuma, T.; Sudimoto, S.; Nakano, H.; Lee, Y. S.; Simen, B. B.; Argon, Y.; Felts, S.; Toft, D. O.; Neckers, L. M.; Sharma, S. V. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones Mol. Endocrinol. 1999, 13, 1435-1448 (Pubitemid 30650587)
-
(1999)
Molecular Endocrinology
, vol.13
, Issue.9
, pp. 1435-1448
-
-
Schulte, T.W.1
Akinaga, S.2
Murakata, T.3
Agatsuma, T.4
Sugimoto, S.5
Nakano, H.6
Lee, Y.S.7
Simen, B.B.8
Argon, Y.9
Felts, S.10
Toft, D.O.11
Neckers, L.M.12
Sharma, S.V.13
-
51
-
-
0032959590
-
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
-
DOI 10.1021/jm980403y
-
Roe, S. M.; Prodromou, C.; O'Brien, R.; Ladbury, J. E.; Piper, P. W.; Pearl, L. H. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin J. Med. Chem. 1999, 42, 260-266 (Pubitemid 29069861)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.2
, pp. 260-266
-
-
Roe, S.M.1
Prodromou, C.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
52
-
-
0035798570
-
Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism
-
Marina, A.; Mott, C.; Auyzenberg, A.; Hendrickson, W. A.; Waldburger, C. D. Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism J. Biol. Chem. 2001, 276, 41182-41190
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 41182-41190
-
-
Marina, A.1
Mott, C.2
Auyzenberg, A.3
Hendrickson, W.A.4
Waldburger, C.D.5
-
53
-
-
44649092678
-
Are natural products still the best source for antibacterial discovery? The bacterial entry factor
-
DOI 10.1517/17460441.3.5.487
-
Silver, L. L. Are natural products still the best source for antibacterial discovery? The bacterial entry factor Expert Opin. Drug Discovery 2008, 3, 487-500 (Pubitemid 351771990)
-
(2008)
Expert Opinion on Drug Discovery
, vol.3
, Issue.5
, pp. 487-500
-
-
Silver, L.L.1
-
54
-
-
42949160050
-
Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
-
DOI 10.1021/jm0704090
-
Newman, D. J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J. Med. Chem. 2008, 51, 2589-2599 (Pubitemid 351620778)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.9
, pp. 2589-2599
-
-
Newman, D.J.1
-
55
-
-
0037431421
-
Kinase inhibitors: Not just for kinases anymore
-
DOI 10.1021/jm020427b
-
McGovern, S. L.; Shoichet, B. K. Kinase inhibitors: not just for kinases anymore J. Med. Chem. 2003, 46, 1478-1483 (Pubitemid 36512711)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.8
, pp. 1478-1483
-
-
McGovern, S.L.1
Shoichet, B.K.2
-
56
-
-
0027478123
-
Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes
-
Shaw, K. J.; Rather, P. N.; Hare, R. S.; Miller, G. H. Molecular genetics of aminoglycoside resistance genes and familiar relationships of the aminoglycoside-modifying enzymes Microbiol. Mol. Biol. Rev. 1993, 57, 138-163 (Pubitemid 23078440)
-
(1993)
Microbiological Reviews
, vol.57
, Issue.1
, pp. 138-163
-
-
Shaw, K.J.1
Rather, P.N.2
Hare, R.S.3
Miller, G.H.4
-
57
-
-
0032774575
-
Aminoglycoside antibiotic phosphotransferases are also serine protein kinases
-
DOI 10.1016/S1074-5521(99)80016-7
-
Daigle, D. M.; McKay, G. A.; Thompson, P. R.; Wright, G. D. Aminoglycoside antibiotic phosphotransferases are also serine protein kinases Chem. Biol. 1999, 6, 11-18 (Pubitemid 29363041)
-
(1999)
Chemistry and Biology
, vol.6
, Issue.1
, pp. 11-18
-
-
Daigle, D.M.1
McKay, G.A.2
Thompson, P.R.3
Wright, G.D.4
-
58
-
-
58949090837
-
ATP competitive inhibitors of d -alanine- d -alanine ligase based on protein kinase inhibitors scaffolds
-
Triola, G.; Wetzel, S.; Ellinger, B.; Koch, M. A.; Hübel, K.; Rauh, D.; Waldmann, H. ATP competitive inhibitors of d -alanine- d -alanine ligase based on protein kinase inhibitors scaffolds Bioorg. Med. Chem. 2009, 17, 1079-1087
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 1079-1087
-
-
Triola, G.1
Wetzel, S.2
Ellinger, B.3
Koch, M.A.4
Hübel, K.5
Rauh, D.6
Waldmann, H.7
-
59
-
-
39149083088
-
Cytoplasmic steps of peptidoglycan biosynthesis
-
Barreteau, H.; Kovač, A.; Boniface, A.; Sova, M.; Gobec, S.; Blanot, D. Cytoplasmic steps of peptidoglycan biosynthesis FEMS Microbiol. Rev. 2008, 32, 68-207
-
(2008)
FEMS Microbiol. Rev.
, vol.32
, pp. 68-207
-
-
Barreteau, H.1
Kovač, A.2
Boniface, A.3
Sova, M.4
Gobec, S.5
Blanot, D.6
-
60
-
-
0026589363
-
D -Alanine: D -alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzyme
-
Al-Bar, O. A. M.; O'Connor, C. D.; Giles, I. G.; Akhtar, M. d -Alanine: d -alanine ligase of Escherichia coli. Expression, purification and inhibitory studies on the cloned enzyme Biochem. J. 1992, 282, 747-752
-
(1992)
Biochem. J.
, vol.282
, pp. 747-752
-
-
Al-Bar, O.A.M.1
O'Connor, C.D.2
Giles, I.G.3
Akhtar, M.4
-
61
-
-
0028085434
-
Three-dimensional structure of the biotin carboxylase subunit of acetyl- CoA carboxylase
-
Waldrop, G. L.; Rayment, I.; Holden, H. M. Three-dimensional structure of biotin carboxylase subunit of acetyl-CoA carboxylase Biochemistry 1994, 33, 10249-10256 (Pubitemid 24281789)
-
(1994)
Biochemistry
, vol.33
, Issue.34
, pp. 10249-10256
-
-
Waldrop, G.L.1
Rayment, I.2
Holden, H.M.3
-
62
-
-
67649295267
-
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches
-
Mochalkin, I.; Miller, J. R.; Narasimhan, L.; Thanabal, V.; Erdman, P.; Cox, P. B.; Vara Prasad, J. V. N.; Lightle, S.; Hunband, M. D.; Kendall Stover, C. Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches ACS Chem. Biol. 2009, 4, 472-483
-
(2009)
ACS Chem. Biol.
, vol.4
, pp. 472-483
-
-
Mochalkin, I.1
Miller, J.R.2
Narasimhan, L.3
Thanabal, V.4
Erdman, P.5
Cox, P.B.6
Vara Prasad, J.V.N.7
Lightle, S.8
Hunband, M.D.9
Kendall Stover, C.10
-
63
-
-
52949102964
-
Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase
-
Mochalkin, I.; Miller, J. R.; Evdokimov, A.; Lightle, S.; Yan, C.; Stover, C. K.; Waldrop, G. L. Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase Protein Sci. 2008, 17, 1706-1718
-
(2008)
Protein Sci.
, vol.17
, pp. 1706-1718
-
-
Mochalkin, I.1
Miller, J.R.2
Evdokimov, A.3
Lightle, S.4
Yan, C.5
Stover, C.K.6
Waldrop, G.L.7
-
64
-
-
70350346470
-
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase
-
Hung, A. W.; Silvestre, L.; Wen, S.; Ciulli, A.; Blundell, T. L.; Abell, C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase Angew. Chem., Int. Ed. 2009, 48, 8452-8456
-
(2009)
Angew. Chem., Int. Ed.
, vol.48
, pp. 8452-8456
-
-
Hung, A.W.1
Silvestre, L.2
Wen, S.3
Ciulli, A.4
Blundell, T.L.5
Abell, C.6
-
65
-
-
0037407932
-
Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate
-
DOI 10.1110/ps.0241803
-
Wang, S.; Eisenberg, D. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate Protein Sci. 2003, 12, 1097-1108 (Pubitemid 36505443)
-
(2003)
Protein Science
, vol.12
, Issue.5
, pp. 1097-1108
-
-
Wang, S.1
Eisenberg, D.2
-
66
-
-
41849134287
-
5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3- carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: Initiating a quest for new antitubercular drugs
-
DOI 10.1021/jm701372r
-
Velaparthi, S.; Brunsteiner, M.; Uddin, R.; Wan, B.; Franzblau, S. G.; Petukhov, P. A. 5- tert -Butyl- N -pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[ d ]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs J. Med. Chem. 2008, 51, 1999-2002 (Pubitemid 351503254)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.7
, pp. 1999-2002
-
-
Velaparthi, S.1
Brunsteiner, M.2
Uddin, R.3
Wan, B.4
Franzblau, S.G.5
Petukhov, P.A.6
-
67
-
-
0031020216
-
D-alanine:D-alanine ligase: Phosphonate and phosphinate intermediates with wild type and the Y216F mutant
-
DOI 10.1021/bi962431t
-
Fan, C.; Park, I. S.; Walsh, C. T.; Knox, J. R. d -Alanine: d -alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant Biochemistry 1997, 36, 2531-2538 (Pubitemid 27106645)
-
(1997)
Biochemistry
, vol.36
, Issue.9
, pp. 2531-2538
-
-
Fan, C.1
Park, I.-S.2
Walsh, C.T.3
Knox, J.R.4
-
68
-
-
57349130997
-
Discovery of new inhibitors of d -alanine: D -alanine ligase by structure-based virtual screening
-
Kovač, A.; Konc, J.; Vehar, B.; Bostock, J. M.; Chopra, I.; Janežič, D.; Gobec, S. Discovery of new inhibitors of d -alanine: d -alanine ligase by structure-based virtual screening J. Med. Chem. 2008, 52, 7442-7448
-
(2008)
J. Med. Chem.
, vol.52
, pp. 7442-7448
-
-
Kovač, A.1
Konc, J.2
Vehar, B.3
Bostock, J.M.4
Chopra, I.5
Janežič, D.6
Gobec, S.7
-
69
-
-
1642288258
-
Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening
-
DOI 10.1021/jm000017s
-
Boehm, H. J.; Boehringer, M.; Bur, D.; Gmuender, H.; Huber, W.; Klaus, W.; Kostrewa, D.; Kuehne, H.; Luebbers, T.; Meunier-Keller, N.; Mueller, F. Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alernative to random screening J. Med. Chem. 2000, 43, 2664-2674 (Pubitemid 30463915)
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, Issue.14
, pp. 2664-2674
-
-
Boehm, H.-J.1
Boehringer, M.2
Bur, D.3
Gmuender, H.4
Huber, W.5
Klaus, W.6
Kostrewa, D.7
Kuehne, H.8
Luebbers, T.9
Meunier-Keller, N.10
Mueller, F.11
-
70
-
-
71749089252
-
Discovery and optimization of antibacterial AccC inhibitors
-
Cheng, C. C.; Shipps, G. W., Jr.; Yang, Z.; Sun, B.; Kawahata, N.; Soucy, K. A.; Soriano, A.; Orth, P.; Xiao, L.; Mann, P.; Black, T. Discovery and optimization of antibacterial AccC inhibitors Bioorg. Med. Chem. Lett. 2009, 19, 6507-6514
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 6507-6514
-
-
Cheng, C.C.1
Shipps, Jr.G.W.2
Yang, Z.3
Sun, B.4
Kawahata, N.5
Soucy, K.A.6
Soriano, A.7
Orth, P.8
Xiao, L.9
Mann, P.10
Black, T.11
-
71
-
-
46849089254
-
Recent developments in fragment-based drug discovery
-
DOI 10.1021/jm8000373
-
Congreve, M.; Chessari, G.; Tisi, D.; Woodhead, A. J. Recent developments in fragment-based drug discovery J. Med. Chem. 2008, 51, 3661-3680 (Pubitemid 351956496)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.13
, pp. 3661-3680
-
-
Congreve, M.1
Chessari, G.2
Tisi, D.3
Woodhead, A.J.4
-
72
-
-
77950816491
-
Optimization of the interligand Overhauser effect for fragment linking: Application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase
-
Sledz, P.; Silvestre, L.; Hung, A. W.; Ciulli, A.; Blundell, T. L.; Abell, C. Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase J. Am. Chem. Soc. 2010, 132, 4544-4545
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 4544-4545
-
-
Sledz, P.1
Silvestre, L.2
Hung, A.W.3
Ciulli, A.4
Blundell, T.L.5
Abell, C.6
-
73
-
-
15044349115
-
The efficiency of multi-target drugs: The network approach might help drug design
-
DOI 10.1016/j.tips.2005.02.007
-
Csermely, P.; Ágoston, V.; Pongor, S. The efficiency of multi-target drugs: the network approach may help drug design Trends Pharmacol. Sci. 2005, 26, 178-182 (Pubitemid 40432652)
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, Issue.4
, pp. 178-182
-
-
Csermely, P.1
Agoston, V.2
Pongor, S.3
-
74
-
-
51849112827
-
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: Intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships
-
Charifson, P. S.; Grillot, A.; Grossman, T. H.; Parsons, J. D.; Badia, M.; Bellon, S.; Deininger, D. D.; Drumm, J. E.; Gross, C. H.; Le Tiran, A.; Liao, Y.; Mani, N.; Nicolau, D. P.; Perola, E.; Ronkin, S.; Shannon, D.; Swenson, L. L.; Tang, Q.; Tessier, P. R.; Tian, S.; Trudeau, M.; Wang, T.; Wei, Y.; Zhang, H.; Stamos, D. Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships J. Med. Chem. 2008, 51, 5243-5263
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5243-5263
-
-
Charifson, P.S.1
Grillot, A.2
Grossman, T.H.3
Parsons, J.D.4
Badia, M.5
Bellon, S.6
Deininger, D.D.7
Drumm, J.E.8
Gross, C.H.9
Le Tiran, A.10
Liao, Y.11
Mani, N.12
Nicolau, D.P.13
Perola, E.14
Ronkin, S.15
Shannon, D.16
Swenson, L.L.17
Tang, Q.18
Tessier, P.R.19
Tian, S.20
Trudeau, M.21
Wang, T.22
Wei, Y.23
Zhang, H.24
Stamos, D.25
more..
-
75
-
-
0035979336
-
Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase
-
DOI 10.1021/bi010504p
-
Burk, D. L.; Hon, W. C.; Leung, A. K.-W; Berghuis, A. M. Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase Biochemistry 2001, 40, 8756-8764 (Pubitemid 32709507)
-
(2001)
Biochemistry
, vol.40
, Issue.30
, pp. 8756-8764
-
-
Burk, D.L.1
Hon, W.C.2
Leung, A.K.-W.3
Berghuis, A.M.4
-
76
-
-
0036851016
-
Analysis of the π-π stacking interactions between the aminoglycoside antibiotic kinase APH(3′)-IIIa and its nucleotide ligands
-
DOI 10.1016/S1074-5521(02)00245-4, PII S1074552102002454
-
Boehr, D. D.; Farley, A. R.; Wright, G. D.; Cox, J. R. Analysis of the π-π stacking interactions between the aminoglycoside antibiotic kinase APH(3′)-IIIa and its nucleotide ligands Chem. Biol. 2002, 9, 1209-1217 (Pubitemid 35348274)
-
(2002)
Chemistry and Biology
, vol.9
, Issue.11
, pp. 1209-1217
-
-
Boehr, D.D.1
Farley, A.R.2
Wright, G.D.3
Cox, J.R.4
-
77
-
-
24944521513
-
Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3′)-IIIa]
-
DOI 10.1021/bi051085p
-
Boehr, D. D.; Farley, A. R.; LaRonde, F. J.; Murdock, T. R.; Wright, G. D.; Cox, J. R. Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3′)-IIIa] Biochemistry 2005, 44, 12445-12453 (Pubitemid 41324336)
-
(2005)
Biochemistry
, vol.44
, Issue.37
, pp. 12445-12453
-
-
Boehr, D.D.1
Farley, A.R.2
LaRonde, F.J.3
Murdock, T.R.4
Wright, G.D.5
Cox, J.R.6
-
78
-
-
32344437061
-
Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action
-
DOI 10.1021/bi051873e
-
Wang, S.; Eisenberg, D. Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action Biochemistry 2006, 45, 1554-1561 (Pubitemid 43222099)
-
(2006)
Biochemistry
, vol.45
, Issue.6
, pp. 1554-1561
-
-
Wang, S.1
Eisenberg, D.2
-
79
-
-
0038333266
-
Positional isotope exchange analysis of the pantothenate synthetase reaction
-
DOI 10.1021/bi0340853
-
Williams, L.; Zheng, R.; Blanchard, J. S.; Raushel, F. M. Positional isotope exchange analysis of the pantothenate synthetase reaction Biochemistry 2003, 42, 5108-5113 (Pubitemid 36532065)
-
(2003)
Biochemistry
, vol.42
, Issue.17
, pp. 5108-5113
-
-
Williams, L.1
Zheng, R.2
Blanchard, J.S.3
Raushel, F.M.4
-
80
-
-
33748952703
-
The design and synthesis of inhibitors of pantothenate synthetase
-
DOI 10.1039/b609482a
-
Tuck, K. L.; Saldanha, S. A.; Birch, L. M.; Smith, A. G.; Abell, C. The design and synthesis of inhibitors of pantothenate synthetase Org. Biomol. Chem. 2006, 4, 3598-3610 (Pubitemid 44439880)
-
(2006)
Organic and Biomolecular Chemistry
, vol.4
, Issue.19
, pp. 3598-3610
-
-
Tuck, K.L.1
Saldanha, S.A.2
Birch, L.M.3
Smith, A.G.4
Abell, C.5
-
81
-
-
59449099151
-
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate
-
Ciulli, A.; Scott, D. E.; Ando, M.; Reyes, F.; Saldanha, S. A.; Tuck, K. L.; Chirgadze, D. Y.; Blundel, T. L.; Abell, C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate ChemBioChem 2008, 9, 2606-2611
-
(2008)
ChemBioChem
, vol.9
, pp. 2606-2611
-
-
Ciulli, A.1
Scott, D.E.2
Ando, M.3
Reyes, F.4
Saldanha, S.A.5
Tuck, K.L.6
Chirgadze, D.Y.7
Blundel, T.L.8
Abell, C.9
-
82
-
-
73149092359
-
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry
-
Scott, D. E.; Dawes, G. J.; Ando, M.; Abell, C.; Ciulli, A. A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry ChemBioChem 2009, 10, 2772-2779
-
(2009)
ChemBioChem
, vol.10
, pp. 2772-2779
-
-
Scott, D.E.1
Dawes, G.J.2
Ando, M.3
Abell, C.4
Ciulli, A.5
-
83
-
-
77952849162
-
ProBiS algorithm for detection of structurally similar protein binding sites by local structural alignment
-
Konc, J.; Janezic, D. ProBiS algorithm for detection of structurally similar protein binding sites by local structural alignment Bioinformatics 2010, 26, 1160-1168
-
(2010)
Bioinformatics
, vol.26
, pp. 1160-1168
-
-
Konc, J.1
Janezic, D.2
-
84
-
-
77954292764
-
ProBiS: A Web server for detection of structurally similar protein binding sites
-
Konc, J.; Janezic, D. ProBiS: a Web server for detection of structurally similar protein binding sites Nucleic Acids Res. 2010, 38, 436-440
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 436-440
-
-
Konc, J.1
Janezic, D.2
-
86
-
-
24944497371
-
Features of selective kinase inhibitors
-
DOI 10.1016/j.chembiol.2005.04.011
-
Knight, Z. A.; Shokat, K. M. Features of selective kinase inhibitors Chem. Biol. 2005, 12, 621-637 (Pubitemid 43142039)
-
(2005)
Chemistry and Biology
, vol.12
, Issue.6
, pp. 621-637
-
-
Knight, Z.A.1
Shokat, K.M.2
|