A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 6, 2009, Pages 1737-1742

  Miller, J Richard ^a   Dunham, Steve ^a   Mochalkin, Igor ^a   Banotai, Craig ^a   Bowman, Matthew ^a   Buist, Susan ^a   Dunkle, Bill ^a   Hanna, Debra ^a   Harwood, H James ^a   Huband, Michael D ^a   Karnovsky, Alla ^a   Kuhn, Michael ^a   Limberakis, Chris ^a   Liu, Jia Y ^a   Mehrens, Shawn ^a   Mueller, W Thomas ^a   Narasimhan, Lakshmi ^a   Ogden, Adam ^a   Ohren, Jeff ^a   Prasad, J V N Vara ^a   Shelly, John A ^a   Skerlos, Laura ^a   Sulavik, Mark ^a   Thomas, V Hayden ^a   VanderRoest, Steve ^a   Wang, LiAnn ^a   Wang, Zhigang ^a   Whitton, Amy ^a   Zhu, Tong ^a   Stover, C Kendall ^a   more..

^a PFIZER INC   (United States)

Author keywords

Acetylcoenzyme A carboxylase; Biotin carboxylase; Crystal structure; Fatty acid biosynthesis; High throughput screening

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; ANTIINFECTIVE AGENT; BIOTIN CARBOXYLASE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PYRIDOPYRIMIDINE COMPOUND 1; PYRIDOPYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CELL SCREENING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; GRAM NEGATIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT;

ANTI-BACTERIAL AGENTS; CARBON-NITROGEN LIGASES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GRAM-NEGATIVE BACTERIA; HAEMOPHILUS INFLUENZAE; MORAXELLA (BRANHAMELLA) CATARRHALIS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; SMALL MOLECULE LIBRARIES;

BACTERIA (MICROORGANISMS); EUKARYOTA; HAEMOPHILUS INFLUENZAE; NEGIBACTERIA;

EID: 60549115249     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811275106     Document Type: Article

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