Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3′)-IIIa]

Biochemistry

Volumn 44, Issue 37, 2005, Pages 12445-12453

  Boehr, David D ^a,c   Farley, Adam R ^b,d   LaRonde, Frank J ^a   Murdock, Tera Rica ^b   Wright, Gerard D ^a   Cox, James R ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b MURRAY STATE UNIVERSITY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; COMPLEXATION; ENZYME INHIBITION; HYDROGEN BONDS; MOLECULAR STRUCTURE;

ADENINE BINDING; MOLECULAR RECOGNITION; PROTEIN KINASES; WATER MOLECULES;

ENZYMES;

1 DEAZAADENOSINE; 2 CHLOROADENOSINE; 3 DEAZAADENOSINE; 8 BROMOADENOSINE; ADENINE; ADENOSINE; ADENOSINE DERIVATIVE; ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDE 3' PHOSPHOTRANSFERASE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; KANAMYCIN; NEBULARINE; PHOSPHOTRANSFERASE; TUBERCIDIN; UNCLASSIFIED DRUG;

ANTIBIOTIC THERAPY; ARTICLE; DRUG PROTEIN BINDING; ENZYME BINDING; HYDROGEN BOND; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ADENINE; AMINO ACID SEQUENCE; BINDING SITES; DNA PRIMERS; ELECTROSTATICS; KANAMYCIN KINASE; KINETICS; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN KINASES; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PROPERTIES; THERMODYNAMICS;

PYRONIA TITHONUS;

EID: 24944521513     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051085p     Document Type: Article

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