Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol

Chemistry - An Asian Journal

Volumn 6, Issue 2, 2011, Pages 459-473

  Paterson, Ian ^a   Naylor, Guy J ^a   Gardner, Nicola M ^a   Guzmán, Esther ^b   Wright, Amy E ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

cytotoxicity; hybrids; natural products; total synthesis; tubulin

Indexed keywords

ANTI-CANCER AGENTS; ANTI-PROLIFERATIVE; BIOLOGICAL ASSAYS; BIOLOGICAL EVALUATION; CELL LINES; DICTYOSTATIN; DISCODERMOLIDE; DIVERSIFICATION STRATEGIES; ESTER LINKAGES; ETHER DERIVATIVES; FRANKENSTEINS; HUMAN CANCER CELLS; HYBRIDS; MACROCYCLICS; MACROLIDES; MARINE NATURAL PRODUCTS; METHOXY; MICROTUBULES; MODE OF ACTION; NATURAL PRODUCTS; POLYKETIDES; SIDE-CHAIN; STRUCTURAL COMPONENT; STRUCTURE ACTIVITY RELATIONSHIPS; SYNTHETIC ROUTES; TAXOTERE; TOTAL SYNTHESIS; TUBULIN;

CELL CULTURE; ESTERS; ETHERS;

CYTOTOXICITY;

ALKANE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; DICTYOSTATIN; DISCODERMOLIDE; DRUG DERIVATIVE; LACTONE; MACROLIDE; PACLITAXEL; PYRONE DERIVATIVE;

ARTICLE; CHEMISTRY; DRUG SCREENING; HUMAN; NEOPLASM; SYNTHESIS; TUMOR CELL LINE;

ALKANES; ANTIMITOTIC AGENTS; ANTINEOPLASTIC AGENTS; CARBAMATES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTONES; MACROLIDES; NEOPLASMS; PACLITAXEL; PYRONES;

EID: 79251515768     PISSN: 18614728     EISSN: 1861471X     Source Type: Journal    
DOI: 10.1002/asia.201000541     Document Type: Article

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