Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): A Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 5, 2004, Pages 1856-1864

  Bellon, Steven ^a,b   Parsons, Jonathan D ^a   Wei, Yunyi ^a   Hayakawa, Koto ^a   Swenson, Lora L ^a   Charifson, Paul S ^a   Lippke, Judith A ^a   Aldape, Robert ^a   Gross, Christian H ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; AMINO ACID; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; NOVOBIOCIN; PROTEIN PARE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL GENOME; CATALYSIS; CHROMOSOME REPLICATION; CRYSTAL STRUCTURE; DNA SUPERCOILING; DRUG DNA BINDING; DRUG MECHANISM; ENZYME KINETICS; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROLYSIS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANTI-BACTERIAL AGENTS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; NOVOBIOCIN; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2142814314     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.5.1856-1864.2004     Document Type: Article

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