The design and synthesis of inhibitors of pantothenate synthetase

Organic and Biomolecular Chemistry

Volumn 4, Issue 19, 2006, Pages 3598-3610

  Tuck, Kellie L ^a   Saldanha, S Adrian ^a   Birch, Louise M ^a   Smith, Alison G ^b   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Department of Plant Sciences ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CATALYSIS; CONDENSATION; ENZYMES; ESTERS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

PANTOTHENATE SYNTHETASE; PANTOYL ADENYLATE; STRUCTURAL SIMILARITY; SULFAMOYL GROUP;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; ENZYME INHIBITOR; ESTER; PANTOTHENATE SYNTHETASE; PEPTIDE SYNTHASE; SULFONAMIDE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; PROTEIN SECONDARY STRUCTURE; SYNTHESIS; TEMPERATURE;

ADENOSINE TRIPHOSPHATE; ENZYME INHIBITORS; ESCHERICHIA COLI; ESTERS; KINETICS; MODELS, MOLECULAR; PEPTIDE SYNTHASES; PROTEIN STRUCTURE, SECONDARY; SULFONAMIDES; TEMPERATURE;

EID: 33748952703     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b609482a     Document Type: Article

References (30)

1. F. Neidhardt, Escherichia coli and Salmonella typhimurium: cellular and molecular biology, American Society for Microbiology, Washington, DC, 2nd edn, 1996, vol. 1, p. 687
2. J. E. Cronan, Jr. K. J. Little S. Jackowski J. Bacteriol. 1982 149 916
3. M. E. Webb A. G. Smithh C. Abell Nat. Prod. Rep. 2004 21 695
4. R. Zheng S. Blanchard Biochemistry 2001 40 12904
5. K. Miyatake Y. Nakano S. Kitaoka J. Nutr. Sci. Vitaminol. 1978 24 243
6. F. von Delft A. Lewendon V. Dhanaraj T. L. Blundell C. Abell A. G. Smith Structure 2001 9 439
7. J. Lee S. U. Kang S. Y. Kim S. E. Kim M. K. Kang Y. J. Jo S. Kim Bioorg. Med. Chem. Lett. 2001 11 961
8. J. Lee S. U. Kang S. Y. Kim S. E. Kim Y. J. Jo S. Kim Bioorg. Med. Chem. Lett. 2001 11 965
9. L. Koroniak M. Ciustea J. A. Gutierrez N. G. J. Richards Org. Lett. 2003 5 2033
10. D. Heacock C. J. Forsyth S. Kiyotaka K. Musier-Forsyth Bioorg. Chem. 1996 24 273
11. J. Lee S. E. Kim J. Y. Lee S. Y. Kim S. U. Kang S. H. Seo M. W. Chun T. Kang S. Y. Choi H. O. Kim Bioorg. Med. Chem. Lett. 2003 13 1087
12. A. C. Baillie C. L. Cornell B. J. Wright K. Wright Tetrahedron Lett. 1992 33 5133
13. V. H. Cheldelin C. A. Schink J. Am. Chem. Soc. 1947 69 2625
14. S. S. Wang D. Eisenberg Protein Sci. 2003 12 1097
15. S. Wang D. Eisenberg Biochemistry 2006 45 1554
16. J. D. Thompson D. G. Higgins T. J. Gibson Nucleic Acids Res. 1994 22 4673
17. A. C. Wallace R. A. Laskowski J. M. Thornton Protein Eng. 1995 8 127
18. Tripos SYBYL v6.5, Tripos, Inc, South Hanley Road, St Louis, Missouri, 63144, USA, 1699
19. G. Jones P. Willet R. C. Glen J. Mol. Biol. 1995 245 43
20. G. Jones P. Willet R. C. Glen A. R. Leach R. Taylor J. Mol. Biol. 1997 267 727
21. D. L. Hughes The Mitsunobu reaction Org. React. 1992 42 337
22. C. J. Koch S. Simonyiová J. Pabel A. Kärtner K. Polborn K. T. Wanner Eur. J. Org. Chem. 2003 7 1244
23. H. C. Aspinall N. Greeves W. Lee E. G. McIver P. M. Smith Tetrahedron Lett. 1997 38 4679
24. A. K. Forrest R. L. Jarvest L. M. Mensah P. J. O'Hanlon A. J. Pope R. J. Sheppard Bioorg. Med. Chem. Lett. 2000 10 1871
25. I. D. Jenkins P. H. Verheyden J. G. Moffatt J. Am. Chem. Soc. 1976 98 3346
26. J. Castro-Pichel M. T. Garcia-López F. G. De las Heras Tetrahedron 1987 43 383
27. G. W. Anderson J. E. Zimmerman F. M. Callahan J. Am. Chem. Soc. 1964 86 183
28. K. Miyatake Y. Nakano S. Kitaoka Agric. Biol. Chem. 1973 37 1205
29. A. Cornish-Bowden, Fundamentals of Enzyme Kinetics, Portland Press, London, 2004, pp. 113-140
30. E. F. Pettersen T. D. Goddard C. C. Huang G. S. Couch D. M. Greenblatt E. C. Meng T. E. Ferrin J. Comput. Chem. 2004 25 1605