Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

Nature Communications

Volumn 1, Issue 8, 2010, Pages

  Uemura, Kengo ^a,d   Farner, Katherine C ^a   Hashimoto, Tadafumi ^a   Nasser Ghodsi, Navine ^a   Wolfe, Michael S ^b   Koo, Edward H ^c   Hyman, Bradley T ^a   Berezovska, Oksana ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1;

ALLOSTERISM; ANIMAL CELL; ARTICLE; ASSAY; CONFORMATION; EMBRYO; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR DOCKING; MOUSE; NONHUMAN;

EID: 78650047391     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1129     Document Type: Article

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