5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3- carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: Initiating a quest for new antitubercular drugs

Journal of Medicinal Chemistry

Volumn 51, Issue 7, 2008, Pages 1999-2002

  Velaparthi, Subash ^a   Brunsteiner, Michael ^a   Uddin, Reaz ^a   Wan, Baojie ^a   Franzblau, Scott G ^a   Petukhov, Pavel A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 TERT BUTYL N PYRAZOL 4 YL 4,5,6,7 TETRAHDYROBENZO[D]ISOXAZOLE 3 CARBOXAMIDE; PANTOTHENIC ACID; SYNTHETASE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; IC 50; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; ISOXAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41849134287     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701372r     Document Type: Article

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